Entry
Name
Kaposi sarcoma-associated herpesvirus infection - Mus musculus (house mouse)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
mmu05167 Kaposi sarcoma-associated herpesvirus infection
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
106759 Ticam1; TIR domain containing adaptor molecule 1 [KO:K05842 ]
22031 Traf3; TNF receptor-associated factor 3 [KO:K03174 ]
15975 Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130 ]
15976 Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131 ]
20846 Stat1; signal transducer and activator of transcription 1 [KO:K11220 ]
20847 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
19106 Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195 ] [EC:2.7.11.1 ]
12981 Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427 ]
12770 Ccr1l1; C-C motif chemokine receptor 1 like 1 [KO:K04176 ]
14082 Fadd; Fas associated via death domain [KO:K02373 ]
12122 Bid; BH3 interacting domain death agonist [KO:K04726 ]
21937 Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158 ]
71609 Tradd; TNFRSF1A-associated via death domain [KO:K03171 ]
16151 Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210 ]
18035 Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
22059 Trp53; transformation related protein 53 [KO:K04451 ]
12575 Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625 ]
19645 Rb1; RB transcriptional corepressor 1 [KO:K06618 ]
14990 H2-M2; histocompatibility 2, M region locus 2 [KO:K06751 ]
14991 H2-M3; histocompatibility 2, M region locus 3 [KO:K06751 ]
14997 H2-M9; histocompatibility 2, M region locus 9 [KO:K06751 ]
15006 H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751 ]
15007 H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751 ]
15013 H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751 ]
15018 H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751 ]
15039 H2-T22; histocompatibility 2, T region locus 22 [KO:K06751 ]
15040 H2-T23; histocompatibility 2, T region locus 23 [KO:K06751 ]
15042 H2-T24; histocompatibility 2, T region locus 24 [KO:K06751 ]
15043 H2-T3; histocompatibility 2, T region locus 3 [KO:K06751 ]
224753 H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751 ]
224754 H2-M11; histocompatibility 2, M region locus 11 [KO:K06751 ]
224756 H2-M1; histocompatibility 2, M region locus 1 [KO:K06751 ]
224761 H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751 ]
333715 H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751 ]
399549 H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751 ]
15024 H2-T10; histocompatibility 2, T region locus 10 [KO:K06751 ]
110557 H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751 ]
110696 H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751 ]
14963 H2-Bl; histocompatibility 2, blastocyst [KO:K06751 ]
14964 H2-D1; histocompatibility 2, D region locus 1 [KO:K06751 ]
14972 H2-K1; histocompatibility 2, K1, K region [KO:K06751 ]
14985 H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751 ]
110558 H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751 ]
667977 H2-T26; histocompatibility 2, T region locus 26 [KO:K06751 ]
14980 H2-L; histocompatibility 2, D region locus L [KO:K06751 ]
15015 H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751 ]
240095 H2-M5; histocompatibility 2, M region locus 5 [KO:K06751 ]
630294 H2-T25; histocompatibility-2, T region locus 25 [KO:K06751 ]
15894 Icam1; intercellular adhesion molecule 1 [KO:K06490 ]
94071 Clec2h; C-type lectin domain family 2, member h [KO:K10071 ]
22186 Uba52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927 ]
66734 Map1lc3a; microtubule-associated protein 1 light chain 3 alpha [KO:K10435 ]
67443 Map1lc3b; microtubule-associated protein 1 light chain 3 beta [KO:K10435 ]
14688 Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536 ]
14693 Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537 ]
14695 Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825 ]
14696 Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538 ]
14697 Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539 ]
14702 Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826 ]
14704 Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540 ]
14706 Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541 ]
14708 Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543 ]
14709 Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544 ]
14700 Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545 ]
66066 Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546 ]
14701 Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347 ]
64337 Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547 ]
14699 Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548 ]
14710 Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
16653 Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827 ]
15251 Hif1a; hypoxia inducible factor 1, alpha subunit [KO:K08268 ]
30955 Pik3cg; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289 ] [EC:2.7.1.153 ]
320207 Pik3r5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290 ]
104709 Pik3r6; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
277360 Prex1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [KO:K12365 ]
16438 Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958 ]
16439 Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959 ]
16440 Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960 ]
19057 Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
19055 Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
19058 Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268 ]
19059 Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268 ]
18018 Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446 ]
18019 Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332 ]
18021 Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333 ]
73181 Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334 ]
14825 Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505 ]
20310 Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505 ]
22339 Vegfa; vascular endothelial growth factor A [KO:K05448 ]
18591 Pdgfb; platelet derived growth factor, B polypeptide [KO:K17386 ]
16195 Il6st; interleukin 6 signal transducer [KO:K05060 ]
20848 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
21414 Tcf7; transcription factor 7, T cell specific [KO:K02620 ]
21415 Tcf7l1; transcription factor 7 like 1 (T cell specific, HMG box) [KO:K04490 ]
21416 Tcf7l2; transcription factor 7 like 2, T cell specific, HMG box [KO:K04491 ]
16842 Lef1; lymphoid enhancer binding factor 1 [KO:K04492 ]
12912 Creb1; cAMP responsive element binding protein 1 [KO:K05870 ]
Compound
C00350 Phosphatidylethanolamine
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Lee HR, Brulois K, Wong L, Jung JU
Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
Journal
Reference
Authors
Liang C, Lee JS, Jung JU
Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
Journal
Reference
Authors
Cai Q, Verma SC, Lu J, Robertson ES
Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
Journal
Reference
Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
Journal
Reference
Authors
Areste C, Blackbourn DJ
Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
Journal
Reference
Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
Journal
Reference
Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
Journal
Reference
Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
Journal
Blood 95:1151-7 (2000)
Reference
Authors
Schulz TF, Cesarman E
Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
Journal
Reference
Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
Journal
Reference
Authors
Choi YB, Nicholas J
Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
Journal
Reference
Authors
McCormick C, Ganem D
Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
Journal
Reference
Authors
Wang HW, Boshoff C
Title
Linking Kaposi virus to cancer-associated cytokines.
Journal
Reference
Authors
Jarviluoma A, Ojala PM
Title
Cell signaling pathways engaged by KSHV.
Journal
Reference
Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
Journal
Reference
Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
Journal
Reference
Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
Journal
Reference
Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
Journal
Reference
Authors
Mesri EA, Cesarman E, Boshoff C
Title
Kaposi's sarcoma and its associated herpesvirus.
Journal
Reference
Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
Journal
Reference
Authors
Li Q, Means R, Lang S, Jung JU
Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
Journal
Reference
Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
Journal
Reference
Authors
Coscoy L, Ganem D
Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
Journal
Reference
Authors
Pratt ZL, Sugden B
Title
How human tumor viruses make use of autophagy.
Journal
Reference
Authors
Schulz TF, Moore PS
Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
Journal
Reference
Authors
Moore PS, Chang Y
Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
Journal
Reference
Authors
Verma SC, Robertson ES
Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
Journal
Reference
Authors
Jenner RG, Boshoff C
Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
Journal
Reference
Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
Journal
Reference
Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
Journal
Cancer Res 60:4873-80 (2000)
Reference
Authors
Abere B, Schulz TF
Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
Journal
Reference
Authors
Sodhi A, Montaner S, Gutkind JS
Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
Journal
Reference
Authors
Montaner S
Title
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
Journal
Reference
Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
Journal
Reference
Authors
Lagunoff M, Majeti R, Weiss A, Ganem D
Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
Journal
Reference
Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
Journal
Reference
Authors
Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
Journal
Reference
Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
Journal
Reference
Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
Journal
Reference
Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
Journal
Reference
Authors
Purushothaman P, Uppal T, Verma SC
Title
Molecular biology of KSHV lytic reactivation.
Journal
Reference
Authors
Fujimuro M, Hayward SD
Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
Journal
Reference
Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
Title
KSHV Genome Replication and Maintenance.
Journal
Related pathway
mmu04610 Complement and coagulation cascades
mmu04620 Toll-like receptor signaling pathway
mmu04650 Natural killer cell mediated cytotoxicity
KO pathway
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