Entry Name Thyroid cancer - Mus musculus (house mouse)
Description Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Ortholog table Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 76551 Ccdc6; coiled-coil domain containing 6 [KO:K09288 ]
27057 Ncoa4; nuclear receptor coactivator 4 [KO:K09289 ]
108989 Tpr; translocated promoter region, nuclear basket protein [KO:K09291 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
16653 Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827 ]
19016 Pparg; peroxisome proliferator activated receptor gamma [KO:K08530 ]
22059 Trp53; transformation related protein 53 [KO:K04451 ]
12575 Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625 ]
13197 Gadd45a; growth arrest and DNA-damage-inducible 45 alpha [KO:K04402 ]
17873 Gadd45b; growth arrest and DNA-damage-inducible 45 beta [KO:K04402 ]
23882 Gadd45g; growth arrest and DNA-damage-inducible 45 gamma [KO:K04402 ]
107986 Ddb2; damage specific DNA binding protein 2 [KO:K10140 ]
21414 Tcf7; transcription factor 7, T cell specific [KO:K02620 ]
21415 Tcf7l1; transcription factor 7 like 1 (T cell specific, HMG box) [KO:K04490 ]
21416 Tcf7l2; transcription factor 7 like 2, T cell specific, HMG box [KO:K04491 ]
16842 Lef1; lymphoid enhancer binding factor 1 [KO:K04492 ]
Reference Authors Kondo T, Ezzat S, Asa SL.
Title Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
Journal Reference Authors Chiloeches A, Marais R.
Title Is BRAF the Achilles' Heel of thyroid cancer?
Journal Reference Authors Reddi HV, McIver B, Grebe SK, Eberhardt NL
Title The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
Journal Reference Authors Santoro M, Melillo RM, Fusco A.
Title RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
Journal Reference Authors Pierotti MA, Greco A.
Title Oncogenic rearrangements of the NTRK1/NGF receptor.
Journal Reference Authors Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
Title Molecular pathology of well-differentiated thyroid carcinomas.
Journal Reference Authors Gimm O.
Title Thyroid cancer.
Journal Reference Authors Williams D.
Title Cancer after nuclear fallout: lessons from the Chernobyl accident.
Journal Related KO pathway LinkDB All DBs
