KEGG   PATHWAY: oaa04015
Entry
oaa04015                    Pathway                                
Name
Rap1 signaling pathway - Ornithorhynchus anatinus (platypus)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
oaa04015  Rap1 signaling pathway
oaa04015

Other DBs
GO: 0007264
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100076731  RAP1A; ras-related protein Rap-1A [KO:K04353]
100079331  RAP1B; ras-related protein Rap-1b [KO:K07836]
103169212  MRAS; ras-related protein M-Ras [KO:K07831]
100083319  RAPGEF5; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 5 [KO:K08019]
103166047  DOCK4; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 4 [KO:K17697]
100082705  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100074436  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100090612  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100075369  CALM1; calmodulin-1 [KO:K02183]
100083509  CALM2; calmodulin-2 [KO:K02183]
100085837  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103165382  calmodulin-A-like [KO:K02183]
114812128  CALM3; calmodulin-3 [KO:K02183]
114816270  CALML3; calmodulin-like protein 3 [KO:K02183]
114813183  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
100080814  F2RL3; proteinase-activated receptor 4 [KO:K04236]
100080337  P2RY1; P2Y purinoceptor 1 isoform X1 [KO:K04270]
100083506  fMet-Leu-Phe receptor-like [KO:K04172]
100083486  fMet-Leu-Phe receptor-like [KO:K04172]
100077696  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100079033  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
114812808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
114807801  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103166702  ADORA2A; adenosine receptor A2a [KO:K04266]
100078270  ADORA2B; adenosine receptor A2b [KO:K04267]
100080392  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103168601  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100089708  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100085901  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103168714  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
114811232  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100081118  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100076221  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100077908  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100080569  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100680839  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
100084234  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
100080691  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100078508  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100084272  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100081349  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100086536  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100080124  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100090421  RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100078822  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114815531  FGF2; fibroblast growth factor 2 [KO:K18497]
100075228  FGF4; fibroblast growth factor 4 [KO:K04358]
100075300  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
100089319  FGF9; fibroblast growth factor 9 [KO:K04358]
100073730  FGF5; fibroblast growth factor 5 [KO:K04358]
100093377  FGF18; fibroblast growth factor 18 [KO:K04358]
100089414  FGF22; fibroblast growth factor 22 [KO:K04358]
100088500  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100089135  FGF20; fibroblast growth factor 20 [KO:K04358]
100080372  FGF8; fibroblast growth factor 8 [KO:K04358]
100075757  FGF10; fibroblast growth factor 10 [KO:K04358]
103165700  FGF6; fibroblast growth factor 6 [KO:K04358]
100084373  FGF16; fibroblast growth factor 16 [KO:K04358]
114813732  FGF7; fibroblast growth factor 7 [KO:K04358]
100075189  FGF19; fibroblast growth factor 19 [KO:K22603]
114807786  FGF23; fibroblast growth factor 23 [KO:K22428]
100074403  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
114810063  INS; insulin [KO:K04526]
100075905  IGF1; insulin-like growth factor I isoform X7 [KO:K05459]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100073393  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100080577  KITLG; kit ligand isoform X1 [KO:K05461]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100093060  PGF; placenta growth factor [KO:K16859]
100082290  VEGFD; vascular endothelial growth factor D [KO:K05449]
100084886  VEGFC; vascular endothelial growth factor C [KO:K05449]
100074892  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100075440  ANGPT1; angiopoietin-1 [KO:K05465]
100073414  ANGPT2; angiopoietin-2 [KO:K05466]
100085755  EFNA1; ephrin-A1 [KO:K05462]
100082899  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100085461  EFNA2; ephrin-A2 [KO:K05462]
100086594  ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [KO:K05462]
114807932  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100074240  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100084641  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100084071  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100081967  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100091625  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114816147  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
100079104  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100077556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100079755  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100075317  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100090501  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100090796  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100087557  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100075389  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100074264  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100090952  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100092854  CRK; adapter molecule crk isoform X1 [KO:K04438]
100076081  CRKL; crk-like protein [KO:K04438]
100075047  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
100085802  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100079609  CDH1; cadherin-1 [KO:K05689]
100080628  CTNNB1; catenin beta-1 [KO:K02105]
100080123  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100075875  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100075085  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X2 [KO:K06112]
100079239  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
100079932  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
114809080  LAT; linker for activation of T-cells family member 1 [KO:K07362]
100076091  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
100077740  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
100092542  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100082317  PRKD1; serine/threonine-protein kinase D1 isoform X3 [KO:K06070] [EC:2.7.11.13]
100086293  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
100681475  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
100093143  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
100076148  CNR1; cannabinoid receptor 1 [KO:K04277]
100075665  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100089995  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100077742  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100079602  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100087082  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
100074999  rap1 GTPase-activating protein 1-like isoform X1 [KO:K17700]
100073503  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 [KO:K17701]
100087074  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
100073785  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
100091089  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
100092988  THBS1; thrombospondin-1 [KO:K16857]
100080818  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100075904  RALA; ras-related protein Ral-A [KO:K07834]
100087330  RALB; ras-related protein Ral-B [KO:K07835]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100092844  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114808823  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100075248  amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
100080260  TLN2; talin-2 [KO:K06271]
100093518  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
114815046  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100087807  PFN3; profilin-3 [KO:K05759]
100076098  PFN2; profilin-2 isoform X1 [KO:K05759]
100078341  PFN4; profilin-4 isoform X2 [KO:K05759]
114808039  PFN1; profilin-1 [KO:K05759]
100092830  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
100081889  ENAH; protein enabled homolog isoform X1 [KO:K05746]
100082156  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
100085078  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100092493  actin, cytoplasmic type 5 [KO:K05692]
100078865  ACTB; actin, cytoplasmic 1 [KO:K05692]
100076932  ARAP3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100079193  transforming protein RhoA-like [KO:K04513]
107547224  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100082565  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
100086186  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100075831  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100073433  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100085604  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100088712  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100077371  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100086925  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100077211  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
114807305  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
100089779  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100077834  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100074808  AFDN; afadin isoform X1 [KO:K05702]
100089625  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
100093203  KRIT1; krev interaction trapped protein 1 [KO:K17705]
114807467  RGS14; regulator of G-protein signaling 14 [KO:K17706]
100092666  RASSF5; ras association domain-containing protein 5 [KO:K08015]
100090742  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100085462  integrin alpha-M isoform X3 [KO:K06461]
100092394  ITGB2; integrin beta-2 [KO:K06464]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100086380  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100080734  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100078394  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100078507  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100091330  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100092264  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100093026  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103169567  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
114814624  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
oaa04010  MAPK signaling pathway
oaa04014  Ras signaling pathway
oaa04020  Calcium signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa04510  Focal adhesion
oaa04520  Adherens junction
oaa04660  T cell receptor signaling pathway
oaa04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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