KEGG   PATHWAY: oaa04151
Entry
oaa04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Ornithorhynchus anatinus (platypus)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
oaa04151  PI3K-Akt signaling pathway
oaa04151

Other DBs
GO: 0043491
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100090413  TGFA; protransforming growth factor alpha [KO:K08774]
100080142  EREG; proepiregulin [KO:K09784]
100080112  AREG; amphiregulin [KO:K09782]
100078822  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114815531  FGF2; fibroblast growth factor 2 [KO:K18497]
100075228  FGF4; fibroblast growth factor 4 [KO:K04358]
100075300  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
100089319  FGF9; fibroblast growth factor 9 [KO:K04358]
100073730  FGF5; fibroblast growth factor 5 [KO:K04358]
100093377  FGF18; fibroblast growth factor 18 [KO:K04358]
100089414  FGF22; fibroblast growth factor 22 [KO:K04358]
100088500  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100089135  FGF20; fibroblast growth factor 20 [KO:K04358]
100080372  FGF8; fibroblast growth factor 8 [KO:K04358]
100075757  FGF10; fibroblast growth factor 10 [KO:K04358]
103165700  FGF6; fibroblast growth factor 6 [KO:K04358]
100084373  FGF16; fibroblast growth factor 16 [KO:K04358]
114813732  FGF7; fibroblast growth factor 7 [KO:K04358]
100075189  FGF19; fibroblast growth factor 19 [KO:K22603]
114807786  FGF23; fibroblast growth factor 23 [KO:K22428]
100074403  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
100081142  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
100081420  NTF3; neurotrophin-3 [KO:K04356]
114814648  NTF4; neurotrophin-4 [KO:K12457]
114810063  INS; insulin [KO:K04526]
100075905  IGF1; insulin-like growth factor I isoform X7 [KO:K05459]
791102  IGF2; insulin-like growth factor II [KO:K13769]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100073393  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100080577  KITLG; kit ligand isoform X1 [KO:K05461]
103165584  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100093060  PGF; placenta growth factor [KO:K16859]
100082290  VEGFD; vascular endothelial growth factor D [KO:K05449]
100084886  VEGFC; vascular endothelial growth factor C [KO:K05449]
100074892  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100075440  ANGPT1; angiopoietin-1 [KO:K05465]
100073414  ANGPT2; angiopoietin-2 [KO:K05466]
100085755  EFNA1; ephrin-A1 [KO:K05462]
100082899  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100085461  EFNA2; ephrin-A2 [KO:K05462]
100086594  ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [KO:K05462]
114807932  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100081598  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
100077878  NRTN; neurturin [KO:K25414]
100088966  ARTN; artemin [KO:K25415]
100082429  PSPN; persephin [KO:K25416]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100091139  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100079793  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100077353  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100074240  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100084641  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100084071  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100081967  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100091625  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114816147  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
103167743  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100080080  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100079104  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100077556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100079755  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100075317  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100090467  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100090501  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100090796  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100087557  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100075389  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100074264  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100090952  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100076319  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100075806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103170729  IRS1; insulin receptor substrate 1 [KO:K16172]
100081248  TLR2; toll-like receptor 2 [KO:K10159]
114811053  TLR4; toll-like receptor 4 [KO:K10160]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103166634  Ig heavy chain Mem5 [KO:K06856]
114808729  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103167269  LOW QUALITY PROTEIN: tyrosine-protein kinase SYK-like [KO:K05855] [EC:2.7.10.2]
107546899  CD19; B-lymphocyte antigen CD19 [KO:K06465]
100088978  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
114815005  GH1; LOW QUALITY PROTEIN: somatotropin [KO:K05438]
100083427  PRL; prolactin [KO:K05439]
100083298  IL6; interleukin-6 [KO:K05405]
114813216  IL7; interleukin-7 [KO:K05431]
100075323  IFN3; type I interferon 3 [KO:K05414]
100082925  IFNB1; interferon beta [KO:K05415]
114808091  EPO; erythropoietin [KO:K05437]
114815000  CSF3; granulocyte colony-stimulating factor [KO:K05423]
100085538  GHR; growth hormone receptor isoform X1 [KO:K05080]
100078100  PRLR; prolactin receptor [KO:K05081]
100076213  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
103165385  IL2RA; interleukin-2 receptor subunit alpha isoform X2 [KO:K05068]
100092851  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
114812802  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
114808214  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
103164911  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
100078445  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100083477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103170687  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
100088007  EPOR; erythropoietin receptor [KO:K05079]
100080173  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100082981  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100074305  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100085612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100681278  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100078516  COL27A1; collagen alpha-1(XXVII) chain [KO:K06236]
100079519  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100091569  COL2A1; collagen alpha-1(II) chain [KO:K19719]
100084401  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100073948  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100084415  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100078067  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100078102  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
103170730  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
100083653  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100093454  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100083924  collagen alpha-4(VI) chain-like [KO:K06238]
100083849  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
100076164  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100083893  collagen alpha-6(VI) chain isoform X1 [KO:K06238]
100079705  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
100074565  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100075830  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
100078011  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
100079917  LAMA1; laminin subunit alpha-1 [KO:K05637]
100074317  LAMA3; laminin subunit alpha-3 [KO:K06240]
100074506  LAMA5; laminin subunit alpha-5 [KO:K06240]
100074197  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100078794  LAMB1; laminin subunit beta-1 [KO:K05636]
103170249  laminin subunit beta-2-like isoform X1 [KO:K06243]
100075055  LAMB2; laminin subunit beta-2 [KO:K06243]
100079022  LAMB3; laminin subunit beta-3 [KO:K06244]
100085738  LAMC1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
100085748  LAMC2; laminin subunit gamma-2 [KO:K06246]
100075439  LAMC3; laminin subunit gamma-3 [KO:K06247]
107546986  CHAD; chondroadherin [KO:K06248]
100076682  RELN; reelin [KO:K06249] [EC:3.4.21.-]
100092988  THBS1; thrombospondin-1 [KO:K16857]
100082089  THBS2; thrombospondin-2 [KO:K04659]
100087962  THBS4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
100092744  cartilage oligomeric matrix protein [KO:K04659]
107546926  THBS3; thrombospondin-3 [KO:K04659]
100078116  FN1; fibronectin isoform X5 [KO:K05717]
100085686  SPP1; osteopontin [KO:K06250]
100086729  VTN; vitronectin [KO:K06251]
100084981  TNR; tenascin-R [KO:K06252]
100084954  TNN; tenascin-N isoform X1 [KO:K06252]
100076692  TNC; tenascin isoform X1 [KO:K06252]
100089817  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
103166232  VWF; von Willebrand factor isoform X1 [KO:K03900]
100085666  bone sialoprotein 2 [KO:K06253]
100085556  ITGA1; integrin alpha-1 [KO:K06480]
100076348  ITGA2; integrin alpha-2 [KO:K06481]
114815046  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
100080433  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100085588  ITGA4; integrin alpha-4 [KO:K06483]
100090507  ITGA5; integrin alpha-5 [KO:K06484]
100084141  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100087799  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100077343  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100086578  ITGA9; integrin alpha-9 [KO:K06585]
100088855  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
100085786  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100085661  ITGAV; integrin alpha-V [KO:K06487]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100090852  ITGB4; integrin beta-4 [KO:K06525]
100083529  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100081941  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
100087765  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100084596  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100076789  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
114813183  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
100086064  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
114815970  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04129]
100075952  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100077696  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100079033  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
114812808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
114807801  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103170464  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100077049  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114807890  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100090311  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100073829  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100081114  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100084993  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100082845  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114805646  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100092247  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100076953  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100088135  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100081252  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114813799  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
100078907  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100081920  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100085219  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100077961  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
114815157  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100078046  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100084050  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
103169312  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100089083  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100090823  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
114808770  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100075352  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100088284  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100084473  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100080641  TSC1; hamartin isoform X4 [KO:K07206]
100086661  TSC2; tuberin isoform X1 [KO:K07207]
100082482  RHEB; GTP-binding protein Rheb [KO:K07208]
100084442  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100079751  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100090165  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
100084037  EIF4EBP1; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100082898  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100084131  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100090683  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X2 [KO:K03259]
100087780  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100078852  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100090195  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100074741  RPS6; 40S ribosomal protein S6 [KO:K02991]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100086875  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
100075522  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
100075015  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
100073891  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
100080312  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
100079213  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100080123  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100075875  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100074365  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100081588  acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
100082155  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100082697  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100090340  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100075412  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100089094  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100082907  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100089164  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
100682117  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100081222  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
100680948  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
120638867  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100078965  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100079597  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584]
100078692  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100077457  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
114810293  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100082891  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100089224  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100076224  HSP90B1; endoplasmin [KO:K09487]
100081344  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
114808055  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
100076821  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
100079031  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100084106  MTCP1; protein p13 MTCP-1 [KO:K16837]
100091599  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
103167900  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
100092089  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100074446  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
107547250  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100073969  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100088404  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
100083297  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
100088723  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100092475  G6PC1; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
100079391  MYC; myc proto-oncogene protein [KO:K04377]
100075081  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114813305  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100090228  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114814505  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100091822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100088940  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100088334  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100075784  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100087197  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100080284  FOXO3; forkhead box protein O3 [KO:K09408]
100091282  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100081646  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100073859  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
100077972  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100089391  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
100093516  YWHAQ; 14-3-3 protein theta [KO:K16197]
100089523  YWHAE; 14-3-3 protein epsilon [KO:K06630]
100073451  YWHAH; 14-3-3 protein eta [KO:K16198]
100087373  YWHAG; 14-3-3 protein gamma [KO:K16198]
114810030  BAD; bcl2-associated agonist of cell death [KO:K02158]
107546921  BCL2L1; bcl-2-like protein 1 [KO:K04570]
114807635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100092345  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100093310  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100077942  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100089902  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100078176  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100092528  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100076562  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103165821  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100080655  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
100080771  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
114807992  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100074625  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
114811257  retinoic acid receptor RXR-alpha-like [KO:K08524]
100080213  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
100073613  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100082351  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100078925  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100074633  RELA; transcription factor p65 isoform X1 [KO:K04735]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100080477  MYB; transcriptional activator Myb isoform X2 [KO:K09420]
100080712  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100092821  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
oaa00010  Glycolysis / Gluconeogenesis
oaa04010  MAPK signaling pathway
oaa04012  ErbB signaling pathway
oaa04062  Chemokine signaling pathway
oaa04064  NF-kappa B signaling pathway
oaa04068  FoxO signaling pathway
oaa04110  Cell cycle
oaa04115  p53 signaling pathway
oaa04150  mTOR signaling pathway
oaa04210  Apoptosis
oaa04370  VEGF signaling pathway
oaa04510  Focal adhesion
oaa04620  Toll-like receptor signaling pathway
oaa04630  JAK-STAT signaling pathway
oaa04662  B cell receptor signaling pathway
oaa04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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