Entry Name Axon guidance - Ornithorhynchus anatinus (platypus)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Other DBs Organism Ornithorhynchus anatinus (platypus) [GN:
oaa ]
Gene 100073470 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
100073725 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
100073776 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100073788 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100073922 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
100074083 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100074273 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100075120 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 [KO:K24609 ]
100075265 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
100075665 GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
100076911 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
100077211 PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093 ]
100077742 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
100077893 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
100078427 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
100078715 DPYSL5; dihydropyrimidinase-related protein 5 isoform X1 [KO:K07529 ]
100078757 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
100079279 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100079408 TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
100080187 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
100082075 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100083890 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100086186 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
100086270 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100086594 ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [KO:K05462 ]
100086925 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
100087467 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100087638 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
100089453 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100089905 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100089995 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
103167126 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
114807305 PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093 ]
114814545 LRRC4; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4 [KO:K16351 ]
114815911 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related oaa04060 Cytokine-cytokine receptor interaction
oaa04810 Regulation of actin cytoskeleton
KO pathway 
