KEGG   PATHWAY: oaa04360
Entry
oaa04360                    Pathway                                
Name
Axon guidance - Ornithorhynchus anatinus (platypus)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
oaa04360  Axon guidance
oaa04360

Other DBs
GO: 0007411
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100075739  NTNG1; netrin-G1 isoform X1 [KO:K07522]
100085640  NTNG2; netrin-G2 [KO:K16359]
100073707  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
114814545  LRRC4; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4 [KO:K16351]
100082439  NTN1; netrin-1 [KO:K06843]
100085155  NTN3; netrin-3 [KO:K06843]
100078948  NTN4; LOW QUALITY PROTEIN: netrin-4 [KO:K06845]
100090531  netrin-4-like [KO:K06845]
100078379  DCC; LOW QUALITY PROTEIN: netrin receptor DCC [KO:K06765]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100076776  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100073725  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
100082395  TRPC3; short transient receptor potential channel 3 [KO:K04966]
100078427  TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967]
100073537  TRPC5; short transient receptor potential channel 5 [KO:K04968]
100079408  TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969]
100087467  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083890  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100073776  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083665  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
100077893  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100073470  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114815911  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100076789  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100073798  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
107547224  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100092844  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114808823  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100086186  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100083142  ABLIM1; actin-binding LIM protein 1 isoform X1 [KO:K07520]
100081668  ABLIM3; actin-binding LIM protein 3 isoform X1 [KO:K07520]
100083393  ABLIM2; actin-binding LIM protein 2 isoform X1 [KO:K07520]
100079992  NCK1; cytoplasmic protein NCK1 isoform X1 [KO:K07365]
100086384  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100075896  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100073584  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
103169124  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100084350  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100084781  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100079193  transforming protein RhoA-like [KO:K04513]
100079648  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100073941  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100084806  UNC5A; netrin receptor UNC5A [KO:K07521]
100083025  UNC5D; netrin receptor UNC5D isoform X1 [KO:K07521]
100077372  UNC5B; netrin receptor UNC5B isoform X1 [KO:K07521]
103167271  UNC5C; netrin receptor UNC5C isoform X1 [KO:K07521]
100089978  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100086381  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100074293  RGMA; repulsive guidance molecule A [KO:K23096]
100091678  repulsive guidance molecule A-like [KO:K23096]
100076606  NEO1; neogenin isoform X1 [KO:K06766]
100083806  MYL5; myosin light chain 5 [KO:K12753]
100073924  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100092114  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
100073922  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100075120  LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 [KO:K24609]
100085755  EFNA1; ephrin-A1 [KO:K05462]
100082899  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100085461  EFNA2; ephrin-A2 [KO:K05462]
100086594  ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [KO:K05462]
114807932  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100082180  EFNB2; ephrin-B2 [KO:K05463]
114808219  EFNB3; ephrin-B3 [KO:K05463]
114812803  EFNB1; ephrin-B1 [KO:K05463]
103169683  EPHA1; ephrin type-A receptor 1 isoform X1 [KO:K05102] [EC:2.7.10.1]
100090952  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100084577  EPHA3; ephrin type-A receptor 3 isoform X1 [KO:K05104] [EC:2.7.10.1]
100074435  EPHA4; LOW QUALITY PROTEIN: ephrin type-A receptor 4 [KO:K05105] [EC:2.7.10.1]
100079886  EPHA5; ephrin type-A receptor 5 isoform X1 [KO:K05106] [EC:2.7.10.1]
100089864  EPHA6; ephrin type-A receptor 6 isoform X3 [KO:K05107] [EC:2.7.10.1]
100073935  EPHA7; ephrin type-A receptor 7 isoform X6 [KO:K05108] [EC:2.7.10.1]
100087901  EPHA8; ephrin type-A receptor 8 isoform X1 [KO:K05109] [EC:2.7.10.1]
103166460  EPHB1; LOW QUALITY PROTEIN: ephrin type-B receptor 1 [KO:K05110] [EC:2.7.10.1]
100681631  EPHB2; ephrin type-B receptor 2 isoform X1 [KO:K05111] [EC:2.7.10.1]
100084066  EPHB3; ephrin type-B receptor 3 isoform X1 [KO:K05112] [EC:2.7.10.1]
100093589  EPHB4; LOW QUALITY PROTEIN: ephrin type-B receptor 4 [KO:K05113] [EC:2.7.10.1]
100077309  EPHB6; ephrin type-B receptor 6 isoform X1 [KO:K05114] [EC:2.7.10.1]
100075676  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100081889  ENAH; protein enabled homolog isoform X1 [KO:K05746]
100080153  RASA1; ras GTPase-activating protein 1 [KO:K04352]
100092272  NGEF; ephexin-1 [KO:K07525]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100077602  NCK2; cytoplasmic protein NCK2 [KO:K19862]
100082099  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
100079713  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100075665  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100089995  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100077742  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100681912  SLIT1; slit homolog 1 protein [KO:K06838]
100082591  SLIT2; slit homolog 2 protein isoform X1 [KO:K06839]
100078056  SLIT3; slit homolog 3 protein [KO:K06850]
100081300  ROBO1; roundabout homolog 1 isoform X1 [KO:K06753]
100081406  ROBO2; roundabout homolog 2 isoform X1 [KO:K06754]
100076265  ROBO3; LOW QUALITY PROTEIN: roundabout homolog 3 [KO:K06755]
100075265  SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
100076911  SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526]
100087638  SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526]
100075544  SEMA3C; semaphorin-3C [KO:K06840]
100077547  SEMA3F; semaphorin-3F isoform X1 [KO:K06840]
100074295  SEMA3D; semaphorin-3D isoform X1 [KO:K06840]
100074470  SEMA3E; semaphorin-3E isoform X1 [KO:K06840]
100074380  SEMA3A; semaphorin-3A isoform X2 [KO:K06840]
100087124  SEMA3G; semaphorin-3G [KO:K06840]
100681233  SEMA3B; semaphorin-3B isoform X1 [KO:K06840]
114812921  semaphorin-3F-like [KO:K06840]
100087728  PLXNA3; plexin-A3 [KO:K06820]
100078207  PLXNA2; plexin-A2 isoform X1 [KO:K06820]
100075458  PLXNA1; plexin-A1 isoform X1 [KO:K06820]
100681276  PLXNA4; plexin-A4 [KO:K06820]
100077040  NRP1; neuropilin-1 isoform X4 [KO:K06724]
100084300  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
100079954  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100074515  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
100081338  CFL2; LOW QUALITY PROTEIN: cofilin-2 [KO:K05765]
114810163  CFL1; cofilin-1 [KO:K05765]
100079730  RHOD; rho-related GTP-binding protein RhoD [KO:K07530]
100077610  RND1; rho-related GTP-binding protein Rho6 [KO:K07531]
100087242  FES; tyrosine-protein kinase Fes/Fps [KO:K07527] [EC:2.7.10.2]
100078715  DPYSL5; dihydropyrimidinase-related protein 5 isoform X1 [KO:K07529]
100090337  DPYSL2; dihydropyrimidinase-related protein 2 [KO:K07528]
100091902  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
100092089  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100078567  semaphorin-4E-like isoform X1 [KO:K06521]
100079247  SEMA4A; semaphorin-4A isoform X2 [KO:K06521]
100091021  SEMA4C; semaphorin-4C [KO:K06521]
100081255  SEMA4G; semaphorin-4G isoform X1 [KO:K06521]
100075233  SEMA4B; semaphorin-4B [KO:K06521]
100681253  SEMA4F; semaphorin-4F [KO:K06521]
100089807  SEMA5A; LOW QUALITY PROTEIN: semaphorin-5A [KO:K06841]
114815420  SEMA5B; semaphorin-5B [KO:K06841]
100082422  SEMA6A; semaphorin-6A isoform X7 [KO:K06842]
100088259  SEMA6D; semaphorin-6D isoform X1 [KO:K06842]
100090179  SEMA6B; semaphorin-6B isoform X2 [KO:K06842]
114808065  SEMA6C; semaphorin-6C [KO:K06842]
100088165  PLXNB2; plexin-B2 [KO:K06821]
100078327  PLXNB1; plexin-B1 [KO:K06821]
100080201  PLXNB3; plexin-B3 isoform X1 [KO:K06821]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114814624  RRAS; ras-related protein R-Ras [KO:K07829]
100076441  SEMA7A; semaphorin-7A [KO:K06529]
100079272  PLXNC1; plexin-C1 [KO:K06572]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100081692  SHH; sonic hedgehog protein [KO:K11988]
100079214  PTCH1; protein patched homolog 1 isoform X2 [KO:K06225]
100078770  SMO; smoothened homolog [KO:K06226]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114807332  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
100082574  BOC; brother of CDO isoform X4 [KO:K20020]
100085809  WNT5B; protein Wnt-5b [KO:K00444]
100088897  WNT5A; protein Wnt-5a [KO:K00444]
100086058  FZD3; frizzled-3 [KO:K02329]
100075140  RYK; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
100089453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100079279  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100074083  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100089905  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100075238  WNT4; protein Wnt-4 [KO:K00408]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100089083  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100077371  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100089779  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100086925  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100077211  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
114807305  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
100079088  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100076705  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103167640  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100079347  BMP7; bone morphogenetic protein 7 [KO:K16621]
100080533  GDF7; growth/differentiation factor 7 [KO:K20013]
100077247  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
100086574  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
oaa04010  MAPK signaling pathway
oaa04060  Cytokine-cytokine receptor interaction
oaa04310  Wnt signaling pathway
oaa04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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