KEGG   PATHWAY: oaa04510
Entry
oaa04510                    Pathway                                
Name
Focal adhesion - Ornithorhynchus anatinus (platypus)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
oaa04510  Focal adhesion
oaa04510

Other DBs
GO: 0005925
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073424  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100073427  EMP2; epithelial membrane protein 2 [KO:K26256]
100073433  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100073541  MYL10; myosin regulatory light chain 10 [KO:K12756]
100073584  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100073798  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100073894  EMP1; epithelial membrane protein 1 [KO:K26255]
100073924  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100073941  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
100073948  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100074197  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100074263  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100074317  LAMA3; laminin subunit alpha-3 [KO:K06240]
100074365  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100074395  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X3 [KO:K06269] [EC:3.1.3.16]
100074506  LAMA5; laminin subunit alpha-5 [KO:K06240]
100074559  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100074565  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100074892  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100075047  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
100075055  LAMB2; laminin subunit beta-2 [KO:K06243]
100075081  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100075389  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100075439  LAMC3; laminin subunit gamma-3 [KO:K06247]
100075715  VCL; vinculin isoform X1 [KO:K05700]
100075806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100075830  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
100075831  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100075896  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100075905  IGF1; insulin-like growth factor I isoform X7 [KO:K05459]
100076033  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100076081  CRKL; crk-like protein [KO:K04438]
100076164  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100076348  ITGA2; integrin alpha-2 [KO:K06481]
100076682  RELN; reelin [KO:K06249] [EC:3.4.21.-]
100076692  TNC; tenascin isoform X1 [KO:K06252]
100076731  RAP1A; ras-related protein Rap-1A [KO:K04353]
100076789  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100077046  FLNA; filamin-A isoform X1 [KO:K04437]
100077235  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100077243  [KO:K16060]
100077343  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100077407  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100077556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100078011  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
100078067  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100078102  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
100078116  FN1; fibronectin isoform X5 [KO:K05717]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100078635  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100078794  LAMB1; laminin subunit beta-1 [KO:K05636]
100078865  ACTB; actin, cytoplasmic 1 [KO:K05692]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100079022  LAMB3; laminin subunit beta-3 [KO:K06244]
100079091  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100079193  [KO:K04513]
100079331  RAP1B; ras-related protein Rap-1b [KO:K07836]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100079519  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100079536  CAV1; caveolin-1 [KO:K06278]
100079648  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100079705  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100079765  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100079889  [KO:K04725] [EC:2.3.2.27]
100079917  LAMA1; laminin subunit alpha-1 [KO:K05637]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100080260  TLN2; talin-2 [KO:K06271]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100080433  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100080469  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100080490  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100080628  CTNNB1; catenin beta-1 [KO:K02105]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100081397  SHC2; SHC-transforming protein 2 [KO:K17447]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100081577  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100081782  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
100081941  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100082089  THBS2; thrombospondin-2 [KO:K04659]
100082290  VEGFD; vascular endothelial growth factor D [KO:K05449]
100082590  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100083529  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100083653  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100083806  MYL5; myosin light chain 5 [KO:K12753]
100083849  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
100083893  [KO:K06238]
100083924  [KO:K06238]
100084141  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100084350  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100084401  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100084415  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100084462  FLNB; filamin-B isoform X1 [KO:K27392]
100084596  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100084781  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100084886  VEGFC; vascular endothelial growth factor C [KO:K05449]
100084954  TNN; tenascin-N isoform X1 [KO:K06252]
100084981  TNR; tenascin-R [KO:K06252]
100085078  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100085356  ACTL8; actin-like protein 8 [KO:K05692]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100085556  ITGA1; integrin alpha-1 [KO:K06480]
100085588  ITGA4; integrin alpha-4 [KO:K06483]
100085604  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100085661  ITGAV; integrin alpha-V [KO:K06487]
100085666  [KO:K06253]
100085686  SPP1; osteopontin [KO:K06250]
100085738  LAMC1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
100085748  LAMC2; laminin subunit gamma-2 [KO:K06246]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100085786  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100085802  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100086186  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100086380  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100086384  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100086578  ITGA9; integrin alpha-9 [KO:K06585]
100086729  VTN; vitronectin [KO:K06251]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100087416  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
100087557  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100087765  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100087799  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100087962  THBS4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
100088334  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100088546  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100088855  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
100088940  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100089083  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100089387  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100089817  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100090193  PARVB; beta-parvin [KO:K06275]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100090501  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100090507  ITGA5; integrin alpha-5 [KO:K06484]
100090796  [KO:K05096] [EC:2.7.10.1]
100090852  ITGB4; integrin beta-4 [KO:K06525]
100091139  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100091153  [KO:K12754]
100091283  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
100091379  [KO:K12958]
100091569  COL2A1; collagen alpha-1(II) chain [KO:K19719]
100092089  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100092114  [KO:K12757]
100092226  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100092243  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
100092267  PXN; paxillin isoform X1 [KO:K05760]
100092442  MYLK3; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100092493  [KO:K05692]
100092744  [KO:K04659]
100092830  [KO:K06274]
100092844  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100092854  CRK; adapter molecule crk isoform X1 [KO:K04438]
100092988  THBS1; thrombospondin-1 [KO:K16857]
100093060  PGF; placenta growth factor [KO:K16859]
100093454  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100093518  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
100681278  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100681469  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
100681591  PARVA; alpha-parvin [KO:K06275]
103165750  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
103166232  VWF; von Willebrand factor isoform X1 [KO:K03900]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
103168219  PARVG; gamma-parvin [KO:K06275]
103168955  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
103169124  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103169480  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
103169684  ZYX; zyxin [KO:K06273]
103170249  [KO:K06243]
103170730  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
107546926  THBS3; thrombospondin-3 [KO:K04659]
107546986  CHAD; chondroadherin [KO:K06248]
107547224  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114806542  CAV3; caveolin-3 [KO:K12959]
114807332  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
114807635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114808180  SHC1; SHC-transforming protein 1 [KO:K06279]
114808823  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
114809992  HRAS; GTPase HRas [KO:K02833]
114810030  BAD; bcl2-associated agonist of cell death [KO:K02158]
114814756  CAV2; caveolin-2 [KO:K12958]
114815046  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
114815109  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
oaa04010  MAPK signaling pathway
oaa04060  Cytokine-cytokine receptor interaction
oaa04070  Phosphatidylinositol signaling system
oaa04110  Cell cycle
oaa04151  PI3K-Akt signaling pathway
oaa04310  Wnt signaling pathway
oaa04512  ECM-receptor interaction
oaa04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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