KEGG   PATHWAY: oaa05202
Entry
oaa05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Ornithorhynchus anatinus (platypus)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
oaa05202  Transcriptional misregulation in cancer
oaa05202

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100082553  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
100079755  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100078069  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
100073405  RUNX1T1; protein CBFA2T1 isoform X2 [KO:K10053]
100093591  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100078158  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
100081304  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100076684  NCOR1; nuclear receptor corepressor 1 isoform X3 [KO:K04650]
100078506  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
100074740  PER2; period circadian protein homolog 2 isoform X1 [KO:K02633]
100076432  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
100682230  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100085462  integrin alpha-M isoform X3 [KO:K06461]
100093395  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100086720  junction plakoglobin isoform X1 [KO:K10056]
100076474  PML; protein PML [KO:K10054] [EC:2.3.2.-]
100092826  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
100080719  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100082357  CCNA2; cyclin-A2 [KO:K06627]
100087091  CEBPE; CCAAT/enhancer-binding protein epsilon isoform X1 [KO:K10051]
100076556  BCL2A1; bcl-2-related protein A1 [KO:K02162]
100075814  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
100079391  MYC; myc proto-oncogene protein [KO:K04377]
114816698  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100091463  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
100077375  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
100077974  WNT16; protein Wnt-16 [KO:K01558]
100092457  ETV6; transcription factor ETV6 [KO:K03211]
100093103  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
103168722  defensin-A3 isoform X2 [KO:K05230]
114807316  defensin-A2-like [KO:K05230]
114807392  defensin-A4-like [KO:K05230]
791113  neutrophil elastase [KO:K01327] [EC:3.4.21.37]
791103  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
100079691  granzyme B(G,H)-like isoform X1 [KO:K01353] [EC:3.4.21.79]
100082304  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
100086068  KMT2A; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
100085607  AFF1; AF4/FMR2 family member 1 isoform X3 [KO:K15184]
100091817  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
100081231  CCNT1; cyclin-T1 [KO:K15188]
100089894  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
100082585  MLLT1; protein ENL isoform X1 [KO:K15187]
100082672  MLLT3; protein AF-9 isoform X6 [KO:K15187]
114808748  protein ENL-like isoform X1 [KO:K15187]
100088528  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
114810262  LMO2; rhombotin-2 [KO:K15612]
100077727  PBX3; pre-B-cell leukemia transcription factor 3 isoform X3 [KO:K15610]
100080409  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
100079987  SMAD1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
100091522  KLF3; Krueppel-like factor 3 isoform X1 [KO:K15605]
100079500  MEF2C; myocyte-specific enhancer factor 2C isoform X4 [KO:K04454]
100077575  HOXA9; homeobox protein Hox-A9 [KO:K21950]
100077626  HOXA10; homeobox protein Hox-A10 [KO:K17443]
100079866  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
114816405  HMGA2; high mobility group protein HMGI-C [KO:K09283]
114807400  high mobility group protein HMGI-C-like [KO:K09283]
100081798  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
100087463  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
100084810  PROM1; prominin-1 precursor [KO:K06532]
103171467  prominin-1-A-like isoform X1 [KO:K06532]
100090467  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100075176  BMP2K; BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
100077556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100090228  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100085783  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
100078403  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
100077672  HOXA11; homeobox protein Hox-A11 [KO:K21951]
114816621  SIX1; homeobox protein SIX1 [KO:K15614]
100087264  SIX4; homeobox protein SIX4 [KO:K15615]
100090225  EYA1; eyes absent homolog 1 [KO:K15616] [EC:3.1.3.48]
114805449  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100089678  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
100079680  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100087301  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
114806584  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
100080821  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
100081882  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
100080236  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
100079450  LYL1; protein lyl-1 [KO:K15604]
114810021  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
100077645  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
100081576  REL; proto-oncogene c-Rel [KO:K09254]
100088940  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100077243  baculoviral IAP repeat-containing protein 2 [KO:K16060]
100681677  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
107546921  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100086970  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
114806068  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
100080402  BCL6; B-cell lymphoma 6 protein isoform X2 [KO:K15618]
103166634  Ig heavy chain Mem5 [KO:K06856]
103166486  MAF; LOW QUALITY PROTEIN: transcription factor Maf [KO:K09035]
100087765  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100086259  NSD2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
100078536  histone H3-like [KO:K11253]
100093165  histone H3 [KO:K11253]
100093188  histone H3-like [KO:K11253]
100093260  uncharacterized protein LOC100093260 [KO:K11253]
100093334  histone H3-like [KO:K11253]
100077438  histone H3.3A [KO:K11253]
100079219  uncharacterized protein LOC100079219 [KO:K11253]
100076264  histone H3.3A [KO:K11253]
100089717  histone H3.3A [KO:K11253]
114808073  histone H3 [KO:K11253]
114808000  histone H3 [KO:K11253]
100084219  histone H3 [KO:K11253]
120638153  histone H3 [KO:K11253]
100092203  uncharacterized protein LOC100092203 [KO:K11253]
100078238  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
100092700  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
100080852  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
100074625  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
114811257  retinoic acid receptor RXR-alpha-like [KO:K08524]
114817203  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
103169137  PRCC; proline-rich protein PRCC [KO:K13105]
100076328  TFE3; transcription factor E3 isoform X1 [KO:K09105]
114813305  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100080302  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
100079009  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
100079618  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100078960  PLAT; tissue-type plasminogen activator isoform X3 [KO:K01343] [EC:3.4.21.68]
100077197  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
100076732  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
100084042  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
100089180  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
103171380  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
100087347  ETV4; ETS translocation variant 4 [KO:K15592]
100087621  ETV5; ETS translocation variant 5 isoform X1 [KO:K15593]
100085616  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
100075154  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100079853  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100086701  MYCN; N-myc proto-oncogene protein [KO:K09109]
100084460  MAX; protein max isoform X1 [KO:K04453]
100080712  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100076789  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100092821  TP53; cellular tumor antigen p53 [KO:K04451]
100075752  polycomb complex protein BMI-1 [KO:K11459]
114814764  SP1; transcription factor Sp1 [KO:K04684]
100076280  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
103167743  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100091625  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114816147  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
103169404  MEN1; menin [KO:K14970]
100086321  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
100092331  FLI1; Friend leukemia integration 1 transcription factor [KO:K09436]
100075905  IGF1; insulin-like growth factor I isoform X7 [KO:K05459]
100084227  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
100076965  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100076387  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
114811993  FEV; protein FEV [KO:K09437]
100078805  ATF1; cyclic AMP-dependent transcription factor ATF-1 [KO:K09053]
100092280  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X3 [KO:K15589]
100078971  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100091078  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
100075190  WT1; Wilms tumor protein isoform X1 [KO:K09234]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100092851  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100074872  BAIAP3; LOW QUALITY PROTEIN: BAI1-associated protein 3 [KO:K15621]
100082670  TSPAN7; tetraspanin-7 isoform X1 [KO:K06571]
100085399  MLF1; myeloid leukemia factor 1 isoform X2 [KO:K15622]
100075565  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
100089670  TAF15; TATA-binding protein-associated factor 2N isoform X2 [KO:K14651]
100087740  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
103167225  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
103165264  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
100083298  IL6; interleukin-6 [KO:K05405]
100089070  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100074633  RELA; transcription factor p65 isoform X1 [KO:K04735]
103170567  interleukin-8-like [KO:K10030]
100074477  paired box protein Pax-3 [KO:K09381]
100088370  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
114813131  paired box protein Pax-3-like [KO:K09381]
100082288  FOXO1; forkhead box protein O1 [KO:K07201]
100090501  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100090796  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100074290  SS18L1; calcium-responsive transactivator [KO:K15623]
100073669  SS18; protein SSXT isoform X1 [KO:K15623]
103167506  ASPSCR1; tether containing UBX domain for GLUT4 [KO:K15627]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100081893  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114814649  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
114813317  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100088212  DDB2; DNA damage-binding protein 2 [KO:K10140]
100077423  POLK; DNA polymerase kappa isoform X2 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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Haematologica 94:78-86 (2009)
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Leuk Lymphoma 34:25-33 (1999)
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Leuk Lymphoma 36:435-45 (2000)
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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PMID:20153925
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MYCN oncoprotein targets and their therapeutic potential.
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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Cancer Res 69:7140-50 (2009)
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Oncogene 22:41-9 (2003)
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Semin Cancer Biol 15:197-205 (2005)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Int J Cancer 115:556-60 (2005)
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Oncogene 28:270-8 (2009)
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Expression of MET in alveolar soft part sarcoma.
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
oaa04115  p53 signaling pathway
oaa05211  Renal cell carcinoma
oaa05215  Prostate cancer
oaa05216  Thyroid cancer
oaa05221  Acute myeloid leukemia
KO pathway
ko05202   
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