KEGG   PATHWAY: ocu04360
Entry
ocu04360                    Pathway                                
Name
Axon guidance - Oryctolagus cuniculus (rabbit)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
ocu04360  Axon guidance
ocu04360

Other DBs
GO: 0007411
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008628  [KO:K05128] [EC:2.7.10.1]
100008826  [KO:K16621]
100008859  [KO:K17333]
100008898  [KO:K05719]
100008965  [KO:K04393]
100009220  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100009352  TRPC1; short transient receptor potential channel 1 [KO:K04964]
100009381  WNT5A; protein Wnt-5a precursor [KO:K00444]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009487  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100009535  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100009538  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100009574  TRPC5; short transient receptor potential channel 5 [KO:K04968]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100101556  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100101557  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
100126565  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100303773  [KO:K00408]
100328662  SEMA6C; semaphorin-6C precursor [KO:K06842]
100328746  L1CAM; neural cell adhesion molecule L1 precursor [KO:K06550]
100328763  PLXNA3; plexin-A3 precursor [KO:K06820]
100337822  [KO:K00922] [EC:2.7.1.153]
100338073  [KO:K05109] [EC:2.7.10.1]
100338309  [KO:K06850]
100338391  [KO:K04630]
100338427  [KO:K07521]
100338483  [KO:K05102] [EC:2.7.10.1]
100338590  [KO:K07520]
100338775  [KO:K05463]
100338780  [KO:K07527] [EC:2.7.10.2]
100338816  [KO:K06840]
100339066  [KO:K04630]
100339215  [KO:K20013]
100339517  [KO:K07293] [EC:3.1.3.48]
100339544  [KO:K02329]
100339559  [KO:K06840]
100339712  [KO:K07520]
100339741  [KO:K05703] [EC:2.7.10.2]
100339802  [KO:K07521]
100339873  [KO:K04392]
100340118  [KO:K07532]
100340139  [KO:K05859] [EC:3.1.4.11]
100340273  [KO:K06843]
100340354  [KO:K05114] [EC:2.7.10.1]
100340404  [KO:K06840]
100340661  [KO:K04513]
100340738  [KO:K07521]
100340742  [KO:K05736] [EC:2.7.11.1]
100340755  [KO:K06841]
100341119  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100341130  [KO:K23096]
100341507  [KO:K04515] [EC:2.7.11.17]
100341589  [KO:K05765]
100341599  [KO:K05704] [EC:2.7.10.2]
100341879  [KO:K07522]
100341934  [KO:K05734] [EC:2.7.11.1]
100342035  [KO:K16351]
100342042  [KO:K06821]
100342051  [KO:K06521]
100342258  [KO:K06755]
100342451  [KO:K04515] [EC:2.7.11.17]
100342531  [KO:K07531]
100343368  [KO:K04513]
100343384  [KO:K12755]
100343398  [KO:K04352]
100343414  [KO:K06820]
100343518  [KO:K05103] [EC:2.7.10.1]
100343668  [KO:K04966]
100343680  [KO:K04513]
100344018  [KO:K05743] [EC:2.7.11.1]
100344241  [KO:K07828]
100344245  [KO:K06753]
100344455  [KO:K07523]
100344482  [KO:K04393]
100344496  [KO:K05104] [EC:2.7.10.1]
100344533  [KO:K06268]
100344577  [KO:K05108] [EC:2.7.10.1]
100344825  [KO:K06765]
100344921  [KO:K05462]
100345030  [KO:K04237]
100345046  [KO:K06225]
100345181  [KO:K00922] [EC:2.7.1.153]
100345250  [KO:K02649]
100345257  [KO:K06754]
100345279  [KO:K06724]
100345523  [KO:K05106] [EC:2.7.10.1]
100345573  [KO:K06521]
100345591  [KO:K12757]
100345703  [KO:K07526]
100345909  [KO:K06619] [EC:2.7.10.2]
100346112  [KO:K12757]
100346189  [KO:K04189]
100346280  [KO:K06840]
100346504  [KO:K06766]
100346590  [KO:K06521]
100346617  [KO:K06572]
100346790  [KO:K06820]
100346837  [KO:K17388] [EC:2.7.11.39]
100346856  [KO:K04513]
100346924  [KO:K06521]
100347003  [KO:K17334]
100347202  [KO:K06844]
100347206  [KO:K04969]
100347273  [KO:K05733] [EC:2.7.11.1]
100347330  [KO:K05112] [EC:2.7.10.1]
100347345  [KO:K04371] [EC:2.7.11.24]
100347407  [KO:K04366] [EC:2.7.11.1]
100347455  [KO:K05725] [EC:2.7.10.2]
100347487  [KO:K07827]
100347510  [KO:K20020]
100347832  [KO:K24609]
100347884  [KO:K06521]
100347954  [KO:K06276] [EC:2.7.11.1]
100348083  [KO:K05110] [EC:2.7.10.1]
100348211  [KO:K06839]
100348561  [KO:K04371] [EC:2.7.11.24]
100348663  [KO:K00922] [EC:2.7.1.153]
100348771  [KO:K06521]
100348842  [KO:K03083] [EC:2.7.11.26]
100348921  [KO:K05735] [EC:2.7.11.1]
100348967  [KO:K04513]
100349557  [KO:K06093]
100349579  [KO:K00444]
100349958  [KO:K01116] [EC:3.1.4.11]
100350246  [KO:K04671] [EC:2.7.11.30]
100350899  [KO:K06093]
100350940  [KO:K06838]
100351024  [KO:K07521]
100351135  [KO:K07528]
100351275  [KO:K13578] [EC:2.7.11.30]
100351936  [KO:K05746]
100352056  [KO:K04409] [EC:2.7.11.1]
100352661  [KO:K06226]
100352774  [KO:K11988]
100352775  [KO:K02090] [EC:2.7.11.22]
100352864  [KO:K05463]
100353114  [KO:K06842]
100353321  [KO:K06093]
100353500  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100353506  [KO:K07529]
100353755  [KO:K19862]
100353818  [KO:K04967]
100353824  [KO:K17332]
100354300  [KO:K06841]
100355525  [KO:K06842]
100355759  [KO:K06272] [EC:2.7.11.1]
100355992  [KO:K06821]
100356245  [KO:K04348] [EC:3.1.3.16]
100356250  [KO:K04513]
100356520  [KO:K07860]
100356658  [KO:K07524]
100356755  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100356835  [KO:K05744] [EC:2.7.11.1]
100356958  [KO:K06845]
100356972  [KO:K06840]
100357064  [KO:K05105] [EC:2.7.10.1]
100357227  [KO:K06840]
100357479  [KO:K05463]
100357841  [KO:K02649]
100357849  [KO:K05107] [EC:2.7.10.1]
100357985  [KO:K07526]
100358004  [KO:K05462]
100358301  [KO:K16359]
100358703  [KO:K07365]
100358783  [KO:K06820]
100358959  [KO:K05462]
100359147  [KO:K04630]
100359205  [KO:K05765]
100359223  [KO:K05111] [EC:2.7.10.1]
100359286  [KO:K05113] [EC:2.7.10.1]
100359287  [KO:K06840]
103345545  [KO:K10031]
103346036  [KO:K06821]
103346352  [KO:K06529]
103347420  [KO:K07520]
103350046  [KO:K05462]
103352092  [KO:K07526]
103352487  [KO:K07525]
108178303  [KO:K05765]
127486605  [KO:K02833]
127488313  [KO:K02090] [EC:2.7.11.22]
127489207  [KO:K05462]
127489236  [KO:K07827]
127489362  [KO:K07829]
127489660  [KO:K04513]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
ocu04010  MAPK signaling pathway
ocu04060  Cytokine-cytokine receptor interaction
ocu04310  Wnt signaling pathway
ocu04810  Regulation of actin cytoskeleton
KO pathway
ko04360   

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