KEGG   PATHWAY: ocu04530
Entry
ocu04530                    Pathway                                
Name
Tight junction - Oryctolagus cuniculus (rabbit)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ocu04530  Tight junction
ocu04530

Other DBs
GO: 0005923
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
103346639  protein crumbs homolog 3 [KO:K06090]
100350530  claudin-23 [KO:K06087]
100346496  claudin-14 [KO:K06087]
108175450  claudin-34 [KO:K06087]
100340963  claudin-4 [KO:K06087]
100341220  claudin-3 [KO:K06087]
100337855  claudin-9 [KO:K06087]
100342165  claudin-6 [KO:K06087]
100357702  claudin-15 [KO:K06087]
100354623  claudin-17 [KO:K06087]
100354880  claudin-8 [KO:K06087]
100356567  claudin-20 [KO:K06087]
100340730  claudin-22 [KO:K06087]
100352273  claudin-11 [KO:K06087]
100037713  CLDN1; claudin-1 [KO:K06087]
100357396  claudin-19 isoform X1 [KO:K06087]
100349260  claudin-18 [KO:K06087]
100356384  claudin-16 [KO:K06087]
100338591  claudin-7 [KO:K06087]
100351218  claudin-5 [KO:K06087]
100341067  putative claudin-25 [KO:K06087]
100355124  claudin-10 isoform X2 [KO:K06087]
108175401  putative claudin-24 [KO:K06087]
100328633  CLDN12; claudin-12 [KO:K06087]
100338492  occludin [KO:K06088]
100340669  junctional adhesion molecule A [KO:K06089]
100357246  junctional adhesion molecule B isoform X1 [KO:K06735]
100346498  junctional adhesion molecule C isoform X1 [KO:K06785]
100346465  blood vessel epicardial substance [KO:K21108]
100008965  cell division control protein 42 homolog isoform X1 [KO:K04393]
100344482  cell division control protein 42 homolog [KO:K04393]
100353321  partitioning defective 6 homolog beta [KO:K06093]
100350899  partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
100349557  partitioning defective 6 homolog gamma [KO:K06093]
100340603  PALS1; protein PALS1 [KO:K06091]
100349491  MAGUK p55 subfamily member 4 [KO:K21109]
100356380  inaD-like protein [KO:K06092]
100341484  multiple PDZ domain protein isoform X1 [KO:K06095]
100009538  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100348584  protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100358386  angiomotin isoform X1 [KO:K16819]
100348712  angiomotin-like protein 1 isoform X4 [KO:K06104]
100345255  angiomotin-like protein 2 isoform X2 [KO:K06104]
100357058  rho GTPase-activating protein 17 isoform X1 [KO:K20638]
100339873  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100357691  merlin isoform X2 [KO:K16684]
103345790  LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
100339253  disks large homolog 1 isoform X8 [KO:K12076]
100009252  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100009300  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100355092  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100355758  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100328617  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
100009139  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100328616  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100348286  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100345030  partitioning defective 3 homolog isoform X1 [KO:K04237]
100338333  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100346390  tight junction protein ZO-1 isoform X1 [KO:K05701]
100351415  tight junction-associated protein 1 isoform X1 [KO:K06105]
100345988  disks large homolog 2 isoform X28 [KO:K12075]
100349185  disks large homolog 3 isoform X7 [KO:K21098]
100009418  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100353099  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
100328675  CGN; cingulin [KO:K06102]
100341711  cingulin-like protein 1 isoform X4 [KO:K21110]
100346634  rho guanine nucleotide exchange factor 2 isoform X2 [KO:K12791]
100356250  transforming protein RhoA [KO:K04513]
100348967  transforming protein RhoA-like [KO:K04513]
100340661  transforming protein RhoA [KO:K04513]
100346856  LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
100343368  transforming protein RhoA-like [KO:K04513]
100343680  transforming protein RhoA-like [KO:K04513]
127489660  transforming protein RhoA-like [KO:K04513]
100008858  transcription factor GATA-4 isoform X2 [KO:K09183]
103344968  MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
100348484  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100008856  JUN; transcription factor Jun [KO:K04448]
100009419  CD1C; T-cell surface glycoprotein CD1c precursor [KO:K06448]
100301530  CD1D; antigen-presenting glycoprotein CD1d precursor [KO:K06448]
100037708  CD1A; T-cell surface glycoprotein CD1a precursor [KO:K06448]
100037709  CD1B; T-cell surface glycoprotein CD1b precursor [KO:K06448]
100008782  CD1E; T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
100356376  T-cell surface glycoprotein CD1a isoform X1 [KO:K06448]
100009471  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100009039  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100344193  Y-box-binding protein 3 isoform X1 [KO:K06099]
100348044  symplekin [KO:K06100]
100339381  proliferating cell nuclear antigen [KO:K04802]
100009554  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100358993  runt-related transcription factor 1 isoform X1 [KO:K08367]
100338049  heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100009196  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100008846  EZR; ezrin [KO:K08007]
100341234  radixin isoform X1 [KO:K05762]
100338273  moesin [KO:K05763]
103348079  LOW QUALITY PROTEIN: moesin-like [KO:K05763]
100009103  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
100008822  actin, cytoplasmic 1 [KO:K05692]
100009272  ACTB; actin, cytoplasmic 1 [KO:K05692]
100341037  LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [KO:K05692]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100340498  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103345313  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100341599  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100337860  src substrate cortactin isoform X1 [KO:K06106]
100340933  hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
100339213  actin-related protein 2 [KO:K17260]
100343474  actin-related protein 3B isoform X2 [KO:K18584]
100008790  actin-related protein 3 isoform X2 [KO:K18584]
100358336  actin-related protein 3 [KO:K18584]
100346759  actin-related protein 2/3 complex subunit 1B [KO:K05757]
100347020  actin-related protein 2/3 complex subunit 1A [KO:K05757]
100349913  actin-related protein 2/3 complex subunit 2 [KO:K05758]
100357607  actin-related protein 2/3 complex subunit 3 [KO:K05756]
103345506  actin-related protein 2/3 complex subunit 4 [KO:K05755]
127485982  actin-related protein 2/3 complex subunit 4 [KO:K05755]
100344359  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103346289  actin-related protein 2/3 complex subunit 5 [KO:K05754]
103345805  WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
100354471  actin nucleation-promoting factor WAS isoform X4 [KO:K05747]
100349467  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
127486002  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100357147  ras-related protein Rab-13 [KO:K06109]
100351703  rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
100009220  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100346837  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100353304  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108177971  band 4.1-like protein 4B isoform X1 [KO:K21111]
127489204  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100340670  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
100358166  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100348780  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100340412  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100353180  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
100356542  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
100352581  5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
100009001  myosin-9 [KO:K10352]
100009002  myosin-10 isoform X3 [KO:K10352]
100009145  MYH11; myosin-11 [KO:K10352]
100355039  myosin light polypeptide 6-like [KO:K12751]
103348296  myosin light chain 6B isoform X1 [KO:K12751]
100349824  myosin light polypeptide 6 isoform X3 [KO:K12751]
108176653  myosin light polypeptide 6 isoform X1 [KO:K12751]
127487399  myosin light chain 6B isoform X1 [KO:K12751]
100343384  myosin regulatory light polypeptide 9 [KO:K12755]
100345591  myosin regulatory light chain 12B [KO:K12757]
100346112  LOW QUALITY PROTEIN: myosin regulatory light polypeptide 9 [KO:K12757]
103346180  immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
100339815  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5 [KO:K05631]
100344553  synaptopodin isoform X1 [KO:K21112]
100351066  alpha-actinin-4 isoform X1 [KO:K05699]
100341378  alpha-actinin-1 isoform X1 [KO:K05699]
103345363  ras-related protein Rab-8A [KO:K07901]
100349093  ras-related protein Rab-8B [KO:K07902]
100358155  rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
100351588  ras-related protein Rap-1A [KO:K04353]
100008898  integrin beta-1 isoform X2 [KO:K05719]
100346256  afadin isoform X1 [KO:K05702]
100356517  tight junction protein ZO-2 isoform X1 [KO:K06098]
100346752  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
100344104  ras-related protein Rap-2c [KO:K07839]
100337735  MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
100348075  tubulin alpha-1B chain [KO:K07374]
100350046  tubulin alpha-3 chain [KO:K07374]
100353478  tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100355248  tubulin alpha-8 chain [KO:K07374]
100349209  tubulin alpha-3 chain [KO:K07374]
100350967  tubulin alpha-3 chain [KO:K07374]
100350027  tubulin alpha-3 chain [KO:K07374]
100346652  tubulin alpha-1C chain [KO:K07374]
100009327  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100340483  tubulin alpha-1A chain [KO:K07374]
100357567  tubulin alpha-1C chain [KO:K07374]
100354352  tubulin alpha-4A chain isoform X2 [KO:K07374]
100340939  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ocu04520  Adherens junction
ocu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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