KEGG   PATHWAY: rno00562
Entry
rno00562                    Pathway                                
Name
Inositol phosphate metabolism - Rattus norvegicus (rat)
Class
Metabolism; Carbohydrate metabolism
Pathway map
rno00562  Inositol phosphate metabolism
rno00562

Module
rno_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:rno00562]
rno_M00131  Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:rno00562]
rno_M00132  Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:rno00562]
Other DBs
GO: 0006020
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
65052  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
288762  Mtm1; myotubularin isoform 1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
315422  Mtmr2; myotubularin-related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
317296  Mtmr1; myotubularin-related protein 1 isoform 1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
287607  Mtmr4; myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
305482  Mtmr3; myotubularin-related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
312634  Mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
64161  Pi4ka; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
81747  Pi4kb; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
114554  Pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
305419  Pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
116482  Sacm1l; phosphatidylinositol-3-phosphatase SAC1 isoform 1 [KO:K21797] [EC:3.1.3.-]
309008  Inpp5f; phosphatidylinositide phosphatase SAC2 [KO:K21798] [EC:3.1.3.-]
309419  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
314641  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c [KO:K00889] [EC:2.7.1.68]
365865  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
687758  Pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
317576  Ocrl; inositol polyphosphate 5-phosphatase OCRL [KO:K01099] [EC:3.1.3.36]
362590  Inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase [KO:K01099] [EC:3.1.3.36]
114089  Inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
84018  Synj2; synaptojanin-2 isoform 1 [KO:K20279] [EC:3.1.3.36]
85238  Synj1; synaptojanin-1 isoform 1 [KO:K20279] [EC:3.1.3.36]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
298947  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
50557  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
54259  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
65038  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 1 [KO:K15909] [EC:3.1.3.86]
116720  Pik3c2g; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
361632  Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
289021  Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
80849  Inpp4a; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
116699  Inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase [KO:K01109] [EC:3.1.3.66]
316457  Pikfyve; 1-phosphatidylinositol-3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
309855  Fig4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
140607  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
116723  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
89812  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
24655  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
287745  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
140693  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
114633  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
497197  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
310463  Plch1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 [KO:K19006] [EC:3.1.4.11]
313756  Plch2; phospholipase C, eta 2 isoform 1 [KO:K19006] [EC:3.1.4.11]
83523  Impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
282636  Impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
192260  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
290651  Isyna1; inositol-3-phosphate synthase 1 [KO:K01858] [EC:5.5.1.4]
316376  Inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
365382  Inpp5a; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
287533  Inpp5k; inositol polyphosphate 5-phosphatase K [KO:K24222] [EC:3.1.3.56]
171088  Inpp5j; phosphatidylinositol 4,5-bisphosphate 5-phosphatase A [KO:K24222] [EC:3.1.3.56]
29688  Minpp1; multiple inositol polyphosphate phosphatase 1 precursor [KO:K03103] [EC:3.1.3.62 3.1.3.80]
499084  RGD1564801; multiple inositol polyphosphate phosphatase 1-like isoform X1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]
81677  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
54260  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
308451  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
500709  Itpk1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
171458  Ipmk; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
306808  Ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
252899  Miox; inositol oxygenase [KO:K00469] [EC:1.13.99.1]
81708  Aldh6a1; methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial precursor [KO:K00140] [EC:1.2.1.18 1.2.1.27]
24849  Tpi1; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
500959  Tpi1l1; triosephosphate isomerase 1 like 1 [KO:K01803] [EC:5.3.1.1]
498731  Tpi1l2; triosephosphate isomerase-like [KO:K01803] [EC:5.3.1.1]
Compound
C00024  Acetyl-CoA
C00092  D-Glucose 6-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00137  myo-Inositol
C00191  D-Glucuronate
C00222  3-Oxopropanoate
C00558  D-Tagaturonate
C00641  1,2-Diacyl-sn-glycerol
C00691  2,4,6/3,5-Pentahydroxycyclohexanone
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C03659  D-Bornesitol
C03660  L-Bornesitol
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04287  3D-3,5/4-Trihydroxycyclohexane-1,2-dione
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04520  1D-myo-Inositol 3,4,5,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04563  D-myo-Inositol 1,2,4,5,6-pentakisphosphate
C04579  Inositol 1,2,3,5,6-pentakisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06153  scyllo-Inositol
C06892  2-Deoxy-5-keto-D-gluconic acid
C06893  2-Deoxy-5-keto-D-gluconic acid 6-phosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C16737  5-Deoxy-D-glucuronate
C19794  CDP-1L-myo-inositol
C19799  Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate
C19891  1D-chiro-Inositol
C20251  1-Keto-D-chiro-inositol
C21643  3-Dehydro-scyllo-inosose
C21644  5-Dehydro-L-gluconate
Reference
PMID:14993306
  Authors
Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y
  Title
The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase.
  Journal
Microbiology 150:571-80 (2004)
DOI:10.1099/mic.0.26768-0
Reference
PMID:18310071
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y.
  Title
myo-Inositol catabolism in Bacillus subtilis.
  Journal
J Biol Chem 283:10415-24 (2008)
DOI:10.1074/jbc.M708043200
Related
pathway
rno00010  Glycolysis / Gluconeogenesis
rno00020  Citrate cycle (TCA cycle)
rno00040  Pentose and glucuronate interconversions
rno00564  Glycerophospholipid metabolism
KO pathway
ko00562   
LinkDB

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