KEGG   PATHWAY: rno04024
Entry
rno04024                    Pathway                                
Name
cAMP signaling pathway - Rattus norvegicus (rat)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
rno04024  cAMP signaling pathway
rno04024

Other DBs
GO: 0019933
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
117064  Vip; VIP peptides preproprotein [KO:K05264]
81648  Crh; corticoliberin precursor [KO:K05256]
116700  Cga; glycoprotein hormones alpha chain precursor [KO:K08522]
25329  Lhb; lutropin subunit beta isoform 1 precursor [KO:K08521]
171158  Gpha2; glycoprotein hormone alpha-2 precursor [KO:K25483]
366668  Gphb5; glycoprotein hormone beta-5 precursor [KO:K25484]
25653  Tshb; thyrotropin subunit beta precursor [KO:K05251]
24664  Pomc; pro-opiomelanocortin precursor [KO:K05228]
24952  Gcg; pro-glucagon preproprotein [KO:K05259]
25040  Gip; gastric inhibitory polypeptide precursor [KO:K05258]
25447  Fshb; follitropin subunit beta precursor [KO:K05250]
24602  Nppa; natriuretic peptides A precursor [KO:K12334]
24166  Adcyap1; pituitary adenylate cyclase-activating polypeptide precursor [KO:K05262]
24925  Adrb1; beta-1 adrenergic receptor [KO:K04141]
24176  Adrb2; beta-2 adrenergic receptor [KO:K04142]
24316  Drd1; D(1A) dopamine receptor [KO:K04144]
25195  Drd5; D(1B) dopamine receptor [KO:K05840]
25369  Adora2a; adenosine receptor A2a A2AR [KO:K04266]
25324  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
64354  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
81752  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
24167  Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor [KO:K04587]
29555  Vipr2; vasoactive intestinal polypeptide receptor 2 precursor [KO:K04590]
58959  Crhr1; corticotropin-releasing factor receptor 1 isoform 1 precursor [KO:K04578]
64680  Crhr2; corticotropin-releasing factor receptor 2 precursor [KO:K04579]
25477  Lhcgr; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
25360  Tshr; thyrotropin receptor precursor [KO:K04249]
282839  Mc2r; adrenocorticotropic hormone receptor [KO:K04200]
25051  Glp1r; glucagon-like peptide 1 receptor precursor [KO:K04581]
25024  Gipr; gastric inhibitory polypeptide receptor precursor [KO:K04580]
302813  Gpr119; glucose-dependent insulinotropic receptor [KO:K08424]
25449  Fshr; follicle-stimulating hormone receptor precursor [KO:K04247]
24603  Npr1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
24323  Edn1; endothelin-1 preproprotein [KO:K16366]
24324  Edn2; endothelin-2 precursor [KO:K16367]
366270  Edn3; endothelin-3 precursor [KO:K05227]
24797  Sst; somatostatin precursor [KO:K05237]
24604  Npy; pro-neuropeptide Y preproprotein [KO:K05232]
59301  Ghrl; appetite-regulating hormone preproprotein [KO:K05254]
25504  Oxt; oxytocin-neurophysin 1 preproprotein [KO:K05243]
24473  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
25075  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
25323  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
60448  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
25229  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
81645  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
24318  Drd2; D(2) dopamine receptor isoform 1 [KO:K04145]
81657  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 precursor [KO:K04615]
83633  Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 precursor [KO:K04615]
29290  Adora1; adenosine receptor A1 [KO:K04265]
24326  Ednra; endothelin-1 receptor precursor [KO:K04197]
29358  Npy1r; neuropeptide Y receptor type 1 [KO:K04204]
25033  Sstr1; somatostatin receptor type 1 [KO:K04217]
54305  Sstr2; somatostatin receptor type 2 [KO:K04218]
25354  Sstr5; somatostatin receptor type 5 [KO:K04221]
689936  Hcar1; hydroxycarboxylic acid receptor 1 [KO:K08401]
353250  Hcar2; hydroxycarboxylic acid receptor 2 [KO:K08402]
292794  Ffar2; free fatty acid receptor 2 [KO:K04328]
408199  Sucnr1; succinate receptor 1 [KO:K10042]
24929  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
25342  Oxtr; oxytocin receptor [KO:K04229]
84022  Ghsr; growth hormone secretagogue receptor type 1 [KO:K04284]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
59320  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
85259  Cnga1; cGMP-gated cation channel alpha-1 [KO:K04948]
25411  Cnga2; cyclic nucleotide-gated olfactory channel [KO:K04949]
85257  Cnga3; cyclic nucleotide-gated cation channel alpha-3 isoform 1 [KO:K04950]
85258  Cnga4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
500418  Cngb3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
50663  Calm2; calmodulin-2 [KO:K02183]
25400  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
24246  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
24245  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515] [EC:2.7.11.17]
171140  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
25050  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
365603  Bves; blood vessel epicardial substance [KO:K21108]
360718  Popdc2; popeye domain-containing protein 2 [KO:K26206]
641520  Popdc3; popeye domain-containing protein 3 isoform 2 [KO:K26207]
170899  Kcnk2; potassium channel subfamily K member 2 isoform 2 [KO:K04913]
114244  Hcn2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
59266  Hcn4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
170924  Abcc4; ATP-binding cassette subfamily C member 4 [KO:K05673]
59326  Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
252857  Rapgef4; rap guanine nucleotide exchange factor 4 [KO:K04351]
361568  Rras; ras-related protein R-Ras [KO:K07829]
365355  Rras2; ras-related protein R-Ras2 [KO:K07830]
25097  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
25096  Pld1; phospholipase D1 isoform 2 [KO:K01115] [EC:3.1.4.4]
114633  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
295347  Rap1a; ras-related protein Rap-1A [KO:K04353]
171337  Rap1b; ras-related protein Rap-1b precursor [KO:K07836]
304109  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
25156  Vav1; proto-oncogene vav [KO:K05730]
295378  Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
296603  Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
361314  Arap3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
117273  Rhoa; transforming protein RhoA [KO:K04513]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
26955  Afdn; afadin [KO:K05702]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
360616  Ppp1r1b; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
24668  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
24669  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16]
25594  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
54244  Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
170915  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
24225  Bdnf; brain-derived neurotrophic factor isoform 3 preproprotein [KO:K04355]
314322  Fos; protein c-Fos [KO:K04379]
24516  Jun; transcription factor Jun [KO:K04448]
140588  Gli3; transcriptional activator GLI3 [KO:K06230]
140589  Gli1; zinc finger protein GLI1 [KO:K16797]
89830  Ptch1; protein patched homolog 1 isoform 2 [KO:K06225]
291936  Hhip; hedgehog-interacting protein precursor [KO:K06231]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
140586  Sox9; transcription factor SOX-9 [KO:K18435]
25378  Amh; muellerian-inhibiting factor precursor [KO:K04665]
25747  Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
83522  Acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
50681  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform 2 [KO:K00232] [EC:1.3.3.6]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
25439  F2r; proteinase-activated receptor 1 precursor [KO:K03914]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
25330  Lipe; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
116670  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
296313  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
29248  Tnni3; troponin I, cardiac muscle [KO:K12044]
64672  Pln; cardiac phospholamban [KO:K05852]
116601  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
25391  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
29693  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b [KO:K05853] [EC:7.2.2.10]
689560  Ryr2; ryanodine receptor 2 isoform 1 [KO:K04962]
24408  Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208]
24409  Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209]
24410  Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
24411  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
24412  Grin2d; glutamate receptor ionotropic, NMDA 2D precursor [KO:K05212]
191573  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform 1 precursor [KO:K05213]
170796  Grin3b; glutamate receptor ionotropic, NMDA 3B precursor [KO:K05214]
50592  Gria1; glutamate receptor 1 precursor [KO:K05197]
29627  Gria2; glutamate receptor 2 isoform 2 precursor [KO:K05198]
29628  Gria3; glutamate receptor 3 isoform 2 precursor [KO:K05199]
29629  Gria4; glutamate receptor 4 isoform 2 precursor [KO:K05200]
24255  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
24211  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 precursor [KO:K01539] [EC:7.2.2.13]
24212  Atp1a2; sodium/potassium-transporting ATPase subunit alpha-2 precursor [KO:K01539] [EC:7.2.2.13]
24213  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
29132  Atp1a4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
84396  Atp1b4; protein ATP1B4 [KO:K01540]
25650  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
24214  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
25390  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
29639  Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform a [KO:K01538]
58971  Fxyd1; phospholemman precursor [KO:K13360]
24782  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
304496  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
29600  Atp2b4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
29599  Atp2b3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
24215  Atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
29598  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform 3 [KO:K05850] [EC:7.2.2.10]
24239  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
114493  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
682930  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
50678  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
29516  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
25638  Pde4a; 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 [KO:K13293] [EC:3.1.4.53]
24626  Pde4b; 3',5'-cyclic-AMP phosphodiesterase 4B isoform 2 [KO:K13293] [EC:3.1.4.53]
290646  Pde4c; 3',5'-cyclic-AMP phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
24627  Pde4d; 3',5'-cyclic-AMP phosphodiesterase 4D isoform 1 [KO:K13293] [EC:3.1.4.53]
63885  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
rno00071  Fatty acid degradation
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04260  Cardiac muscle contraction
rno04340  Hedgehog signaling pathway
rno04720  Long-term potentiation
rno04740  Olfactory transduction
rno04972  Pancreatic secretion
rno04976  Bile secretion
KO pathway
ko04024   
LinkDB

DBGET integrated database retrieval system