Entry
Name
Cellular senescence - Rattus norvegicus (rat)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
59086 Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375 ]
81809 Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
25717 Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377 ]
29357 Smad2; mothers against decapentaplegic homolog 2 [KO:K04500 ]
25631 Smad3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
25164 Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685 ]
24708 Rb1; retinoblastoma-associated protein [KO:K06618 ]
684111 E2f2; transcription factor E2F2 isoform X2 [KO:K09389 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
24747 RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751 ]
24973 RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751 ]
24974 RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751 ]
24988 RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751 ]
294213 RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751 ]
309600 RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751 ]
309603 RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751 ]
309607 RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751 ]
361787 RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751 ]
365527 RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751 ]
368153 RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751 ]
414779 RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751 ]
414783 RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751 ]
414784 RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751 ]
414785 RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751 ]
414786 RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751 ]
414789 RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751 ]
414790 RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751 ]
414791 RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751 ]
414792 RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751 ]
414793 RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751 ]
414819 RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751 ]
406194 RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751 ]
414788 RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751 ]
680842 RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751 ]
102546590 H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
499400 RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58921 Foxm1; forkhead box protein M1 isoform 1 [KO:K09406 ]
25163 Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621 ]
54355 Rassf5; ras association domain-containing protein 5 [KO:K08015 ]
361765 Btrc; F-box/WD repeat-containing protein 1A [KO:K03362 ]
303024 Fbxw11; F-box/WD repeat-containing protein 11 isoform 1 [KO:K03362 ]
24668 Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
24669 Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269 ] [EC:3.1.3.16 ]
25594 Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
25112 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
291005 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
299626 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
64046 Mre11; double-strand break repair protein MRE11 [KO:K10865 ]
64012 Rad50; DNA repair protein RAD50 [KO:K10866 ] [EC:3.6.-.-]
363924 Rad9b; cell cycle checkpoint control protein RAD9B [KO:K10995 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
24484 Igfbp3; insulin-like growth factor-binding protein 3 precursor [KO:K10138 ]
24617 Serpine1; plasminogen activator inhibitor 1 precursor [KO:K03982 ]
116636 Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
29344 Zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753 ]
298765 Zfp36l2; mRNA decay activator protein ZFP36L2 [KO:K18753 ]
29716 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
66026 Trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973 ]
679906 Trpm7; transient receptor potential cation channel subfamily M member 7 [KO:K04982 ] [EC:2.7.11.1 ]
24675 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
171378 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
100361818 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446 ]
311658 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
361400 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
305897 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
25262 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958 ]
81678 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
25679 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
498885 Slc25a6; solute carrier family 25 member 6 [KO:K05863 ]
83529 Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
83531 Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
83532 Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041 ]
294560 Mcu; calcium uniporter protein, mitochondrial precursor [KO:K20858 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Munoz-Espin D, Serrano M
Title
Cellular senescence: from physiology to pathology.
Journal
Reference
Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Journal
Reference
Authors
Sharpless NE, Sherr CJ
Title
Forging a signature of in vivo senescence.
Journal
Reference
Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
Title
Senescence as a general cellular response to stress: A mini-review.
Journal
Reference
Authors
Lujambio A
Title
To clear, or not to clear (senescent cells)? That is the question.
Journal
Reference
Authors
Di Mitri D, Alimonti A
Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
Journal
Reference
Authors
Francica P, Aebersold DM, Medova M
Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
Journal
Reference
Authors
Bartling B
Title
Cellular senescence in normal and premature lung aging.
Journal
Reference
Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
Title
Programmed cell senescence during mammalian embryonic development.
Journal
Reference
Authors
Herranz N, Gallage S, Gil J
Title
TORn about SASP regulation.
Journal
Reference
Authors
Martin N, Bernard D
Title
Calcium signaling and cellular senescence.
Journal
Reference
Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
Title
Calcium homeostasis in cancer: A focus on senescence.
Journal
Reference
Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
Journal
Reference
Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
Title
Ras signaling through RASSF proteins.
Journal
Reference
Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Journal
Reference
Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Journal
Reference
Authors
Cao X, Li M
Title
A New Pathway for Senescence Regulation.
Journal
Reference
Authors
Gire V, Dulic V
Title
Senescence from G2 arrest, revisited.
Journal
Reference
Authors
Mowla SN, Lam EW, Jat PS
Title
Cellular senescence and aging: the role of B-MYB.
Journal
Reference
Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Journal
Reference
Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
Journal
Related pathway
KO pathway
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