KEGG   PATHWAY: rno04360
Entry
rno04360                    Pathway                                
Name
Axon guidance - Rattus norvegicus (rat)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
rno04360  Axon guidance
rno04360

Other DBs
GO: 0007411
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
114523  Ntn1; netrin-1 precursor [KO:K06843]
114524  Ntn3; netrin-3 precursor [KO:K06844]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116683  Efna5; ephrin-A5 precursor [KO:K05462]
117273  Rhoa; transforming protein RhoA [KO:K04513]
134484121  [KO:K00922] [EC:2.7.1.153]
140585  Ryk; tyrosine-protein kinase RYK precursor [KO:K05128] [EC:2.7.10.1]
140590  Bmpr2; bone morphogenetic protein receptor type-2 precursor [KO:K04671] [EC:2.7.11.30]
140908  Cdk5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
140933  Trpc5; short transient receptor potential channel 5 [KO:K04968]
170901  Efna3; ephrin-A3 isoform X1 [KO:K05462]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170922  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
171140  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
171287  Epha7; ephrin type-A receptor 7 precursor [KO:K05108] [EC:2.7.10.1]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
24245  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515] [EC:2.7.11.17]
24246  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
24338  Ephb1; ephrin type-B receptor 1 precursor [KO:K05110] [EC:2.7.10.1]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
24525  Kras; GTPase KRas [KO:K07827]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
24605  Nras; GTPase NRas [KO:K07828]
246217  Ngef; ephexin-1 [KO:K07525]
246262  Sema3d; semaphorin-3D [KO:K06840]
246331  Nrp1; neuropilin-1 precursor [KO:K06724]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24772  Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031]
25150  Fyn; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
25186  Efnb1; ephrin-B1 precursor [KO:K05463]
25273  Smo; protein smoothened precursor [KO:K06226]
252833  Gdf7; growth/differentiation factor 7 isoform 2 precursor [KO:K20013]
25311  Dcc; netrin receptor DCC precursor [KO:K06765]
25400  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
25416  Dpysl2; dihydropyrimidinase-related protein 2 [KO:K07528]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25522  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
25622  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform 2 [KO:K07293] [EC:3.1.3.48]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
25676  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
266715  Fzd3; frizzled-3 precursor [KO:K02329]
282582  Wnt5b; protein Wnt-5b precursor [KO:K00444]
287989  Ephb3; ephrin type-B receptor 3 precursor [KO:K05112] [EC:2.7.10.1]
289392  Plxna2; plexin-A2 [KO:K06820]
290562  Sema3g; semaphorin-3G precursor [KO:K06840]
29202  Epha6; ephrin type-A receptor 6 [KO:K05107] [EC:2.7.10.1]
29210  Epha3; ephrin type-A receptor 3 precursor [KO:K05104] [EC:2.7.10.1]
29271  Cfl1; cofilin-1 [KO:K05765]
292756  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
293042  Sema4b; semaphorin-4B precursor [KO:K06521]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
293621  Hras; GTPase HRas [KO:K02833]
293660  Rhod; rho-related GTP-binding protein RhoD [KO:K07530]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
29432  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
29433  Pak3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
29499  Shh; sonic hedgehog protein precursor [KO:K11988]
29524  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
295382  Ntng1; netrin-G1 precursor [KO:K07522]
296078  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
296313  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
296787  Sema3c; semaphorin-3C precursor [KO:K06840]
296789  Sema3e; semaphorin-3E precursor [KO:K06840]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
29744  Sema6c; semaphorin-6C precursor [KO:K06842]
29745  Sema4f; semaphorin-4F precursor [KO:K06521]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
29751  Sema3a; semaphorin-3A precursor [KO:K06840]
299737  Ntn4; netrin-4 precursor [KO:K06845]
300955  Nck1; cytoplasmic protein NCK1 [KO:K07365]
301346  Sema4c; semaphorin-4C precursor [KO:K06521]
303342  Ssh2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
303901  Sema5b; semaphorin-5B precursor [KO:K06841]
304580  Ssh1; protein phosphatase Slingshot homolog 1 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
305897  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
306534  Unc5d; netrin receptor UNC5D precursor [KO:K07521]
306636  Efnb2; ephrin-B2 [KO:K05463]
306790  Sema4d; semaphorin-4D precursor [KO:K06521]
307237  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
307395  Ablim3; actin-binding LIM protein 3 [KO:K07520]
307799  Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093]
307989  Ablim1; actin-binding LIM protein 1 isoform 1 [KO:K07520]
308739  Rgma; repulsive guidance molecule A [KO:K23096]
309280  Plxna3; plexin-A3 precursor [KO:K06820]
310207  Sema5a; semaphorin-5A precursor [KO:K06841]
310630  Sema4a; semaphorin-4A precursor [KO:K06521]
310643  Efna4; ephrin-A4 precursor [KO:K05462]
310753  Lrig2; leucine-rich repeats and immunoglobulin-like domains protein 2 precursor [KO:K24609]
310914  Bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
311236  Lrrc4c; leucine-rich repeat-containing protein 4C precursor [KO:K07523]
311384  Sema6d; semaphorin-6D precursor [KO:K06842]
311450  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
311836  Ntng2; netrin-G2 precursor [KO:K16359]
311860  Abl1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
312213  Plxna4; plexin-A4 precursor [KO:K06820]
312275  Ephb6; ephrin type-B receptor 6 precursor [KO:K05114] [EC:2.7.10.1]
312279  Epha1; ephrin type-A receptor 1 precursor [KO:K05102] [EC:2.7.10.1]
313633  Ephb2; ephrin type-B receptor 2 precursor [KO:K05111] [EC:2.7.10.1]
314903  Srgap1; SLIT-ROBO Rho GTPase-activating protein 1 [KO:K07526]
315217  Plxnb2; plexin-B2 precursor [KO:K06821]
315564  Robo3; roundabout homolog 3 [KO:K06755]
315711  Sema7a; semaphorin-7A precursor [KO:K06529]
315996  Sema3f; semaphorin-3F precursor [KO:K06840]
316009  Plxnb1; plexin-B1 precursor [KO:K06821]
316369  Nck2; cytoplasmic protein NCK2 [KO:K19862]
316539  Epha4; ephrin type-A receptor 4 precursor [KO:K05105] [EC:2.7.10.1]
360272  Slit2; slit homolog 2 protein precursor [KO:K06839]
360546  Efnb3; ephrin-B3 precursor [KO:K05463]
360715  Boc; brother of CDO precursor [KO:K20020]
360840  Srgap2; SLIT-ROBO Rho GTPase-activating protein 2 isoform 1 [KO:K07526]
360891  Enah; protein enabled homolog isoform 2 [KO:K05746]
360958  Ablim2; actin-binding LIM protein 2 isoform a [KO:K07520]
361324  Sema6a; semaphorin-6A isoform 1 precursor [KO:K06842]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
361568  Rras; ras-related protein R-Ras [KO:K07829]
361597  Fes; tyrosine-protein kinase Fes/Fps [KO:K07527] [EC:2.7.10.2]
361764  Sema4g; semaphorin-4G precursor [KO:K06521]
362049  Unc5c; netrin receptor UNC5C isoform 2 precursor [KO:K07521]
362279  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
362398  Plxna1; plexin-A1 [KO:K06820]
362873  Plxnc1; plexin-C1 precursor [KO:K06572]
362993  Rnd1; rho-related GTP-binding protein Rho6 [KO:K07531]
363142  Sema3b; semaphorin-3B precursor [KO:K06840]
363517  Plxnb3; plexin-B3 precursor [KO:K06821]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
365396  Ssh3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
366492  Epha2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
366624  Cfl2; cofilin-2 [KO:K05765]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
367072  Arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
500287  Srgap3; SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526]
501203  Myl12a; myosin regulatory light chain RLC-A [KO:K12757]
50685  Myl12b; myosin regulatory light chain 12B [KO:K12757]
50687  L1cam; neural cell adhesion molecule L1 precursor [KO:K06550]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54293  Rgs3; regulator of G-protein signaling 3 [KO:K07524]
58946  Robo1; roundabout homolog 1 isoform 1 precursor [KO:K06753]
60395  Trpc3; short transient receptor potential channel 3 [KO:K04966]
60589  Epha8; ephrin type-A receptor 8 precursor [KO:K05109] [EC:2.7.10.1]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
60629  Unc5a; netrin receptor UNC5A precursor [KO:K07521]
60630  Unc5b; netrin receptor UNC5B precursor [KO:K07521]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
641521  Lrrc4; leucine-rich repeat-containing protein 4 precursor [KO:K16351]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64566  Wnt5a; protein Wnt-5a precursor [KO:K00444]
65047  Slit1; slit homolog 1 protein precursor [KO:K06838]
65172  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
65208  Dpysl5; dihydropyrimidinase-related protein 5 [KO:K07529]
686310  Ephb4; ephrin type-B receptor 4 isoform X1 [KO:K05113] [EC:2.7.10.1]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
688430  Cfl1l1; cofilin-1-like [KO:K05765]
79208  Epha5; ephrin type-A receptor 5 isoform 2 [KO:K05106] [EC:2.7.10.1]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
81735  Neo1; neogenin precursor [KO:K06766]
81745  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
81918  Pard3; partitioning defective 3 homolog [KO:K04237]
83467  Slit3; slit homolog 3 protein precursor [KO:K06850]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
84358  Efna2; ephrin-A2 precursor [KO:K05462]
84409  Robo2; roundabout homolog 2 isoform 2 precursor [KO:K06754]
84426  Wnt4; protein Wnt-4 precursor [KO:K00408]
84494  Trpc4; short transient receptor potential channel 4 isoform beta [KO:K04967]
84609  Sema6b; semaphorin-6B precursor [KO:K06842]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85272  Bmp7; bone morphogenetic protein 7 precursor [KO:K16621]
89821  Trpc1; short transient receptor potential channel 1 isoform 2 [KO:K04964]
89823  Trpc6; short transient receptor potential channel 6 [KO:K04969]
89830  Ptch1; protein patched homolog 1 isoform 2 [KO:K06225]
94268  Efna1; ephrin-A1 precursor [KO:K05462]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
rno04010  MAPK signaling pathway
rno04060  Cytokine-cytokine receptor interaction
rno04310  Wnt signaling pathway
rno04810  Regulation of actin cytoskeleton
KO pathway
ko04360   

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