KEGG   PATHWAY: rno04530
Entry
rno04530                    Pathway                                
Name
Tight junction - Rattus norvegicus (rat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
rno04530  Tight junction
rno04530

Other DBs
GO: 0005923
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
301112  Crb3; protein crumbs homolog 3 precursor [KO:K06090]
290485  Cldn10; claudin-10 [KO:K06087]
290789  Cldn23; claudin-23 [KO:K06087]
298487  Cldn19; claudin-19 [KO:K06087]
300920  Cldn2; claudin-2 [KO:K06087]
304073  Cldn14; claudin-14 [KO:K06087]
304124  Cldn8; claudin-8 [KO:K06087]
304125  Cldn17; claudin-17 [KO:K06087]
304388  Cldn15; claudin-15 [KO:K06087]
304407  Cldn4; claudin-4 [KO:K06087]
306454  Cldn22; claudin-22 [KO:K06087]
315953  Cldn18; claudin-18 precursor [KO:K06087]
65129  Cldn1; claudin-1 [KO:K06087]
65130  Cldn3; claudin-3 [KO:K06087]
65131  Cldn5; claudin-5 [KO:K06087]
84588  Cldn11; claudin-11 [KO:K06087]
100361422  Cldn34c4; claudin 34C4 [KO:K06087]
155268  Cldn16; claudin-16 [KO:K06087]
287098  Cldn6; claudin-6 precursor [KO:K06087]
287099  Cldn9; claudin-9 [KO:K06087]
680178  Cldn20; claudin-20 precursor [KO:K06087]
65132  Cldn7; claudin-7 precursor [KO:K06087]
680489  Cldn34e; uncharacterized protein LOC680489 [KO:K06087]
680370  Cldn34d; claudin 34D [KO:K06087]
502083  Cldn24; putative claudin-24 [KO:K06087]
100360390  Cldn25; putative claudin-25 [KO:K06087]
500000  Cldn12; claudin-12 [KO:K06087]
83497  Ocln; occludin [KO:K06088]
116479  F11r; junctional adhesion molecule A precursor [KO:K06089]
619374  Jam2; junctional adhesion molecule B precursor [KO:K06735]
315509  Jam3; junctional adhesion molecule C precursor [KO:K06785]
365603  Bves; blood vessel epicardial substance [KO:K21108]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
307237  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
307799  Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093]
362279  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
314259  Pals1; protein PALS1 [KO:K06091]
58808  Mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
314640  Tjp3; tight junction protein ZO-3 [KO:K06097]
140581  Patj; inaD-like protein [KO:K06092]
29365  Mpdz; multiple PDZ domain protein [KO:K06095]
25522  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
84006  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
300289  Amot; angiomotin isoform X1 [KO:K16819]
315430  Amotl1; angiomotin-like protein 1 isoform X1 [KO:K06104]
65157  Amotl2; angiomotin-like protein 2 [KO:K06104]
63994  Arhgap17; rho GTPase-activating protein 17 isoform 1 [KO:K20638]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
25744  Nf2; merlin [KO:K16684]
54265  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
360661  Llgl2; LLGL scribble cell polarity complex component 2 [KO:K06094]
25252  Dlg1; disks large homolog 1 isoform 1 [KO:K12076]
362938  Scrib; protein scribble homolog [KO:K16175]
24672  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
24673  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100362453  Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
117281  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
315648  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
246255  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
60660  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1 [KO:K04354]
117256  Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1 [KO:K04354]
117104  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
81918  Pard3; partitioning defective 3 homolog [KO:K04237]
304109  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
292994  Tjp1; tight junction protein ZO-1 [KO:K05701]
316233  Tjap1; tight junction-associated protein 1 [KO:K06105]
64053  Dlg2; disks large homolog 2 [KO:K12075]
58948  Dlg3; disks large homolog 3 [KO:K21098]
25489  Nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
291553  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
310655  Cgn; cingulin isoform X1 [KO:K06102]
315795  Cgnl1; cingulin-like protein 1 [KO:K21110]
310635  Arhgef2; rho guanine nucleotide exchange factor 2 [KO:K12791]
117273  Rhoa; transforming protein RhoA [KO:K04513]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
54254  Gata4; transcription factor GATA-4 [KO:K09183]
498950  Marveld3; MARVEL domain-containing protein 3 [KO:K21099]
116667  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
24516  Jun; transcription factor Jun [KO:K04448]
25109  Cd1d1; antigen-presenting glycoprotein CD1d precursor [KO:K06448]
24255  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
83807  Ybx3; Y-box-binding protein 3 [KO:K06099]
292683  Sympk; symplekin [KO:K06100]
25737  Pcna; proliferating cell nuclear antigen [KO:K04802]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
24337  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
50662  Runx1; runt-related transcription factor 1 [KO:K08367]
266759  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
59114  Nherf1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
54319  Ezr; ezrin [KO:K08007]
315655  Rdx; radixin [KO:K05762]
81521  Msn; moesin [KO:K05763]
29340  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
100361457  Actg1l1; actin, gamma 1 propeptide-like [KO:K05692]
81822  Actb; actin, cytoplasmic 1 [KO:K05692]
287876  Actg1; actin, cytoplasmic 2 [KO:K05692]
120098222  POTE ankyrin domain family member F [KO:K05692]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
365057  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
363855  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431] [EC:2.7.12.2]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
288077  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
60465  Cttn; src substrate cortactin isoform 2 [KO:K06106]
289820  Actr2; actin-related protein 2 [KO:K17260]
362298  Actr3b; actin-related protein 3B [KO:K18584]
81732  Actr3; actin-related protein 3 [KO:K18584]
54227  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
81824  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
301511  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
288669  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
297518  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
296710  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
360854  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
293057  Whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
361517  Vasp; vasodilator-stimulated phosphoprotein [KO:K06274]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
81756  Rab13; ras-related protein Rab-13 [KO:K06109]
304193  Arhgef18; rho guanine nucleotide exchange factor 18 [KO:K21066]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
363925  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
500464  Epb41l4b; band 4.1-like protein 4B isoform 2 [KO:K21111]
314621  Stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
65248  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
78975  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
83803  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
64562  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
25520  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
301518  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
25745  Myh9; myosin-9 [KO:K10352]
308572  Myh14; myosin-14 [KO:K10352]
79433  Myh10; myosin-10 [KO:K10352]
24582  Myh11; myosin-11 [KO:K10352]
685867  Myl6; myosin light polypeptide 6 [KO:K12751]
304447  RGD1559821; myosin light polypeptide 6-like [KO:K12751]
102551071  myosin light polypeptide 6-like [KO:K12751]
296313  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
501203  Myl12a; myosin regulatory light chain RLC-A [KO:K12757]
50685  Myl12b; myosin regulatory light chain 12B [KO:K12757]
304000  Igsf5; immunoglobulin superfamily member 5 precursor [KO:K06786]
500261  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2 [KO:K05631]
60324  Synpo; synaptopodin [KO:K21112]
63836  Actn4; alpha-actinin-4 [KO:K05699]
81634  Actn1; alpha-actinin-1 [KO:K05699]
288515  Micall2; mICAL-like protein 2 [KO:K21068]
117103  Rab8a; ras-related protein Rab-8A [KO:K07901]
266688  Rab8b; ras-related protein Rab-8B [KO:K07902]
303141  Rapgef6; rap guanine nucleotide exchange factor 6 [KO:K08020]
295347  Rap1a; ras-related protein Rap-1A [KO:K04353]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
26955  Afdn; afadin [KO:K05702]
115769  Tjp2; tight junction protein ZO-2 isoform 1 [KO:K06098]
310533  Rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018]
302495  Rap2c; ras-related protein Rap-2c [KO:K07839]
365657  Marveld2; MARVEL domain-containing protein 2 [KO:K17291]
64158  Tuba1a; tubulin alpha-1A chain [KO:K07374]
291287  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
300218  Tuba1c; tubulin alpha-1C chain [KO:K07374]
316531  Tuba4a; tubulin alpha-4A chain [KO:K07374]
500319  Tuba3a; tubulin alpha-3 chain [KO:K07374]
500363  Tuba3b; tubulin alpha-3 chain [KO:K07374]
500377  Tuba8; tubulin alpha-8 chain [KO:K07374]
500929  Tuba1b; tubulin alpha-1B chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
rno04520  Adherens junction
rno04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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