KEGG   PATHWAY: rno04714
Entry
rno04714                    Pathway                                
Name
Thermogenesis - Rattus norvegicus (rat)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
rno04714  Thermogenesis
rno04714

Other DBs
GO: 1990845
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
25645  Adrb3; beta-3 adrenergic receptor [KO:K04143]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
59320  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100366024  Prdm16; PR/SET domain 16 [KO:K22410] [EC:2.1.1.367]
291406  Zfp516; zinc finger protein 516 isoform 1 [KO:K22411]
500569  Kdm1a; lysine-specific histone demethylase 1A [KO:K11450] [EC:1.14.99.66]
24860  Ucp1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
312440  Kdm3a; lysine-specific demethylase 3A isoform 2 [KO:K15601] [EC:1.14.11.65]
682469  Kdm3b; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
361745  Smarca2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
171379  Smarca4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
361825  Smarcb1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [KO:K11648]
301020  Smarcc1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
685179  Smarcc2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 [KO:K11649]
363002  Smarcd1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
83833  Smarcd2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
296732  Smarcd3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1 [KO:K11650]
303518  Smarce1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform 2 [KO:K11651]
100361457  Actg1l1; actin, gamma 1 propeptide-like [KO:K05692]
81822  Actb; actin, cytoplasmic 1 [KO:K05692]
287876  Actg1; actin, cytoplasmic 2 [KO:K05692]
120098222  POTE ankyrin domain family member F [KO:K05692]
361925  Actl6a; actin-like protein 6A [KO:K11340]
288563  Actl6b; actin-like protein 6B [KO:K11652]
297867  Arid1a; AT-rich interactive domain-containing protein 1A isoform 1 [KO:K11653]
282546  Arid1b; AT-rich interactive domain-containing protein 1B [KO:K11653]
50545  Dpf1; zinc finger protein neuro-d4 [KO:K22198]
299186  Dpf3; zinc finger protein DPF3 [KO:K22198]
25664  Pparg; peroxisome proliferator-activated receptor gamma isoform 1 [KO:K08530]
365057  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
303200  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
83516  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
299638  Sirt6; NAD-dependent protein deacylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
170580  Fgf21; fibroblast growth factor 21 precursor [KO:K22429]
25629  Plin1; perilipin-1 [KO:K08768]
25330  Lipe; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
361676  Pnpla2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
29254  Mgll; monoglyceride lipase isoform 2 [KO:K01054] [EC:3.1.1.23]
65248  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
78975  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
83803  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
64562  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
25520  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
301518  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
24952  Gcg; pro-glucagon preproprotein [KO:K05259]
679119  Bmp8b; bone morphogenetic protein 8B isoform X2 [KO:K16622]
680931  Bmp8a; bone morphogenetic protein 8A precursor [KO:K16622]
25248  Cnr1; cannabinoid receptor 1 [KO:K04277]
24602  Nppa; natriuretic peptides A precursor [KO:K12334]
25105  Nppb; natriuretic peptides B precursor [KO:K12335]
24603  Npr1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
54286  Prkg1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
25523  Prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
289625  Klb; beta-klotho [KO:K22404]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
314850  Frs2; fibroblast growth factor receptor substrate 2 [KO:K12461]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
293621  Hras; GTPase HRas [KO:K02833]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
81771  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
117269  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
501560  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
317203  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
60445  Tsc1; hamartin [KO:K07206]
24855  Tsc2; tuberin [KO:K07207]
26954  Rheb; GTP-binding protein Rheb [KO:K07208]
287871  Rptor; regulatory-associated protein of mTOR [KO:K07204]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
64226  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
292887  Akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
83840  Rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
361696  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
29304  Rps6; small ribosomal subunit protein eS6 [KO:K02991]
94340  Acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
113976  Acsl4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
114024  Acsl3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
117243  Acsl6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
25288  Acsl1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
26193  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26194  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26199  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26201  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26200  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26202  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26203  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
301458  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
289218  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
295923  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
499529  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
362588  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
679739  Ndufs6; NADH:ubiquinone oxidoreductase subunit S6-like 1 [KO:K03939]
362837  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
293652  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
293655  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
81728  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
64539  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2 [KO:K03944]
363441  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
291660  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
120099907  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
691001  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
681024  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100362331  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
25488  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
315167  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
299643  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
120101567  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
296658  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
362440  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
316632  Ndufa10l1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like [KO:K03954]
678759  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
293453  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
301123  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
299739  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100911483  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
362344  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
301427  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103690609  Ndufb3l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
103694107  Ndufb3l3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
103691697  Ndufb3l2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
120098318  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
288088  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
499131  Ndufb4l3; similar to NADH:ubiquinone oxidoreductase B15 subunit [KO:K03960]
100361934  Ndufb4l4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
103691107  Ndufb4l5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
120094308  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
501886  Ndufb4l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
294964  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
297990  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
361385  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
293991  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
299954  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
681418  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
299310  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
689938  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
293130  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
296086  Ndufaf1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
361894  Ndufaf2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
56769  Ndufaf3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform a [KO:K09008]
362495  Ndufaf4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
296190  Ndufaf5; arginine-hydroxylase NDUFAF5, mitochondrial precursor [KO:K18162] [EC:2.1.1.-]
297821  Ndufaf6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor [KO:K18163]
298748  Ndufaf7; protein arginine methyltransferase NDUFAF7, mitochondrial precursor [KO:K18164]
690871  Ndufaf8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
157074  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
298596  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
289217  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
363061  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
291103  Uqcrfs1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
26192  CYTB; cytochrome b [KO:K00412]
300047  Cyc1; cytochrome c-1 [KO:K00413]
301011  Uqcrc1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
293448  Uqcrc2; cytochrome b-c1 complex subunit 2, mitochondrial precursor [KO:K00415]
366448  Uqcrh; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
362897  Uqcrb; cytochrome b-c1 complex subunit 7 [KO:K00417]
103693740  Uqcrbl2; cytochrome b-c1 complex subunit 7-like [KO:K00417]
685596  Uqcrbl1; cytochrome b-c1 complex subunit 7-like [KO:K00417]
497902  Uqcrq; cytochrome b-c1 complex subunit 8 [KO:K00418]
685322  Uqcr10; ubiquinol-cytochrome c reductase complex 7.2kDa protein [KO:K00419]
690848  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
120097699  cytochrome b-c1 complex subunit 10-like [KO:K00420]
100362798  Uqcr11l1; cytochrome b-c1 complex subunit 10-like [KO:K00420]
26195  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26198  COX2; cytochrome c oxidase subunit II [KO:K02261]
26204  COX3; cytochrome c oxidase subunit III [KO:K02262]
84683  Cox4i2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor [KO:K02263]
29445  Cox4i1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
252934  Cox5a; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
100361008  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
94194  Cox5b; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
25278  Cox6a2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
25282  Cox6a1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
688869  Cox6b1; cytochrome c oxidase subunit 6B1 [KO:K02267]
654441  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
120103152  cytochrome c oxidase subunit 6B1-like [KO:K02267]
54322  Cox6c; cytochrome c oxidase subunit 6C-2 [KO:K02268]
120098258  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
29507  Cox7a2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270]
298762  Cox7a2l; cytochrome c oxidase subunit 7A2 like isoform 1 [KO:K02270]
688386  Cox7a2l2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
687508  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
303393  Cox7b; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
100361960  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
100188937  Cox7c; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100360357  Cox7cl1; cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
120095266  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
25250  Cox8b; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273]
360229  Cox8c; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
171335  Cox8a; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
691853  Cox10; cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [KO:K02257] [EC:2.5.1.141]
103693419  Cox11; cytochrome c oxidase copper chaperone COX11 [KO:K02258]
681219  Cox14; cytochrome c oxidase assembly protein COX14 [KO:K18181]
309391  Cox15; COX15 homolog [KO:K02259] [EC:1.17.99.9]
100302447  Cox16; COX16 cytochrome c oxidase assembly homolog [KO:K18182]
89786  Cox17; COX17 homolog, cytochrome c oxidase assembly protein [KO:K02260]
289522  Cox18; mitochondrial inner membrane protein COX18 [KO:K17797]
304330  Cox19; COX19 cytochrome c oxidase assembly homolog [KO:K18183]
289278  Cox20; cytochrome c oxidase assembly factor COX20 [KO:K18184]
498000  Coa3; coiled-coil domain-containing protein 56 [KO:K18175]
499214  Coa4; coiled-coil-helix-coiled-coil-helix domain-containing protein 8 [KO:K18177]
503252  Coa5; uncharacterized protein LOC503252 [KO:K18178]
102556031  Coa6; cytochrome c oxidase assembly factor 6 [KO:K18179]
298377  Coa7; sel1 repeat-containing protein 1 [KO:K18180]
65262  Atp5f1a; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
171374  Atp5f1b; ATP synthase subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
116550  Atp5f1c; ATP synthase subunit gamma, mitochondrial [KO:K02136]
245965  Atp5f1d; ATP synthase subunit delta, mitochondrial precursor [KO:K02134]
245958  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100361879  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
192241  Atp5po; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
26197  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
171375  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
171082  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
114630  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
29754  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
100361833  Atp5mc2l1; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
499512  Atp5mc2l2; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
689961  Atp5mc1l1; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
366614  Atp5mc1l2; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
120098314  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
641434  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
688022  Atp5pdl1; ATP synthase subunit d, mitochondrial-like [KO:K02138]
140608  Atp5me; ATP synthase subunit e, mitochondrial [KO:K02129]
120095138  LOW QUALITY PROTEIN: ATP synthase subunit e, mitochondrial-like [KO:K02129]
690441  Atp5mf; ATP synthase subunit f, mitochondrial [KO:K02130]
94271  Atp5pf; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
26196  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
300677  Atp5mg; ATP synthase subunit g, mitochondrial [KO:K02140]
120097069  ATP synthase subunit g, mitochondrial-like [KO:K02140]
679690  Atp5mgl3; ATP synthase subunit g, mitochondrial-like [KO:K02140]
680026  Atp5mgl4; ATP synthase subunit g, mitochondrial-like [KO:K02140]
120094169  ATP synthase subunit g, mitochondrial-like [KO:K02140]
120095262  ATP synthase subunit g, mitochondrial-like [KO:K02140]
25413  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial precursor [KO:K08766] [EC:2.3.1.21]
117035  Slc25a20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
314441  Slc25a29; mitochondrial basic amino acids transporter [KO:K15109]
25757  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
25756  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
308579  Cpt1c; palmitoyl thioesterase CPT1C [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00190  Oxidative phosphorylation
rno04010  MAPK signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04150  mTOR signaling pathway
rno04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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