KEGG   PATHWAY: rno04810
Entry
rno04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Rattus norvegicus (rat)
Class
Cellular Processes; Cell motility
Pathway map
rno04810  Regulation of actin cytoskeleton
rno04810

Other DBs
GO: 0030036
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
116744  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
302378  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
500317  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
24772  Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
29251  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
25439  F2r; proteinase-activated receptor 1 precursor [KO:K03914]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
25313  Egf; pro-epidermal growth factor precursor [KO:K04357]
25317  Fgf1; fibroblast growth factor 1 [KO:K18496]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
170633  Fgf3; fibroblast growth factor 3 precursor [KO:K04358]
116499  Fgf4; fibroblast growth factor 4 precursor [KO:K04358]
60662  Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
170700  Fgf6; fibroblast growth factor 6 [KO:K04358]
29348  Fgf7; fibroblast growth factor 7 precursor [KO:K04358]
25444  Fgf9; fibroblast growth factor 9 [KO:K04358]
25443  Fgf10; fibroblast growth factor 10 precursor [KO:K04358]
60464  Fgf16; fibroblast growth factor 16 [KO:K04358]
29368  Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358]
29369  Fgf18; fibroblast growth factor 18 precursor [KO:K04358]
66017  Fgf20; fibroblast growth factor 20 [KO:K04358]
170579  Fgf22; fibroblast growth factor 22 precursor [KO:K04358]
170582  Fgf19; fibroblast growth factor 19 precursor [KO:K22603]
170580  Fgf21; fibroblast growth factor 21 precursor [KO:K22429]
170583  Fgf23; fibroblast growth factor 23 precursor [KO:K22428]
25266  Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
24628  Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
79429  Pdgfc; platelet-derived growth factor C precursor [KO:K05450]
66018  Pdgfd; platelet-derived growth factor D precursor [KO:K05450]
60663  Insrr; insulin receptor-related protein precursor [KO:K05086] [EC:2.7.10.1]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
25022  Fgfr2; fibroblast growth factor receptor 2 isoform b [KO:K05093] [EC:2.7.10.1]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
25114  Fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
25661  Fn1; fibronectin precursor [KO:K05717]
25118  Itga1; integrin alpha-1 precursor [KO:K06480]
170921  Itga2; integrin alpha-2 precursor [KO:K06481]
685269  Itga2b; integrin alpha-IIb precursor [KO:K06476]
360606  Itga3; integrin alpha-3 isoform 1 [KO:K06482]
311144  Itga4; integrin alpha-4 [KO:K06483]
315346  Itga5; integrin alpha-5 [KO:K06484]
114517  Itga6; integrin alpha-6 precursor [KO:K06485]
81008  Itga7; integrin alpha-7 precursor [KO:K06583]
364786  Itga8; integrin alpha-8 [KO:K06584]
685004  Itga9; integrin alpha-9 precursor [KO:K06585]
310683  Itga10; integrin alpha-10 precursor [KO:K06586]
315744  Itga11; integrin alpha-11 precursor [KO:K06587]
296456  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
308995  Itgal; integrin alpha-L precursor [KO:K05718]
25021  Itgam; integrin alpha-M precursor [KO:K06461]
499271  Itgax; integrin alpha-X precursor [KO:K06462]
64350  Itgad; integrin alpha-D precursor [KO:K06594]
83577  Itgae; integrin alpha-E precursor [KO:K06524]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
309684  Itgb2; integrin beta-2 precursor [KO:K06464]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
25724  Itgb4; integrin beta-4 precursor [KO:K06525]
257645  Itgb5; integrin beta-5 precursor [KO:K06588]
311061  Itgb6; integrin beta-6 precursor [KO:K06589]
25713  Itgb7; integrin beta-7 precursor [KO:K06590]
362800  Itgb8; integrin beta-8 precursor [KO:K06591]
24903  Kng2; T-kininogen 1 precursor [KO:K03898]
25087  Kng2l1; kininogen-1 isoform 1 precursor [KO:K03898]
288001  Kng1; T-kininogen 2 precursor [KO:K03898]
81509  Bdkrb1; B1 bradykinin receptor [KO:K03915]
25245  Bdkrb2; B2 bradykinin receptor isoform 2 [KO:K03916]
25229  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
81645  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
24260  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
25111  Chrm4; muscarinic acetylcholine receptor M4 [KO:K04132]
53949  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
362119  C5; complement C5 precursor [KO:K03994]
24237  C6; complement component C6 precursor [KO:K03995]
117517  C7; complement component C7 isoform X1 [KO:K03996]
298288  C8a; complement component C8 alpha chain precursor [KO:K03997]
313421  C8b; complement component C8 beta chain precursor [KO:K03998]
117512  C9; complement component C9 [KO:K04000]
81663  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
303634  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
363460  Fgd1; FYVE, RhoGEF and PH domain-containing protein 1 isoform 1 [KO:K05720]
361223  Fgd3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
25414  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform 3 [KO:K05726]
54245  Crk; adapter molecule crk [KO:K04438]
287942  Crkl; crk-like protein [KO:K04438]
309081  Dock1; dedicator of cytokinesis protein 1 [KO:K13708]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
293621  Hras; GTPase HRas [KO:K02833]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
361568  Rras; ras-related protein R-Ras [KO:K07829]
365355  Rras2; ras-related protein R-Ras2 [KO:K07830]
25482  Mras; ras-related protein M-Ras [KO:K07831]
363509  Arhgef6; rho guanine nucleotide exchange factor 6 [KO:K05729]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
25156  Vav1; proto-oncogene vav [KO:K05730]
295378  Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
296603  Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
304109  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
64363  Araf; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24559  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117183  Rgcc; regulator of cell cycle RGCC [KO:K26108]
683573  Rgccl1; regulator of cell cycle RGCC-like [KO:K26108]
60323  Arhgef1; rho guanine nucleotide exchange factor 1 [KO:K12330]
367072  Arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
306400  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
117273  Rhoa; transforming protein RhoA [KO:K04513]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
29432  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
29433  Pak3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
292756  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
311450  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
296078  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
114559  Arhgef7; rho guanine nucleotide exchange factor 7 isoform b [KO:K13710]
83709  Git1; ARF GTPase-activating protein GIT1 [KO:K05737]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
288057  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117558  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
291926  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100911165  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
24668  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
24669  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16]
25594  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116670  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
304813  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
499076  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
363925  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
289759  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
296313  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
501831  Myl10; myosin regulatory light chain 10 [KO:K12756]
501203  Myl12a; myosin regulatory light chain RLC-A [KO:K12757]
50685  Myl12b; myosin regulatory light chain 12B [KO:K12757]
24584  Myl11; myosin regulatory light chain 11 [KO:K12758]
25745  Myh9; myosin-9 [KO:K10352]
308572  Myh14; myosin-14 [KO:K10352]
79433  Myh10; myosin-10 [KO:K10352]
24582  Myh11; myosin-11 [KO:K10352]
307483  Diaph1; protein diaphanous homolog 1 isoform 1 [KO:K05740]
317189  Diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
24782  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
309419  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
314641  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c [KO:K00889] [EC:2.7.1.68]
365865  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
140607  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
116723  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
89812  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
316457  Pikfyve; 1-phosphatidylinositol-3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
65172  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
29524  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
290396  Diaph3; protein diaphanous homolog 3 [KO:K05745]
117542  Baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
360891  Enah; protein enabled homolog isoform 2 [KO:K05746]
682507  Wasl; actin nucleation-promoting factor WASL [KO:K23612]
313024  Wasf2; actin-binding protein WASF2 [KO:K05748]
308666  Cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
315348  Nckap1l; nck-associated protein 1-like isoform 2 [KO:K05750]
58823  Nckap1; nck-associated protein 1 [KO:K05750]
286928  Abi2; abl interactor 2 isoform 2 [KO:K05751]
679934  Brk1; protein BRICK1 [KO:K05752]
294568  Wasf1; actin-binding protein WASF1 [KO:K05753]
289820  Actr2; actin-related protein 2 [KO:K17260]
362298  Actr3b; actin-related protein 3B [KO:K18584]
81732  Actr3; actin-related protein 3 [KO:K18584]
54227  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
81824  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
301511  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
288669  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
297518  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
296710  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
360854  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100361457  Actg1l1; actin, gamma 1 propeptide-like [KO:K05692]
81822  Actb; actin, cytoplasmic 1 [KO:K05692]
287876  Actg1; actin, cytoplasmic 2 [KO:K05692]
120098222  POTE ankyrin domain family member F [KO:K05692]
171436  Mk1; Mk1 protein [KO:K05759]
64303  Pfn1; profilin-1 [KO:K05759]
81531  Pfn2; profilin-2 [KO:K05759]
685936  Pfn3; profilin-3 [KO:K05759]
494222  Pfn4; profilin-4 [KO:K05759]
102551431  profilin-2-like [KO:K05759]
360820  Pxn; paxillin isoform 1 [KO:K05760]
54319  Ezr; ezrin [KO:K08007]
315655  Rdx; radixin [KO:K05762]
81521  Msn; moesin [KO:K05763]
81814  Tmsb4x; thymosin beta-4 [KO:K05764]
120096885  thymosin beta-4-like [KO:K05764]
120095326  thymosin beta-4-like [KO:K05764]
103692338  Tmsb4xl2; thymosin beta-4-like [KO:K05764]
120094392  thymosin beta-4-like [KO:K05764]
29271  Cfl1; cofilin-1 [KO:K05765]
366624  Cfl2; cofilin-2 [KO:K05765]
688430  Cfl1l1; cofilin-1-like [KO:K05765]
303342  Ssh2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
365396  Ssh3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
304580  Ssh1; protein phosphatase Slingshot homolog 1 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
305679  Vcl; vinculin [KO:K05700]
361598  Iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
310621  Iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
100360623  Iqgap2; IQ motif containing GTPase activating protein 2 [KO:K05767]
296654  Gsn; gelsolin precursor [KO:K05768]
298975  Scin; scinderin [KO:K05768]
63836  Actn4; alpha-actinin-4 [KO:K05699]
81634  Actn1; alpha-actinin-1 [KO:K05699]
24205  Apc; adenomatous polyposis coli protein [KO:K02085]
299611  Apc2; adenomatous polyposis coli protein 2 [KO:K02085]
305938  Spata13; spermatogenesis-associated protein 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
rno04010  MAPK signaling pathway
rno04510  Focal adhesion
rno04520  Adherens junction
KO pathway
ko04810   
LinkDB

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