Entry
Name
Gastric acid secretion - Rattus norvegicus (rat)
Description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class
Organismal Systems; Digestive system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
24260 Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131 ]
25706 Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195 ]
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
25262 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958 ]
81678 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
25679 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
25400 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
24246 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
24245 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
171140 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
24896 Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632 ]
25686 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
25643 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
81664 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
171138 Kcne2; potassium voltage-gated channel subfamily E member 2 [KO:K04896 ]
84020 Kcnq1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
24521 Kcnj1; ATP-sensitive inward rectifier potassium channel 1 isoform 2 [KO:K04995 ]
29712 Kcnj2; inward rectifier potassium channel 2 [KO:K04996 ]
29718 Kcnj10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003 ]
170847 Kcnj15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008 ]
29719 Kcnj16; inward rectifier potassium channel 16 [KO:K05009 ]
170899 Kcnk2; potassium channel subfamily K member 2 isoform 2 [KO:K04913 ]
65272 Kcnk10; potassium channel subfamily K member 10 [KO:K04920 ]
24211 Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 precursor [KO:K01539 ] [EC:7.2.2.13 ]
24212 Atp1a2; sodium/potassium-transporting ATPase subunit alpha-2 precursor [KO:K01539 ] [EC:7.2.2.13 ]
25650 Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
24214 Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
25390 Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
24785 Slc9a4; sodium/hydrogen exchanger 4 precursor [KO:K13961 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Schubert ML, Peura DA
Title
Control of gastric acid secretion in health and disease.
Journal
Reference
Authors
Urushidani T, Forte JG
Title
Signal transduction and activation of acid secretion in the parietal cell.
Journal
Reference
Authors
Yao X, Forte JG
Title
Cell biology of acid secretion by the parietal cell.
Journal
Reference
Authors
Heitzmann D, Warth R
Title
No potassium, no acid: K+ channels and gastric acid secretion.
Journal
Reference
Authors
Kopic S, Murek M, Geibel JP
Title
Revisiting the parietal cell.
Journal
Reference
Authors
Schubert ML
Title
Gastric secretion.
Journal
Reference
Authors
Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title
From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal
J Physiol Pharmacol 56:507-30 (2005)
Reference
Authors
Forte JG, Zhu L
Title
Apical recycling of the gastric parietal cell H,K-ATPase.
Journal
Reference
Authors
Szaszak M, Christian F, Rosenthal W, Klussmann E
Title
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal
Reference
Authors
Heitzmann D, Warth R
Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal
Reference
Authors
Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal
Reference
Authors
Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title
Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal
Related pathway
rno04974 Protein digestion and absorption
KO pathway
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