Entry
Name
Alzheimer disease - Rattus norvegicus (rat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
29650 Adam10; disintegrin and metalloproteinase domain-containing protein 10 precursor [KO:K06704 ] [EC:3.4.24.81 ]
57027 Adam17; disintegrin and metalloproteinase domain-containing protein 17 precursor [KO:K06059 ] [EC:3.4.24.86 ]
54226 App; amyloid-beta precursor protein precursor [KO:K04520 ]
84019 Nae1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532 ]
29722 Apbb1; amyloid beta precursor protein binding family B member 1 [KO:K04529 ]
691658 Aph1bl2; similar to anterior pharynx defective 1b homolog [KO:K06172 ]
29477 Mapt; microtubule-associated protein tau [KO:K04380 ]
293655 Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942 ] [EC:7.1.1.2 ]
81728 Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943 ] [EC:7.1.1.2 ]
64539 Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2 [KO:K03944 ]
363441 Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945 ]
291660 Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946 ]
120099907 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946 ]
691001 Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947 ]
681024 Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948 ]
100362331 Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948 ]
25488 Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949 ]
315167 Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950 ]
299643 Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951 ]
120101567 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951 ]
296658 Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952 ]
362440 Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953 ]
316632 Ndufa10l1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like [KO:K03954 ]
678759 Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954 ]
293453 Ndufab1; acyl carrier protein, mitochondrial [KO:K03955 ]
301123 Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956 ]
299739 Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352 ]
100911483 Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353 ]
362344 Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958 ]
301427 Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959 ]
103690609 Ndufb3l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959 ]
103694107 Ndufb3l3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959 ]
103691697 Ndufb3l2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959 ]
120098318 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959 ]
288088 Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960 ]
499131 Ndufb4l3; similar to NADH:ubiquinone oxidoreductase B15 subunit [KO:K03960 ]
100361934 Ndufb4l4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960 ]
103691107 Ndufb4l5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960 ]
120094308 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960 ]
501886 Ndufb4l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960 ]
294964 Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961 ]
297990 Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962 ]
361385 Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963 ]
293991 Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964 ]
299954 Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965 ]
681418 Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966 ]
299310 Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351 ]
301458 Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934 ] [EC:7.1.1.2 ]
289218 Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935 ] [EC:7.1.1.2 ]
295923 Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936 ] [EC:7.1.1.2 ]
499529 Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937 ]
362588 Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938 ]
679739 Ndufs6; NADH:ubiquinone oxidoreductase subunit S6-like 1 [KO:K03939 ]
362837 Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940 ] [EC:7.1.1.2 ]
293652 Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941 ] [EC:7.1.1.2 ]
689938 Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967 ]
293130 Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968 ]
157074 Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234 ] [EC:1.3.5.1 ]
298596 Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235 ] [EC:1.3.5.1 ]
289217 Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236 ]
363061 Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237 ]
301011 Uqcrc1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414 ]
293448 Uqcrc2; cytochrome b-c1 complex subunit 2, mitochondrial precursor [KO:K00415 ]
366448 Uqcrh; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416 ]
685596 Uqcrbl1; cytochrome b-c1 complex subunit 7-like [KO:K00417 ]
685322 Uqcr10; ubiquinol-cytochrome c reductase complex 7.2kDa protein [KO:K00419 ]
690848 Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420 ]
26204 COX3; cytochrome c oxidase subunit III [KO:K02262 ]
26198 COX2; cytochrome c oxidase subunit II [KO:K02261 ]
84683 Cox4i2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor [KO:K02263 ]
29445 Cox4i1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263 ]
252934 Cox5a; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264 ]
94194 Cox5b; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265 ]
25278 Cox6a2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266 ]
25282 Cox6a1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266 ]
54322 Cox6c; cytochrome c oxidase subunit 6C-2 [KO:K02268 ]
29507 Cox7a2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270 ]
298762 Cox7a2l; cytochrome c oxidase subunit 7A2 like isoform 1 [KO:K02270 ]
688386 Cox7a2l2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270 ]
303393 Cox7b; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271 ]
100188937 Cox7c; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272 ]
100360357 Cox7cl1; cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272 ]
25250 Cox8b; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273 ]
360229 Cox8c; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273 ]
171335 Cox8a; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273 ]
65262 Atp5f1a; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132 ]
116550 Atp5f1c; ATP synthase subunit gamma, mitochondrial [KO:K02136 ]
245965 Atp5f1d; ATP synthase subunit delta, mitochondrial precursor [KO:K02134 ]
245958 Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135 ]
171375 Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127 ]
171082 Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128 ]
114630 Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128 ]
29754 Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128 ]
100361833 Atp5mc2l1; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128 ]
499512 Atp5mc2l2; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128 ]
689961 Atp5mc1l1; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128 ]
366614 Atp5mc1l2; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128 ]
120098314 LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128 ]
641434 Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138 ]
688022 Atp5pdl1; ATP synthase subunit d, mitochondrial-like [KO:K02138 ]
192241 Atp5po; ATP synthase subunit O, mitochondrial precursor [KO:K02137 ]
94271 Atp5pf; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131 ]
83529 Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
83531 Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
83532 Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041 ]
498885 Slc25a6; solute carrier family 25 member 6 [KO:K05863 ]
282819 Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565 ] [EC:5.2.1.8 ]
299858 Lrp1; prolow-density lipoprotein receptor-related protein 1 precursor [KO:K04550 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
266610 Fadd; FAS-associated death domain protein [KO:K02373 ]
64625 Bid; BH3-interacting domain death agonist [KO:K04726 ]
24675 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
171378 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
64639 Bad; bcl2-associated agonist of cell death [KO:K02158 ]
78963 Apaf1; apoptotic protease-activating factor 1 [KO:K02084 ]
25229 Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129 ]
24260 Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131 ]
53949 Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133 ]
24418 Grm5; metabotropic glutamate receptor 5 precursor [KO:K04604 ]
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
24408 Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208 ]
24409 Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209 ]
24410 Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210 ]
24411 Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211 ]
24412 Grin2d; glutamate receptor ionotropic, NMDA 2D precursor [KO:K05212 ]
24239 Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
29716 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
114493 Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
682930 Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
25302 Chrna7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809 ]
294560 Mcu; calcium uniporter protein, mitochondrial precursor [KO:K20858 ]
25262 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958 ]
81678 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
25679 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
29693 Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b [KO:K05853 ] [EC:7.2.2.10 ]
304962 Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054 ]
289754 Xbp1; X-box-binding protein 1 isoform XBP1(U) [KO:K09027 ]
29467 Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452 ]
498013 Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
29702 Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 precursor [KO:K08860 ] [EC:2.7.11.1 ]
363855 Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431 ] [EC:2.7.12.2 ]
54318 Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
79255 Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
25581 Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061 ]
117263 Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062 ]
117262 Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063 ]
289990 Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064 ]
29677 Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065 ]
81827 Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066 ]
287984 Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028 ]
83806 Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032 ]
287670 Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033 ]
161475 Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693 ]
287772 Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035 ]
303353 Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036 ]
289924 Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037 ]
307821 Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038 ]
365388 Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039 ]
83499 Psmd4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029 ]
311078 Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030 ]
292766 Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031 ]
65138 Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691 ]
680532 Sem1; 26S proteasome complex subunit SEM1 [KO:K10881 ]
116671 Cdk5r1; cyclin-dependent kinase 5 activator 1 [KO:K11716 ]
294281 Slc39a7; zinc transporter SLC39A7 precursor [KO:K14713 ]
295455 Slc39a8; metal cation symporter ZIP8 precursor [KO:K14714 ]
363229 Slc39a10; zinc transporter ZIP10 precursor [KO:K14716 ]
291328 Slc39a12; zinc transporter ZIP12 precursor [KO:K14718 ]
295928 Slc39a13; zinc transporter ZIP13 isoform 1 precursor [KO:K14719 ]
306009 Slc39a14; metal cation symporter ZIP14 precursor [KO:K14720 ]
25715 Slc11a2; natural resistance-associated macrophage protein 2 isoform 1 [KO:K21398 ]
293897 Dkk1; dickkopf-related protein 1 precursor [KO:K02165 ]
295445 Dkk2; dickkopf-related protein 2 precursor [KO:K02165 ]
502097 Dkk4; dickkopf-related protein 4 precursor [KO:K02165 ]
293649 Lrp5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068 ]
312781 Lrp6; low-density lipoprotein receptor-related protein 6 isoform 2 precursor [KO:K03068 ]
83721 Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
303811 Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
303251 Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
81650 Csnk2b; casein kinase II subunit beta [KO:K03115 ]
24205 Apc; adenomatous polyposis coli protein [KO:K02085 ]
299611 Apc2; adenomatous polyposis coli protein 2 [KO:K02085 ]
81722 Ager; advanced glycosylation end product-specific receptor precursor [KO:K19722 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
66021 Cybb; cytochrome b-245 beta chain [KO:K21421 ] [EC:1.-.-.-]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
78965 Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453 ]
54287 Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195 ] [EC:2.7.11.1 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
300240 Atg101; autophagy-related protein 101 isoform 2 [KO:K19730 ]
312927 Rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589 ]
59319 Ambra1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985 ]
305831 Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889 ]
58839 Nrbf2; nuclear receptor-binding factor 2 [KO:K21246 ]
499670 RGD1560263; nuclear receptor-binding factor 2-like isoform X1 [KO:K21246 ]
689688 Atg2a; autophagy-related protein 2 homolog A [KO:K17906 ]
288498 Wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908 ]
303630 Wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C16514 Amyloid beta protein 40
C16515 Amyloid beta protein 42
C21011 [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012 [Protein]-N(epsilon)-(carboxyethyl)lysine
Reference
Authors
Dickson DW
Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
Journal
Reference
Authors
Takuma K, Yan SS, Stern DM, Yamada K
Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
Journal
Reference
Authors
Bezprozvanny I, Mattson MP
Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
Journal
Reference
Authors
Holscher C
Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
Journal
Reference
Authors
Bojarski L, Herms J, Kuznicki J
Title
Calcium dysregulation in Alzheimer's disease.
Journal
Reference
Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
Title
Ion channels in the regulation of apoptosis.
Journal
Reference
Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
Journal
Reference
Authors
Tan Y, Deng Y, Qing H
Title
Calcium channel blockers and Alzheimer's disease.
Journal
Reference
Authors
Small DH, Mok SS, Bornstein JC
Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
Journal
Reference
Authors
Parihar MS, Hemnani T
Title
Alzheimer's disease pathogenesis and therapeutic interventions.
Journal
Reference
Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
Title
Presenilin-mediated signal transduction.
Journal
Reference
Authors
Honarnejad K, Herms J
Title
Presenilins: role in calcium homeostasis.
Journal
Reference
Authors
Supnet C, Bezprozvanny I
Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
Journal
Reference
Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
Journal
Reference
Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
Journal
Reference
Authors
Eckert A, Nisbet R, Grimm A, Gotz J
Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
Journal
Reference
Authors
Strickland MR, Holtzman DM
Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
Journal
Reference
Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
Journal
Reference
Authors
Sushma, Mondal AC
Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
Journal
Reference
Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
Journal
Reference
Authors
Mattson MP
Title
ER calcium and Alzheimer's disease: in a state of flux.
Journal
Reference
Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
Journal
Reference
Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
Journal
Reference
Authors
Lane-Donovan C, Herz J
Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
Journal
Reference
Authors
Wasser CR, Herz J
Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
Journal
Reference
Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
Journal
Reference
Authors
Anastasio TJ
Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
Journal
Reference
Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
Journal
Reference
Authors
Tu S, Okamoto S, Lipton SA, Xu H
Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
Journal
Reference
Authors
Palomer E, Buechler J, Salinas PC
Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
Journal
Reference
Authors
Vallee A, Lecarpentier Y
Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
Journal
Reference
Authors
Origlia N, Arancio O, Domenici L, Yan SS
Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
Journal
Reference
Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
Journal
Reference
Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
Journal
Reference
Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
Title
Axonal transport defects: a common theme in neurodegenerative diseases.
Journal
Reference
Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
Journal
Reference
Authors
De Felice FG, Lourenco MV, Ferreira ST
Title
How does brain insulin resistance develop in Alzheimer's disease?
Journal
Reference
Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
Journal
Reference
Authors
Funderburk SF, Marcellino BK, Yue Z
Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
Journal
Related pathway
rno04141 Protein processing in endoplasmic reticulum
rno04933 AGE-RAGE signaling pathway in diabetic complications
KO pathway
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