Entry
Name
Hepatitis C - Rattus norvegicus (rat)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
300438 Ldlr; low-density lipoprotein receptor precursor [KO:K12473 ]
25073 Scarb1; scavenger receptor class B member 1 [KO:K13885 ]
680489 Cldn34e; uncharacterized protein LOC680489 [KO:K06087 ]
311430 Mavs; mitochondrial antiviral-signaling protein [KO:K12648 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
363328 Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
245920 Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
27137 Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194 ] [EC:2.7.11.1 ]
54287 Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195 ] [EC:2.7.11.1 ]
29702 Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 precursor [KO:K08860 ] [EC:2.7.11.1 ]
56824 Ifit1; interferon-induced protein with tetratricopeptide repeats 1-like protein [KO:K14217 ]
294090 Ifit1bl; interferon-induced protein with tetratricopeptide repeats 1 isoform 1 [KO:K14217 ]
299872 Eif3e; eukaryotic translation initiation factor 3 subunit E [KO:K03250 ]
100365062 Eif3el1; eukaryotic translation initiation factor 3 subunit E-like [KO:K03250 ]
54318 Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
25125 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
89829 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
288264 Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130 ]
686326 Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131 ]
25124 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220 ]
288774 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
286918 Mx2; interferon-induced GTP-binding protein Mx2 [KO:K14754 ]
24575 Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754 ]
65190 Rsad2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 [KO:K15045 ]
117281 Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
315648 Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
246255 Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
60660 Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1 [KO:K04354 ]
117256 Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1 [KO:K04354 ]
117104 Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354 ]
24672 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
24673 Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
100362453 Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382 ] [EC:3.1.3.16 ]
300772 Pias1; E3 SUMO-protein ligase PIAS1 [KO:K04706 ] [EC:2.3.2.-]
25313 Egf; pro-epidermal growth factor precursor [KO:K04357 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
134484121 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
64639 Bad; bcl2-associated agonist of cell death [KO:K02158 ]
114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
24708 Rb1; retinoblastoma-associated protein [KO:K06618 ]
684111 E2f2; transcription factor E2F2 isoform X2 [KO:K09389 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
246756 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
25385 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
266610 Fadd; FAS-associated death domain protein [KO:K02373 ]
117279 Cflar; CASP8 and FADD-like apoptosis regulator isoform 1 [KO:K04724 ]
64625 Bid; BH3-interacting domain death agonist [KO:K04726 ]
78963 Apaf1; apoptotic protease-activating factor 1 [KO:K02084 ]
287716 Psme3; proteasome activator complex subunit 3 [KO:K06698 ]
25271 Rxra; retinoic acid receptor RXR-alpha [KO:K08524 ]
25747 Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
Journal
Reference
Authors
Yamauchi Y, Helenius A
Title
Virus entry at a glance.
Journal
Reference
Authors
Feneant L, Levy S, Cocquerel L
Title
CD81 and hepatitis C virus (HCV) infection.
Journal
Reference
Authors
Dubuisson J, Helle F, Cocquerel L
Title
Early steps of the hepatitis C virus life cycle.
Journal
Reference
Authors
Liang TJ, Ghany MG
Title
Current and future therapies for hepatitis C virus infection.
Journal
Reference
Authors
Scheel TK, Rice CM
Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
Journal
Reference
Authors
Holmes JA, Thompson AJ
Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
Journal
Reference
Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
Journal
Reference
Authors
Horner SM, Gale M Jr
Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Journal
Reference
Authors
Lemon SM
Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
Journal
Reference
Authors
Horner SM, Gale M Jr
Title
Regulation of hepatic innate immunity by hepatitis C virus.
Journal
Reference
Authors
Ortega-Prieto AM, Dorner M
Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
Journal
Reference
Authors
Yang DR, Zhu HZ
Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
Journal
Reference
Authors
Gale M Jr, Foy EM
Title
Evasion of intracellular host defence by hepatitis C virus.
Journal
Reference
Authors
Bode JG, Brenndorfer ED, Haussinger D
Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
Journal
Reference
Authors
Panteva M, Korkaya H, Jameel S
Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
Journal
Reference
Authors
Pang R, Tse E, Poon RT
Title
Molecular pathways in hepatocellular carcinoma.
Journal
Reference
Authors
Macdonald A, Harris M
Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
Journal
Reference
Authors
He Y, Staschke KA, Tan SL
Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
Journal
Reference
Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
Journal
Reference
Authors
Hassan M, Ghozlan H, Abdel-Kader O
Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
Journal
Reference
Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
Journal
Reference
Authors
Yamanaka T, Uchida M, Doi T
Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
Journal
Reference
Authors
Lim EJ, Chin R, Angus PW, Torresi J
Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
Journal
Reference
Authors
Fischer R, Baumert T, Blum HE
Title
Hepatitis C virus infection and apoptosis.
Journal
Reference
Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
Journal
Reference
Authors
Koike K
Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
Journal
Reference
Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
Journal
Reference
Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
Title
Viral hepatocarcinogenesis: from infection to cancer.
Journal
Related pathway
rno04620 Toll-like receptor signaling pathway
rno04622 RIG-I-like receptor signaling pathway
KO pathway
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