KEGG   PATHWAY: rno05165
Entry
rno05165                    Pathway                                
Name
Human papillomavirus infection - Rattus norvegicus (rat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05165  Human papillomavirus infection
rno05165

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24881  Wnt1; proto-oncogene Wnt-1 precursor [KO:K03209]
116466  Wnt2b; protein Wnt-2b [KO:K00182]
114487  Wnt2; protein Wnt-2 precursor [KO:K00182]
24882  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
303181  Wnt3a; protein Wnt-3a precursor [KO:K00312]
84426  Wnt4; protein Wnt-4 precursor [KO:K00408]
64566  Wnt5a; protein Wnt-5a precursor [KO:K00444]
282582  Wnt5b; protein Wnt-5b precursor [KO:K00444]
316526  Wnt6; protein Wnt-6 precursor [KO:K00445]
114850  Wnt7a; protein Wnt-7a precursor [KO:K00572]
315196  Wnt7b; protein Wnt-7b isoform 1 [KO:K00572]
291678  Wnt8a; protein Wnt-8a precursor [KO:K00714]
293990  Wnt8b; protein Wnt-8b precursor [KO:K00714]
287357  Wnt9a; protein Wnt-9a precursor [KO:K01064]
303586  Wnt9b; protein Wnt-9b precursor [KO:K01064]
315294  Wnt10b; protein Wnt-10b precursor [KO:K01357]
316527  Wnt10a; protein Wnt-10a precursor [KO:K01357]
140584  Wnt11; protein Wnt-11 [KO:K01384]
500047  Wnt16; protein Wnt-16 precursor [KO:K01558]
58868  Fzd1; frizzled-1 precursor [KO:K02432]
100360552  Fzd7; frizzled-7 precursor [KO:K02432]
64512  Fzd2; frizzled-2 precursor [KO:K02235]
266715  Fzd3; frizzled-3 precursor [KO:K02329]
64558  Fzd4; frizzled-4 precursor [KO:K02354]
317674  Fzd5; frizzled-5 precursor [KO:K02375]
364754  Fzd8; frizzled-8 precursor [KO:K02375]
282581  Fzd6; frizzled-6 precursor [KO:K02376]
266608  Fzd9; frizzled-9 precursor [KO:K02842]
363913  Fzd10; frizzled-10 precursor [KO:K02842]
83721  Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
303811  Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
303251  Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
79257  Axin1; axin-1 [KO:K02157]
29134  Axin2; axin-2 [KO:K04385]
24205  Apc; adenomatous polyposis coli protein [KO:K02085]
299611  Apc2; adenomatous polyposis coli protein 2 [KO:K02085]
84353  Ctnnb1; catenin beta-1 [KO:K02105]
113927  Csnk1a1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
301965  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
363595  Tcf7; transcription factor 7 [KO:K02620]
312451  Tcf7l1; transcription factor 7-like 1 [KO:K04490]
679869  Tcf7l2; transcription factor 7-like 2 [KO:K04491]
361585  Ube3a; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
364594  Tlr3; toll-like receptor 3 precursor [KO:K05401]
363328  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
24481  Ifnb1; interferon beta precursor [KO:K05415]
54244  Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
170915  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
362414  Tada3; transcriptional adapter 3 [KO:K11315]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
500261  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2 [KO:K05631]
50557  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
81918  Pard3; partitioning defective 3 homolog [KO:K04237]
307237  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
307799  Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093]
362279  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
84006  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
25522  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
362938  Scrib; protein scribble homolog [KO:K16175]
25252  Dlg1; disks large homolog 1 isoform 1 [KO:K12076]
64053  Dlg2; disks large homolog 2 [KO:K12075]
58948  Dlg3; disks large homolog 3 [KO:K21098]
54265  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
360661  Llgl2; LLGL scribble cell polarity complex component 2 [KO:K06094]
301112  Crb3; protein crumbs homolog 3 precursor [KO:K06090]
140581  Patj; inaD-like protein [KO:K06092]
314259  Pals1; protein PALS1 [KO:K06091]
116669  Vwf; von Willebrand factor precursor [KO:K03900]
445442  Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857]
25304  Comp; cartilage oligomeric matrix protein precursor [KO:K04659]
29220  Thbs4; thrombospondin-4 precursor [KO:K04659]
292406  Thbs2; thrombospondin-2 precursor [KO:K04659]
681309  Thbs3; thrombospondin-3 precursor [KO:K04659]
25661  Fn1; fibronectin precursor [KO:K05717]
84352  Col1a2; collagen alpha-2(I) chain precursor [KO:K06236]
29393  Col1a1; collagen alpha-1(I) chain precursor [KO:K06236]
25412  Col2a1; collagen alpha-1(II) chain isoform 2 precursor [KO:K19719]
290905  Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237]
306628  Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237]
363457  Col4a5; collagen alpha-5(IV) chain precursor [KO:K06237]
363265  Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237]
363458  Col4a6; collagen type IV alpha 6 chain precursor [KO:K06237]
315981  Col6a4; collagen alpha-4(VI) chain precursor [KO:K06238]
361821  Col6a2; collagen alpha-2(VI) chain precursor [KO:K06238]
294337  Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238]
315979  Col6a6; collagen alpha-6(VI) chain isoform X3 [KO:K06238]
367313  Col6a3; collagen alpha-3(VI) chain precursor [KO:K06238]
501047  Col6a5; collagen alpha-5(VI) chain isoform X3 [KO:K06238]
305104  Col9a1; collagen alpha-1(IX) chain precursor [KO:K08131]
362584  Col9a2; collagen alpha-2(IX) chain precursor [KO:K08131]
362285  Col9a3; collagen alpha-3(IX) chain precursor [KO:K08131]
309368  Lama2; laminin subunit alpha-2 precursor [KO:K05637]
316758  Lama1; laminin subunit alpha-1 precursor [KO:K05637]
140433  Lama5; laminin subunit alpha-5 precursor [KO:K06240]
309816  Lama4; laminin subunit alpha-4 precursor [KO:K06241]
298941  Lamb1; laminin subunit beta-1 precursor [KO:K05636]
25473  Lamb2; laminin subunit beta-2 precursor [KO:K06243]
305078  Lamb3; laminin subunit beta-3 precursor [KO:K06244]
117036  Lamc1; laminin subunit gamma-1 precursor [KO:K05635]
192362  Lamc2; laminin subunit gamma-2 precursor [KO:K06246]
311862  Lamc3; laminin subunit gamma-3 precursor [KO:K06247]
29195  Chad; chondroadherin precursor [KO:K06248]
24718  Reln; reelin precursor [KO:K06249] [EC:3.4.21.-]
25353  Spp1; osteopontin precursor [KO:K06250]
29169  Vtn; vitronectin precursor [KO:K06251]
25567  Tnr; tenascin-R precursor [KO:K06252]
116640  Tnc; tenascin precursor [KO:K06252]
304913  Tnn; tenascin-N precursor [KO:K06252]
24477  Ibsp; bone sialoprotein 2 precursor [KO:K06253]
25118  Itga1; integrin alpha-1 precursor [KO:K06480]
170921  Itga2; integrin alpha-2 precursor [KO:K06481]
685269  Itga2b; integrin alpha-IIb precursor [KO:K06476]
360606  Itga3; integrin alpha-3 isoform 1 [KO:K06482]
311144  Itga4; integrin alpha-4 [KO:K06483]
315346  Itga5; integrin alpha-5 [KO:K06484]
114517  Itga6; integrin alpha-6 precursor [KO:K06485]
81008  Itga7; integrin alpha-7 precursor [KO:K06583]
364786  Itga8; integrin alpha-8 [KO:K06584]
685004  Itga9; integrin alpha-9 precursor [KO:K06585]
310683  Itga10; integrin alpha-10 precursor [KO:K06586]
315744  Itga11; integrin alpha-11 precursor [KO:K06587]
296456  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
25724  Itgb4; integrin beta-4 precursor [KO:K06525]
257645  Itgb5; integrin beta-5 precursor [KO:K06588]
311061  Itgb6; integrin beta-6 precursor [KO:K06589]
25713  Itgb7; integrin beta-7 precursor [KO:K06590]
362800  Itgb8; integrin beta-8 precursor [KO:K06591]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
360820  Pxn; paxillin isoform 1 [KO:K05760]
24835  Tnf; tumor necrosis factor [KO:K03156]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
59114  Nherf1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
24672  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
24673  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100362453  Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
117281  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
315648  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
246255  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
60660  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1 [KO:K04354]
117256  Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1 [KO:K04354]
117104  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
682033  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
362739  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
363122  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
309179  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
691318  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4 [KO:K11584]
363193  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
299147  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
312754  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
60445  Tsc1; hamartin [KO:K07206]
24855  Tsc2; tuberin [KO:K07207]
26954  Rheb; GTP-binding protein Rheb [KO:K07208]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
116636  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
83840  Rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
361696  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
84482  Foxo1; forkhead box protein O1 [KO:K07201]
83571  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
64033  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
25193  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
362485  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
25729  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
24708  Rb1; retinoblastoma-associated protein [KO:K06618]
680111  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
81758  Rbl2; retinoblastoma-like protein 2 [KO:K16332]
117263  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
399489  E2f1; transcription factor E2F1 [KO:K17454]
114494  Ccna2; cyclin-A2 [KO:K06627]
295052  Ccna1; cyclin-A1 [KO:K06627]
300711  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
685055  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
313166  Nfx1; transcriptional repressor NF-X1 [KO:K12236]
297893  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
84576  Hdac1l; histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
84577  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
117535  Chd4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
24508  Irf1; interferon regulatory factor 1 [KO:K09444]
117526  Tbp; TATA-box-binding protein [KO:K03120]
680050  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
689030  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
293852  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
685232  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117596  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
312488  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
299971  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
362802  Atp6v1c2; V-type proton ATPase subunit C 2 [KO:K02148]
299159  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
297566  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
366545  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
116664  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
289407  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
298103  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
368044  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
501686  Atp6v1g1l1; V-type proton ATPase subunit G 1-like [KO:K02152]
297797  Atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144]
29757  Atp6v0a1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
296981  Atp6v0a4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
293650  Tcirg1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
116455  Atp6v0a2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
291969  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
297932  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
94170  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
436582  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
170667  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
298451  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
83615  Atp6ap1; V-type proton ATPase subunit S1 precursor [KO:K03662]
25313  Egf; pro-epidermal growth factor precursor [KO:K04357]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
293621  Hras; GTPase HRas [KO:K02833]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
29527  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
84023  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
24887  Bax; apoptosis regulator BAX [KO:K02159]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
681314  apoptosis regulator BAX-like [KO:K02159]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
313658  Ubr4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
252921  Tubg1; tubulin gamma-1 chain [KO:K10389]
680991  Tubg2; tubulin gamma-2 chain [KO:K10389]
25630  Pkm; pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
100362738  Pkml1; pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
100912314  interferon alpha-1-like [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
134487075  interferon alpha-1-like [KO:K05414]
134487077  interferon alpha-1-like [KO:K05414]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912356  interferon alpha-1-like precursor [KO:K05414]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100361294  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
54287  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
304545  Oasl; 2'-5'-oligoadenylate synthase-like protein 1 [KO:K14608]
304549  Oasl2; 2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
286918  Mx2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
24575  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
298693  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
29146  Jag1; protein jagged-1 precursor [KO:K06052]
25496  Notch1; neurogenic locus notch homolog protein 1 precursor [KO:K02599]
29492  Notch2; neurogenic locus notch homolog protein 2 precursor [KO:K20994]
56761  Notch3; neurogenic locus notch homolog protein 3 precursor [KO:K20995]
406162  Notch4; neurogenic locus notch homolog protein 4 precursor [KO:K20996]
29192  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
315119  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
170905  Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor [KO:K05948] [EC:2.4.1.222]
60433  Rfng; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
689844  Maml2; mastermind-like protein 2 isoform X1 [KO:K06061]
310405  Maml3; mastermind-like protein 3 [KO:K06061]
362268  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
679028  Rbpj; recombining binding protein suppressor of hairless isoform 1 [KO:K06053]
29577  Hes1; transcription factor HES-1 [KO:K06054]
29567  Hes2; transcription factor HES-2 [KO:K09087]
316626  Hes6; transcription cofactor HES-6 [KO:K09087]
287423  Hes7; transcription factor HES-7 isoform 1 [KO:K09087]
64628  Hes3; transcription factor HES-3 [KO:K09088]
79225  Hes5; transcription factor HES-5 [KO:K06055]
313575  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
155430  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
155437  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
PMID:25752815
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Reference
PMID:19684440
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Reference
PMID:23164805
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Human papillomavirus proteins as prospective therapeutic targets.
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Reference
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  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
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Kim YT, Zhao M
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
PMID:15342967
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  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Reference
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  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
PMID:19029942
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Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
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  Authors
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  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Arch Virol 151:2321-35 (2006)
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Reference
PMID:26022660
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Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Mol Cancer 14:87 (2015)
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Reference
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  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
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Mol Cancer 10:140 (2011)
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Reference
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Oncogene 20:7866-73 (2001)
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Reference
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Ganguly N
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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Cell Oncol (Dordr) 35:67-76 (2012)
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Reference
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The E5 proteins.
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Reference
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Oxidative stress and HPV carcinogenesis.
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Reference
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Reference
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Chung CH, Gillison ML
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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Control of interferon signaling in human papillomavirus infection.
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Reference
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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Reference
PMID:22499770
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Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
rno04064  NF-kappa B signaling pathway
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04310  Wnt signaling pathway
rno04330  Notch signaling pathway
rno04510  Focal adhesion
rno04520  Adherens junction
rno04530  Tight junction
rno04612  Antigen processing and presentation
rno04620  Toll-like receptor signaling pathway
rno04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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