KEGG   PATHWAY: rno05170
Entry
rno05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Rattus norvegicus (rat)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05170  Human immunodeficiency virus 1 infection
rno05170

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24932  Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
361765  Btrc; F-box/WD repeat-containing protein 1A [KO:K03362]
303024  Fbxw11; F-box/WD repeat-containing protein 11 isoform 1 [KO:K03362]
287280  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
362356  Cul1; cullin-1 [KO:K03347]
300084  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
117029  Ccr5; C-C chemokine receptor type 5 [KO:K04180]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
50664  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform B [KO:K04534]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
50646  Ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
360820  Pxn; paxillin isoform 1 [KO:K05760]
54245  Crk; adapter molecule crk [KO:K04438]
287942  Crkl; crk-like protein [KO:K04438]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
83840  Rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
361696  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
314322  Fos; protein c-Fos [KO:K04379]
24516  Jun; transcription factor Jun [KO:K04448]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
293621  Hras; GTPase HRas [KO:K02833]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
81662  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
50663  Calm2; calmodulin-2 [KO:K02183]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
305897  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24400  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
81667  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
60449  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
294962  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
83579  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
80850  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114117  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114118  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
79218  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
58979  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
245986  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114119  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
64199  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
685451  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
680149  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
690825  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
29432  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
29433  Pak3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
292756  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
311450  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
296078  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
65172  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
29524  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
29271  Cfl1; cofilin-1 [KO:K05765]
366624  Cfl2; cofilin-2 [KO:K05765]
688430  Cfl1l1; cofilin-1-like [KO:K05765]
24835  Tnf; tumor necrosis factor [KO:K03156]
156767  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
363520  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
315139  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
308267  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
100912314  interferon alpha-1-like [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
134487075  interferon alpha-1-like [KO:K05414]
134487077  interferon alpha-1-like [KO:K05414]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912356  interferon alpha-1-like precursor [KO:K05414]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
24481  Ifnb1; interferon beta precursor [KO:K05415]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
682147  Cgas; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
498840  Sting1; stimulator of interferon genes protein [KO:K12654]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
315137  Apobec3; DNA dC->dU-editing enzyme APOBEC3 [KO:K18750] [EC:3.5.4.-]
311580  Samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
499223  Trim30d; tripartite motif-containing protein 30A-like isoform X1 [KO:K10648] [EC:2.3.2.27]
308906  Trim5; tripartite motif-containing protein 5 [KO:K10648] [EC:2.3.2.27]
378947  Bst2; bone marrow stromal antigen 2 [KO:K06731]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
306886  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
684173  Traf5; TNF receptor-associated factor 5 [KO:K09849]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
303200  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
114495  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
363855  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431] [EC:2.7.12.2]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
64625  Bid; BH3-interacting domain death agonist [KO:K04726]
24887  Bax; apoptosis regulator BAX [KO:K02159]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
681314  apoptosis regulator BAX-like [KO:K02159]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
120099910  cytochrome c, somatic-like [KO:K08738]
690675  Cycsl2; cytochrome c, somatic-like [KO:K08738]
679794  Cycsl1; cytochrome c, somatic-like [KO:K08738]
290019  Cycsl3; cytochrome c, somatic-like [KO:K08738]
58918  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
315609  Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
300678  Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
25710  Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
25300  Cd247; T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor [KO:K06453]
24811  Tap1; antigen peptide transporter 1 precursor [KO:K05653] [EC:7.4.2.14]
24812  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
25217  Tapbp; tapasin precursor [KO:K08058]
29468  Pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
64202  Calr; calreticulin precursor [KO:K08057]
689537  Calr4; calreticulin isoform X1 [KO:K08057]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
29663  Ap1b1; AP-1 complex subunit beta-1 [KO:K12392]
171494  Ap1g1; AP-1 complex subunit gamma-1 isoform 1 [KO:K12391]
100362547  Ap1g2; adaptor related protein complex 1 subunit gamma 2 [KO:K12391]
306332  Ap1m1; AP-1 complex subunit mu-1 [KO:K12393]
367038  Ap1m2; AP-1 complex subunit mu-2 [KO:K12393]
302671  Ap1s2; AP-1 complex subunit sigma-2 [KO:K12394]
360785  Ap1s1; adaptor-related protein complex 1, sigma 1 subunit [KO:K12394]
367304  Ap1s3; AP-1 complex subunit sigma-3 [KO:K12395]
24223  B2m; beta-2-microglobulin precursor [KO:K08055]
81807  Elob; elongin-B [KO:K03873]
134486081  elongin-B-like [KO:K03873]
120101893  Elob-ps3; elongin-B-like [KO:K03873]
134486082  elongin-B-like [KO:K03873]
690241  Elob-ps14; elongin-B-like [KO:K03873]
502620  Elob-ps8; elongin-B-like [KO:K03873]
134486083  elongin-B-like [KO:K03873]
120101899  Elob-ps15; elongin-B-like [KO:K03873]
134486084  elongin-B-like [KO:K03873]
120101894  Elob-ps13; elongin-B-like [KO:K03873]
120101896  Elob-ps7; elongin-B-like [KO:K03873]
120101895  Elob-ps5; elongin-B-like [KO:K03873]
134486085  elongin-B-like [KO:K03873]
64525  Eloc; elongin-C [KO:K03872]
134482479  elongin-C-like [KO:K03872]
134482480  elongin-C-like [KO:K03872]
134482485  elongin-C-like [KO:K03872]
103691088  Elocl1; elongin-C-like [KO:K03872]
120097475  elongin-C-like [KO:K03872]
120099279  elongin-C-like [KO:K03872]
64624  Cul5; cullin-5 [KO:K10612]
300948  Rnf7; RING-box protein 2 [KO:K10611]
315987  Dcaf1; DDB1- and CUL4-associated factor 1 [KO:K11789] [EC:2.7.11.1]
64470  Ddb1; DNA damage-binding protein 1 [KO:K10610]
302502  Cul4b; cullin-4B [KO:K10609]
361181  Cul4a; cullin-4A [KO:K10609]
300711  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
685055  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
140583  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
308937  Wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
502750  Wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
25203  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
363088  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
317389  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
54237  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
PMID:28358311
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
PMID:18178131
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
DOI:10.1016/j.it.2007.10.008
Reference
PMID:24453421
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
PMID:23986795
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
DOI:10.2174/1874357920130621001
Reference
PMID:21368875
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
DOI:10.1038/cddis.2010.77
Reference
PMID:12766761
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
Reference
PMID:21994747
  Authors
Fevrier M, Dorgham K, Rebollo A
  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
  Journal
Viruses 3:586-612 (2011)
DOI:10.3390/v3050586
Reference
PMID:11237054
  Authors
Ross TM
  Title
Using death to one's advantage: HIV modulation of apoptosis.
  Journal
Leukemia 15:332-41 (2001)
DOI:10.1038/sj.leu.2402028
Reference
PMID:22767237
  Authors
Hurley JH, Bonifacino JS
  Title
Nef-arious goings-on at the Golgi.
  Journal
Nat Struct Mol Biol 19:661-2 (2012)
DOI:10.1038/nsmb.2304
Reference
PMID:21762823
  Authors
Wonderlich ER, Leonard JA, Collins KL
  Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
  Journal
Adv Virus Res 80:103-27 (2011)
DOI:10.1016/B978-0-12-385987-7.00005-1
Reference
PMID:20594957
  Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
  Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
  Journal
Mol Aspects Med 31:418-33 (2010)
DOI:10.1016/j.mam.2010.05.003
Reference
PMID:27161574
  Authors
Pereira EA, daSilva LL
  Title
HIV-1 Nef: Taking Control of Protein Trafficking.
  Journal
Traffic 17:976-96 (2016)
DOI:10.1111/tra.12412
Reference
PMID:26950141
  Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
  Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
  Journal
Viruses 8:67 (2016)
DOI:10.3390/v8030067
Reference
PMID:24906315
  Authors
Bagga S, Bouchard MJ
  Title
Cell cycle regulation during viral infection.
  Journal
Methods Mol Biol 1170:165-227 (2014)
DOI:10.1007/978-1-4939-0888-2_10
Reference
PMID:15638722
  Authors
Andersen JL, Planelles V
  Title
The role of Vpr in HIV-1 pathogenesis.
  Journal
Curr HIV Res 3:43-51 (2005)
DOI:10.2174/1570162052772988
Reference
PMID:17140287
  Authors
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
  Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
  Journal
PLoS Pathog 2:e127 (2006)
DOI:10.1371/journal.ppat.0020127
Reference
PMID:23430691
  Authors
Takaori-Kondo A, Shindo K
  Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
  Journal
Front Microbiol 4:34 (2013)
DOI:10.3389/fmicb.2013.00034
Reference
PMID:19038776
  Authors
Malim MH
  Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
DOI:10.1098/rstb.2008.0185
Reference
PMID:21835787
  Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
  Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
  Journal
J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
rno03050  Proteasome
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04064  NF-kappa B signaling pathway
rno04110  Cell cycle
rno04141  Protein processing in endoplasmic reticulum
rno04142  Lysosome
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04612  Antigen processing and presentation
rno04620  Toll-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04668  TNF signaling pathway
rno04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

DBGET integrated database retrieval system