KEGG   PATHWAY: sce04011
Entry
sce04011                    Pathway                                
Name
MAPK signaling pathway - yeast - Saccharomyces cerevisiae (budding yeast)
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
Pathway map
sce04011  MAPK signaling pathway - yeast
sce04011

Other DBs
GO: 0000165
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YAL041W  CDC24; Rho family guanine nucleotide exchange factor CDC24 [KO:K11236]
YBL016W  FUS3; mitogen-activated serine/threonine-protein kinase FUS3 [KO:K04371] [EC:2.7.11.24]
YBL105C  PKC1; protein kinase C [KO:K02677] [EC:2.7.11.13]
YBR083W  TEC1; Tec1p [KO:K09448]
YBR112C  CYC8; transcription regulator CYC8 [KO:K06665]
YBR133C  HSL7; protein arginine N-methyltransferase [KO:K02516] [EC:2.1.1.320]
YBR160W  CDC28; cyclin-dependent serine/threonine-protein kinase CDC28 [KO:K04563] [EC:2.7.11.22]
YBR182C  SMP1; Smp1p [KO:K19807]
YBR200W  BEM1; phosphatidylinositol-3-phosphate-binding protein BEM1 [KO:K11237]
YBR279W  PAF1; Paf1p [KO:K15174]
YCL027W  FUS1; Fus1p [KO:K11243]
YCL032W  STE50; Ste50p [KO:K19841]
YCR073C  SSK22; mitogen-activated protein kinase kinase kinase SSK22 [KO:K11230] [EC:2.7.11.25]
YCR084C  TUP1; chromatin-silencing transcriptional regulator TUP1 [KO:K06666]
YDL006W  PTC1; type 2C protein phosphatase PTC1 [KO:K19704] [EC:3.1.3.16]
YDL022W  GPD1; glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 [KO:K00006] [EC:1.1.1.8]
YDL159W  STE7; mitogen-activated protein kinase kinase STE7 [KO:K11226] [EC:2.7.12.2]
YDL235C  YPD1; Ypd1p [KO:K11232]
YDR099W  BMH2; 14-3-3 family protein BMH2 [KO:K06630]
YDR103W  STE5; Ste5p [KO:K11239]
YDR144C  MKC7; aspartyl protease [KO:K06009] [EC:3.4.23.41]
YDR208W  MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase [KO:K00889] [EC:2.7.1.68]
YDR256C  CTA1; catalase A [KO:K03781] [EC:1.11.1.6]
YDR379W  RGA2; GTPase-activating protein RGA2 [KO:K19839]
YDR389W  SAC7; GTPase-activating protein SAC7 [KO:K19845]
YDR420W  HKR1; Hkr1p [KO:K19848]
YDR461W  MFA1; mating pheromone A [KO:K11235]
YDR466W  PKH3; protein kinase PKH3 [KO:K06276] [EC:2.7.11.1]
YDR480W  DIG2; Dig2p [KO:K11242]
YDR490C  PKH1; serine/threonine protein kinase PKH1 [KO:K06276] [EC:2.7.11.1]
YER075C  PTP3; tyrosine protein phosphatase PTP3 [KO:K19806] [EC:3.1.3.48]
YER111C  SWI4; SBF complex DNA-binding subunit SWI4 [KO:K06649]
YER118C  SHO1; osmosensor SHO1 [KO:K11246]
YER125W  RSP5; NEDD4 family E3 ubiquitin-protein ligase [KO:K10591] [EC:2.3.2.26]
YER155C  BEM2; GTPase-activating protein BEM2 [KO:K19844]
YER177W  BMH1; 14-3-3 family protein BMH1 [KO:K06630]
YFL026W  STE2; alpha-factor pheromone receptor STE2 [KO:K11213]
YGL089C  MF(ALPHA)2; Mf(Alpha)2p [KO:K11234]
YGR014W  MSB2; Msb2p [KO:K19849]
YGR023W  MTL1; Mtl1p [KO:K11245]
YGR032W  GSC2; 1,3-beta-glucan synthase GSC2 [KO:K00706] [EC:2.4.1.34]
YGR040W  KSS1; mitogen-activated serine/threonine-protein kinase KSS1 [KO:K04371] [EC:2.7.11.24]
YGR070W  ROM1; Rho family guanine nucleotide exchange factor ROM1 [KO:K19842]
YGR088W  CTT1; catalase T [KO:K03781] [EC:1.11.1.6]
YGR108W  CLB1; B-type cyclin CLB1 [KO:K02220]
YGR109C  CLB6; B-type cyclin CLB6 [KO:K06651]
YHL007C  STE20; mitogen-activated protein kinase kinase kinase kinase STE20 [KO:K04409] [EC:2.7.11.1]
YHR005C  GPA1; guanine nucleotide-binding protein subunit alpha [KO:K19860]
YHR030C  SLT2; mitogen-activated serine/threonine-protein kinase SLT2 [KO:K04464] [EC:2.7.11.24]
YHR084W  STE12; homeodomain family transcription factor STE12 [KO:K11215]
YHR135C  YCK1; serine/threonine protein kinase YCK1 [KO:K02218] [EC:2.7.11.1]
YIL015W  BAR1; aspartyl protease BAR1 [KO:K01383] [EC:3.4.23.35]
YIL113W  SDP1; mitogen-activated protein kinase tyrosine protein phosphatase SDP1 [KO:K19812] [EC:3.1.3.48]
YIL147C  SLN1; histidine kinase [KO:K11231] [EC:2.7.13.3]
YIL159W  BNR1; formin BNR1 [KO:K17971]
YIR019C  FLO11; Flo11p [KO:K19851]
YJL095W  BCK1; mitogen-activated protein kinase kinase kinase BCK1 [KO:K11229] [EC:2.7.11.25]
YJL128C  PBS2; mitogen-activated protein kinase kinase PBS2 [KO:K11227] [EC:2.7.12.2]
YJL157C  FAR1; cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 [KO:K06652]
YJL187C  SWE1; tyrosine protein kinase SWE1 [KO:K03114] [EC:2.7.11.1]
YJR086W  STE18; Ste18p [KO:K07973]
YKL062W  MSN4; stress-responsive transcriptional activator MSN4 [KO:K09468]
YKL101W  HSL1; protein kinase HSL1 [KO:K02515] [EC:2.7.11.-]
YKL161C  KDX1; putative protein kinase KDX1 [KO:K19847]
YKL178C  STE3; Ste3p [KO:K04627]
YLL021W  SPA2; Spa2p [KO:K19846]
YLR006C  SSK1; mitogen-activated protein kinase kinase kinase SSK1 [KO:K11233]
YLR079W  SIC1; cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 [KO:K03085]
YLR113W  HOG1; mitogen-activated protein kinase HOG1 [KO:K04441] [EC:2.7.11.24]
YLR120C  YPS1; aspartyl protease [KO:K06009] [EC:3.4.23.41]
YLR182W  SWI6; transcriptional regulator SWI6 [KO:K06648]
YLR229C  CDC42; Rho family GTPase CDC42 [KO:K04393]
YLR305C  STT4; 1-phosphatidylinositol 4-kinase STT4 [KO:K00888] [EC:2.7.1.67]
YLR332W  MID2; Mid2p [KO:K11245]
YLR342W  FKS1; 1,3-beta-D-glucan synthase [KO:K00706] [EC:2.4.1.34]
YLR362W  STE11; mitogen-activated protein kinase kinase kinase STE11 [KO:K11228] [EC:2.7.11.25]
YLR371W  ROM2; Rho family guanine nucleotide exchange factor ROM2 [KO:K19842]
YLR425W  TUS1; Rho family guanine nucleotide exchange factor TUS1 [KO:K19843]
YLR452C  SST2; GTPase-activating protein SST2 [KO:K19838]
YMR036C  MIH1; putative tyrosine protein phosphatase MIH1 [KO:K02555] [EC:3.1.3.48]
YMR037C  MSN2; stress-responsive transcriptional activator MSN2 [KO:K09468]
YMR043W  MCM1; transcription factor MCM1 [KO:K12412]
YMR164C  MSS11; Mss11p [KO:K19816]
YMR172W  HOT1; Hot1p [KO:K19815]
YMR199W  CLN1; cyclin CLN1 [KO:K12760]
YMR306W  FKS3; putative 1,3-beta-D-glucan synthase [KO:K00706] [EC:2.4.1.34]
YNL053W  MSG5; tyrosine/serine/threonine protein phosphatase MSG5 [KO:K11240] [EC:3.1.3.48]
YNL145W  MFA2; mating pheromone A [KO:K11235]
YNL154C  YCK2; serine/threonine protein kinase YCK2 [KO:K02218] [EC:2.7.11.1]
YNL167C  SKO1; Sko1p [KO:K09051]
YNL271C  BNI1; formin BNI1 [KO:K11238]
YNL283C  WSC2; Wsc2p [KO:K11244]
YNL298W  CLA4; serine/threonine protein kinase CLA4 [KO:K19833] [EC:2.7.11.1]
YNR031C  SSK2; mitogen-activated protein kinase kinase kinase SSK2 [KO:K11230] [EC:2.7.11.25]
YOL059W  GPD2; glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [KO:K00006] [EC:1.1.1.8]
YOL100W  PKH2; serine/threonine protein kinase PKH2 [KO:K06276] [EC:2.7.11.1]
YOL105C  WSC3; Wsc3p [KO:K11244]
YOL113W  SKM1; putative serine/threonine protein kinase SKM1 [KO:K19833] [EC:2.7.11.1]
YOL151W  GRE2; methylglyoxal reductase (NADPH-dependent) GRE2 [KO:K17741] [EC:1.1.1.283]
YOR008C  SLG1; Slg1p [KO:K11244]
YOR127W  RGA1; GTPase-activating protein RGA1 [KO:K19839]
YOR208W  PTP2; tyrosine protein phosphatase PTP2 [KO:K19806] [EC:3.1.3.48]
YOR212W  STE4; G protein subunit beta [KO:K04536]
YOR231W  MKK1; mitogen-activated protein kinase kinase MKK1 [KO:K08294] [EC:2.7.12.2]
YPL049C  DIG1; Dig1p [KO:K11241]
YPL089C  RLM1; Rlm1p [KO:K09265]
YPL115C  BEM3; GTPase-activating protein BEM3 [KO:K19840]
YPL140C  MKK2; putative mitogen-activated protein kinase kinase MKK2 [KO:K08294] [EC:2.7.12.2]
YPL187W  MF(ALPHA)1; Mf(Alpha)1p [KO:K11234]
YPL256C  CLN2; cyclin CLN2 [KO:K06650]
YPR075C  OPY2; Opy2p [KO:K19850]
YPR119W  CLB2; B-type cyclin CLB2 [KO:K23469]
YPR120C  CLB5; B-type cyclin CLB5 [KO:K06651]
YPR165W  RHO1; Rho family GTPase RHO1 [KO:K04513]
Reference
PMID:15690603
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
PMID:15944456
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
PMID:22174182
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
PMID:17875410
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
PMID:23028184
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
PMID:22219507
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
PMID:17604854
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003
Related
pathway
sce04111  Cell cycle - yeast
KO pathway
ko04011   

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