KEGG   PATHWAY: spo04011
Entry
spo04011                    Pathway                                
Name
MAPK signaling pathway - yeast - Schizosaccharomyces pombe (fission yeast)
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
Pathway map
spo04011  MAPK signaling pathway - yeast
spo04011

Other DBs
GO: 0000165
Organism
Schizosaccharomyces pombe (fission yeast) [GN:spo]
Gene
SPAC11H11.04  mam2; pheromone p-factor receptor [KO:K11213]
SPAC3F10.10c  map3; pheromone M-factor receptor Map3 [KO:K04627]
SPBC1347.06c  cki1; serine/threonine protein kinase Cki1 [KO:K02218] [EC:2.7.11.1]
SPAC1805.05  cki3; serine/threonine protein kinase Cki3 [KO:K02218] [EC:2.7.11.1]
SPBP35G2.05c  cki2; serine/threonine protein kinase Cki2 [KO:K02218] [EC:2.7.11.1]
SPAC11G7.02  pub1; HECT-type ubiquitin-protein ligase E3 Pub1 [KO:K10591] [EC:2.3.2.26]
SPAC1805.15c  pub2; HECT-type ubiquitin-protein ligase Pub2 [KO:K10591] [EC:2.3.2.26]
SPBC16E9.11c  pub3; putative HECT-type ubiquitin-protein ligase Pub3 [KO:K10591] [EC:2.3.2.26]
SPBC32H8.07  git5; heterotrimeric G protein beta subunit Git5 [KO:K04536]
SPAC16E8.09  scd1; RhoGEF Scd1 [KO:K11236]
SPAC110.03  cdc42; Rho family GTPase Cdc42 [KO:K04393]
SPAC22H10.07  scd2; scaffold protein Scd2 [KO:K11237]
SPBC1604.14c  shk1; PAK-like kinase Shk1 [KO:K04409] [EC:2.7.11.1]
SPCC895.05  for3; formin For3 [KO:K11238]
SPAC1F5.04c  cdc12; formin Cdc12 [KO:K11238]
SPBC1D7.05  byr2; MAP kinase kinase kinase Byr2 [KO:K11228] [EC:2.7.11.25]
SPAC1D4.13  byr1; MAP kinase kinase Byr1 [KO:K11226] [EC:2.7.12.2]
SPAC31G5.09c  spk1; MAP kinase Spk1 [KO:K04371] [EC:2.7.11.24]
SPBC1685.01  pmp1; dual-specificity MAP kinase phosphatase Pmp1 [KO:K11240] [EC:3.1.3.48]
SPBC11B10.09  cdc2; cyclin-dependent protein kinase Cdk1/Cdc2 [KO:K04563] [EC:2.7.11.22]
SPBC30B4.01c  wsc1; putative transmembrane receptor Wsc1 [KO:K11244]
SPCC645.07  rgf1; RhoGEF family guanine nucleotide exchange factor Rgf1 [KO:K19842]
SPAC1006.06  rgf2; RhoGEF Rgf2 [KO:K19842]
SPBC577.06c  stt4; putative 1-phosphatidylinositol 4-kinase Stt4 [KO:K00888] [EC:2.7.1.67]
SPAC19G12.14  its3; 1-phosphatidylinositol-4-phosphate 5-kinase Its3 [KO:K00889] [EC:2.7.1.68]
SPAC1F7.04  rho1; Rho family GTPase Rho1 [KO:K04513]
SPAC20H4.11c  rho5; Rho family GTPase Rho5 [KO:K04513]
SPAC20G4.02c  fus1; formin Fus1 [KO:K17971]
SPAC17G8.14c  pck1; protein kinase C (PKC)-like Pck1 [KO:K02677] [EC:2.7.11.13]
SPBC12D12.04c  pck2; protein kinase C (PKC)-like Pck2 [KO:K02677] [EC:2.7.11.13]
SPCC576.15c  ksg1; serine/threonine protein kinase Ksg1 [KO:K06276] [EC:2.7.11.1]
SPAC1F3.02c  mkh1; MEK kinase (MEKK) Mkh1 [KO:K11229] [EC:2.7.11.25]
SPBC543.07  pek1; MAP kinase kinase Pek1 [KO:K08294] [EC:2.7.12.2]
SPBC119.08  pmk1; MAP kinase Pmk1 [KO:K04464] [EC:2.7.11.24]
SPBC19G7.05c  bgs1; 1,3-beta-glucan synthase catalytic subunit Bgs1 [KO:K00706] [EC:2.4.1.34]
SPCC1840.02c  bgs4; 1,3-beta-glucan synthase subunit Bgs4 [KO:K00706] [EC:2.4.1.34]
SPAC24C9.07c  bgs2; 1,3-beta-glucan synthase subunit Bgs2 [KO:K00706] [EC:2.4.1.34]
SPAC19B12.03  bgs3; 1,3-beta-glucan synthase subunit Bgs3 [KO:K00706] [EC:2.4.1.34]
SPAC664.03  putative RNA polymerase II-associated Paf1 complex protein [KO:K15174]
SPBC336.12c  cdc10; MBF transcription factor complex subunit Cdc10 [KO:K06648]
SPAC24H6.05  cdc25; M phase inducer phosphatase Cdc25 [KO:K02555] [EC:3.1.3.48]
SPAPB2B4.03  cig2; G1/S-specific B-type cyclin Cig2 [KO:K23469]
SPBC582.03  cdc13; G2/M B-type cyclin Cdc13 [KO:K23469]
SPBC725.02  mpr1; histidine-containing response regulator phosphotransferase Mpr1 [KO:K11232]
SPBC887.10  mcs4; response regulator Mcs4 [KO:K11233]
SPAC9G1.02  wis4; MAP kinase kinase kinase Wis4 [KO:K11230] [EC:2.7.11.25]
SPAC1006.09  win1; MAP kinase kinase kinase Win1 [KO:K11230] [EC:2.7.11.25]
SPBC409.07c  wis1; MAP kinase kinase Wis1 [KO:K11227] [EC:2.7.12.2]
SPAC24B11.06c  sty1; MAP kinase Sty1 [KO:K04441] [EC:2.7.11.24]
SPCC4F11.02  ptc1; protein phosphatase 2C Ptc1 [KO:K19704] [EC:3.1.3.16]
SPAC23D3.04c  gpd2; glycerol-3-phosphate dehydrogenase Gpd2 [KO:K00006] [EC:1.1.1.8]
SPBC215.05  gpd1; glycerol-3-phosphate dehydrogenase Gpd1 [KO:K00006] [EC:1.1.1.8]
SPCC757.07c  ctt1; catalase [KO:K03781] [EC:1.11.1.6]
SPBC29B5.01  atf1; Atf-CREB family transcription factor Atf1 [KO:K09051]
SPAC21E11.03c  pcr1; transcription factor Pcr1 [KO:K09051]
SPBC23E6.09  ssn6; transcriptional corepressor Ssn6 [KO:K06665]
SPAC18B11.10  tup11; transcriptional corepressor Tup11 [KO:K06666]
SPAC630.14c  tup12; transcriptional corepressor Tup12 [KO:K06666]
SPBC16H5.11c  skb1; protein arginine N-methyltransferase Skb1 [KO:K02516] [EC:2.1.1.320]
SPCC18B5.03  wee1; protein kinase Wee1 [KO:K03114] [EC:2.7.11.1]
SPAC8E11.02c  rad24; 14-3-3 protein Rad24 [KO:K06630]
SPAC17A2.13c  rad25; 14-3-3 protein Rad25 [KO:K06630]
Reference
PMID:15690603
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
PMID:15944456
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
PMID:22174182
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
PMID:17875410
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
PMID:23028184
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
PMID:22219507
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
PMID:17604854
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003
KO pathway
ko04011   
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