KEGG   PATHWAY: xla04010
Entry
xla04010                    Pathway                                
Name
MAPK signaling pathway - Xenopus laevis (African clawed frog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
xla04010  MAPK signaling pathway
xla04010

Other DBs
GO: 0000165
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
373828  cacna1a.S; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
108710372  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
108699890  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100462926  cacna1b.S; voltage-dependent N-type calcium channel subunit alpha-1B isoform X3 [KO:K04849]
100462911  cacna1c.S; voltage-dependent L-type calcium channel subunit alpha-1C isoform X11 [KO:K04850]
108704565  cacna1c.L; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100462912  cacna1d.L; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108704388  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108715639  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100462927  cacna1e.L; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100462913  cacna1f.L; voltage-dependent L-type calcium channel subunit alpha-1D isoform X3 [KO:K04853]
100462914  cacna1g.L; voltage-dependent T-type calcium channel subunit alpha-1G isoform X6 [KO:K04854]
108702791  voltage-dependent T-type calcium channel subunit alpha-1G isoform X4 [KO:K04854]
108702319  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
100462915  cacna1h.L; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
100462928  cacna1i.L; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
108715019  cacna1i.S; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100381134  cacna1s.S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
108707491  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
108713061  cacna2d1.S; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X8 [KO:K04858]
108711204  cacna2d1.L; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5 [KO:K04858]
108714609  cacna2d2.L; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
108715833  cacna2d2.S; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2 [KO:K04859]
373777  cacna2d3.S; calcium channel, voltage-dependent, alpha 2/delta subunit 3 S homeolog precursor [KO:K04860]
108704004  cacna2d3.L; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
108704584  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X5 [KO:K04861]
100127255  cacnb1.S; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
108700783  cacnb1.L; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
108719866  cacnb2.S; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
108718812  cacnb2.L; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
378546  cacnb3.L; calcium channel, voltage-dependent, beta 3 subunit L homeolog [KO:K04864]
373616  cacnb3.S; calcium channel, voltage-dependent, beta 3 subunit S homeolog [KO:K04864]
108702958  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
108701326  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100036935  cacng1.L; calcium channel, voltage-dependent, gamma subunit 1 L homeolog [KO:K04866]
108702165  cacng1.S; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
108714564  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
108715802  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
108703206  cacng3.S; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
108701906  cacng3.L; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
108702163  cacng4.S; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
108701210  cacng4.L; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
444605  cacng5.L; calcium channel, voltage-dependent, gamma subunit 5 L homeolog [KO:K04870]
108702164  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
108697824  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
108696779  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
108696777  cacng7.L; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
108697821  cacng7.S; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
108696778  cacng8.L; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
108697822  cacng8.S; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
380388  prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345] [EC:2.7.11.11]
100101276  prkaca.S; protein kinase, cAMP-dependent, alpha catalytic subunit S homeolog [KO:K04345] [EC:2.7.11.11]
108714187  prkacb.L; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108711677  prkaca.L; protein kinase, cAMP-dependent, alpha catalytic subunit L homeolog [KO:K04345] [EC:2.7.11.11]
447031  prkca.L; protein kinase C, alpha L homeolog [KO:K02677] [EC:2.7.11.13]
108702159  prkca.S; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
108701647  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108703204  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108697820  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
108696776  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
595043  gng12.L; guanine nucleotide binding protein (G protein), gamma 12 L homeolog [KO:K04347]
108715518  gng12.S; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
447196  ppp3ca.L; protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog [KO:K04348] [EC:3.1.3.16]
432106  ppp3cb.L; protein phosphatase 3, catalytic subunit, beta isozyme L homeolog [KO:K04348] [EC:3.1.3.16]
380507  ppp3ca.S; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
108712283  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100381102  ppp3cc.L; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108705261  ppp3cc.S; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
399215  ppp3r1.S; calcineurin subunit B type 1 [KO:K06268]
108716580  ppp3r1.L; calcineurin subunit B type 1 [KO:K06268]
494866  rasgrf1.S; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
108711521  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
108717634  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
108707246  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
414479  rasgrp1.L; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
108699715  rasgrp1.S; RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
108698641  rasgrp4.L; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
447008  rasgrp2.L; RAS guanyl-releasing protein 2-B [KO:K12361]
379250  rasgrp2.S; RAS guanyl-releasing protein 2-A [KO:K12361]
108717828  rasgrp3.S; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
108716683  rasgrp3.L; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
447229  rapgef2.L; Rap guanine nucleotide exchange factor 2 L homeolog [KO:K08018]
108706643  rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
108709669  nf1.S; neurofibromin isoform X1 [KO:K08052]
108708369  nf1.L; neurofibromin isoform X2 [KO:K08052]
108707239  rasa1.S; ras GTPase-activating protein 1 isoform X4 [KO:K04352]
106557444  rasa1.L; ras GTPase-activating protein 1 isoform X4 [KO:K04352]
108717133  rasa2.L; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
414290  rap1a.S; RAP1A, member of RAS oncogene family S homeolog [KO:K04353]
779127  rap1a.L; RAP1A, member of RAS oncogene family L homeolog [KO:K04353]
379883  rap1b.L; ras-related protein Rap-1b [KO:K07836]
108713157  ras-related protein Rap-1b [KO:K07836]
108710179  egf.L; pro-epidermal growth factor [KO:K04357]
496037  tgfa.L; transforming growth factor alpha L homeolog precursor [KO:K08774]
108712769  tgfa.S; protransforming growth factor alpha [KO:K08774]
108696277  XB5893022.L; protransforming growth factor alpha isoform X1 [KO:K08774]
108711073  ereg.L; proepiregulin [KO:K09784]
108706766  ereg.S; proepiregulin [KO:K09784]
108706765  areg.S; amphiregulin isoform X1 [KO:K09782]
108711064  areg.L; amphiregulin [KO:K09782]
444686  fgf1.L; fibroblast growth factor 1 [KO:K18496]
108712499  fgf1.S; fibroblast growth factor 1 [KO:K18496]
100101279  fgf2; fibroblast growth factor 2 [KO:K18497]
108706695  fgf2.S; fibroblast growth factor 2-like [KO:K18497]
399183  fgf8.L; fibroblast growth factor 8 L homeolog precursor [KO:K04358]
373569  fgf10.S; fibroblast growth factor 10 S homeolog [KO:K04358]
378562  fgf9.S; fibroblast growth factor 9 [KO:K04358]
399105  fgf20.L; fibroblast growth factor 20 L homeolog [KO:K04358]
734697  fgf7.L; fibroblast growth factor 7 L homeolog [KO:K04358]
378587  fgf4.S; fibroblast growth factor 4B precursor [KO:K04358]
373669  fgf3.L; fibroblast growth factor 3 precursor [KO:K04358]
108712902  fgf7.S; fibroblast growth factor 7 [KO:K04358]
108712445  fgf6.S; fibroblast growth factor 6 [KO:K04358]
108697431  fgf8.S; fibroblast growth factor 8 isoform X1 [KO:K04358]
108700069  fgf16.S; fibroblast growth factor 16 [KO:K04358]
378586  fgf4.L; fibroblast growth factor 4A precursor [KO:K04358]
108713205  fgf22.L; fibroblast growth factor 22 [KO:K04358]
108718395  fgf10.L; fibroblast growth factor 10 [KO:K04358]
108706603  fgf20.S; fibroblast growth factor 20 [KO:K04358]
101027307  fgf5.S; fibroblast growth factor 5 [KO:K04358]
108715251  fgf3.S; fibroblast growth factor 3 S homeolog precursor [KO:K04358]
108698341  fibroblast growth factor 16 [KO:K04358]
108708721  fibroblast growth factor 9-like [KO:K04358]
108710781  fgf6.L; fibroblast growth factor 6 [KO:K04358]
101027274  fgf19.L; fibroblast growth factor 19 [KO:K22603]
108715066  fgf19.S; fibroblast growth factor 19 [KO:K22603]
108696768  fibroblast growth factor 21 [KO:K22429]
108712444  fgf23.1.S; fibroblast growth factor 23 [KO:K22428]
108710561  fgf23.1.L; fibroblast growth factor 23 [KO:K22428]
108712265  fgf23.2.S; fibroblast growth factor 23 [KO:K22428]
108710189  fgf23.2.L; fibroblast growth factor 23 [KO:K22428]
108708058  ngf.L; nerve growth factor-like [KO:K02582]
108709389  ngf.S; nerve growth factor isoform X2 [KO:K02582]
100048914  bdnf.S; brain-derived neurotrophic factor precursor [KO:K04355]
108715060  brain-derived neurotrophic factor isoform X2 [KO:K04355]
444638  ntf3.S; neurotrophin 3 S homeolog precursor [KO:K04356]
399298  ntf3.L; neurotrophin-3 precursor [KO:K04356]
108696759  ntf4.L; neurotrophin-4-like [KO:K12457]
108706157  ntf4.S; neurotrophin-4 [KO:K12457]
378696  ins.S; insulin-1 precursor [KO:K04526]
378695  ins.L; insulin-2 precursor [KO:K04526]
108696734  XB5961731.L; insulin [KO:K04526]
108712492  insulin-like growth factor I-A [KO:K05459]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
432206  igf2.L; insulin-like growth factor II-B precursor [KO:K13769]
398240  igf2.S; insulin-like growth factor II-A precursor [KO:K13769]
108697782  insulin-like growth factor III [KO:K13769]
398245  igf3.L; insulin-like growth factor III precursor [KO:K13769]
397765  pdgfa.S; platelet-derived growth factor subunit A precursor [KO:K04359]
108701573  pdgfa.L; platelet-derived growth factor subunit A-like isoform X2 [KO:K04359]
493575  pdgfb.S; platelet-derived growth factor subunit B [KO:K17386]
108714525  pdgfb.L; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108699243  pdgfc.L; platelet-derived growth factor C [KO:K05450]
108706647  pdgfc.S; platelet-derived growth factor C [KO:K05450]
108707572  platelet-derived growth factor D-like [KO:K05450]
108709984  pdgfd.S; platelet-derived growth factor D [KO:K05450]
101243553  csf1.S; colony stimulating factor-1 S homeolog precursor [KO:K05453]
379817  kitlg.L; KIT ligand L homeolog precursor [KO:K05461]
373760  kitlg.S; KIT ligand S homeolog precursor [KO:K05461]
108696754  flt3lg.L; uncharacterized protein flt3lg.L [KO:K05454]
108697795  flt3lg.S; fms-related tyrosine kinase 3 ligand [KO:K05454]
373589  vegfa.L; vascular endothelial growth factor A L homeolog precursor [KO:K05448]
100037058  vegfa.S; vascular endothelial growth factor A S homeolog precursor [KO:K05448]
100158352  vegfd.L; vascular endothelial growth factor D [KO:K05449]
734331  vegfc.S; vascular endothelial growth factor C S homeolog precursor [KO:K05449]
108698878  vegfc.L; vascular endothelial growth factor C [KO:K05449]
108713062  hgf.S; hepatocyte growth factor [KO:K05460]
108711206  hgf.L; hepatocyte growth factor [KO:K05460]
444230  angpt1.S; angiopoietin 1 S homeolog precursor [KO:K05465]
108719381  angpt1.L; angiopoietin-1 [KO:K05465]
108718020  angpt2.S; angiopoietin-2 [KO:K05466]
108716902  angpt2.L; angiopoietin-2 [KO:K05466]
108709546  angiopoietin-2 [KO:K05466]
108708071  angiopoietin-2 [KO:K05466]
380188  efna3.L; ephrin A3 L homeolog precursor [KO:K05462]
100158452  efna4.L; ephrin-A4 isoform X2 [KO:K05462]
496064  efna1.L; ephrin-A1 L homeolog precursor [KO:K05462]
108700621  ephrin-A4 [KO:K05462]
397809  efna1.S; ephrin-A1 precursor [KO:K05462]
108706841  efna2.S; ephrin-A2 [KO:K05462]
108707220  efna5.S; ephrin-A5 isoform X1 [KO:K05462]
108699476  ephrin-A3 [KO:K05462]
108717355  efna5.L; ephrin-A5 isoform X1 [KO:K05462]
108719890  efna2.L; ephrin-A2 isoform X1 [KO:K05462]
779087  gdnf.L; glial cell line-derived neurotrophic factor precursor [KO:K05452]
100337571  gdnf.S; glial cell derived neurotrophic factor S homeolog precursor [KO:K05452]
108706858  neurturin [KO:K25414]
108712727  neurturin [KO:K25414]
108715550  artn.S; glial cell line-derived neurotrophic factor-like isoform X1 [KO:K25415]
108714259  artn.L; glial cell line-derived neurotrophic factor-like [KO:K25415]
108710374  pspn.L; persephin [KO:K25416]
108719997  egfr.S; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
724072  egfr.L; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108702492  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108700774  erbb2.L; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108709833  erbb3.S; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
108708565  erbb3.L; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
724070  erbb4.L; erb-b2 receptor tyrosine kinase 4 L homeolog precursor [KO:K05085] [EC:2.7.10.1]
108703039  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
399444  fgfr1.L; fibroblast growth factor receptor 1 L homeolog precursor [KO:K04362] [EC:2.7.10.1]
397782  xfgfra2; fibroblast growth factor receptor precursor [KO:K04362] [EC:2.7.10.1]
399325  fgfr2.L; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
108697372  fgfr2.S; fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
399347  fgfr3.S; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
779370  fgfr3.L; fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog [KO:K05094] [EC:2.7.10.1]
397701  fgfr4.L; fibroblast growth factor receptor 4 L homeolog precursor [KO:K05095] [EC:2.7.10.1]
398181  fgfr4.S; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
398129  ngfr.L; nerve growth factor receptor L homeolog precursor [KO:K02583]
398134  nradd.L; neurotrophin receptor associated death domain L homeolog precursor [KO:K02583]
432338  nradd.S; neurotrophin receptor associated death domain S homeolog precursor [KO:K02583]
373821  ngfr.S; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108700358  ntrk1.S; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108699388  ntrk1.L; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
379266  ntrk2.L; neurotrophic receptor tyrosine kinase 2 L homeolog [KO:K04360] [EC:2.7.10.1]
779173  ntrk2.S; neurotrophic receptor tyrosine kinase 2 S homeolog precursor [KO:K04360] [EC:2.7.10.1]
398006  insr.L; insulin receptor precursor [KO:K04527] [EC:2.7.10.1]
100158430  insr.S; uncharacterized protein LOC100158430 [KO:K04527] [EC:2.7.10.1]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
380245  pdgfra.L; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
108706592  pdgfra.S; platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
108712643  pdgfrb.S; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101243554  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
373772  kit.S; KIT proto-oncogene receptor tyrosine kinase S homeolog precursor [KO:K05091] [EC:2.7.10.1]
373579  kit.L; mast/stem cell growth factor receptor-related protein Kit precursor [KO:K05091] [EC:2.7.10.1]
373727  g67.L; mast/stem cell growth factor receptor-related protein Kit-like [KO:K05091] [EC:2.7.10.1]
108707566  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
108709958  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
379546  flt1.S; uncharacterized protein LOC379546 precursor [KO:K05096] [EC:2.7.10.1]
373789  flt1.L; fms-related tyrosine kinase 1 L homeolog precursor [KO:K05096] [EC:2.7.10.1]
108698372  kdrl.L; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
108700541  kdrl.S; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
108710830  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108712628  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108706593  kdr.S; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
108698463  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
373551  met.L; MET proto-oncogene, receptor tyrosine kinase L homeolog precursor [KO:K05099] [EC:2.7.10.1]
108712362  met.S; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108713943  tek.L; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
398263  tek.S; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100191024  G50; ephrin receptor EphA2 (tyrosine kinase family)-like precursor [KO:K05103] [EC:2.7.10.1]
394370  epha2.L; EPH receptor A2 L homeolog precursor [KO:K05103] [EC:2.7.10.1]
373625  ret.S; ret proto-oncogene S homeolog precursor [KO:K05126] [EC:2.7.10.1]
108696288  ret.L; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
100505423  uncharacterized protein LOC100505423 [KO:K07827]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108697792  kras.S; GTPase HRas [KO:K07827]
399446  nras.L; GTPase NRas [KO:K07828]
444191  rras2.S; RAS related 2 S homeolog [KO:K07830]
779088  ras-related protein R-Ras2 [KO:K07830]
108696729  ras-related protein R-Ras2 isoform X1 [KO:K07830]
108697778  ras-related protein R-Ras2 [KO:K07830]
443932  mras.L; muscle RAS oncogene homolog L homeolog [KO:K07831]
108702900  mras.S; ras-related protein M-Ras [KO:K07831]
398892  araf.L; A-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K08845] [EC:2.7.11.1]
399056  araf.S; A-Raf proto-oncogene, serine/threonine kinase S homeolog [KO:K08845] [EC:2.7.11.1]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
379557  lamtor3.L; ragulator complex protein LAMTOR3-B [KO:K04370]
380570  lamtor3-like.L; ragulator complex protein LAMTOR3-A [KO:K04370]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
387327  mknk1.S; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
399068  mknk2.L; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
100036803  mknk2.S; uncharacterized protein LOC100036803 [KO:K04372] [EC:2.7.11.1]
445821  rps6ka1.L; ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
443729  rps6ka6.S; ribosomal protein S6 kinase 2 alpha [KO:K04373] [EC:2.7.11.1]
399376  rps6ka3.L; ribosomal protein S6 kinase A3 L homeolog [KO:K04373] [EC:2.7.11.1]
108700150  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
108698451  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
108717877  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
108709331  rps6ka3.S; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
398804  atf4.L; activating transcription factor 4 L homeolog [KO:K04374]
734165  atf4.S; activating transcription factor 4 S homeolog [KO:K04374]
100190767  elk1.S; ELK1, member of ETS oncogene family S homeolog [KO:K04375]
108698108  elk1.L; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
378644  elk4.S; ELK4, ETS transcription factor S homeolog [KO:K04376]
444537  elk4.L; ELK4, ETS transcription factor L homeolog [KO:K04376]
379052  myc.S; transcriptional regulator Myc-A [KO:K04377]
399315  myc.L; transcriptional regulator Myc-B [KO:K04377]
394277  srf.L; serum response factor [KO:K04378]
108717640  srf.S; serum response factor-like isoform X1 [KO:K04378]
447201  fos.S; FBJ murine osteosarcoma viral oncogene homolog S homeolog [KO:K04379]
108698676  fos.L; proto-oncogene c-Fos [KO:K04379]
398307  mapt.L; microtubule-associated protein tau [KO:K04380]
100158413  mapt.S; microtubule-associated protein tau isoform X2 [KO:K04380]
397962  stmn1.L; stathmin-1-A [KO:K04381]
380364  stmn1.S; stathmin-1-B [KO:K04381]
380561  pla2g4a.L; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
108700467  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
108698978  jmjd7-pla2g4b.L; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
108699173  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
108699245  pla2g4f.L; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100137625  tnf.L; tumor necrosis factor L homeolog [KO:K03156]
108700235  tnf.S; tumor necrosis factor [KO:K03156]
373606  il1b.S; interleukin 1 beta S homeolog [KO:K04519]
108711577  il1b.L; interleukin-1 beta [KO:K04519]
108712739  uncharacterized protein LOC108712739 isoform X1 [KO:K04519]
397778  tgfb1.L; transforming growth factor beta-1 proprotein precursor [KO:K13375]
108700276  tgfb1.S; transforming growth factor beta-1 proprotein-like [KO:K13375]
373801  tgfb2.L; transforming growth factor beta-2 proprotein precursor [KO:K13376]
108717706  tgfb2.S; transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
100137626  tnfrsf1a.S; TNF receptor superfamily member 1A S homeolog precursor [KO:K03158]
108696066  tnfrsf1a.L; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108708404  interleukin-1 receptor type 1 [KO:K04386]
108708405  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
108709706  il1r1.S; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
108718047  il1rap.S; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
108716971  il1rap.L; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
399295  tgfbr1.S; transforming growth factor beta receptor I S homeolog precursor [KO:K04674] [EC:2.7.11.30]
108719029  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
108719963  tgfbr2.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108718935  tgfbr2.L; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108702885  tgfbr2l.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
373815  tgfbr2l.L; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100192357  faslg.L; Fas ligand L homeolog [KO:K04389]
108715004  faslg.S; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108697171  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
108696050  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
734382  rac1.L; Rac family small GTPase 1 L homeolog [KO:K04392]
399379  rac3.S; Rac family small GTPase 3 S homeolog [KO:K04392]
444184  rac2.L; Rac family small GTPase 2 L homeolog [KO:K07860]
108715797  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108700975  ras-related C3 botulinum toxin substrate 3 isoform X3 [KO:K07861]
379055  cdc42.L; cell division cycle 42 L homeolog [KO:K04393]
108697660  cdc42.S; cell division control protein 42 homolog isoform X1 [KO:K04393]
733418  tradd.L; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
397720  casp3.2.S; caspase-3 [KO:K02187] [EC:3.4.22.56]
100036910  casp3.2.L; uncharacterized protein LOC100036910 [KO:K02187] [EC:3.4.22.56]
431974  traf2.S; TNF receptor associated factor 2 S homeolog [KO:K03173] [EC:2.3.2.27]
108698135  traf2.L; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
446279  daxx.L; death-associated protein 6 L homeolog [KO:K02308]
394321  myd88.L; myeloid differentiation primary response protein MyD88-A [KO:K04729]
734302  myd88.S; myeloid differentiation primary response protein MyD88-B [KO:K04729]
108704503  irak1.L; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
108700006  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
108711122  irak4.L; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
444777  traf6.L; TNF receptor-associated factor 6-B [KO:K03175] [EC:2.3.2.27]
734929  traf6.S; TNF receptor-associated factor 6-A [KO:K03175] [EC:2.3.2.27]
379224  gadd45a.S; growth arrest and DNA damage inducible alpha S homeolog [KO:K04402]
399196  gadd45g.L; growth arrest and DNA damage inducible gamma L homeolog [KO:K04402]
379285  gadd45g.S; uncharacterized protein LOC379285 [KO:K04402]
101027271  gadd45b.S; growth arrest and DNA damage inducible beta S homeolog [KO:K04402]
108714209  gadd45a.L; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
108712402  gadd45b.L; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
398025  tab1.L; TGF-beta activated kinase 1/MAP3K7 binding protein 1 L homeolog [KO:K04403]
108715765  tab1.S; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108717890  tab2.S; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108716751  tab2.L; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100037194  ecsit.S; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor [KO:K04405]
108717401  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
108716656  map4k3.L; mitogen-activated protein kinase kinase kinase kinase 3 isoform X4 [KO:K04406] [EC:2.7.11.1]
108700131  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
108698432  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
108709705  TRAF2 and NCK-interacting protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
108708403  TRAF2 and NCK-interacting protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
108698644  mitogen-activated protein kinase kinase kinase kinase 1 isoform X3 [KO:K04408] [EC:2.7.11.1]
398126  pak1.S; p21-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
398782  MGC68680; uncharacterized protein LOC398782 [KO:K04409] [EC:2.7.11.1]
399090  pak2.S; p21-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
108717139  pak2.L; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
398925  stk4.S; serine/threonine-protein kinase 4 [KO:K04411]
779226  stk4.L; serine/threonine kinase 4 L homeolog [KO:K04411]
432210  stk3.S; serine/threonine-protein kinase 3 [KO:K04412]
108719348  serine/threonine-protein kinase 3-like isoform X1 [KO:K04412]
108718772  map3k8.L; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
108719849  map3k8.S; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
108704427  map3k1.S; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
108718321  map3k1.L; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
108702901  map3k2.S; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
108701261  map3k2.L; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
734336  map3k22.L; mitogen-activated protein kinase kinase kinase 22 L homeolog [KO:K04421] [EC:2.7.11.25]
108701764  map3k3.L; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
108702560  map3k3.S; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
108719812  map3k22.S; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
108699730  map3k9.S; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
100381159  map3k9.L; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
398612  map3k10.L; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100113430  map3k12.S; mitogen-activated protein kinase kinase kinase 12 S homeolog [KO:K04423] [EC:2.7.11.25]
100337576  map3k12.L; mitogen-activated protein kinase kinase kinase 12 L homeolog [KO:K04423] [EC:2.7.11.25]
100337578  map3k13.L; mitogen-activated protein kinase kinase kinase 13-A [KO:K04422] [EC:2.7.11.25]
100337577  map3k13.S; mitogen-activated protein kinase kinase kinase 13-B [KO:K04422] [EC:2.7.11.25]
108702997  map3k20.S; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
101027300  map3k20.L; mitogen-activated protein kinase kinase kinase 20 L homeolog [KO:K04424] [EC:2.7.11.25]
108717885  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
379399  map3k7.S; mitogen-activated protein kinase kinase kinase 7 S homeolog [KO:K04427] [EC:2.7.11.25]
399459  map3k7.L; mitogen-activated protein kinase kinase kinase 7 L homeolog [KO:K04427] [EC:2.7.11.25]
100126613  map3k4.S; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
444087  taok2.L; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
379165  taok1.S; serine/threonine-protein kinase TAO1-B [KO:K04429] [EC:2.7.11.1]
414526  taok1.L; serine/threonine-protein kinase TAO1-A [KO:K04429] [EC:2.7.11.1]
446778  taok3.L; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
108704239  taok2.S; serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
108707181  taok3.S; serine/threonine-protein kinase TAO3-like isoform X1 [KO:K04429] [EC:2.7.11.1]
431908  map2k4.S; dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04430] [EC:2.7.12.2]
399471  map2k4.L; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04430] [EC:2.7.12.2]
394391  map2k7.L; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
108712658  map2k7.S; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
379638  map2k6.L; mitogen-activated protein kinase kinase 6 L homeolog [KO:K04433] [EC:2.7.12.2]
399150  map2k3; MAP kinase activator XMEK3 [KO:K04433] [EC:2.7.12.2]
108714940  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
108713772  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
108711263  mapk8ip2.L; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
108713013  mapk8ip2.S; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
108701610  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
108703170  mapk8ip3.S; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
108699999  filamin-A isoform X1 [KO:K04437]
108704467  filamin-A isoform X1 [KO:K04437]
398951  crk.L; adapter molecule crk [KO:K04438]
447419  crkl.L; v-crk avian sarcoma virus CT10 oncogene homolog-like L homeolog [KO:K04438]
414569  crkl.S; uncharacterized protein LOC414569 [KO:K04438]
108709342  crk.S; adapter molecule crk-like isoform X1 [KO:K04438]
447732  arrb1.S; arrestin beta 1 S homeolog [KO:K04439]
446401  arrb2.S; arrestin beta 2 S homeolog [KO:K04439]
444007  arrb2.L; arrestin red cell [KO:K04439]
108705153  arrb1.L; beta-arrestin-1 isoform X1 [KO:K04439]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
108715909  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108711159  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108708144  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
108707170  mapkapk5.S; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
108716917  mapkapk5.L; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
432084  mapkapk2.L; MAPK activated protein kinase 2 L homeolog [KO:K04443] [EC:2.7.11.1]
495118  mapkapk2.S; uncharacterized protein LOC495118 [KO:K04443] [EC:2.7.11.1]
779225  mapkapk3.S; MAPK activated protein kinase 3 S homeolog [KO:K04444] [EC:2.7.11.1]
108714604  mapkapk3.L; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
108698712  rps6ka5.L; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100037253  rps6ka4.L; ribosomal protein S6 kinase, 90kDa, polypeptide 4 L homeolog [KO:K16510] [EC:2.7.11.1]
100158454  cdc25b.L; cell division cycle 25B L homeolog [KO:K05866] [EC:3.1.3.48]
100158455  cdc25b.S; cell division cycle 25B S homeolog [KO:K05866] [EC:3.1.3.48]
444346  nfatc1.L; nuclear factor of activated T cells 1 L homeolog [KO:K04446]
108695211  nfatc1.S; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
398297  nfatc3.S; nuclear factor of activated T cells 3 S homeolog [KO:K17333]
108713974  nfatc3.L; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
108700666  transcription factor AP-1-like [KO:K04448]
447259  jund.S; jun D proto-oncogene S homeolog [KO:K04449]
108712993  jund.L; transcription factor jun-D [KO:K04449]
108701386  atf2.L; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
108703012  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
397926  tp53.L; cellular tumor antigen p53 [KO:K04451]
108703451  tp53.S; cellular tumor antigen p53-like [KO:K04451]
398615  ddit3.L; DNA damage inducible transcript 3 L homeolog [KO:K04452]
108709861  ddit3.S; DNA damage-inducible transcript 3 protein [KO:K04452]
504192  max.L; protein max-like isoform X2 [KO:K04453]
373652  max.S; protein max [KO:K04453]
444310  mef2c.L; MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog [KO:K04454]
108707236  mef2c.S; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
447107  hspb1.L; heat shock protein family B (small) member 1 L homeolog [KO:K04455]
447105  hspb1.S; heat shock protein family B (small) member 1 S homeolog [KO:K04455]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108698803  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
380058  ppm1a.S; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
108698826  ppm1a.L; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
108712367  ptprr.S; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
398636  ptprr.L; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
108713695  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
108715327  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
380262  dusp1.L; dual specificity protein phosphatase 1-A [KO:K21278] [EC:3.1.3.16 3.1.3.48]
398254  dusp1.S; dual specificity protein phosphatase 1-B [KO:K21278] [EC:3.1.3.16 3.1.3.48]
444752  dusp5.S; dual specificity phosphatase 5 S homeolog [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108695998  dusp5.L; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108712239  dusp4.L; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108712565  dusp16.S; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108714619  dusp7.L; dual specificity protein phosphatase 7 isoform X2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108704379  dusp16.L; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108715842  dusp7.S; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108696792  dusp8.L; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108697834  dusp8.S; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
495060  dusp6.S; uncharacterized protein LOC495060 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
398829  dusp6.L; dual specificity phosphatase 6 L homeolog [KO:K21946] [EC:3.1.3.16 3.1.3.48]
108713914  dusp10.2.L; uncharacterized protein dusp10.2.L isoform X2 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108715146  dusp10.2.S; dual specificity protein phosphatase 2 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108717702  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108716469  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108700974  dusp3.L; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
398004  ppp5c.S; protein phosphatase 5, catalytic subunit S homeolog [KO:K04460] [EC:3.1.3.16]
108698508  ppp5c.L; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
432133  ppm1b.S; protein phosphatase, Mg2+/Mn2+ dependent 1B S homeolog [KO:K04461] [EC:3.1.3.16]
443768  ppm1b.L; protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog [KO:K04461] [EC:3.1.3.16]
379319  hspa8.L; heat shock protein family A (Hsp70) member 8 L homeolog [KO:K03283]
379760  hspa1l.S; heat shock protein family A (Hsp70) member 1 like S homeolog [KO:K03283]
398343  hsp70.L; heat shock 70 kDa protein [KO:K03283]
108696811  hspa1a.L; heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
100381020  hspa1a.S; heat shock protein family A (Hsp70) member 1A S homeolog [KO:K03283]
734157  mecom.L; MDS1 and EVI1 complex locus protein EVI1-A [KO:K04462] [EC:2.1.1.367]
100301954  mecom.S; MDS1 and EVI1 complex locus protein EVI1-B [KO:K04462] [EC:2.1.1.367]
414694  map2k5.L; mitogen-activated protein kinase kinase 5 L homeolog [KO:K04463] [EC:2.7.12.2]
446599  mapk7.L; mitogen-activated protein kinase 7 L homeolog [KO:K04464] [EC:2.7.11.24]
373674  nr4a1.L; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
379851  nr4a1.S; nuclear receptor subfamily 4 group A member 1 S homeolog [KO:K04465]
108700848  map3k14.L; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
108702551  map3k14.S; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
444556  chuk.S; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
432200  ikbkb.L; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog [KO:K07209] [EC:2.7.11.10]
735069  ikbkg.L; inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog [KO:K07210]
414522  nlk.L; nemo-like kinase L homeolog [KO:K04468] [EC:2.7.11.24]
398295  nlk.2.S; serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
108703801  nlk.2.L; serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
108709347  nlk.S; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
447632  nfkb1.L; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog [KO:K02580]
108706736  nfkb1.S; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
397698  nfkb2.S; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
108696243  nfkb2.L; nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469]
394353  rela.L; putative transcription factor p65 homolog [KO:K04735]
108715128  rela.S; putative transcription factor p65 homolog [KO:K04735]
378663  relb.S; transcription factor RelB homolog [KO:K09253]
108698527  relb.L; transcription factor RelB homolog [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
xla04070  Phosphatidylinositol signaling system
xla04110  Cell cycle
xla04115  p53 signaling pathway
xla04210  Apoptosis
xla04310  Wnt signaling pathway
KO pathway
ko04010   
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