KEGG   PATHWAY: xla04068
Entry
xla04068                    Pathway                                
Name
FoxO signaling pathway - Xenopus laevis (African clawed frog)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
xla04068  FoxO signaling pathway
xla04068

Other DBs
GO: 0009267
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
397778  tgfb1.L; transforming growth factor beta-1 proprotein precursor [KO:K13375]
108700276  tgfb1.S; transforming growth factor beta-1 proprotein-like [KO:K13375]
373801  tgfb2.L; transforming growth factor beta-2 proprotein precursor [KO:K13376]
108717706  tgfb2.S; transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
399295  tgfbr1.S; transforming growth factor beta receptor I S homeolog precursor [KO:K04674] [EC:2.7.11.30]
108719029  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
108719963  tgfbr2.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108718935  tgfbr2.L; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108702885  tgfbr2l.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
373815  tgfbr2l.L; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
403356  smad4.2.L; SMAD family member 4, gene 2 L homeolog 2 [KO:K04501]
780764  smad4.L; SMAD family member 4, gene 1 L homeolog [KO:K04501]
108700426  smad4.2.S; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
108707339  smad4.S; mothers against decapentaplegic homolog 4 [KO:K04501]
378633  smad3.L; SMAD family member 3 L homeolog [KO:K23605]
108712801  smad3.S; mothers against decapentaplegic homolog 3 [KO:K23605]
399100  stk11.L; serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
108706844  stk11.S; serine/threonine-protein kinase stk11-like [KO:K07298] [EC:2.7.11.1]
495290  prkaa1.L; protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog [KO:K07198] [EC:2.7.11.31]
399172  prkaa2.S; protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog [KO:K07198] [EC:2.7.11.31]
108715541  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
108714249  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
443998  prkab1.S; protein kinase, AMP-activated, beta 1 non-catalytic subunit S homeolog [KO:K07199]
380372  prkab2.L; protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog [KO:K07199]
108715739  prkab2.S; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108715919  prkab1.L; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
444397  prkag1.L; protein kinase, AMP-activated, gamma 1 non-catalytic subunit L homeolog [KO:K07200]
380124  prkag3.L; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit [KO:K07200]
398958  prkag2.S; protein kinase, AMP-activated, gamma 2 non-catalytic subunit S homeolog [KO:K07200]
100127310  prkag3.S; protein kinase, AMP-activated, gamma 3 non-catalytic subunit S homeolog [KO:K07200]
108718729  prkag2.L; protein kinase, AMP-activated, gamma 2 non-catalytic subunit L homeolog [KO:K07200]
108709817  prkag1.S; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
414522  nlk.L; nemo-like kinase L homeolog [KO:K04468] [EC:2.7.11.24]
398295  nlk.2.S; serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
108703801  nlk.2.L; serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
108709347  nlk.S; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
734901  skp2.L; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase L homeolog [KO:K03875]
108713153  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108711092  mdm2.L; E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
108699643  setd7.L; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
495689  crebbp.L; CREB binding protein L homeolog [KO:K04498] [EC:2.3.1.48]
108714480  ep300.L; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108715729  ep300.S; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
373795  crebbp.S; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100036963  sirt1.L; sirtuin 1 L homeolog [KO:K11411] [EC:2.3.1.286]
108697451  sirt1.S; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
100158365  usp7.S; ubiquitin specific peptidase 7 (herpes virus-associated) S homeolog [KO:K11838] [EC:3.4.19.12]
108701518  usp7.L; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
444033  slc2a4.L; solute carrier family 2 (facilitated glucose transporter), member 4 L homeolog [KO:K07191]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
398925  stk4.S; serine/threonine-protein kinase 4 [KO:K04411]
779226  stk4.L; serine/threonine kinase 4 L homeolog [KO:K04411]
108712492  insulin-like growth factor I-A [KO:K05459]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
378696  ins.S; insulin-1 precursor [KO:K04526]
378695  ins.L; insulin-2 precursor [KO:K04526]
108696734  XB5961731.L; insulin [KO:K04526]
398006  insr.L; insulin receptor precursor [KO:K04527] [EC:2.7.10.1]
100158430  insr.S; uncharacterized protein LOC100158430 [KO:K04527] [EC:2.7.10.1]
399299  irs1.L; insulin receptor substrate 1-A [KO:K16172]
108718134  insulin receptor substrate 1-B-like [KO:K16172]
108711802  irs2.L; insulin receptor substrate 1 [KO:K16172]
495836  irs4.L; insulin receptor substrate 2-B [KO:K07187]
399388  irs4.S; insulin receptor substrate 2-A [KO:K07187]
108708462  insulin receptor substrate 2 [KO:K07187]
108709741  insulin receptor substrate 2 [KO:K07187]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
444529  pdpk1.L; 3-phosphoinositide dependent protein kinase 1 L homeolog [KO:K06276] [EC:2.7.11.1]
108703133  pdpk1.S; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
444556  chuk.S; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
432200  ikbkb.L; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog [KO:K07209] [EC:2.7.11.10]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108698803  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
399130  sgk1.L; serine/threonine-protein kinase Sgk1-A [KO:K13302] [EC:2.7.11.1]
444618  sgk1.S; serine/threonine-protein kinase Sgk1-B [KO:K13302] [EC:2.7.11.1]
108704609  sgk2.L; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
108695327  sgk3.S; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
108719280  sgk3.L; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
444991  foxo1.L; forkhead box protein O1 [KO:K07201]
108709932  foxo1.S; forkhead box protein O1-like [KO:K07201]
444992  foxo3.L; forkhead box protein O3 [KO:K09408]
108717943  foxo3.S; forkhead box protein O3-like isoform X1 [KO:K09408]
100301976  foxo4.L; forkhead box O4 L homeolog [KO:K12358]
108700533  foxo4.S; forkhead box protein O4 [KO:K12358]
100286797  foxo6.S; forkhead box O6 S homeolog [KO:K17847]
108708088  foxo6.L; forkhead box protein O6 [KO:K17847]
108716694  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
108717837  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
380316  homer3.L; homer scaffold protein 3 L homeolog [KO:K15010]
380401  homer2.L; homer 2 [KO:K15010]
594872  homer1.L; homer scaffold protein 1 L homeolog [KO:K15010]
108712888  homer2.S; homer protein homolog 2 [KO:K15010]
414626  homer3.S; homer protein homolog 3 [KO:K15010]
108707277  homer1.S; homer protein homolog 1 isoform X1 [KO:K15010]
108708599  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
108709870  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
399381  tptep2-csnk1e.L; TPTEP2-CSNK1E readthrough L homeolog [KO:K08960] [EC:2.7.11.1]
108715790  tptep2-csnk1e.S; casein kinase I [KO:K08960] [EC:2.7.11.1]
108718487  il6.L; interleukin-6 [KO:K05405]
108709106  il10.S; interleukin-10 [KO:K05443]
108707703  il10.L; interleukin-10 [KO:K05443]
379264  stat3.2.L; signal transducer and activator of transcription 3.2 [KO:K04692]
779100  stat3.1.L; signal transducer and activator of transcription 3.1 [KO:K04692]
108702458  signal transducer and activator of transcription 3.2-like [KO:K04692]
108710179  egf.L; pro-epidermal growth factor [KO:K04357]
108719997  egfr.S; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
724072  egfr.L; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
100505423  uncharacterized protein LOC100505423 [KO:K07827]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108697792  kras.S; GTPase HRas [KO:K07827]
399446  nras.L; GTPase NRas [KO:K07828]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
398892  araf.L; A-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K08845] [EC:2.7.11.1]
399056  araf.S; A-Raf proto-oncogene, serine/threonine kinase S homeolog [KO:K08845] [EC:2.7.11.1]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
108715909  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108711159  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108708144  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
432036  cdk2.L; uncharacterized protein LOC432036 [KO:K02206] [EC:2.7.11.22]
399314  cdk2.S; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
399121  prmt1.S; protein arginine N-methyltransferase 1-A [KO:K11434] [EC:2.1.1.319]
398716  prmt1.L; protein arginine N-methyltransferase 1-B [KO:K11434] [EC:2.1.1.319]
373732  foxg1.L; forkhead box protein G1 [KO:K09385]
397742  ccnb1.2.S; G2/mitotic-specific cyclin-B1 [KO:K05868]
379888  ccnb1.2.L; cyclin B1 L homeolog [KO:K05868]
398163  ccnb1.S; cyclin B1 S homeolog [KO:K05868]
108718066  ccnb1.L; G2/mitotic-specific cyclin-B1-like [KO:K05868]
397743  ccnb2.S; G2/mitotic-specific cyclin-B2 [KO:K21770]
398888  ccnb2.L; uncharacterized protein LOC398888 [KO:K21770]
398162  cyclin B5 [KO:K21770]
379048  ccnb3.S; cyclin B3 S homeolog [KO:K21771]
779404  ccnb3.L; cyclin B3 L homeolog [KO:K21771]
379161  ccnd1.S; G1/S-specific cyclin-D1 b [KO:K04503]
379937  ccnd1.L; G1/S-specific cyclin-D1 [KO:K04503]
447748  ccndx.L; G1/S-specific cyclin-D1 [KO:K04503]
447541  MGC83948 protein [KO:K04503]
734882  ccnd2.S; cyclin D2 S homeolog [KO:K10151]
373667  ccnd2.L; G1/S-specific cyclin-D2 [KO:K10151]
431934  ccng2.S; cyclin G2 S homeolog [KO:K10146]
444607  ccng2.L; cyclin G2 L homeolog [KO:K10146]
779240  cdkn2b.L; cyclin-dependent kinase inhibitor 2B L homeolog [KO:K04685]
108706939  cdkn2b.S; cyclin-dependent kinase inhibitor 2A [KO:K04685]
446719  cdkn2d.S; cyclin-dependent kinase inhibitor 2D S homeolog [KO:K06623]
108710169  cdkn2d.L; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
492305  cdkn1a.L; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108709405  cdkn1a.S; cyclin-dependent kinase inhibitor 1 [KO:K06625]
492306  cdkn1b.S; cyclin-dependent kinase inhibitor 1B (p27, Kip1) S homeolog [KO:K06624]
108710741  cyclin-dependent kinase inhibitor 1B [KO:K06624]
108714013  rbl2.L; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
380481  plk1.S; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
108701628  plk1.L; serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
379315  plk2.S; polo-like kinase 2 S homeolog [KO:K08861] [EC:2.7.11.21]
379122  plk2.L; polo-like kinase 2 L homeolog [KO:K08861] [EC:2.7.11.21]
100381164  plk3.S; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
100505422  plk3.L; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
398770  plk4.L; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
108706689  plk4.S; serine/threonine-protein kinase PLK4 isoform X1 [KO:K08863] [EC:2.7.11.21]
379224  gadd45a.S; growth arrest and DNA damage inducible alpha S homeolog [KO:K04402]
399196  gadd45g.L; growth arrest and DNA damage inducible gamma L homeolog [KO:K04402]
379285  gadd45g.S; uncharacterized protein LOC379285 [KO:K04402]
101027271  gadd45b.S; growth arrest and DNA damage inducible beta S homeolog [KO:K04402]
108714209  gadd45a.L; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
108712402  gadd45b.L; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100192357  faslg.L; Fas ligand L homeolog [KO:K04389]
108715004  faslg.S; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
734810  bcl2l11.L; BCL2 like 11 L homeolog [KO:K16341]
108717788  bcl2l11.S; bcl-2-like protein 11 [KO:K16341]
100316914  tnfsf10.S; TNF superfamily member 10 S homeolog [KO:K04721]
108717006  tnfsf10.L; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
495412  bcl6.L; BCL6, transcription repressor L homeolog [KO:K15618]
446862  bcl6.S; BCL6, transcription repressor S homeolog [KO:K15618]
398786  bnip3.S; BCL2/adenovirus E1B 19kDa interacting protein 3 S homeolog [KO:K15464]
108696110  bnip3.L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
100126654  atg12.S; autophagy related 12 S homeolog [KO:K08336]
414477  gabarap.L; uncharacterized protein LOC414477 [KO:K08341]
443979  gabarapl1.S; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
494762  gabarapl1.L; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
734814  gabarapl2.L; GABA(A) receptor-associated protein like 2 L homeolog [KO:K08341]
108715442  gabarapl2.S; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121402296  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
495840  cat.1.L; catalase, gene 1 L homeolog [KO:K03781] [EC:1.11.1.6]
380236  cat.2.L; catalase, gene 2 L homeolog [KO:K03781] [EC:1.11.1.6]
100125664  cat.3.L; uncharacterized protein LOC100125664 [KO:K03781] [EC:1.11.1.6]
108713455  catalase [KO:K03781] [EC:1.11.1.6]
108715227  cat.2.S; catalase [KO:K03781] [EC:1.11.1.6]
108715253  cat.3.S; catalase [KO:K03781] [EC:1.11.1.6]
444203  sod2.S; superoxide dismutase 2 S homeolog [KO:K04564] [EC:1.15.1.1]
108716665  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
398148  atm.L; ATM serine/threonine kinase L homeolog [KO:K04728] [EC:2.7.11.1]
399424  pck2.L; phosphoenolpyruvate carboxykinase 2 (mitochondrial) L homeolog [KO:K01596] [EC:4.1.1.32]
379637  pck1.S; phosphoenolpyruvate carboxykinase 1 S homeolog [KO:K01596] [EC:4.1.1.32]
379844  pck1.L; cytosolic phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
108707014  pck2.S; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
379290  g6pc1.2.S; glucose-6-phosphatase, catalytic subunit 1, gene 2 S homeolog [KO:K01084] [EC:3.1.3.9]
379852  g6pc1.1.L; glucose-6-phosphatase, catalytic subunit 1, gene 1 L homeolog [KO:K01084] [EC:3.1.3.9]
398854  g6pc1.3.L; uncharacterized protein LOC398854 [KO:K01084] [EC:3.1.3.9]
447506  g6pc1.1.S; glucose-6-phosphatase, catalytic subunit 1, gene 1 S homeolog [KO:K01084] [EC:3.1.3.9]
398855  g6pc1.2.L; glucose-6-phosphatase, catalytic subunit 1, gene 2 L homeolog [KO:K01084] [EC:3.1.3.9]
108702724  g6pc1.3.S; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108700836  g6pc3.1.L; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
380122  klf2.S; Kruppel-like factor 2 S homeolog [KO:K17845]
108695333  klf2.L; Krueppel-like factor 2 [KO:K17845]
444659  s1pr1.L; sphingosine-1-phosphate receptor 1 L homeolog [KO:K04288]
108715691  s1pr1.S; sphingosine 1-phosphate receptor 1 [KO:K04288]
108703677  s1pr4.S; sphingosine 1-phosphate receptor 4 [KO:K04293]
108696833  s1pr4.L; sphingosine 1-phosphate receptor 4 [KO:K04293]
100337558  rag1.S; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
100337559  rag1.L; V(D)J recombination-activating protein 1 L homeolog [KO:K10628] [EC:2.3.2.27]
100037211  rag2.S; V(D)J recombination-activating protein 2 [KO:K10988]
432121  fbxo25.L; F-box only protein 25 isoform X1 [KO:K10305]
108719406  F-box only protein 32 [KO:K10305]
108717488  F-box only protein 25 [KO:K10305]
108695435  fbxo32.S; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
xla00010  Glycolysis / Gluconeogenesis
xla00020  Citrate cycle (TCA cycle)
xla00190  Oxidative phosphorylation
xla04010  MAPK signaling pathway
xla04110  Cell cycle
xla04120  Ubiquitin mediated proteolysis
xla04140  Autophagy - animal
xla04210  Apoptosis
xla04350  TGF-beta signaling pathway
xla04910  Insulin signaling pathway
KO pathway
ko04068   
LinkDB

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