KEGG   PATHWAY: xla04150
Entry
xla04150                    Pathway                                
Name
mTOR signaling pathway - Xenopus laevis (African clawed frog)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
xla04150  mTOR signaling pathway
xla04150

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036782  rraga.L; Ras-related GTP binding A L homeolog [KO:K16185]
100037232  eif4b.S; eukaryotic translation initiation factor 4B [KO:K03258]
100049152  mios.L; GATOR complex protein MIOS-B [KO:K20407]
100049784  wnt10a.L; Wnt family member 10A L homeolog [KO:K01357]
100137625  tnf.L; tumor necrosis factor L homeolog [KO:K03156]
100137626  tnfrsf1a.S; TNF receptor superfamily member 1A S homeolog precursor [KO:K03158]
100158392  flcn.S; folliculin S homeolog [KO:K09594]
100158430  insr.S; uncharacterized protein LOC100158430 [KO:K04527] [EC:2.7.10.1]
100381089  grb10.L; growth factor receptor-bound protein 10 [KO:K20064]
100381153  dvl1.L; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100462916  wnt9a.L; protein Wnt-9a isoform X1 [KO:K01064]
100462925  wnt9b.2.L; protein Wnt-9b isoform X2 [KO:K01064]
100505423  [KO:K07827]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108695292  atp6v1h.S; V-type proton ATPase subunit H [KO:K02144]
108695410  atp6v1c1.S; V-type proton ATPase subunit C 1 [KO:K02148]
108695427  deptor.S; DEP domain-containing mTOR-interacting protein [KO:K20402]
108696066  tnfrsf1a.L; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108696230  ddit4.L; DNA damage-inducible transcript 4 protein [KO:K08270]
108696239  [KO:K00714]
108696363  [KO:K07203] [EC:2.7.11.1]
108696734  XB5961731.L; insulin [KO:K04526]
108696776  [KO:K19663] [EC:2.7.11.13]
108696943  [KO:K02151]
108697641  [KO:K02353]
108697659  wnt4.S; protein Wnt-4 [KO:K00408]
108697792  kras.S; GTPase HRas [KO:K07827]
108697820  [KO:K19663] [EC:2.7.11.13]
108698219  tsc1.L; hamartin isoform X1 [KO:K07206]
108698451  [KO:K04373] [EC:2.7.11.1]
108698562  atp6v1g2.L; V-type proton ATPase subunit G 2 [KO:K02152]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108698803  [KO:K04456] [EC:2.7.11.1]
108699178  fnip2.L; folliculin-interacting protein 2 isoform X1 [KO:K20401]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108699932  tsc1.S; hamartin isoform X1 [KO:K07206]
108700015  mapkap1.S; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
108700150  [KO:K04373] [EC:2.7.11.1]
108700230  atp6v1g2.S; V-type proton ATPase subunit G 2 [KO:K02152]
108700235  tnf.S; tumor necrosis factor [KO:K03156]
108700516  wnt7c.S; protein Wnt-7b [KO:K00572]
108700827  [KO:K02235]
108700855  strada.L; STE20-related kinase adapter protein alpha isoform X2 [KO:K08271]
108700866  wnt3.L; proto-oncogene Wnt-3 [KO:K00312]
108700989  [KO:K07204]
108701298  wnt6.L; protein Wnt-6 [KO:K00445]
108701438  [KO:K17532]
108701475  fzd5.L; frizzled-5-like [KO:K02375]
108701647  [KO:K19662] [EC:2.7.11.13]
108701656  tsc2.L; tuberin isoform X3 [KO:K07207]
108702036  deptorl.L; LOW QUALITY PROTEIN: DEP domain-containing mTOR-interacting protein [KO:K20402]
108702159  prkca.S; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
108702559  strada.S; STE20-related kinase adapter protein alpha isoform X2 [KO:K08271]
108702571  [KO:K01064]
108702936  wnt10a.S; protein Wnt-10a [KO:K01357]
108703060  fzd7.S; frizzled-7-B-like [KO:K02432]
108703133  pdpk1.S; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
108703204  [KO:K19662] [EC:2.7.11.13]
108703213  tsc2.S; tuberin isoform X1 [KO:K07207]
108703515  lamtor4.S; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399]
108703580  [KO:K02353]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
108704022  [KO:K00444]
108704038  [KO:K00572]
108704404  [KO:K00572]
108704468  atp6v1g1.L; V-type proton ATPase subunit G 1 [KO:K02152]
108704582  wnt5b.L; protein Wnt-5b-like [KO:K00444]
108704602  tti1.L; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
108705399  [KO:K00572]
108706168  [KO:K20397]
108706644  fnip2.S; folliculin-interacting protein 2 isoform X1 [KO:K20401]
108706844  stk11.S; serine/threonine-protein kinase stk11-like [KO:K07298] [EC:2.7.11.1]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108707065  [KO:K02152]
108707109  [KO:K20404]
108707144  ulk1.S; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108707287  slc38a9.S; sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
108707307  rictor.S; rapamycin-insensitive companion of mTOR [KO:K08267]
108707474  rragc.L; ras-related GTP-binding protein C [KO:K16186]
108707992  fzd9.L; frizzled-9 [KO:K02842]
108708293  ulk2.L; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
108708545  wnt10b.L; protein Wnt-10b isoform X1 [KO:K01357]
108708655  eif4b.L; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
108708760  [KO:K02354]
108708822  wnt11.L; protein Wnt-11-like [KO:K01384]
108709283  atp6v1a.S; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
108709318  fzd9.S; frizzled-9 [KO:K02842]
108709331  rps6ka3.S; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
108709614  [KO:K08269] [EC:2.7.11.1]
108709655  [KO:K23081]
108709815  wnt1.S; protein Wnt-1-like [KO:K03209]
108709816  [KO:K01357]
108709918  cab39l.S; calcium-binding protein 39-like [KO:K08272]
108710234  fnip1.L; folliculin-interacting protein 1 isoform X1 [KO:K20400]
108710984  [KO:K03259]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
108711137  wnt2.L; protein Wnt-2 [KO:K00182]
108711143  wnt16.L; protein Wnt-16 [KO:K01558]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108711609  [KO:K02147]
108711777  [KO:K03259]
108711802  irs2.L; insulin receptor substrate 1 [KO:K16172]
108712492  [KO:K05459]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108712529  [KO:K00572]
108712563  [KO:K03068]
108712570  atp6v1e1.S; V-type proton ATPase subunit E 1 [KO:K02150]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108713100  wnt16.S; protein Wnt-16 [KO:K01558]
108713107  [KO:K00182]
108713228  [KO:K03259]
108713280  fnip1.S; folliculin-interacting protein 1 isoform X1 [KO:K20400]
108713288  wnt8a.S; protein Wnt-8-like [KO:K00714]
108713755  prr5l.L; proline-rich protein 5-like isoform X1 [KO:K20411]
108714142  wdr59.L; GATOR complex protein WDR59 isoform X1 [KO:K20409]
108714249  [KO:K07198] [EC:2.7.11.31]
108714639  [KO:K14004]
108715262  prr5l.S; proline-rich protein 5-like isoform X1 [KO:K20411]
108715541  [KO:K07198] [EC:2.7.11.31]
108715700  atp6v1g3.S; V-type proton ATPase subunit G 3-like [KO:K02152]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108716023  [KO:K20404]
108716267  ulk1.L; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
108716876  [KO:K16186]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108717181  atp6v1c2.L; V-type proton ATPase subunit C 2 [KO:K02148]
108717186  lpin1.L; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108717877  [KO:K04373] [EC:2.7.11.1]
108717971  rragd.S; ras-related GTP-binding protein D [KO:K16186]
108718034  [KO:K02353]
108718046  MGC89871.S; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718134  [KO:K16172]
108718187  cab39.S; calcium-binding protein 39 [KO:K08272]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108718244  atp6v1c2.S; V-type proton ATPase subunit C 2 [KO:K02148]
108718250  lpin1.S; phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
108718300  fzd3.S; frizzled-3-like isoform X2 [KO:K02329]
108718341  [KO:K14995]
108718405  [KO:K08267]
108718689  wnt3a.L; protein Wnt-3 [KO:K00312]
108719210  lpin2.L; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
108719371  fzd6.L; frizzled-6 isoform X1 [KO:K02376]
108719396  deptor.L; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
108719801  wnt9a.S; protein Wnt-9a isoform X2 [KO:K01064]
108719819  [KO:K07208]
108719892  [KO:K02432]
108720011  grb10.S; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
373578  wnt1.L; protein Wnt-1 precursor [KO:K03209]
373690  fzd8.L; frizzled-8 precursor [KO:K02375]
373722  lrp5.L; LDL receptor related protein 5 L homeolog precursor [KO:K03068]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
373817  fzd1.L; frizzled-1 precursor [KO:K02432]
373826  lrp6.L; low-density lipoprotein receptor-related protein 6 [KO:K03068]
373834  fzd5.S; frizzled-5 precursor [KO:K02375]
378566  wnt2b.L; protein Wnt-2b-A precursor [KO:K00182]
378676  wnt6.S; protein Wnt-6 [KO:K00445]
378679  wnt3a.S; protein Wnt-3a precursor [KO:K00312]
378689  wnt5a.S; protein Wnt-5a precursor [KO:K00444]
378695  ins.L; insulin-2 precursor [KO:K04526]
378696  ins.S; insulin-1 precursor [KO:K04526]
378787  fzd7.L; frizzled class receptor 7 L homeolog [KO:K02432]
379133  slc3a2.L; solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog [KO:K06519]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
379457  atp6v1e1.L; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 L homeolog [KO:K02150]
379481  ddit4.S; DNA damage-inducible transcript 4 protein [KO:K08270]
379557  lamtor3.L; ragulator complex protein LAMTOR3-B [KO:K04370]
379741  lamtor2.S; ragulator complex protein LAMTOR2-B [KO:K20398]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
379794  nprl2.S; NPR2 like, GATOR1 complex subunit S homeolog [KO:K20405]
379796  atp6v1al.L; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A like L homeolog [KO:K02145] [EC:7.1.2.2]
379842  wnt5b.S; protein Wnt-5b precursor [KO:K00444]
379863  rps6.L; ribosomal protein S6 L homeolog [KO:K02991]
379890  lamtor1.S; ragulator complex protein LAMTOR1 [KO:K20397]
379938  slc3a2.S; solute carrier family 3, member 2 [KO:K06519]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
380036  prr5.L; proline-rich protein 5 [KO:K20411]
380128  atp6v1g1.S; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 S homeolog [KO:K02152]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
380134  sec13.S; SEC13 homolog, nuclear pore and COPII coat complex component S homeolog [KO:K14004]
380158  mapkap1.L; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
380186  rheb.L; Ras homolog, mTORC1 binding L homeolog [KO:K07208]
380281  rps6.S; 40S ribosomal protein S6 [KO:K02991]
380305  atp6v1b2.S; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 S homeolog [KO:K02147]
380357  wdr24.L; GATOR complex protein WDR24 [KO:K20408]
380570  lamtor3-like.L; ragulator complex protein LAMTOR3-A [KO:K04370]
387604  fzd10.L; frizzled-10-A precursor [KO:K02842]
387605  fzd10.S; frizzled class receptor 10 S homeolog precursor [KO:K02842]
394276  rps6kb1.S; ribosomal protein S6 kinase B1 S homeolog [KO:K04688] [EC:2.7.11.1]
394347  rps6kb1.L; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
397706  wnt4.L; protein Wnt-4 isoform 2 precursor [KO:K00408]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
397970  wnt8a.L; protein Wnt-8 precursor [KO:K00714]
398006  insr.L; insulin receptor precursor [KO:K04527] [EC:2.7.10.1]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
398816  lpin2.S; lipin 2 S homeolog [KO:K15728] [EC:3.1.3.4]
398836  nprl3.L; NPR3-like, GATOR1 complex subunit L homeolog [KO:K20406]
398852  atp6v1f.L; V-type proton ATPase subunit F [KO:K02151]
398895  mlst8.L; target of rapamycin complex subunit lst8 [KO:K08266]
398903  cab39l.L; calcium binding protein 39 like L homeolog [KO:K08272]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
398978  slc7a5.L; solute carrier family 7, member 5 b [KO:K13780]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399097  gsk3b.L; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
399098  wnt8b.S; protein Wnt-8b precursor [KO:K00714]
399100  stk11.L; serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
399130  sgk1.L; serine/threonine-protein kinase Sgk1-A [KO:K13302] [EC:2.7.11.1]
399141  fzd2.S; frizzled-2 precursor [KO:K02235]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
399172  prkaa2.S; protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog [KO:K07198] [EC:2.7.11.31]
399190  fzd3.L; frizzled-3 precursor [KO:K02329]
399192  fzd4.S; frizzled-4 precursor [KO:K02354]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
399255  eif4e1b.S; eukaryotic translation initiation factor 4E [KO:K03259]
399299  irs1.L; insulin receptor substrate 1-A [KO:K16172]
399301  dvl2.L; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
399364  wnt7b.L; protein Wnt-7b [KO:K00572]
399367  fzd8.S; frizzled class receptor 8 S homeolog precursor [KO:K02375]
399376  rps6ka3.L; ribosomal protein S6 kinase A3 L homeolog [KO:K04373] [EC:2.7.11.1]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
399441  wnt11b.L; protein Wnt-11b precursor [KO:K01384]
399446  nras.L; GTPase NRas [KO:K07828]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
403358  atp6v1f.S; uncharacterized protein LOC403358 [KO:K02151]
414469  tbc1d7.L; TBC1 domain family member 7 L homeolog [KO:K20396]
414641  sesn2.L; sestrin 2 L homeolog [KO:K20394]
431814  akt1s1.S; AKT1 substrate 1 (proline rich) S homeolog [KO:K16184]
432061  lamtor5.S; ragulator complex protein LAMTOR5 [KO:K16344]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
432200  ikbkb.L; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog [KO:K07209] [EC:2.7.11.10]
432219  cab39.L; calcium binding protein 39 L homeolog [KO:K08272]
443621  telo2.L; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
443672  sesn2.S; sestrin-2 [KO:K20394]
443729  rps6ka6.S; ribosomal protein S6 kinase 2 alpha [KO:K04373] [EC:2.7.11.1]
443816  rraga.S; Ras-related GTP binding A S homeolog [KO:K16185]
443873  [KO:K02149]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
444361  lpin3.L; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
444365  seh1l.S; nucleoporin SEH1-B [KO:K14299]
444373  rnf152.S; E3 ubiquitin-protein ligase rnf152-A [KO:K15705] [EC:2.3.2.27]
444527  dvl3.L; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
444529  pdpk1.L; 3-phosphoinositide dependent protein kinase 1 L homeolog [KO:K06276] [EC:2.7.11.1]
444556  chuk.S; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
444618  sgk1.S; serine/threonine-protein kinase Sgk1-B [KO:K13302] [EC:2.7.11.1]
445821  rps6ka1.L; ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
445831  clip1.S; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
446432  castor1.L; cytosolic arginine sensor for mTORC1 subunit 1 L homeolog [KO:K23080]
446578  castor2.L; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
446845  atp6v1d.L; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D L homeolog [KO:K02149]
446915  wnt11.S; protein Wnt-11 precursor [KO:K01384]
447031  prkca.L; protein kinase C, alpha L homeolog [KO:K02677] [EC:2.7.11.13]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
447373  rnf152.L; E3 ubiquitin-protein ligase rnf152-B [KO:K15705] [EC:2.3.2.27]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
494731  clip1.L; CAP-Gly domain-containing linker protein 1 isoform X2 [KO:K10421]
494825  lamtor2.L; ragulator complex protein LAMTOR2-A [KO:K20398]
495007  fzd6.S; frizzled class receptor 6 S homeolog precursor [KO:K02376]
495075  akt1s1.L; uncharacterized protein LOC495075 [KO:K16184]
495092  atp6v1c1.L; V-type proton ATPase subunit C 1 [KO:K02148]
495258  rragc.S; Ras related GTP binding C S homeolog [KO:K16186]
495264  atp6v1g3.L; V-type proton ATPase subunit G 3 [KO:K02152]
495290  prkaa1.L; protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog [KO:K07198] [EC:2.7.11.31]
495294  mios.S; GATOR complex protein MIOS-A [KO:K20407]
496352  deptorl.S; DEP domain containing MTOR interacting protein like S homeolog [KO:K20402]
734259  eif4e.L; eukaryotic translation initiation factor 4E L homeolog [KO:K03259]
734359  atp6v1h.L; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H L homeolog [KO:K02144]
734605  eif4e2.L; eukaryotic translation initiation factor 4E family member 2 L homeolog [KO:K03259]
734627  atp6v1a.L; ATPase H+ transporting V1 subunit A L homeolog [KO:K02145] [EC:7.1.2.2]
734650  seh1l.L; nucleoporin SEH1-A [KO:K14299]
734669  MGC89871.L; uncharacterized protein LOC734669 [KO:K03259]
734901  skp2.L; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase L homeolog [KO:K03875]
734908  slc7a5.S; solute carrier family 7 member 5 S homeolog [KO:K13780]
779056  [KO:K03083] [EC:2.7.11.26]
779272  atp6v1b1.L; ATPase H+ transporting V1 subunit B1 L homeolog [KO:K02147]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
xla00561  Glycerolipid metabolism
xla04010  MAPK signaling pathway
xla04140  Autophagy - animal
xla04810  Regulation of actin cytoskeleton
xla04910  Insulin signaling pathway
KO pathway
ko04150   

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