KEGG   PATHWAY: xla04510
Entry
xla04510                    Pathway                                
Name
Focal adhesion - Xenopus laevis (African clawed frog)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
xla04510  Focal adhesion
xla04510

Other DBs
GO: 0005925
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036859  birc2.S; uncharacterized protein LOC100036859 [KO:K16060]
100036966  parvg.S; parvin gamma S homeolog [KO:K06275]
100037058  vegfa.S; vascular endothelial growth factor A S homeolog precursor [KO:K05448]
100037170  tln2.S; talin 2 S homeolog [KO:K06271]
100049724  zyx.S; zyxin [KO:K06273]
100127267  XB5844015.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100158352  vegfd.L; vascular endothelial growth factor D [KO:K05449]
100190767  elk1.S; ELK1, member of ETS oncogene family S homeolog [KO:K04375]
100191022  itga2b.1.S; integrin subunit alpha 2b S homeolog precursor [KO:K06476]
100192352  ibsp.S; bone sialoprotein 2 [KO:K06253]
100192353  ibsp.L; integrin-binding sialoprotein L homeolog precursor [KO:K06253]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
100301953  rock2.S; uncharacterized protein LOC100301953 [KO:K17388] [EC:2.7.11.39]
100337595  actg1.S; actin, cytoplasmic type 5 [KO:K05692]
100381143  arhgap5.S; Rho GTPase activating protein 5 isoform 1 [KO:K13709]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100653493  pip5k1a.S; uncharacterized protein LOC100653493 [KO:K00889] [EC:2.7.1.68]
108695261  rock1.S; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
108695262  comp.L; cartilage oligomeric matrix protein [KO:K04659]
108695600  myl12b.S; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
108695689  [KO:K06273]
108696117  dock1.L; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
108696670  [KO:K17457]
108696776  [KO:K19663] [EC:2.7.11.13]
108697104  myl2.L; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108697392  dock1.S; dedicator of cytokinesis protein 1 isoform X3 [KO:K13708]
108697660  cdc42.S; cell division control protein 42 homolog isoform X1 [KO:K04393]
108697741  [KO:K17457]
108697820  [KO:K19663] [EC:2.7.11.13]
108698108  elk1.L; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
108698197  vav2.L; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108698292  cav3.2.L; caveolin-3 [KO:K12959]
108698293  XB5932841.L; caveolin-2 [KO:K12958]
108698372  kdrl.L; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
108698394  col4a6.L; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108698395  col4a5.L; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108698463  [KO:K05098] [EC:2.7.10.1]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108698803  [KO:K04456] [EC:2.7.11.1]
108698866  rapgef1.L; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
108698878  vegfc.L; vascular endothelial growth factor C [KO:K05449]
108698936  tnxb.L; tenascin-X isoform X1 [KO:K06252]
108699237  arhgap5.L; rho GTPase-activating protein 5 [KO:K13709]
108699243  pdgfc.L; platelet-derived growth factor C [KO:K05450]
108699252  pak6.L; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108699471  [KO:K00889] [EC:2.7.1.68]
108699602  itga10.L; integrin alpha-10 [KO:K06586]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108699999  [KO:K04437]
108700035  [KO:K06252]
108700040  XB5932841.S; caveolin-2 [KO:K12958]
108700098  col4a5.S; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
108700099  [KO:K06237]
108700104  pak3.S; serine/threonine-protein kinase PAK 3-like isoform X2 [KO:K05733] [EC:2.7.11.1]
108700189  arhgap35.S; rho GTPase-activating protein 35-like isoform X1 [KO:K05732]
108700290  pak4.S; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
108700316  pak6.S; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108700442  shc1.S; SHC-transforming protein 1-like isoform X1 [KO:K06279]
108700446  thbs3.S; thrombospondin-3 isoform X1 [KO:K04659]
108700541  kdrl.S; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
108700560  [KO:K06274]
108700569  tnxb.S; tenascin-X isoform X1 [KO:K06252]
108700666  [KO:K04448]
108700774  erbb2.L; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108700840  col1a1.L; collagen alpha-1(I) chain [KO:K06236]
108700926  lama5.L; laminin subunit alpha-5 isoform X1 [KO:K06240]
108700969  [KO:K00907] [EC:2.7.11.18]
108700975  [KO:K07861]
108701097  chad.L; chondroadherin [KO:K06248]
108701118  itgb4.L; integrin beta-4 isoform X1 [KO:K06525]
108701256  mylk.L; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
108701397  itga4.L; integrin alpha-4-like [KO:K06483]
108701573  pdgfa.L; platelet-derived growth factor subunit A-like isoform X2 [KO:K04359]
108701647  [KO:K19662] [EC:2.7.11.13]
108701718  [KO:K12758]
108701763  mylkl.L; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108702159  prkca.S; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
108702189  [KO:K06240]
108702240  mylk.S; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
108702277  [KO:K06238]
108702278  [KO:K06238]
108702492  [KO:K05083] [EC:2.7.10.1]
108702534  itga3.S; integrin alpha-3 isoform X2 [KO:K06482]
108702653  col9a3.S; collagen alpha-3(IX) chain [KO:K08131]
108702793  chad.S; chondroadherin [KO:K06248]
108702819  itgb4.S; integrin beta-4 isoform X2 [KO:K06525]
108702890  itgb5.S; integrin beta-5 isoform X1 [KO:K06588]
108702994  itga6.S; integrin alpha-6 isoform X1 [KO:K06485]
108703023  col6a1.S; collagen alpha-1(VI) chain-like [KO:K06238]
108703024  col6a2.S; collagen alpha-2(VI) chain [KO:K06238]
108703086  actb.S; actin, cytoplasmic 1 [KO:K05692]
108703103  emp2.S; epithelial membrane protein 2 [KO:K26256]
108703133  pdpk1.S; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
108703204  [KO:K19662] [EC:2.7.11.13]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108704179  [KO:K06269] [EC:3.1.3.16]
108704467  [KO:K04437]
108705008  [KO:K05730]
108705104  flnb.L; filamin-B isoform X1 [KO:K27392]
108705398  itga1.S; integrin alpha-1 [KO:K06480]
108706592  pdgfra.S; platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
108706593  kdr.S; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
108706647  pdgfc.S; platelet-derived growth factor C [KO:K05450]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706896  shc2.S; SHC-transforming protein 2 [KO:K17447]
108706910  comp.S; cartilage oligomeric matrix protein [KO:K04659]
108706999  [KO:K17448]
108707456  myl10.L; myosin regulatory light chain 2B, cardiac muscle isoform isoform X1 [KO:K12756]
108707572  [KO:K05450]
108708153  ppp1r12b.L; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
108708560  itga7.L; integrin alpha-7 isoform X2 [KO:K06583]
108708650  itgb7.L; integrin beta-7 [KO:K06590]
108708991  itga7.S; integrin alpha-7 isoform X1 [KO:K06583]
108709092  [KO:K12756]
108709342  crk.S; adapter molecule crk-like isoform X1 [KO:K04438]
108709379  lamb3.S; laminin subunit beta-3 [KO:K06244]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
108709589  col9a2.S; collagen alpha-2(IX) chain [KO:K08131]
108709738  col4a2.S; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
108709739  [KO:K06237]
108709984  pdgfd.S; platelet-derived growth factor D [KO:K05450]
108710179  egf.L; pro-epidermal growth factor [KO:K04357]
108710723  parvb.L; beta-parvin isoform X1 [KO:K06275]
108710813  vwf.L; von Willebrand factor [KO:K03900]
108710830  [KO:K05097] [EC:2.7.10.1]
108710882  diaph1.L; protein diaphanous homolog 1 isoform X3 [KO:K05740]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
108711109  ppp1r12a.L; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
108711178  lamb4.L; laminin subunit beta-4 isoform X1 [KO:K06245]
108711179  lamb1.L; laminin subunit beta-1 [KO:K05636]
108711206  hgf.L; hepatocyte growth factor [KO:K05460]
108711290  [KO:K06271]
108711398  shc4.L; SHC-transforming protein 4 [KO:K17449]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
108711510  itga11.L; integrin alpha-11 [KO:K06587]
108711521  [KO:K04349]
108712206  [KO:K00889] [EC:2.7.1.68]
108712318  shc4.S; SHC-transforming protein 4 [KO:K17449]
108712362  met.S; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108712492  [KO:K05459]
108712628  [KO:K05097] [EC:2.7.10.1]
108712643  pdgfrb.S; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108712731  myl7.S; myosin regulatory light chain 2, atrial isoform [KO:K12754]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
108712994  [KO:K06271]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108713062  hgf.S; hepatocyte growth factor [KO:K05460]
108713081  lamb1.S; laminin subunit beta-1 [KO:K05636]
108713157  [KO:K07836]
108713169  shc2.L; SHC-transforming protein 2 [KO:K17447]
108713303  diaph1.S; protein diaphanous homolog 1 [KO:K05740]
108713537  [KO:K06252]
108713738  parva.L; alpha-parvin [KO:K06275]
108713841  [KO:K06270]
108713905  [KO:K02158]
108714133  [KO:K00907] [EC:2.7.11.18]
108714346  tnn.L; tenascin-N [KO:K06252]
108714355  lamc2.L; laminin subunit gamma-2 [KO:K06246]
108714357  lamc1.L; laminin subunit gamma-1 isoform X1 [KO:K05635]
108714432  vav3.L; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108714525  pdgfb.L; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108714631  cav3.1.L; caveolin-3 [KO:K12959]
108714682  XB5969698.L; laminin subunit beta-4 [KO:K06243]
108714850  [KO:K17448]
108715054  [KO:K27392]
108715151  [KO:K02158]
108715193  [KO:K06270]
108715282  parva.S; alpha-parvin [KO:K06275]
108715363  bcar1.S; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
108715487  [KO:K00907] [EC:2.7.11.18]
108715624  [KO:K06252]
108715634  lamc1.S; laminin subunit gamma-1 [KO:K05635]
108715695  vav3.S; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108715715  emp1.S; epithelial membrane protein 1 [KO:K26255]
108715797  [KO:K07860]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108715891  lamb2.S; laminin subunit beta-2 isoform X2 [KO:K06243]
108715892  XB5969698.S; laminin subunit beta-4 [KO:K06243]
108716013  pxn.L; paxillin isoform X1 [KO:K05760]
108716137  [KO:K05637]
108716398  pak5.L; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
108716477  capn8.5.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
108716699  thbs2.L; thrombospondin-2 [KO:K04659]
108716825  lama4.L; laminin subunit alpha-4 isoform X1 [KO:K06241]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108717139  pak2.L; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108717424  [KO:K06241]
108717671  ppp1cb.S; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108717697  capn2.S; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
108717760  pak5.S; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108717845  thbs2.S; thrombospondin-2 [KO:K04659]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108718392  [KO:K06480]
108718494  col6a5.L; collagen alpha-6(VI) chain [KO:K06238]
108718495  col6a6.L; collagen alpha-6(VI) chain [KO:K06238]
108718546  [KO:K05637]
108718553  lama3.L; laminin subunit alpha-3 [KO:K06240]
108718824  itga8.L; integrin alpha-8 [KO:K06584]
108718868  itgb8.L; integrin beta-8 [KO:K06591]
108719000  itga9.L; integrin alpha-9 [KO:K06585]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
108719107  mylk4.L; serine/threonine-protein kinase pakF isoform X1 [KO:K00907] [EC:2.7.11.18]
108719215  rock1.L; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
108719692  col6a6.S; collagen alpha-6(VI) chain [KO:K06238]
108719885  itga8.S; integrin alpha-8 [KO:K06584]
108719903  col1a2.S; collagen alpha-2(I) chain [KO:K06236]
108719918  itgb8.S; integrin beta-8 [KO:K06591]
108719997  egfr.S; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108720081  mylk4.S; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
121393057  [KO:K05717]
121393384  [KO:K27392]
121393385  [KO:K27392]
121393386  [KO:K27392]
373551  met.L; MET proto-oncogene, receptor tyrosine kinase L homeolog precursor [KO:K05099] [EC:2.7.10.1]
373589  vegfa.L; vascular endothelial growth factor A L homeolog precursor [KO:K05448]
373609  fyn.L; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
373647  src.S; tyrosine-protein kinase Src-1 [KO:K05704] [EC:2.7.10.2]
373657  itga3.L; integrin alpha-3 [KO:K06482]
373667  ccnd2.L; G1/S-specific cyclin-D2 [KO:K10151]
373743  itga2.L; integrin alpha-2 [KO:K06481]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
373763  col4a2.L; collagen alpha-2(IV) chain [KO:K06237]
373764  col4a1.L; collagen alpha-1(IV) chain [KO:K06237]
373770  vcl.S; vinculin isoform X2 [KO:K05700]
373789  flt1.L; fms-related tyrosine kinase 1 L homeolog precursor [KO:K05096] [EC:2.7.10.1]
378493  pak3.L; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
378559  itga11.S; integrin alpha-11 [KO:K06587]
378686  itgb6.L; integrin beta-6 isoform X1 [KO:K06589]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
379055  cdc42.L; cell division cycle 42 L homeolog [KO:K04393]
379161  ccnd1.S; G1/S-specific cyclin-D1 b [KO:K04503]
379268  emp2.L; epithelial membrane protein 2 L homeolog [KO:K26256]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
379508  thbs1.L; thrombospondin 1 L homeolog precursor [KO:K16857]
379546  flt1.S; uncharacterized protein LOC379546 precursor [KO:K05096] [EC:2.7.10.1]
379646  vav2.S; vav guanine nucleotide exchange factor 2 S homeolog [KO:K05730]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
379812  fyn.S; proto-oncogene tyrosine-protein kinase fyn [KO:K05703] [EC:2.7.10.2]
379866  cav3.2.S; caveolin 3, gene 2 S homeolog [KO:K12959]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
379883  rap1b.L; ras-related protein Rap-1b [KO:K07836]
379914  ppp1ca.L; protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog [KO:K06269] [EC:3.1.3.16]
379937  ccnd1.L; G1/S-specific cyclin-D1 [KO:K04503]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
380007  mylc2a; myosin light chain, regulatory A [KO:K12754]
380129  col6a1.L; collagen alpha-1(VI) chain [KO:K06238]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
380245  pdgfra.L; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
380339  thbs3.L; thrombospondin 3 L homeolog precursor [KO:K04659]
380419  col1a2.L; collagen type I alpha 2 L homeolog precursor [KO:K06236]
380430  src.L; tyrosine-protein kinase Src-2 [KO:K05704] [EC:2.7.10.2]
380441  ctnnb1.S; catenin beta 1 S homeolog [KO:K02105]
380472  myl12b.L; myosin light chain 12B L homeolog [KO:K12757]
380515  col1a1.S; collagen, type I, alpha 1 S homeolog precursor [KO:K06236]
380598  ppp1cc.S; serine/threonine-protein phosphatase PP1-gamma catalytic subunit B [KO:K06269] [EC:3.1.3.16]
394289  rock2.L; Rho-associated, coiled-coil containing protein kinase 2 L homeolog [KO:K17388] [EC:2.7.11.39]
394366  itga5.L; integrin alpha-5 precursor [KO:K06484]
397699  itgb3.L; integrin beta-3 isoform X1 [KO:K06493]
397738  col2a1.L; collagen alpha-1(II) chain precursor [KO:K19719]
397739  col2a1.S; collagen, type II, alpha 1 S homeolog precursor [KO:K19719]
397744  fn1.S; fibronectin precursor [KO:K05717]
397755  itgb1.L; integrin beta-1-A precursor [KO:K05719]
397765  pdgfa.S; platelet-derived growth factor subunit A precursor [KO:K04359]
397767  ppp1cc.L; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397826  pxn.S; paxillin S homeolog [KO:K05760]
397839  itga4.S; integrin alpha-4 precursor [KO:K06483]
397842  itga5.S; integrin alpha-5-like isoform X1 [KO:K06484]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
397943  thbs4.L; thrombospondin-4 precursor [KO:K04659]
397985  itga6.L; integrin alpha-6 isoform X1 [KO:K06485]
397997  itgav.L; integrin subunit alpha V L homeolog precursor [KO:K06487]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
398126  pak1.S; p21-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
398224  pak4.L; p21-activated kinase 4 [KO:K05734] [EC:2.7.11.1]
398332  tnc.L; tenascin isoform X1 [KO:K06252]
398368  [KO:K06238]
398391  cav2.L; caveolin 2 L homeolog [KO:K12958]
398392  cav1.L; caveolin 1 L homeolog [KO:K06278]
398459  actb.L; actin, cytoplasmic 1 [KO:K05692]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
398547  reln.L; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
398560  col9a1-b; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
398687  pip5k1c.S; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma S homeolog [KO:K00889] [EC:2.7.1.68]
398756  bcar1.L; BCAR1, Cas family scaffold protein L homeolog [KO:K05726]
398782  MGC68680; uncharacterized protein LOC398782 [KO:K04409] [EC:2.7.11.1]
398951  crk.L; adapter molecule crk [KO:K04438]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399006  cav1.S; caveolin 1 S homeolog [KO:K06278]
399075  capn2.L; calpain 2 L homeolog [KO:K03853] [EC:3.4.22.53]
399090  pak2.S; p21-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
399097  gsk3b.L; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
399198  shc1.L; SHC-transforming protein 1 [KO:K06279]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
399251  mylpf.L; myosin light chain, phosphorylatable, fast skeletal muscle L homeolog [KO:K12758]
399274  ctnnb1.L; catenin beta-1 [KO:K02105]
399286  ptk2.L; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
399379  rac3.S; Rac family small GTPase 3 S homeolog [KO:K04392]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
399422  actn1.L; actinin alpha 1 L homeolog [KO:K05699]
399443  itgb1.S; integrin beta-1-B precursor [KO:K05719]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
414290  rap1a.S; RAP1A, member of RAS oncogene family S homeolog [KO:K04353]
414569  crkl.S; uncharacterized protein LOC414569 [KO:K04438]
414634  arhgap35.L; rho GTPase-activating protein 35 [KO:K05732]
431885  actn1.S; uncharacterized protein LOC431885 [KO:K05699]
432072  ptk2.S; uncharacterized protein LOC432072 [KO:K05725] [EC:2.7.10.2]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
443832  cav2.S; caveolin 2 S homeolog [KO:K12958]
443852  ppp1cb.L; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
443914  vasp.L; vasodilator stimulated phosphoprotein L homeolog [KO:K06274]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
444184  rac2.L; Rac family small GTPase 2 L homeolog [KO:K07860]
444199  rapgef1.S; Rap guanine nucleotide exchange factor 1 S homeolog [KO:K06277]
444238  pip5k1b.L; phosphatidylinositol-4-phosphate 5-kinase, type I, beta L homeolog [KO:K00889] [EC:2.7.1.68]
444414  [KO:K06272] [EC:2.7.11.1]
444529  pdpk1.L; 3-phosphoinositide dependent protein kinase 1 L homeolog [KO:K06276] [EC:2.7.11.1]
444747  emp1.L; epithelial membrane protein 1 L homeolog [KO:K26255]
445877  vtn.L; vitronectin L homeolog precursor [KO:K06251]
446423  itgb5.L; integrin subunit beta 5 L homeolog precursor [KO:K06588]
446508  col9a3.L; collagen, type IX, alpha 3 L homeolog precursor [KO:K08131]
446568  birc2.L; baculoviral IAP repeat containing 2 L homeolog [KO:K16060]
446631  col9a1.L; collagen, type IX, alpha 1 L homeolog precursor [KO:K08131]
446640  ilk.S; integrin linked kinase S homeolog [KO:K06272] [EC:2.7.11.1]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
446826  vav1.L; vav guanine nucleotide exchange factor 1 L homeolog [KO:K05730]
446851  myl9.L; myosin light chain 9 L homeolog [KO:K12755]
446865  actn4.S; actinin alpha 4 S homeolog [KO:K05699]
446985  thbs4.S; thrombospondin 4 S homeolog precursor [KO:K04659]
447031  prkca.L; protein kinase C, alpha L homeolog [KO:K02677] [EC:2.7.11.13]
447131  myl2.S; myosin light chain 2 S homeolog [KO:K10351]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
447419  crkl.L; v-crk avian sarcoma virus CT10 oncogene homolog-like L homeolog [KO:K04438]
447541  [KO:K04503]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
447704  myl9.S; myosin light chain 9 S homeolog [KO:K12755]
447748  ccndx.L; G1/S-specific cyclin-D1 [KO:K04503]
493575  pdgfb.S; platelet-derived growth factor subunit B [KO:K17386]
494866  rasgrf1.S; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
494988  lamb2.L; laminin subunit beta 2 L homeolog precursor [KO:K06243]
495051  itga2b.2.L; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), gene 2 L homeolog precursor [KO:K06476]
724072  egfr.L; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
733200  ppp1r12a.S; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
733235  xiap.L; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
733283  [KO:K06271]
734275  col6a2.L; uncharacterized protein LOC734275 precursor [KO:K06238]
734331  vegfc.S; vascular endothelial growth factor C S homeolog precursor [KO:K05449]
734362  col9a2.L; collagen, type IX, alpha 2 L homeolog precursor [KO:K08131]
734382  rac1.L; Rac family small GTPase 1 L homeolog [KO:K04392]
734573  parvb.S; parvin beta S homeolog [KO:K06275]
734882  ccnd2.S; cyclin D2 S homeolog [KO:K10151]
734918  actg1.L; actin, cytoplasmic type 8 [KO:K05692]
734930  actn4.L; uncharacterized protein LOC734930 [KO:K05699]
779026  thbs1.S; thrombospondin-1 [KO:K16857]
779056  [KO:K03083] [EC:2.7.11.26]
779127  rap1a.L; RAP1A, member of RAS oncogene family L homeolog [KO:K04353]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
xla04010  MAPK signaling pathway
xla04060  Cytokine-cytokine receptor interaction
xla04070  Phosphatidylinositol signaling system
xla04110  Cell cycle
xla04310  Wnt signaling pathway
xla04512  ECM-receptor interaction
xla04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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