KEGG   PATHWAY: xla04910
Entry
xla04910                    Pathway                                
Name
Insulin signaling pathway - Xenopus laevis (African clawed frog)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
xla04910  Insulin signaling pathway
xla04910

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
378696  ins.S; insulin-1 precursor [KO:K04526]
378695  ins.L; insulin-2 precursor [KO:K04526]
108696734  XB5961731.L; insulin [KO:K04526]
398006  insr.L; insulin receptor precursor [KO:K04527] [EC:2.7.10.1]
100158430  insr.S; uncharacterized protein LOC100158430 [KO:K04527] [EC:2.7.10.1]
399299  irs1.L; insulin receptor substrate 1-A [KO:K16172]
108718134  insulin receptor substrate 1-B-like [KO:K16172]
108711802  irs2.L; insulin receptor substrate 1 [KO:K16172]
495836  irs4.L; insulin receptor substrate 2-B [KO:K07187]
399388  irs4.S; insulin receptor substrate 2-A [KO:K07187]
108708462  insulin receptor substrate 2 [KO:K07187]
108709741  insulin receptor substrate 2 [KO:K07187]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
444529  pdpk1.L; 3-phosphoinositide dependent protein kinase 1 L homeolog [KO:K06276] [EC:2.7.11.1]
108703133  pdpk1.S; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108698803  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
399097  gsk3b.L; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
779056  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
431912  gys2.L; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
108696758  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
108697802  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
443852  ppp1cb.L; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
379914  ppp1ca.L; protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog [KO:K06269] [EC:3.1.3.16]
380598  ppp1cc.S; serine/threonine-protein phosphatase PP1-gamma catalytic subunit B [KO:K06269] [EC:3.1.3.16]
397767  ppp1cc.L; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
108717671  ppp1cb.S; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108704179  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
444329  ppp1r3c.1.L; protein phosphatase 1, regulatory (inhibitor) subunit 3C, gene 1 L homeolog [KO:K07189]
446643  ppp1r3c.1.S; protein phosphatase 1 regulatory subunit 3C [KO:K07189]
735066  ppp1r3b.L; protein phosphatase 1 regulatory subunit 3B-A [KO:K07189]
414616  ppp1r3c.2.L; uncharacterized protein LOC414616 [KO:K07189]
734374  ppp1r3c.2.S; protein phosphatase 1 regulatory subunit 3C gene 2 S homeolog [KO:K07189]
108713113  ppp1r3a.S; protein phosphatase 1 regulatory subunit 3A [KO:K07189]
108714036  protein phosphatase 1 regulatory subunit 3E [KO:K07189]
108715382  protein phosphatase 1 regulatory subunit 3D [KO:K07189]
108702632  ppp1r3d.S; protein phosphatase 1 regulatory subunit 3D [KO:K07189]
443944  ppp1r3b.S; protein phosphatase 1 regulatory subunit 3B-B [KO:K07189]
108711133  ppp1r3a.L; protein phosphatase 1 regulatory subunit 3A [KO:K07189]
108700936  ppp1r3d.L; protein phosphatase 1 regulatory subunit 3D [KO:K07189]
108714865  ppp1r3e.L; protein phosphatase 1 regulatory subunit 3E [KO:K07189]
373780  phkg1.S; phosphorylase kinase, gamma 1 (muscle) S homeolog [KO:K00871] [EC:2.7.11.19]
496328  phkg2.L; phosphorylase kinase, gamma 2 (testis) L homeolog [KO:K00871] [EC:2.7.11.19]
108708334  phkg1.L; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
108715481  phkb.S; phosphorylase b kinase regulatory subunit beta isoform X3 [KO:K07190]
108714128  phkb.L; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta-like [KO:K07190]
108698269  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X4 [KO:K07190]
108709337  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
108708020  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
380558  calm2.S; calmodulin-2 A [KO:K02183]
606721  calm1.S; calmodulin-1 [KO:K02183]
399259  calm2.L; calmodulin-2 B [KO:K02183]
108711508  calml4.L; calmodulin-like protein 4 isoform X1 [KO:K02183]
108698710  calmodulin-1 [KO:K02183]
108712798  calml4.S; calmodulin-like protein 4 [KO:K02183]
494832  pygl.S; liver glycogen phosphorylase [KO:K00688] [EC:2.4.1.1]
432134  pygm.S; uncharacterized protein LOC432134 [KO:K00688] [EC:2.4.1.1]
379862  pygm.L; brain glycogen phosphorylase [KO:K00688] [EC:2.4.1.1]
108713966  pygb.L; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
100037229  pygb.S; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
108698772  pygl.L; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
496104  pde3b.L; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
108715307  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
380388  prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345] [EC:2.7.11.11]
100101276  prkaca.S; protein kinase, cAMP-dependent, alpha catalytic subunit S homeolog [KO:K04345] [EC:2.7.11.11]
108714187  prkacb.L; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108711677  prkaca.L; protein kinase, cAMP-dependent, alpha catalytic subunit L homeolog [KO:K04345] [EC:2.7.11.11]
414594  prkar2b.S; protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog [KO:K04739]
444805  prkar1a.S; protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog [KO:K04739]
432155  prkar1a.L; cAMP-dependent protein kinase, regulatory subunit alpha 1 [KO:K04739]
108714672  prkar2a.L; cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
108701572  prkar1b.L; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
108715882  prkar2a.S; cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
108703142  prkar1b.S; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
108711183  prkar2b.L; cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1 [KO:K04739]
100174796  lipe.L; lipase, hormone-sensitive L homeolog [KO:K07188] [EC:3.1.1.79]
108697769  lipe.S; hormone-sensitive lipase isoform X3 [KO:K07188] [EC:3.1.1.79]
108697633  prkcz.S; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
373768  prkcz.L; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
399287  prkci.L; protein kinase C iota L homeolog [KO:K06069] [EC:2.7.11.13]
108705375  prkci.S; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
444033  slc2a4.L; solute carrier family 2 (facilitated glucose transporter), member 4 L homeolog [KO:K07191]
398430  flot1.S; flotillin 1 S homeolog [KO:K07192]
398431  flot1.L; flotillin 1 L homeolog [KO:K07192]
379990  flot2.L; flotillin 2 L homeolog [KO:K07192]
108709343  sh2b2.S; SH2B adapter protein 2 isoform X1 [KO:K07193]
108708031  sh2b2.L; SH2B adapter protein 2 isoform X1 [KO:K07193]
108705262  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
108696213  sorbs1.L; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
398194  cbl.L; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
108705407  cbl.S; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
431829  cblb.S; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
443854  cblb.L; E3 ubiquitin-protein ligase CBL-B-A [KO:K22517] [EC:2.3.2.27]
398951  crk.L; adapter molecule crk [KO:K04438]
447419  crkl.L; v-crk avian sarcoma virus CT10 oncogene homolog-like L homeolog [KO:K04438]
414569  crkl.S; uncharacterized protein LOC414569 [KO:K04438]
108709342  crk.S; adapter molecule crk-like isoform X1 [KO:K04438]
444199  rapgef1.S; Rap guanine nucleotide exchange factor 1 S homeolog [KO:K06277]
108698866  rapgef1.L; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
108716422  rho-related GTP-binding protein RhoQ [KO:K07194]
108717736  rhoq.S; rho-related GTP-binding protein RhoQ [KO:K07194]
100158346  exoc7.L; exocyst complex component 7 L homeolog [KO:K07195]
108703239  srebf1.S; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
108701685  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
108709507  acaca.S; acetyl-CoA carboxylase isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
108707483  acaca.L; LOW QUALITY PROTEIN: acetyl-CoA carboxylase-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
108715603  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
108701000  fasn.L; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
108700448  pklr.S; pyruvate kinase PKM-like [KO:K12406] [EC:2.7.1.40]
398967  pklr.L; pyruvate kinase L/R L homeolog [KO:K12406] [EC:2.7.1.40]
394323  hk1.L; hexokinase 1 L homeolog [KO:K00844] [EC:2.7.1.1]
100036846  hk2.L; hexokinase 2 L homeolog [KO:K00844] [EC:2.7.1.1]
108697444  hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
108696205  hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
108712774  hkdc1.S; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
108711534  hkdc1.L; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
108713229  hk2.S; hexokinase-2 isoform X1 [KO:K00844] [EC:2.7.1.1]
108710242  LOW QUALITY PROTEIN: hexokinase-2 [KO:K00844] [EC:2.7.1.1]
378602  gck.L; glucokinase (hexokinase 4) L homeolog [KO:K12407] [EC:2.7.1.2]
108712732  gck.S; hexokinase-4 [KO:K12407] [EC:2.7.1.2]
495290  prkaa1.L; protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog [KO:K07198] [EC:2.7.11.31]
399172  prkaa2.S; protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog [KO:K07198] [EC:2.7.11.31]
108715541  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
108714249  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
443998  prkab1.S; protein kinase, AMP-activated, beta 1 non-catalytic subunit S homeolog [KO:K07199]
380372  prkab2.L; protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog [KO:K07199]
108715739  prkab2.S; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108715919  prkab1.L; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
444397  prkag1.L; protein kinase, AMP-activated, gamma 1 non-catalytic subunit L homeolog [KO:K07200]
380124  prkag3.L; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit [KO:K07200]
398958  prkag2.S; protein kinase, AMP-activated, gamma 2 non-catalytic subunit S homeolog [KO:K07200]
100127310  prkag3.S; protein kinase, AMP-activated, gamma 3 non-catalytic subunit S homeolog [KO:K07200]
108718729  prkag2.L; protein kinase, AMP-activated, gamma 2 non-catalytic subunit L homeolog [KO:K07200]
108709817  prkag1.S; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
444991  foxo1.L; forkhead box protein O1 [KO:K07201]
108709932  foxo1.S; forkhead box protein O1-like [KO:K07201]
100462892  ppargc1a.S; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
108698053  ppargc1a.L; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
379290  g6pc1.2.S; glucose-6-phosphatase, catalytic subunit 1, gene 2 S homeolog [KO:K01084] [EC:3.1.3.9]
379852  g6pc1.1.L; glucose-6-phosphatase, catalytic subunit 1, gene 1 L homeolog [KO:K01084] [EC:3.1.3.9]
398854  g6pc1.3.L; uncharacterized protein LOC398854 [KO:K01084] [EC:3.1.3.9]
447506  g6pc1.1.S; glucose-6-phosphatase, catalytic subunit 1, gene 1 S homeolog [KO:K01084] [EC:3.1.3.9]
398855  g6pc1.2.L; glucose-6-phosphatase, catalytic subunit 1, gene 2 L homeolog [KO:K01084] [EC:3.1.3.9]
108702724  g6pc1.3.S; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
108700836  g6pc3.1.L; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
380220  fbp1.L; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
100381096  fbp2.L; fructose-bisphosphatase 2 L homeolog [KO:K03841] [EC:3.1.3.11]
779029  fbp1.S; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
399424  pck2.L; phosphoenolpyruvate carboxykinase 2 (mitochondrial) L homeolog [KO:K01596] [EC:4.1.1.32]
379637  pck1.S; phosphoenolpyruvate carboxykinase 1 S homeolog [KO:K01596] [EC:4.1.1.32]
379844  pck1.L; cytosolic phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
108707014  pck2.S; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
108696363  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108700989  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
394276  rps6kb1.S; ribosomal protein S6 kinase B1 S homeolog [KO:K04688] [EC:2.7.11.1]
394347  rps6kb1.L; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
379863  rps6.L; ribosomal protein S6 L homeolog [KO:K02991]
380281  rps6.S; 40S ribosomal protein S6 [KO:K02991]
399255  eif4e1b.S; eukaryotic translation initiation factor 4E [KO:K03259]
734669  MGC89871.L; uncharacterized protein LOC734669 [KO:K03259]
734259  eif4e.L; eukaryotic translation initiation factor 4E L homeolog [KO:K03259]
734605  eif4e2.L; eukaryotic translation initiation factor 4E family member 2 L homeolog [KO:K03259]
108713228  eukaryotic translation initiation factor 4E [KO:K03259]
108711777  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
108718046  MGC89871.S; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
108710984  eukaryotic translation initiation factor 4E [KO:K03259]
108699932  tsc1.S; hamartin isoform X1 [KO:K07206]
108698219  tsc1.L; hamartin isoform X1 [KO:K07206]
108703213  tsc2.S; tuberin isoform X1 [KO:K07207]
108701656  tsc2.L; tuberin isoform X3 [KO:K07207]
380186  rheb.L; Ras homolog, mTORC1 binding L homeolog [KO:K07208]
108719819  GTP-binding protein Rheb [KO:K07208]
108715151  bcl2-associated agonist of cell death-like isoform X2 [KO:K02158]
108713905  bcl2-associated agonist of cell death [KO:K02158]
399198  shc1.L; SHC-transforming protein 1 [KO:K06279]
108700442  shc1.S; SHC-transforming protein 1-like isoform X1 [KO:K06279]
108713169  shc2.L; SHC-transforming protein 2 [KO:K17447]
108706896  shc2.S; SHC-transforming protein 2 [KO:K17447]
108714850  SHC-transforming protein 3 [KO:K17448]
108706999  SHC-transforming protein 3 [KO:K17448]
108712318  shc4.S; SHC-transforming protein 4 [KO:K17449]
108711398  shc4.L; SHC-transforming protein 4 [KO:K17449]
444095  grb2.S; growth factor receptor-bound protein 2-B [KO:K04364]
399458  grb2.L; growth factor receptor-bound protein 2-A [KO:K04364]
108717808  sos1.S; son of sevenless homolog 1 [KO:K03099]
108699793  sos2.S; son of sevenless homolog 2 [KO:K03099]
108698752  sos2.L; son of sevenless homolog 2 isoform X2 [KO:K03099]
108716660  sos1.L; son of sevenless homolog 1 [KO:K03099]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
100505423  uncharacterized protein LOC100505423 [KO:K07827]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108697792  kras.S; GTPase HRas [KO:K07827]
399446  nras.L; GTPase NRas [KO:K07828]
398892  araf.L; A-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K08845] [EC:2.7.11.1]
399056  araf.S; A-Raf proto-oncogene, serine/threonine kinase S homeolog [KO:K08845] [EC:2.7.11.1]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
387327  mknk1.S; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
399068  mknk2.L; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
100036803  mknk2.S; uncharacterized protein LOC100036803 [KO:K04372] [EC:2.7.11.1]
100190767  elk1.S; ELK1, member of ETS oncogene family S homeolog [KO:K04375]
108698108  elk1.L; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
443921  socs1.S; suppressor of cytokine signaling 1 S homeolog [KO:K04694]
100294520  socs1.L; suppressor of cytokine signaling 1 L homeolog [KO:K04694]
108715012  suppressor of cytokine signaling 1 [KO:K04694]
734276  socs2.S; suppressor of cytokine signaling 2 S homeolog [KO:K04695]
108711062  socs2.L; suppressor of cytokine signaling 2 isoform X2 [KO:K04695]
380467  socs3.S; suppressor of cytokine signaling 3 S homeolog [KO:K04696]
100158303  socs3l.S; uncharacterized protein LOC100158303 [KO:K04696]
414533  socs3.L; suppressor of cytokine signaling 3 L homeolog [KO:K04696]
108696746  socs3l.L; suppressor of cytokine signaling 3 [KO:K04696]
108699788  socs4.S; suppressor of cytokine signaling 4 [KO:K04697]
108698764  socs4.L; suppressor of cytokine signaling 4 [KO:K04697]
444514  ptpn1.L; protein tyrosine phosphatase non-receptor type 1 L homeolog [KO:K05696] [EC:3.1.3.48]
108702596  ptpn1.S; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
398160  ptprf.L; protein tyrosine phosphatase receptor type F L homeolog precursor [KO:K05695] [EC:3.1.3.48]
108715545  ptprf.S; receptor-type tyrosine-protein phosphatase F isoform X8 [KO:K05695] [EC:3.1.3.48]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
432200  ikbkb.L; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog [KO:K07209] [EC:2.7.11.10]
108698315  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
108708768  inppl1.L; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
447532  inpp5a.1.S; inositol polyphosphate-5-phosphatase A S homeolog [KO:K01106] [EC:3.1.3.56]
108696106  inpp5a.1.L; inositol polyphosphate-5-phosphatase A isoform X2 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
xla00010  Glycolysis / Gluconeogenesis
xla00061  Fatty acid biosynthesis
xla00500  Starch and sucrose metabolism
xla04010  MAPK signaling pathway
xla04070  Phosphatidylinositol signaling system
xla04210  Apoptosis
KO pathway
ko04910   
LinkDB

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