KEGG   PATHWAY: xla04914
Entry
xla04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Xenopus laevis (African clawed frog)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
xla04914  Progesterone-mediated oocyte maturation
xla04914

Other DBs
GO: 0001556
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
373633  pgr.L; progesterone receptor L homeolog [KO:K08556]
108710000  progesterone receptor [KO:K08556]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
108715909  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108711159  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108708144  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
379236  gnai3.S; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
380034  gnai1.L; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
399463  gnai1.S; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
779438  gnai2.S; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 S homeolog [KO:K04630]
108714595  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
108718988  adcy1.L; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
108705348  adcy1.S; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108717252  adcy3.L; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
108718304  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
108707036  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
108715027  adcy4.L; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
108702898  adcy5.S; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
108701255  adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
108708542  adcy6.L; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
414728  adcy6.S; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
399055  adcy7.L; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
414729  adcy8.S; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108719413  adcy8.L; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
378610  adcy9.L; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108703189  adcy9.S; LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
380388  prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345] [EC:2.7.11.11]
100101276  prkaca.S; protein kinase, cAMP-dependent, alpha catalytic subunit S homeolog [KO:K04345] [EC:2.7.11.11]
108714187  prkacb.L; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108711677  prkaca.L; protein kinase, cAMP-dependent, alpha catalytic subunit L homeolog [KO:K04345] [EC:2.7.11.11]
398349  aurka.S; aurora kinase A-B [KO:K11481] [EC:2.7.11.1]
397925  aurka.L; aurora kinase A-A [KO:K11481] [EC:2.7.11.1]
734470  cpeb1.S; cytoplasmic polyadenylation element-binding protein 1-B [KO:K02602]
100505450  cpeb4.S; cytoplasmic polyadenylation element binding protein 4 S homeolog [KO:K02602]
399289  cpeb1.L; cytoplasmic polyadenylation element-binding protein 1-A [KO:K02602]
108696127  cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
108697402  cytoplasmic polyadenylation element-binding protein 3 isoform X2 [KO:K02602]
108698041  cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
108706545  cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
108710949  cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
398012  spdyc.S; speedy protein 1-A [KO:K08694]
398152  spdyc.L; speedy protein 1-B [KO:K08694]
108715031  speedy protein 1-B-like isoform X1 [KO:K08694]
108718769  speedy protein 1-B-like [KO:K08694]
108716633  speedy protein 1-A-like [KO:K08694]
108705682  speedy protein 1-B-like [KO:K08694]
108705931  speedy protein 1-A-like [KO:K08694]
108716505  spdya.L; speedy protein A isoform X1 [KO:K08694]
108710778  speedy protein 1-A-like [KO:K08694]
432036  cdk2.L; uncharacterized protein LOC432036 [KO:K02206] [EC:2.7.11.22]
399314  cdk2.S; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
380246  cdk1.S; cyclin-dependent kinase 1-A [KO:K02087] [EC:2.7.11.22 2.7.11.23]
379785  cdk1.L; cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
397933  ccna2.S; cyclin-A2 [KO:K06627]
447494  ccna1.L; cyclin A1 L homeolog [KO:K06627]
734775  ccna2.L; cyclin A2 L homeolog [KO:K06627]
397885  ccna1.S; cyclin-A1 [KO:K06627]
397924  mos.L; serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
446459  hsp90ab1.S; heat shock protein 90kDa alpha family class B member 1 S homeolog [KO:K04079]
108716102  heat shock protein HSP 90-beta isoform X1 [KO:K04079]
108698781  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
445821  rps6ka1.L; ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
443729  rps6ka6.S; ribosomal protein S6 kinase 2 alpha [KO:K04373] [EC:2.7.11.1]
399376  rps6ka3.L; ribosomal protein S6 kinase A3 L homeolog [KO:K04373] [EC:2.7.11.1]
108700150  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
108698451  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
108717877  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
108709331  rps6ka3.S; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
379626  pkmyt1.S; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
108701724  pkmyt1.L; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase-like isoform X1 [KO:K06633] [EC:2.7.11.1]
397742  ccnb1.2.S; G2/mitotic-specific cyclin-B1 [KO:K05868]
379888  ccnb1.2.L; cyclin B1 L homeolog [KO:K05868]
398163  ccnb1.S; cyclin B1 S homeolog [KO:K05868]
108718066  ccnb1.L; G2/mitotic-specific cyclin-B1-like [KO:K05868]
397743  ccnb2.S; G2/mitotic-specific cyclin-B2 [KO:K21770]
398888  ccnb2.L; uncharacterized protein LOC398888 [KO:K21770]
398162  cyclin B5 [KO:K21770]
379048  ccnb3.S; cyclin B3 S homeolog [KO:K21771]
779404  ccnb3.L; cyclin B3 L homeolog [KO:K21771]
373731  stk10.S; serine/threonine-protein kinase 10-A [KO:K08837] [EC:2.7.11.1]
431827  stk10.L; serine/threonine-protein kinase 10-A-like [KO:K08837] [EC:2.7.11.1]
380481  plk1.S; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
108701628  plk1.L; serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
398141  cdc25a.L; cell division cycle 25A L homeolog [KO:K06645] [EC:3.1.3.48]
734734  cdc25a.S; cell division cycle 25A S homeolog [KO:K06645] [EC:3.1.3.48]
100158454  cdc25b.L; cell division cycle 25B L homeolog [KO:K05866] [EC:3.1.3.48]
100158455  cdc25b.S; cell division cycle 25B S homeolog [KO:K05866] [EC:3.1.3.48]
398119  cdc25c.L; M-phase inducer phosphatase 1-B [KO:K05867] [EC:3.1.3.48]
100337563  cdc25c.S; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
378696  ins.S; insulin-1 precursor [KO:K04526]
378695  ins.L; insulin-2 precursor [KO:K04526]
108696734  XB5961731.L; insulin [KO:K04526]
108712492  insulin-like growth factor I-A [KO:K05459]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108698803  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
496104  pde3b.L; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
108715307  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
100505423  uncharacterized protein LOC100505423 [KO:K07827]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108697792  kras.S; GTPase HRas [KO:K07827]
398892  araf.L; A-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K08845] [EC:2.7.11.1]
399056  araf.S; A-Raf proto-oncogene, serine/threonine kinase S homeolog [KO:K08845] [EC:2.7.11.1]
447268  braf.L; B-Raf proto-oncogene, serine/threonine kinase L homeolog [KO:K04365] [EC:2.7.11.1]
398973  braf.S; B-Raf [KO:K04365] [EC:2.7.11.1]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
398234  bub1.L; BUB1 mitotic checkpoint serine/threonine kinase L homeolog [KO:K02178] [EC:2.7.11.1]
394307  mad1l1.L; mitotic arrest deficient 1 like 1 L homeolog [KO:K06679]
414724  mad2l1.L; uncharacterized protein LOC414724 [KO:K02537]
380433  mad2l1.S; mitotic arrest deficient 2 like 1 S homeolog [KO:K02537]
394380  mad2l2.S; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
380351  fzr1.L; fizzy/cell division cycle 20 related 1 L homeolog [KO:K03364]
108717771  anapc1.S; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100310821  anapc2.L; anaphase-promoting complex subunit 2 [KO:K03349]
443994  cdc27.S; cell division cycle protein 27 homolog [KO:K03350]
108700852  cdc27.L; cell division cycle protein 27 homolog [KO:K03350]
414530  anapc4.L; anaphase promoting complex subunit 4 L homeolog [KO:K03351]
779325  anapc5.L; anaphase promoting complex subunit 5 L homeolog [KO:K03352]
446982  cdc16.L; cell division cycle 16 L homeolog [KO:K03353]
446574  anapc7.L; anaphase promoting complex subunit 7 L homeolog [KO:K03354]
447726  anapc7.S; anaphase promoting complex subunit 7 S homeolog [KO:K03354]
379580  cdc23.L; cell division cycle 23 L homeolog [KO:K03355]
380068  cdc23.S; cell division cycle 23 S homeolog [KO:K03355]
595046  anapc10.L; uncharacterized protein LOC595046 [KO:K03357]
734319  anapc10.S; anaphase promoting complex subunit 10 S homeolog [KO:K03357]
496247  anapc11.L; anaphase promoting complex subunit 11 L homeolog [KO:K03358]
108698127  cdc26.L; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
100037155  anapc13.2.L; anaphase promoting complex subunit 13, gene 2 L homeolog [KO:K12456]
432025  anapc15.S; anaphase-promoting complex subunit 15A [KO:K25228]
734832  anapc15.L; anaphase-promoting complex subunit 15B [KO:K25228]
108697486  anapc16.S; anaphase-promoting complex subunit 16-like [KO:K25229]
443949  anapc16.L; anaphase-promoting complex subunit 16 [KO:K25229]
100337510  kif22.S; kinesin-like protein KIF22-A [KO:K10403]
100337511  kif22.L; kinesin-like protein KIF22-B [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
xla04010  MAPK signaling pathway
xla04110  Cell cycle
KO pathway
ko04914   
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