Entry
Name
Salmonella infection - Xenopus tropicalis (tropical clawed frog)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Xenopus tropicalis (tropical clawed frog) [GN:
xtr ]
Gene
594964 rab5d; muscle RAS oncogene homolog isoform 2 [KO:K07888 ]
394774 MGC75872; uncharacterized protein LOC394774 [KO:K07897 ]
100491541 plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
100101673 vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
448414 vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
100158548 vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
549689 vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
100489726 vps41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184 ]
407935 dync1i2; cytoplasmic dynein 1 intermediate chain 2 [KO:K10415 ]
779754 dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
100498465 dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
101734949 dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
448652 dynll1; dynein light chain 1, cytoplasmic [KO:K10418 ]
549149 dynlrb2; dynein light chain roadblock-type 2 [KO:K10419 ]
394587 arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955 ]
100380102 plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
549402 rhoa.2; ras homolog gene family, member A, gene 2 [KO:K04513 ]
549323 rhoc; rho-related GTP-binding protein RhoC [KO:K04513 ]
493477 m6pr; cation-dependent mannose-6-phosphate receptor precursor [KO:K10089 ]
100158612 gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
496921 s100a10; S100 calcium binding protein A10 [KO:K17274 ]
733715 ahnak; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934 ]
100125013 rhoj; rho-related GTP-binding protein RhoJ isoform X2 [KO:K07864 ]
100216282 rhogl; ras homolog gene family, member G (rho G) like [KO:K07863 ]
100380096 elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366 ]
493485 elmo2; engulfment and cell motility protein 2 [KO:K18985 ]
100135705 myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
100135145 myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
394763 mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
493389 cdc42; cell division control protein 42 homolog isoform 1 [KO:K04393 ]
448118 rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
101734874 cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749 ]
779716 wasf3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
448555 arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757 ]
394565 arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757 ]
448094 arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758 ]
448127 arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755 ]
549996 arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754 ]
734053 arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
493193 myo6; unconventional myosin-VI isoform X11 [KO:K10358 ]
780390 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100144924 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100158519 pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
100038240 pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
100496878 pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
448682 arl11l.1; ADP-ribosylation factor-like 11 like gene 1 [KO:K07937 ]
407864 wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612 ]
733541 tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
549591 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
549217 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
100037849 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
100495158 tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
100486083 nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100488164 nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
780222 hsp90aa1.2; heat shock protein 90kDa alpha (cytosolic), class A member 1, gene 2 [KO:K04079 ]
549036 hsp90aa1.1; heat shock protein 90kDa alpha family class A member 1 [KO:K04079 ]
549273 skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
100144930 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
100494283 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
448041 birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060 ]
100493578 tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
448240 tnfrsf10b; tumor necrosis factor receptor superfamily member 10A precursor [KO:K04722 ]
407883 rhob; rho-related GTP-binding protein RhoB [KO:K07856 ]
116406436 baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807 ]
733844 nlrc4; NLR family CARD domain-containing protein 4 [KO:K12805 ]
101732196 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
xtr04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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