KEGG   PATHWAY: xtr05168
Entry
xtr05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Xenopus tropicalis (tropical clawed frog)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
xtr05168  Herpes simplex virus 1 infection
xtr05168

Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
100135001  lta; lymphotoxin-alpha precursor [KO:K05468]
116409829  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
101733953  tnfrsf14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
100494415  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100491604  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
448125  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
549654  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100145270  ikbkg; NF-kappa-B essential modulator [KO:K07210]
448138  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
100486083  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
407869  rela; transcription factor p65 [KO:K04735]
448041  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
448156  nectin2; nectin-2 precursor [KO:K06081]
100488406  nectin1; nectin-1 isoform X2 [KO:K06081]
100145297  nectin1l1; uncharacterized protein LOC100145297 isoform X1 [KO:K06081]
100145553  nectin1l2.2; nectin-1 isoform X2 [KO:K06081]
100485504  nectin1l2.1; nectin-1 isoform X1 [KO:K06081]
100486498  nectin-1-like [KO:K06081]
549586  ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
548434  ptpn11b; protein tyrosine phosphatase, non-receptor type 11, b [KO:K07293] [EC:3.1.3.48]
100492002  itga5; integrin alpha-5 [KO:K06484]
100498495  itgb3; integrin beta-3 [KO:K06493]
496893  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100486846  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100145327  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
101734275  irf3; interferon regulatory factor 3 [KO:K05411]
431679  tp53; cellular tumor antigen p53 [KO:K04451]
100492966  A.superbus venom factor 1 [KO:K03990]
100170611  A.superbus venom factor 1 [KO:K03990]
100216255  c3; A.superbus venom factor 1 [KO:K03990]
100491968  complement C3 [KO:K03990]
100492134  complement C3 [KO:K03990]
100497762  complement C3 isoform X1 [KO:K03990]
100497914  complement C3 [KO:K03990]
108646250  complement C3 [KO:K03990]
100485433  c5; complement C5 precursor [KO:K03994]
496476  cfp; complement factor properdin precursor [KO:K15412]
100485771  tlr2; toll-like receptor 2 type-2 [KO:K10159]
100485927  toll-like receptor 2 type-2 [KO:K10159]
100485512  toll-like receptor 2 [KO:K10159]
100487973  toll-like receptor 2 [KO:K10159]
116409470  toll-like receptor 2 [KO:K10159]
549591  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100496395  irf7; interferon regulatory factor 7 [KO:K09447]
100486223  tlr3; toll-like receptor 3 [KO:K05401]
101733659  TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
733738  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
448357  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
493524  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100101764  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
549217  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100037849  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100487038  il1b; interleukin-1 beta [KO:K04519]
116409784  uncharacterized protein LOC116409784 isoform X1 [KO:K04519]
100496523  ccl5; C-C motif chemokine 5 isoform X3 [KO:K12499]
100493927  il6; interleukin-6 [KO:K05405]
100134991  tnf; tumor necrosis factor [KO:K03156]
101734580  interleukin-12 subunit alpha [KO:K05406]
100493914  interleukin-12 subunit beta [KO:K05425]
116409688  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
100495207  ddx58; probable ATP-dependent RNA helicase DDX58 isoform X2 [KO:K12646] [EC:5.6.2.6]
100488298  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X2 [KO:K12647] [EC:5.6.2.6]
100485829  mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100498216  traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100487744  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100216212  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105945198  interferon beta [KO:K05414]
116408033  interferon omega-1-like [KO:K05414]
116407924  interferon alpha-3-like [KO:K05414]
100488048  cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
100127621  sting1; stimulator of interferon genes protein [KO:K12654]
407879  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
496958  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100145598  ppp1ca; protein phosphatase 1, catalytic subunit, alpha isozyme [KO:K06269] [EC:3.1.3.16]
733794  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
779992  eif2ak2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
100141483  pkr3; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100190763  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100216307  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
448087  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100491668  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
550040  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
496931  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
549751  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
779817  eif2b4; translation initiation factor eIF-2B subunit delta [KO:K03680]
100487780  eif2b5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
100485535  hcfc1; host cell factor 1 isoform X1 [KO:K14966]
100127587  hcfc2; host cell factor 2 isoform X2 [KO:K27390]
549091  pou2f1; POU domain, class 2, transcription factor 1 [KO:K09364]
100497329  pou2f2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
100490595  pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
100498552  ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
779845  ifnar2.1; interferon (alpha, beta and omega) receptor 2, gene 1 precursor [KO:K05131]
100496877  ifnar2.2; interferon alpha/beta receptor 2 [KO:K05131]
448204  socs3; suppressor of cytokine signaling 3 [KO:K04696]
394588  socs3l; suppressor of cytokine signaling 3-Like [KO:K04696]
100038172  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100489432  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
780397  stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100170174  stat2; signal transducer and activator of transcription 2 [KO:K11221]
100487158  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
779988  znf180; zinc finger protein 180 [KO:K09228]
101731232  zinc finger protein Xfin-like [KO:K09228]
100495066  znf282; zinc finger protein 436 isoform X2 [KO:K09228]
496795  uncharacterized protein LOC496795 [KO:K09228]
100170545  znf329; zinc finger protein 329 [KO:K09228]
779838  zfp2; ZFP2 zinc finger protein [KO:K09228]
100489238  oocyte zinc finger protein XlCOF6-like isoform X2 [KO:K09228]
100038253  znf208; zinc finger protein 208 [KO:K09228]
549148  znf420; zinc finger protein 420 [KO:K09228]
100327247  znf184; zinc finger protein 184 [KO:K09228]
100328608  znf665; zinc finger protein 665 [KO:K09228]
100485218  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
779749  znf71; uncharacterized protein LOC779749 [KO:K09228]
595035  znf250; zinc finger protein 250 [KO:K09228]
733912  znf585b; zinc finger protein 585B [KO:K09228]
549508  uncharacterized protein LOC549508 [KO:K09228]
100488129  zinc finger protein 665-like [KO:K09228]
100487014  hkr1; zinc finger protein OZF-like isoform X2 [KO:K09228]
100494833  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
100496443  zinc finger protein 34 isoform X1 [KO:K09228]
116408025  zinc finger protein 45-like isoform X1 [KO:K09228]
116407549  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100488737  oocyte zinc finger protein XlCOF22-like [KO:K09228]
101730715  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101732789  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108648782  gastrula zinc finger protein XlCGF53.1-like [KO:K09228]
101731361  gastrula zinc finger protein XlCGF53.1-like [KO:K09228]
116407555  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100379873  znf432; oocyte zinc finger protein XlCOF7.1 isoform X1 [KO:K09228]
100487314  znf853; oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101731227  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100487959  oocyte zinc finger protein XlCOF7.1-like isoform X1 [KO:K09228]
101734247  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101731689  oocyte zinc finger protein XlCOF7.1 [KO:K09228]
116407556  oocyte zinc finger protein XlCOF22-like [KO:K09228]
100488817  oocyte zinc finger protein XlCOF7.1-like isoform X1 [KO:K09228]
116407557  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108644779  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100496886  znf234; oocyte zinc finger protein XlCOF22-like [KO:K09228]
101731710  oocyte zinc finger protein XlCOF22-like isoform X1 [KO:K09228]
100485340  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108644767  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116406478  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101732741  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
105945437  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100496815  gastrula zinc finger protein XlCGF53.1 [KO:K09228]
108648775  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116407563  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101733844  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100487471  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101731488  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116407565  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100485943  LOW QUALITY PROTEIN: oocyte zinc finger protein XlCOF7.1 [KO:K09228]
116407567  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
101732003  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116407571  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
116407576  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116407577  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108644772  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116407631  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101733761  zinc finger protein 182 [KO:K09228]
100485688  oocyte zinc finger protein XlCOF6.1 [KO:K09228]
100491483  znf850; gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
105947126  oocyte zinc finger protein XlCOF22-like [KO:K09228]
101732496  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
105945546  zinc finger protein 883 [KO:K09228]
101730425  oocyte zinc finger protein XlCOF6.1-like isoform X1 [KO:K09228]
108648851  oocyte zinc finger protein XlCOF6-like [KO:K09228]
101735065  gastrula zinc finger protein XlCGF53.1-like [KO:K09228]
108648854  oocyte zinc finger protein XlCOF22-like [KO:K09228]
101731242  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
101732793  gastrula zinc finger protein XlCGF28.1-like [KO:K09228]
101731631  oocyte zinc finger protein XlCOF7.1 [KO:K09228]
108648870  gastrula zinc finger protein XlCGF53.1-like [KO:K09228]
101730877  oocyte zinc finger protein XlCOF8.4 [KO:K09228]
105947706  zinc finger protein OZF [KO:K09228]
100493189  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
100485062  gastrula zinc finger protein XlCGF57.1-like isoform X2 [KO:K09228]
101735222  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108644467  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
100487768  RB-associated KRAB zinc finger protein isoform X2 [KO:K09228]
101730426  oocyte zinc finger protein XlCOF7.1 [KO:K09228]
105945432  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108644777  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108644828  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108644829  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
101734591  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108645225  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
116406443  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
101733711  oocyte zinc finger protein XlCOF6-like [KO:K09228]
105945178  zinc finger protein OZF-like [KO:K09228]
101732149  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
100487535  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
100498439  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
101732026  oocyte zinc finger protein XlCOF6-like [KO:K09228]
101732212  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
100487962  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
105945440  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
101732603  gastrula zinc finger protein XlCGF26.1-like isoform X2 [KO:K09228]
101735265  gastrula zinc finger protein XlCGF26.1-like isoform X3 [KO:K09228]
100485704  zinc finger protein 585A-like [KO:K09228]
100493685  zinc finger protein 665-like [KO:K09228]
100493847  gastrula zinc finger protein XlCGF58.1-like [KO:K09228]
100486155  zinc finger protein 585A-like [KO:K09228]
101732725  gastrula zinc finger protein XlCGF26.1-like isoform X3 [KO:K09228]
116411611  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
100498644  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
116411613  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
100487319  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
116406477  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
101734939  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
116411615  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
101734875  gastrula zinc finger protein XlCGF26.1 [KO:K09228]
116411617  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
101730917  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
116411618  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
101735177  gastrula zinc finger protein XlCGF26.1 [KO:K09228]
108647920  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
101732321  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108647923  gastrula zinc finger protein XlCGF26.1 [KO:K09228]
105947707  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108647860  oocyte zinc finger protein XlCOF6-like [KO:K09228]
116406489  gastrula zinc finger protein XlCGF58.1-like [KO:K09228]
116411646  oocyte zinc finger protein XlCOF28-like [KO:K09228]
100485051  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
108645295  oocyte zinc finger protein XlCOF8.4 [KO:K09228]
100488076  zinc finger protein 436-like [KO:K09228]
116411484  zinc finger protein 271-like [KO:K09228]
101732587  zinc finger protein 436-like [KO:K09228]
108644826  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
105945412  zinc finger protein 665 [KO:K09228]
100216446  ifng; interferon gamma [KO:K04687]
780275  ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
100485464  ifngr2.1; interferon gamma receptor 2 [KO:K05133]
100485298  ifngr2.2; interferon gamma receptor 2 isoform X1 [KO:K05133]
100036599  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100038126  daxx; death domain-associated protein 6 [KO:K02308]
108648266  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
100494735  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100489020  tap2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
116406716  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100488899  tapbp; tapasin [KO:K08058]
394954  pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
407962  calr; calreticulin precursor [KO:K08057]
100489027  calr3; calreticulin [KO:K08057]
100127725  hla-a; major histocompatibility complex, class I, A precursor [KO:K06751]
100496024  major histocompatibility complex class I-related gene protein-like [KO:K06751]
100495225  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
100127707  major histocompatibility complex class I antigen precursor [KO:K06751]
100422806  b2m; beta-2-microglobulin isoform X1 [KO:K08055]
100495183  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100495336  mhc2a; class II histocompatibility antigen, M alpha chain [KO:K06752]
100127727  hla-dqa1; major histocompatibility complex, class II, DQ alpha 1 precursor [KO:K06752]
100145508  uncharacterized protein LOC100145508 precursor [KO:K06752]
100486651  cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
780390  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100144924  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
549983  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100486835  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100497001  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100144709  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100490038  akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100380126  tsc1; hamartin isoform X1 [KO:K07206]
100170546  tsc2; tuberin [KO:K07207]
548676  rheb; GTP-binding protein Rheb [KO:K07208]
100491970  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
550105  srpk1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
448766  srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
394953  srsf2; serine/arginine-rich splicing factor 2 [KO:K12891]
448605  srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
448003  srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
448104  srsf5a; serine/arginine-rich splicing factor 5 alpha [KO:K12893]
407954  srsf6; arginine/serine-rich splicing factor 4 isoform 1 [KO:K12893]
100038227  srsf4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
493215  srsf7; serine/arginine-rich splicing factor 7 [KO:K12896]
448015  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
734058  nxf1; nuclear RNA export factor 1 [KO:K14284]
100490733  nuclear RNA export factor 1 [KO:K14284]
549781  alyref; THO complex subunit 4 [KO:K12881]
100124789  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100124750  fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100144930  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
100494283  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100379789  fadd; FAS-associated death domain protein [KO:K02373]
100495471  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100036674  bid; BH3 interacting domain death agonist [KO:K04726]
394793  bax; apoptosis regulator BAX [KO:K02159]
108645783  bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100487418  bad; bcl2-associated agonist of cell death [KO:K02158]
100485267  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
447991  bcl2l1; BCL2 like 1 [KO:K04570]
493538  cyct; cytochrome c, somatic [KO:K08738]
394490  cycs; cytochrome c, testis-specific [KO:K08738]
100127738  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
100144708  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100151728  casp3.2; caspase-3 [KO:K02187] [EC:3.4.22.56]
100486222  casp3.1; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
  Authors
Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
  Authors
Ma Y, He B
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Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
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Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
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The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
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Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
  Authors
Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
PMID:25798530
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
PMID:18508584
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
PMID:15078920
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Sandri-Goldin RM
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Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
xtr03040  Spliceosome
xtr03050  Proteasome
xtr04115  p53 signaling pathway
xtr04210  Apoptosis
xtr04620  Toll-like receptor signaling pathway
xtr04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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