KEGG   REACTION: R00267
Entry
R00267                      Reaction                               
Name
isocitrate:NADP+ oxidoreductase (decarboxylating)
Definition
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
Equation
C00311 + C00006 <=> C00026 + C00011 + C00005 + C00080
Comment
two-step reaction (see R01899+R00268)
Reaction class
RC00001  C00005_C00006
RC00114  C00026_C00311
RC02801  C00011_C00311
Enzyme
1.1.1.42
Pathway
rn00480  Glutathione metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42
     R00267  Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
Overall reaction [br08210.html]
 Carbon fixation
  R00267
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19632
LinkDB

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