U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Duodenal gastrinoma

MedGen UID:
1048764
•Concept ID:
CN372617
•
Finding
HPO: HP:0034953

Definition

A gastrinoma, a neuroendocrine tumors characterized by the secretion of gastrin with resultant excessive gastric acid production, that is localized to the duodenum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDuodenal gastrinoma

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Recent standardization of treatment strategy for pancreatic neuroendocrine tumors.
Imamura M
World J Gastroenterol 2010 Sep 28;16(36):4519-25. doi: 10.3748/wjg.v16.i36.4519. PMID: 20857521Free PMC Article
Management of the Zollinger-Ellison syndrome in patients with multiple endocrine neoplasia type 1.
Jensen RT
J Intern Med 1998 Jun;243(6):477-88. doi: 10.1046/j.1365-2796.1998.00281.x. PMID: 9681846

Recent clinical studies

Etiology

Recurrence after surgical resection of nonmetastatic sporadic gastrinoma: Which prognostic factors and surgical procedure?
Robin L, Sauvanet A, Walter T, Najah H, Falconi M, Pattou F, Gaujoux S; Gastrinoma Surgery Collaborative group
Surgery 2023 May;173(5):1144-1152. Epub 2023 Feb 11 doi: 10.1016/j.surg.2022.12.030. PMID: 36781315
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.
Chen WC, Warner RRP, Harpaz N, Zhu H, Roayaie S, Kim MK
Pancreas 2019 Jan;48(1):131-134. doi: 10.1097/MPA.0000000000001204. PMID: 30531243
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor.
Norton JA
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):699-704. doi: 10.1016/j.bpg.2005.05.001. PMID: 16253894
Management and outcome of patients with sporadic gastrinoma arising in the duodenum.
Zogakis TG, Gibril F, Libutti SK, Norton JA, White DE, Jensen RT, Alexander HR
Ann Surg 2003 Jul;238(1):42-8. doi: 10.1097/01.SLA.0000074963.87688.31. PMID: 12832964Free PMC Article

Diagnosis

Duodenal gastrinoma - case report.
Adamová Z, Chrostek M, Dvořák T, Rada E
Rozhl Chir 2023;102(12):464-469. doi: 10.33699/PIS.2023.102.12.464-469. PMID: 38378461
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.
Chen WC, Warner RRP, Harpaz N, Zhu H, Roayaie S, Kim MK
Pancreas 2019 Jan;48(1):131-134. doi: 10.1097/MPA.0000000000001204. PMID: 30531243
Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review.
Lendel I, Manni A, Ruggiero FM
Endocr Pract 2007 Nov-Dec;13(7):770-5. doi: 10.4158/EP.13.7.770. PMID: 18194935
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor.
Norton JA
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):699-704. doi: 10.1016/j.bpg.2005.05.001. PMID: 16253894

Therapy

An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection.
Shoji H, Kuroki M, Nakano E, Hiramoto K, Matsumura Y, Miura A, Kikuchi Y, Hirakawa H, Matsuda M
Nihon Shokakibyo Gakkai Zasshi 2011 Jan;108(1):80-7. PMID: 21212598
Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review.
Lendel I, Manni A, Ruggiero FM
Endocr Pract 2007 Nov-Dec;13(7):770-5. doi: 10.4158/EP.13.7.770. PMID: 18194935
Preoperative detection of duodenal gastrinomas and peripancreatic lymph nodes by somatostatin receptor scintigraphy. Groupe D'etude Du Syndrome De Zollinger-Ellison.
Cadiot G, Lebtahi R, Sarda L, Bonnaud G, Marmuse JP, Vissuzaine C, Ruszniewski P, Le Guludec D, Mignon M
Gastroenterology 1996 Oct;111(4):845-54. doi: 10.1016/s0016-5085(96)70052-5. PMID: 8831579
Control of the Zollinger-Ellison syndrome by excision of primary and metastatic tumor.
Landor JH
Am J Surg 1984 Mar;147(3):406-9. doi: 10.1016/0002-9610(84)90178-8. PMID: 6703215

Prognosis

Recurrence after surgical resection of nonmetastatic sporadic gastrinoma: Which prognostic factors and surgical procedure?
Robin L, Sauvanet A, Walter T, Najah H, Falconi M, Pattou F, Gaujoux S; Gastrinoma Surgery Collaborative group
Surgery 2023 May;173(5):1144-1152. Epub 2023 Feb 11 doi: 10.1016/j.surg.2022.12.030. PMID: 36781315
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas.
Fendrich V, Ramerth R, Waldmann J, Maschuw K, Langer P, Bartsch DK, Slater EP, Ramaswamy A, Rothmund M
Endocr Relat Cancer 2009 Jun;16(2):613-22. Epub 2009 Feb 24 doi: 10.1677/ERC-08-0204. PMID: 19240184
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor.
Norton JA
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):699-704. doi: 10.1016/j.bpg.2005.05.001. PMID: 16253894
Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study.
Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT
Ann Surg 2003 May;237(5):650-7; discussion 657-9. doi: 10.1097/01.SLA.0000064375.51939.48. PMID: 12724631Free PMC Article
Gastrointestinal endocrine tumours. Pathology.
Bishop AE, Polak JM
Baillieres Clin Gastroenterol 1996 Dec;10(4):555-69. doi: 10.1016/s0950-3528(96)90013-5. PMID: 9113312

Clinical prediction guides

Recurrence after surgical resection of nonmetastatic sporadic gastrinoma: Which prognostic factors and surgical procedure?
Robin L, Sauvanet A, Walter T, Najah H, Falconi M, Pattou F, Gaujoux S; Gastrinoma Surgery Collaborative group
Surgery 2023 May;173(5):1144-1152. Epub 2023 Feb 11 doi: 10.1016/j.surg.2022.12.030. PMID: 36781315
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.
Chen WC, Warner RRP, Harpaz N, Zhu H, Roayaie S, Kim MK
Pancreas 2019 Jan;48(1):131-134. doi: 10.1097/MPA.0000000000001204. PMID: 30531243
Recent standardization of treatment strategy for pancreatic neuroendocrine tumors.
Imamura M
World J Gastroenterol 2010 Sep 28;16(36):4519-25. doi: 10.3748/wjg.v16.i36.4519. PMID: 20857521Free PMC Article
Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas.
Anlauf M, Perren A, Meyer CL, Schmid S, Saremaslani P, Kruse ML, Weihe E, Komminoth P, Heitz PU, Klöppel G
Gastroenterology 2005 May;128(5):1187-98. doi: 10.1053/j.gastro.2005.01.058. PMID: 15887103
Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study.
Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT
Ann Surg 2003 May;237(5):650-7; discussion 657-9. doi: 10.1097/01.SLA.0000064375.51939.48. PMID: 12724631Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...