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Synovial fluid crystals

MedGen UID:
1053707
•Concept ID:
CN376761
•
Finding
HPO: HP:6000248

Definition

The presence of crystals (microscopic solids that form distinct lattices, with definable fixed angles, faces, walls) in the joint (synovial) fluid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSynovial fluid crystals

Professional guidelines

PubMed

Role of NLRP3 in the pathogenesis and treatment of gout arthritis.
Liu YR, Wang JQ, Li J
Front Immunol 2023;14:1137822. Epub 2023 Mar 27 doi: 10.3389/fimmu.2023.1137822. PMID: 37051231Free PMC Article
2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout.
Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castaneda J, Coyfish M, Guillo S, Jansen T, Janssens H, Lioté F, Mallen CD, Nuki G, Perez-Ruiz F, Pimentao J, Punzi L, Pywell A, So AK, Tausche AK, Uhlig T, Zavada J, Zhang W, Tubach F, Bardin T
Ann Rheum Dis 2020 Jan;79(1):31-38. Epub 2019 Jun 5 doi: 10.1136/annrheumdis-2019-215315. PMID: 31167758
Diagnosis, treatment, and prevention of gout.
Hainer BL, Matheson E, Wilkes RT
Am Fam Physician 2014 Dec 15;90(12):831-6. PMID: 25591183

Recent clinical studies

Etiology

The preservation of synovial fluid using dimethyl sulfoxide.
Pavic K, McGill V, D'Souza M, McGill N
Ann Clin Biochem 2022 Jul;59(4):296-301. Epub 2022 Mar 11 doi: 10.1177/00045632221076349. PMID: 35044280
Evaluation for septic arthritis of the native adult knee is aided by multivariable assessment.
Holzmeister A, Frazzetta J, Yuan FFN, Cherones A, Summers H, Cohen J, Lack WD
Am J Emerg Med 2021 Aug;46:614-618. Epub 2020 Nov 26 doi: 10.1016/j.ajem.2020.11.048. PMID: 33280970
Gram and acridine orange staining for diagnosis of septic arthritis in different patient populations.
Cunningham G, Seghrouchni K, Ruffieux E, Vaudaux P, Gayet-Ageron A, Cherkaoui A, Godinho E, Lew D, Hoffmeyer P, Uçkay I
Int Orthop 2014 Jun;38(6):1283-90. Epub 2014 Feb 5 doi: 10.1007/s00264-014-2284-3. PMID: 24496757Free PMC Article
Does the presence of crystal arthritis rule out septic arthritis?
Shah K, Spear J, Nathanson LA, McCauley J, Edlow JA
J Emerg Med 2007 Jan;32(1):23-6. doi: 10.1016/j.jemermed.2006.07.019. PMID: 17239729

Diagnosis

Evaluation for septic arthritis of the native adult knee is aided by multivariable assessment.
Holzmeister A, Frazzetta J, Yuan FFN, Cherones A, Summers H, Cohen J, Lack WD
Am J Emerg Med 2021 Aug;46:614-618. Epub 2020 Nov 26 doi: 10.1016/j.ajem.2020.11.048. PMID: 33280970
Wide-field imaging of birefringent synovial fluid crystals using lens-free polarized microscopy for gout diagnosis.
Zhang Y, Lee SY, Zhang Y, Furst D, Fitzgerald J, Ozcan A
Sci Rep 2016 Jun 30;6:28793. doi: 10.1038/srep28793. PMID: 27356625Free PMC Article
Gram and acridine orange staining for diagnosis of septic arthritis in different patient populations.
Cunningham G, Seghrouchni K, Ruffieux E, Vaudaux P, Gayet-Ageron A, Cherkaoui A, Godinho E, Lew D, Hoffmeyer P, Uçkay I
Int Orthop 2014 Jun;38(6):1283-90. Epub 2014 Feb 5 doi: 10.1007/s00264-014-2284-3. PMID: 24496757Free PMC Article
Does the presence of crystal arthritis rule out septic arthritis?
Shah K, Spear J, Nathanson LA, McCauley J, Edlow JA
J Emerg Med 2007 Jan;32(1):23-6. doi: 10.1016/j.jemermed.2006.07.019. PMID: 17239729
Identification of crystals in synovial fluids and joint tissues.
Rosenthal AK, Mandel N
Curr Rheumatol Rep 2001 Feb;3(1):11-6. doi: 10.1007/s11926-001-0045-y. PMID: 11177766

Therapy

Synovial fluid crystals in osteoarthritis.
Gibilisco PA, Schumacher HR Jr, Hollander JL, Soper KA
Arthritis Rheum 1985 May;28(5):511-5. doi: 10.1002/art.1780280507. PMID: 2988572

Prognosis

Evaluation for septic arthritis of the native adult knee is aided by multivariable assessment.
Holzmeister A, Frazzetta J, Yuan FFN, Cherones A, Summers H, Cohen J, Lack WD
Am J Emerg Med 2021 Aug;46:614-618. Epub 2020 Nov 26 doi: 10.1016/j.ajem.2020.11.048. PMID: 33280970
Gram and acridine orange staining for diagnosis of septic arthritis in different patient populations.
Cunningham G, Seghrouchni K, Ruffieux E, Vaudaux P, Gayet-Ageron A, Cherkaoui A, Godinho E, Lew D, Hoffmeyer P, Uçkay I
Int Orthop 2014 Jun;38(6):1283-90. Epub 2014 Feb 5 doi: 10.1007/s00264-014-2284-3. PMID: 24496757Free PMC Article
Identification of crystals in synovial fluids and joint tissues.
Rosenthal AK, Mandel N
Curr Rheumatol Rep 2001 Feb;3(1):11-6. doi: 10.1007/s11926-001-0045-y. PMID: 11177766

Clinical prediction guides

Evaluation for septic arthritis of the native adult knee is aided by multivariable assessment.
Holzmeister A, Frazzetta J, Yuan FFN, Cherones A, Summers H, Cohen J, Lack WD
Am J Emerg Med 2021 Aug;46:614-618. Epub 2020 Nov 26 doi: 10.1016/j.ajem.2020.11.048. PMID: 33280970
Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies.
Nalbant S, Martinez JA, Kitumnuaypong T, Clayburne G, Sieck M, Schumacher HR Jr
Osteoarthritis Cartilage 2003 Jan;11(1):50-4. doi: 10.1053/joca.2002.0861. PMID: 12505487
Synovial fluid crystals derived from erythrocyte degradation products.
Tate GA, Schumacher HR Jr, Reginato AJ, Algeo SB, Gratwick GM, Di Battista WT
J Rheumatol 1992 Jul;19(7):1111-4. PMID: 1512767
Acute pseudogout following parathyroidectomy.
White JC, Brandt FB, Geelhoed GW
Am Surg 1988 Aug;54(8):506-9. PMID: 3395029
Synovial fluid crystals in osteoarthritis.
Gibilisco PA, Schumacher HR Jr, Hollander JL, Soper KA
Arthritis Rheum 1985 May;28(5):511-5. doi: 10.1002/art.1780280507. PMID: 2988572

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