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Excessive guilt

MedGen UID:
1054747
•Concept ID:
CN376526
•
Finding
HPO: HP:6000011

Definition

Guilt that is excessive in that it is based on an incorrect judgment (that one is responsible for a negative outcome) or is out of proportion to the committed offense. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExcessive guilt

Professional guidelines

PubMed

Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features.
Mallinckrodt CH, Watkin JG, Liu C, Wohlreich MM, Raskin J
BMC Psychiatry 2005 Jan 4;5:1. doi: 10.1186/1471-244X-5-1. PMID: 15631624Free PMC Article

Recent clinical studies

Etiology

Guilt and Burnout in Medical Students.
Greenmyer JR, Montgomery M, Hosford C, Burd M, Miller V, Storandt MH, Lakpa KL, Tiongson C
Teach Learn Med 2022 Jan-Mar;34(1):69-77. Epub 2021 Mar 15 doi: 10.1080/10401334.2021.1891544. PMID: 33722144
Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial.
Bondar J, Caye A, Chekroud AM, Kieling C
Lancet Psychiatry 2020 Apr;7(4):337-343. doi: 10.1016/S2215-0366(20)30060-2. PMID: 32199509
Emergence of Depressive Symptoms from Kindergarten to Sixth Grade.
Gudmundsen GR, Rhew IC, McCauley E, Kim J, Vander Stoep A
J Clin Child Adolesc Psychol 2019 May-Jun;48(3):501-515. Epub 2018 Feb 7 doi: 10.1080/15374416.2017.1410823. PMID: 29411996
Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk.
Trivedi MH, Wisniewski SR, Morris DW, Fava M, Gollan JK, Warden D, Nierenberg AA, Gaynes BN, Husain MM, Luther JF, Zisook S, Rush AJ
J Clin Psychiatry 2011 Jun;72(6):757-64. doi: 10.4088/JCP.11m06837. PMID: 21733476
Characterization and factors associated with sleep quality in adolescents with bipolar I disorder.
Roybal DJ, Chang KD, Chen MC, Howe ME, Gotlib IH, Singh MK
Child Psychiatry Hum Dev 2011 Dec;42(6):724-40. doi: 10.1007/s10578-011-0239-0. PMID: 21701911Free PMC Article

Diagnosis

Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial.
Bondar J, Caye A, Chekroud AM, Kieling C
Lancet Psychiatry 2020 Apr;7(4):337-343. doi: 10.1016/S2215-0366(20)30060-2. PMID: 32199509
Emergence of Depressive Symptoms from Kindergarten to Sixth Grade.
Gudmundsen GR, Rhew IC, McCauley E, Kim J, Vander Stoep A
J Clin Child Adolesc Psychol 2019 May-Jun;48(3):501-515. Epub 2018 Feb 7 doi: 10.1080/15374416.2017.1410823. PMID: 29411996
Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk.
Trivedi MH, Wisniewski SR, Morris DW, Fava M, Gollan JK, Warden D, Nierenberg AA, Gaynes BN, Husain MM, Luther JF, Zisook S, Rush AJ
J Clin Psychiatry 2011 Jun;72(6):757-64. doi: 10.4088/JCP.11m06837. PMID: 21733476
The empirical status of melancholia: implications for psychology.
Leventhal AM, Rehm LP
Clin Psychol Rev 2005 Jan;25(1):25-44. doi: 10.1016/j.cpr.2004.09.001. PMID: 15596079
A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease.
Zubenko GS, Zubenko WN, McPherson S, Spoor E, Marin DB, Farlow MR, Smith GE, Geda YE, Cummings JL, Petersen RC, Sunderland T
Am J Psychiatry 2003 May;160(5):857-66. doi: 10.1176/appi.ajp.160.5.857. PMID: 12727688

Therapy

Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial.
Bondar J, Caye A, Chekroud AM, Kieling C
Lancet Psychiatry 2020 Apr;7(4):337-343. doi: 10.1016/S2215-0366(20)30060-2. PMID: 32199509
Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk.
Trivedi MH, Wisniewski SR, Morris DW, Fava M, Gollan JK, Warden D, Nierenberg AA, Gaynes BN, Husain MM, Luther JF, Zisook S, Rush AJ
J Clin Psychiatry 2011 Jun;72(6):757-64. doi: 10.4088/JCP.11m06837. PMID: 21733476
Characterization and factors associated with sleep quality in adolescents with bipolar I disorder.
Roybal DJ, Chang KD, Chen MC, Howe ME, Gotlib IH, Singh MK
Child Psychiatry Hum Dev 2011 Dec;42(6):724-40. doi: 10.1007/s10578-011-0239-0. PMID: 21701911Free PMC Article
Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features.
Mallinckrodt CH, Watkin JG, Liu C, Wohlreich MM, Raskin J
BMC Psychiatry 2005 Jan 4;5:1. doi: 10.1186/1471-244X-5-1. PMID: 15631624Free PMC Article
Patterns of improvement in depressive symptoms with fluoxetine treatment.
Worthington J, Fava M, Davidson K, Alpert J, Nierenberg AA, Rosenbaum JF
Psychopharmacol Bull 1995;31(2):223-6. PMID: 7491372

Prognosis

Symptom characteristics of depressive episodes prior to the onset of mania or hypomania.
Pfennig A, Ritter PS, Höfler M, Lieb R, Bauer M, Wittchen HU, Beesdo-Baum K
Acta Psychiatr Scand 2016 Mar;133(3):196-204. Epub 2015 Aug 7 doi: 10.1111/acps.12469. PMID: 26252885
Within-Person Changes in Individual Symptoms of Depression Predict Subsequent Depressive Episodes in Adolescents: a Prospective Study.
Kouros CD, Morris MC, Garber J
J Abnorm Child Psychol 2016 Apr;44(3):483-94. doi: 10.1007/s10802-015-0046-3. PMID: 26105209Free PMC Article
Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk.
Trivedi MH, Wisniewski SR, Morris DW, Fava M, Gollan JK, Warden D, Nierenberg AA, Gaynes BN, Husain MM, Luther JF, Zisook S, Rush AJ
J Clin Psychiatry 2011 Jun;72(6):757-64. doi: 10.4088/JCP.11m06837. PMID: 21733476
Patterns of improvement in depressive symptoms with fluoxetine treatment.
Worthington J, Fava M, Davidson K, Alpert J, Nierenberg AA, Rosenbaum JF
Psychopharmacol Bull 1995;31(2):223-6. PMID: 7491372
Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program.
Dryman A, Eaton WW
Acta Psychiatr Scand 1991 Jul;84(1):1-5. doi: 10.1111/j.1600-0447.1991.tb01410.x. PMID: 1927557

Clinical prediction guides

Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial.
Bondar J, Caye A, Chekroud AM, Kieling C
Lancet Psychiatry 2020 Apr;7(4):337-343. doi: 10.1016/S2215-0366(20)30060-2. PMID: 32199509
Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk.
Trivedi MH, Wisniewski SR, Morris DW, Fava M, Gollan JK, Warden D, Nierenberg AA, Gaynes BN, Husain MM, Luther JF, Zisook S, Rush AJ
J Clin Psychiatry 2011 Jun;72(6):757-64. doi: 10.4088/JCP.11m06837. PMID: 21733476
Characterization and factors associated with sleep quality in adolescents with bipolar I disorder.
Roybal DJ, Chang KD, Chen MC, Howe ME, Gotlib IH, Singh MK
Child Psychiatry Hum Dev 2011 Dec;42(6):724-40. doi: 10.1007/s10578-011-0239-0. PMID: 21701911Free PMC Article
Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features.
Mallinckrodt CH, Watkin JG, Liu C, Wohlreich MM, Raskin J
BMC Psychiatry 2005 Jan 4;5:1. doi: 10.1186/1471-244X-5-1. PMID: 15631624Free PMC Article
A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease.
Zubenko GS, Zubenko WN, McPherson S, Spoor E, Marin DB, Farlow MR, Smith GE, Geda YE, Cummings JL, Petersen RC, Sunderland T
Am J Psychiatry 2003 May;160(5):857-66. doi: 10.1176/appi.ajp.160.5.857. PMID: 12727688

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