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Terminal insomnia

MedGen UID:
107755
•Concept ID:
C0541798
•
Mental or Behavioral Dysfunction
Synonyms: Awakening, Early; Early Awakening
SNOMED CT: Terminal insomnia (67062000); Matutinal insomnia (67062000); Early morning waking (401236004); Early waking (67062000); Wakes and cannot sleep again (67062000); Wakes early (67062000)
 
HPO: HP:0031356

Definition

A type of insomnia characterized by waking up too early in the morning is known as early morning awakening. The termination of sleep must occur at least 30 minutes before the desired time. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTerminal insomnia

Professional guidelines

PubMed

Insomnia as an expression of obstructive sleep apnea syndrome--the effect of treatment with nocturnal ventilatory support.
Mendes MS, dos Santos JM
Rev Port Pneumol (2006) 2015 Jul-Aug;21(4):203-8. Epub 2015 Feb 11 doi: 10.1016/j.rppnen.2014.11.002. PMID: 25926264
Off-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybate.
Murali H, Kotagal S
Sleep 2006 Aug;29(8):1025-9. doi: 10.1093/sleep/29.8.1025. PMID: 16944670

Recent clinical studies

Etiology

Sleep disturbances and dementia risk: A multicenter study.
Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang HX, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M
Alzheimers Dement 2018 Oct;14(10):1235-1242. Epub 2018 Jul 17 doi: 10.1016/j.jalz.2018.05.012. PMID: 30030112
Insomnia as an expression of obstructive sleep apnea syndrome--the effect of treatment with nocturnal ventilatory support.
Mendes MS, dos Santos JM
Rev Port Pneumol (2006) 2015 Jul-Aug;21(4):203-8. Epub 2015 Feb 11 doi: 10.1016/j.rppnen.2014.11.002. PMID: 25926264
Insomnia subtypes and their relationship to excessive daytime sleepiness in Brazilian community-dwelling older adults.
Hara C, Stewart R, Lima-Costa MF, Rocha FL, Fuzikawa C, Uchoa E, Firmo JO, Castro-Costa É
Sleep 2011 Aug 1;34(8):1111-7. doi: 10.5665/SLEEP.1172. PMID: 21804673Free PMC Article
Association between insomnia symptoms and hemoglobin A1c level in Japanese men.
Kachi Y, Nakao M, Takeuchi T, Yano E
PLoS One 2011;6(7):e21420. Epub 2011 Jul 1 doi: 10.1371/journal.pone.0021420. PMID: 21747936Free PMC Article
Modelling late-life depression.
Parker G, Snowdon J, Parker K
Int J Geriatr Psychiatry 2003 Dec;18(12):1102-9. doi: 10.1002/gps.1020. PMID: 14677142

Diagnosis

Differences in anxiety levels among symptoms of insomnia. The HUNT study.
Bragantini D, Sivertsen B, Gehrman P, Lydersen S, Güzey IC
Sleep Health 2019 Aug;5(4):370-375. Epub 2019 Feb 8 doi: 10.1016/j.sleh.2019.01.002. PMID: 31400882
Distress Related to Individual Depressive Symptoms: A Cross-sectional Study in Thai Patients with Major Depression.
Rungpetchwong T, Likhitsathian S, Jaranai S, Srisurapanont M
East Asian Arch Psychiatry 2017 Sep;27(3):115-20. PMID: 28993544
The Role of Sleep Disturbance in Suicidal and Nonsuicidal Self-Injurious Behavior among Adolescents.
McGlinchey EL, Courtney-Seidler EA, German M, Miller AL
Suicide Life Threat Behav 2017 Feb;47(1):103-111. Epub 2016 Jun 7 doi: 10.1111/sltb.12268. PMID: 27273654
Age-related characteristics of depression: a preliminary STAR*D report.
Husain MM, Rush AJ, Sackeim HA, Wisniewski SR, McClintock SM, Craven N, Holiner J, Mitchell JR, Balasubramani GK, Hauger R
Am J Geriatr Psychiatry 2005 Oct;13(10):852-60. doi: 10.1176/appi.ajgp.13.10.852. PMID: 16223963
Nightmares and terminal insomnia in depressed patients with and without melancholic features.
Besiroglu L, Agargun MY, Inci R
Psychiatry Res 2005 Feb 28;133(2-3):285-7. doi: 10.1016/j.psychres.2004.12.001. PMID: 15741005

Therapy

Exploring adverse events of Vilazodone: evidence from the FAERS database.
Jiang Y, Qu Y, Du Z, Ou M, Shen Y, Zhou Q, Tian L, Zhu H
BMC Psychiatry 2024 May 16;24(1):371. doi: 10.1186/s12888-024-05813-0. PMID: 38755677Free PMC Article
Insomnia and inflammation in phase 1 of the clinical antipsychotic trials of intervention effectiveness study.
Miller BJ, McCall WV, McEvoy JP, Lu XY
Psychiatry Res 2021 Nov;305:114195. Epub 2021 Aug 29 doi: 10.1016/j.psychres.2021.114195. PMID: 34481199
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Long-Term Safety and Efficacy of Lisdexamfetamine Dimesylate in Children and Adolescents with ADHD: A Phase IV, 2-Year, Open-Label Study in Europe.
Coghill DR, Banaschewski T, Nagy P, Otero IH, Soutullo C, Yan B, Caballero B, Zuddas A
CNS Drugs 2017 Jul;31(7):625-638. doi: 10.1007/s40263-017-0443-y. PMID: 28667569Free PMC Article
Off-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybate.
Murali H, Kotagal S
Sleep 2006 Aug;29(8):1025-9. doi: 10.1093/sleep/29.8.1025. PMID: 16944670

Prognosis

Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Sleep disturbances and dementia risk: A multicenter study.
Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang HX, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M
Alzheimers Dement 2018 Oct;14(10):1235-1242. Epub 2018 Jul 17 doi: 10.1016/j.jalz.2018.05.012. PMID: 30030112
Long-Term Safety and Efficacy of Lisdexamfetamine Dimesylate in Children and Adolescents with ADHD: A Phase IV, 2-Year, Open-Label Study in Europe.
Coghill DR, Banaschewski T, Nagy P, Otero IH, Soutullo C, Yan B, Caballero B, Zuddas A
CNS Drugs 2017 Jul;31(7):625-638. doi: 10.1007/s40263-017-0443-y. PMID: 28667569Free PMC Article
The Role of Sleep Disturbance in Suicidal and Nonsuicidal Self-Injurious Behavior among Adolescents.
McGlinchey EL, Courtney-Seidler EA, German M, Miller AL
Suicide Life Threat Behav 2017 Feb;47(1):103-111. Epub 2016 Jun 7 doi: 10.1111/sltb.12268. PMID: 27273654
Age-related characteristics of depression: a preliminary STAR*D report.
Husain MM, Rush AJ, Sackeim HA, Wisniewski SR, McClintock SM, Craven N, Holiner J, Mitchell JR, Balasubramani GK, Hauger R
Am J Geriatr Psychiatry 2005 Oct;13(10):852-60. doi: 10.1176/appi.ajgp.13.10.852. PMID: 16223963

Clinical prediction guides

Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Differences in anxiety levels among symptoms of insomnia. The HUNT study.
Bragantini D, Sivertsen B, Gehrman P, Lydersen S, Güzey IC
Sleep Health 2019 Aug;5(4):370-375. Epub 2019 Feb 8 doi: 10.1016/j.sleh.2019.01.002. PMID: 31400882
Distress Related to Individual Depressive Symptoms: A Cross-sectional Study in Thai Patients with Major Depression.
Rungpetchwong T, Likhitsathian S, Jaranai S, Srisurapanont M
East Asian Arch Psychiatry 2017 Sep;27(3):115-20. PMID: 28993544
Insomnia as an expression of obstructive sleep apnea syndrome--the effect of treatment with nocturnal ventilatory support.
Mendes MS, dos Santos JM
Rev Port Pneumol (2006) 2015 Jul-Aug;21(4):203-8. Epub 2015 Feb 11 doi: 10.1016/j.rppnen.2014.11.002. PMID: 25926264
Modelling late-life depression.
Parker G, Snowdon J, Parker K
Int J Geriatr Psychiatry 2003 Dec;18(12):1102-9. doi: 10.1002/gps.1020. PMID: 14677142

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