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Infection by Trypanosoma rhodesiense

MedGen UID:
11934
•Concept ID:
C0041233
•
Disease or Syndrome
Synonyms: Acute sleeping sickness; acute sleeping sickness; infection by Trypanosoma rhodesiense; infection by trypanosoma rhodesiense; Infection caused by Trypanosoma rhodesiense; infection caused by trypanosoma rhodesiense; Rhodesian sleeping sickness; rhodesian sleeping sickness; Rhodesian trypanosomiasis; Rhodesian Trypanosomiasis; rhodesian trypanosomiasis
SNOMED CT: Infection caused by Trypanosoma rhodesiense (42872003); Infection by Trypanosoma rhodesiense (42872003); Rhodesian trypanosomiasis (42872003); Rhodesian sleeping sickness (42872003); Acute sleeping sickness (42872003)
 
Monarch Initiative: MONDO:0021941

Definition

An infection with Trypanosoma brucei rhodesiense. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfection by Trypanosoma rhodesiense

Professional guidelines

PubMed

A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis.
Babokhov P, Sanyaolu AO, Oyibo WA, Fagbenro-Beyioku AF, Iriemenam NC
Pathog Glob Health 2013 Jul;107(5):242-52. doi: 10.1179/2047773213Y.0000000105. PMID: 23916333Free PMC Article
Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness).
Kennedy PG
Lancet Neurol 2013 Feb;12(2):186-94. Epub 2012 Dec 21 doi: 10.1016/S1474-4422(12)70296-X. PMID: 23260189
Treatment of human African trypanosomiasis--present situation and needs for research and development.
Legros D, Ollivier G, Gastellu-Etchegorry M, Paquet C, Burri C, Jannin J, Büscher P
Lancet Infect Dis 2002 Jul;2(7):437-40. doi: 10.1016/s1473-3099(02)00321-3. PMID: 12127356

Recent clinical studies

Etiology

Antitrypanosomal Chloronitrobenzamides.
Carrillo AK, Kadayat TM, Hwang JY, Chen Y, Zhu F, Holbrook G, Gillingwater K, Connelly MC, Yang L, Kaiser M, Guy RK
J Med Chem 2024 Mar 14;67(5):3437-3447. Epub 2024 Feb 16 doi: 10.1021/acs.jmedchem.3c01680. PMID: 38363074
Trypanosoma brucei gambiense Group 2: The Unusual Suspect.
Jamonneau V, Truc P, Grébaut P, Herder S, Ravel S, Solano P, De Meeus T
Trends Parasitol 2019 Dec;35(12):983-995. Epub 2019 Oct 24 doi: 10.1016/j.pt.2019.09.002. PMID: 31668893
Update on human African trypanosomiasis (sleeping sickness).
Kennedy PGE
J Neurol 2019 Sep;266(9):2334-2337. Epub 2019 Jun 17 doi: 10.1007/s00415-019-09425-7. PMID: 31209574
Tsetse fly evolution, genetics and the trypanosomiases - A review.
Krafsur ES, Maudlin I
Infect Genet Evol 2018 Oct;64:185-206. Epub 2018 Jun 6 doi: 10.1016/j.meegid.2018.05.033. PMID: 29885477
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR
Science 2010 Aug 13;329(5993):841-5. Epub 2010 Jul 15 doi: 10.1126/science.1193032. PMID: 20647424Free PMC Article

Diagnosis

Update on human African trypanosomiasis (sleeping sickness).
Kennedy PGE
J Neurol 2019 Sep;266(9):2334-2337. Epub 2019 Jun 17 doi: 10.1007/s00415-019-09425-7. PMID: 31209574
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.
Kennedy PGE, Rodgers J
Front Immunol 2019;10:39. Epub 2019 Jan 25 doi: 10.3389/fimmu.2019.00039. PMID: 30740102Free PMC Article
Human African Trypanosomiasis: Progress and Stagnation.
Bottieau E, Clerinx J
Infect Dis Clin North Am 2019 Mar;33(1):61-77. doi: 10.1016/j.idc.2018.10.003. PMID: 30712768
Human African trypanosomiasis.
Lejon V, Bentivoglio M, Franco JR
Handb Clin Neurol 2013;114:169-81. doi: 10.1016/B978-0-444-53490-3.00011-X. PMID: 23829907
Sleeping sickness.
Malvy D, Chappuis F
Clin Microbiol Infect 2011 Jul;17(7):986-95. doi: 10.1111/j.1469-0691.2011.03536.x. PMID: 21722252

Therapy

Antitrypanosomal Chloronitrobenzamides.
Carrillo AK, Kadayat TM, Hwang JY, Chen Y, Zhu F, Holbrook G, Gillingwater K, Connelly MC, Yang L, Kaiser M, Guy RK
J Med Chem 2024 Mar 14;67(5):3437-3447. Epub 2024 Feb 16 doi: 10.1021/acs.jmedchem.3c01680. PMID: 38363074
100 years since the publication of the suramin formula.
Steverding D, Troeberg L
Parasitol Res 2023 Dec 7;123(1):11. doi: 10.1007/s00436-023-08027-7. PMID: 38057659Free PMC Article
100 Years of Suramin.
Wiedemar N, Hauser DA, Mäser P
Antimicrob Agents Chemother 2020 Feb 21;64(3) doi: 10.1128/AAC.01168-19. PMID: 31844000Free PMC Article
Human African Trypanosomiasis: Progress and Stagnation.
Bottieau E, Clerinx J
Infect Dis Clin North Am 2019 Mar;33(1):61-77. doi: 10.1016/j.idc.2018.10.003. PMID: 30712768
African trypanosomiasis.
Maudlin I
Ann Trop Med Parasitol 2006 Dec;100(8):679-701. doi: 10.1179/136485906X112211. PMID: 17227648

Prognosis

Human African trypanosomiasis cases diagnosed in non-endemic countries (2011-2020).
Franco JR, Cecchi G, Priotto G, Paone M, Kadima Ebeja A, Simarro PP, Diarra A, Sankara D, Zhao W, Dagne DA
PLoS Negl Trop Dis 2022 Nov;16(11):e0010885. Epub 2022 Nov 7 doi: 10.1371/journal.pntd.0010885. PMID: 36342910Free PMC Article
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.
Kennedy PGE, Rodgers J
Front Immunol 2019;10:39. Epub 2019 Jan 25 doi: 10.3389/fimmu.2019.00039. PMID: 30740102Free PMC Article
Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.
Schmidt RS, Macêdo JP, Steinmann ME, Salgado AG, Bütikofer P, Sigel E, Rentsch D, Mäser P
FEBS J 2018 Mar;285(6):1012-1023. Epub 2017 Nov 13 doi: 10.1111/febs.14302. PMID: 29063677
A search for Trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning.
Manful T, Mulindwa J, Frank FM, Clayton CE, Matovu E
PLoS One 2010 Mar 10;5(3):e9630. doi: 10.1371/journal.pone.0009630. PMID: 20224787Free PMC Article
The epidemiology and control of human African trypanosomiasis.
Pépin J, Méda HA
Adv Parasitol 2001;49:71-132. doi: 10.1016/s0065-308x(01)49038-5. PMID: 11461032

Clinical prediction guides

Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda.
Mutuku CN, Bateta R, Rono MK, Njunge JM, Awuoche EO, Ndung'u K, Mang'era CM, Akoth MO, Adung'a VO, Ondigo BN, Mireji PO
Int J Parasitol Drugs Drug Resist 2021 Apr;15:57-67. Epub 2021 Feb 9 doi: 10.1016/j.ijpddr.2021.02.001. PMID: 33588295Free PMC Article
Dynamical and optimal control analysis of a seasonal Trypanosoma brucei rhodesiense model.
Helikumi M, Kgosimore M, Kuznetsov D, Mushayabasa S
Math Biosci Eng 2020 Feb 27;17(3):2530-2556. doi: 10.3934/mbe.2020139. PMID: 32233553
Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.
Schmidt RS, Macêdo JP, Steinmann ME, Salgado AG, Bütikofer P, Sigel E, Rentsch D, Mäser P
FEBS J 2018 Mar;285(6):1012-1023. Epub 2017 Nov 13 doi: 10.1111/febs.14302. PMID: 29063677
Relationship between Trypanosoma brucei rhodesiense genetic diversity and clinical spectrum among sleeping sickness patients in Uganda.
Kato CD, Mugasa CM, Nanteza A, Matovu E, Alibu VP
BMC Res Notes 2017 Oct 27;10(1):518. doi: 10.1186/s13104-017-2860-x. PMID: 29078807Free PMC Article
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Wilkinson SR, Szular J, Kaiser M
Eur J Med Chem 2016 Jul 19;117:179-86. Epub 2016 Apr 8 doi: 10.1016/j.ejmech.2016.04.010. PMID: 27092415Free PMC Article

Recent systematic reviews

A systematic review and meta-analysis of small ruminant and porcine trypanosomiasis prevalence in sub-Saharan Africa (1986 to 2018).
Ebhodaghe F, Ohiolei JA, Isaac C
Acta Trop 2018 Dec;188:118-131. Epub 2018 Sep 1 doi: 10.1016/j.actatropica.2018.08.034. PMID: 30179607

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