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Pulmonary tuberculosis

MedGen UID:
11947
•Concept ID:
C0041327
•
Disease or Syndrome
Synonyms: Consumption, Pulmonary; Consumptions, Pulmonary; Phthises, Pulmonary; Phthisis, Pulmonary; Pulmonary Consumption; Pulmonary Consumptions; Pulmonary Phthises; Pulmonary Phthisis; Pulmonary Tuberculoses; Pulmonary Tuberculosis; Tuberculoses, Pulmonary; Tuberculosis, Pulmonary
SNOMED CT: PTB - Pulmonary tuberculosis (154283005); TB - Pulmonary tuberculosis (154283005); Pulmonary tuberculosis (154283005); Tuberculosis of respiratory system (700272008); Respiratory tuberculosis (700272008)
 
HPO: HP:0032262
Monarch Initiative: MONDO:0006052

Definition

A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary tuberculosis

Conditions with this feature

X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency
MedGen UID:
370369
•Concept ID:
C1970859
•
Disease or Syndrome
IMD34 results in predisposition to infections by poorly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccines and nontuberculous environmental bacteria. Affected individuals are also susceptible to the more virulent species Mycobacterium tuberculosis (Bustamante et al., 2007).
See: Condition Record
X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency

Professional guidelines

PubMed

Review of advances in diagnosis and treatment of pulmonary tuberculosis.
Tendolkar MS, Tyagi R, Handa A
Indian J Tuberc 2021 Oct;68(4):510-515. Epub 2021 Jul 7 doi: 10.1016/j.ijtb.2021.07.002. PMID: 34752322
Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management.
Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa EJ Jr, Shroff GS, Ocazionez D, Schlesinger AE, Katz SI, Hammer MM
Radiographics 2017 Jan-Feb;37(1):52-72. doi: 10.1148/rg.2017160032. PMID: 28076011
Pulmonary tuberculosis: Improving diagnosis and management.
Singer-Leshinsky S
JAAPA 2016 Feb;29(2):20-5. doi: 10.1097/01.JAA.0000476207.96819.a7. PMID: 26757063

Recent clinical studies

Etiology

Pulmonary tuberculosis and diabetes mellitus: Clinical profile and outcomes.
George JT, Miraclin AT, Sathyendra S, Michael JS, Prasad J, Rebekah G
Int J Mycobacteriol 2022 Oct-Dec;11(4):400-406. doi: 10.4103/ijmy.ijmy_154_22. PMID: 36510925
Obstetrics outcome in pulmonary tuberculosis.
Yadav V, Sharma JB, Kriplani A, Bhatla N, Kachhawa G, Mahey R, Kumari R
Indian J Tuberc 2022 Jul;69(3):305-310. Epub 2021 Jan 7 doi: 10.1016/j.ijtb.2020.12.006. PMID: 35760479
Is pulmonary tuberculosis a true risk-factor for chronic obstructive pulmonary disease?
Jindal SK
Indian J Tuberc 2022 Apr;69(2):131-133. Epub 2021 Oct 4 doi: 10.1016/j.ijtb.2021.09.013. PMID: 35379391
Transbronchial tuberculosis cavity plugging therapy for pulmonary tuberculosis.
Han J, Yuan L, Li J, Liang C, Zhang D, Mei Z
J Int Med Res 2021 Aug;49(8):3000605211035889. doi: 10.1177/03000605211035889. PMID: 34463564Free PMC Article
Gastrointestinal tuberculosis.
Sheer TA, Coyle WJ
Curr Gastroenterol Rep 2003 Aug;5(4):273-8. doi: 10.1007/s11894-003-0063-1. PMID: 12864956

Diagnosis

Role of chest radiography in the diagnosis of pulmonary tuberculosis during nCovid19 pandemic.
Vishnu Sharma M, Arora VK, Anupama N
Indian J Tuberc 2022 Oct;69(4):385-388. Epub 2022 Mar 11 doi: 10.1016/j.ijtb.2022.03.008. PMID: 36460367
Clinical features and risk factors of pulmonary tuberculosis complicated with pulmonary aspergillosis.
Teng GL, Huang Q, Xu L, Chi JY, Wang C, Hu H
Eur Rev Med Pharmacol Sci 2022 Apr;26(8):2692-2701. doi: 10.26355/eurrev_202204_28599. PMID: 35503614
Review of advances in diagnosis and treatment of pulmonary tuberculosis.
Tendolkar MS, Tyagi R, Handa A
Indian J Tuberc 2021 Oct;68(4):510-515. Epub 2021 Jul 7 doi: 10.1016/j.ijtb.2021.07.002. PMID: 34752322
Overt and Subclinical Adrenal Insufficiency in Pulmonary Tuberculosis.
Neogi S, Mukhopadhyay P, Sarkar N, Datta PK, Basu M, Ghosh S
Endocr Pract 2021 Jun;27(6):601-606. Epub 2020 Dec 14 doi: 10.1016/j.eprac.2020.11.012. PMID: 33645514
Radiographic appearance of pulmonary tuberculosis: dogma disproved.
Rozenshtein A, Hao F, Starc MT, Pearson GD
AJR Am J Roentgenol 2015 May;204(5):974-8. doi: 10.2214/AJR.14.13483. PMID: 25905930

Therapy

TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis.
Berry C, du Cros P, Fielding K, Gajewski S, Kazounis E, McHugh TD, Merle C, Motta I, Moore DAJ, Nyang'wa BT
Trials 2022 Jun 13;23(1):484. doi: 10.1186/s13063-022-06331-8. PMID: 35698158Free PMC Article
ADVANCES IN PHARMACOTHERAPY OF TUBERCULOSIS.
Pstragowski M, Zbrzezna M, Bujalska-Zadrozny M
Acta Pol Pharm 2017 Jan;74(1):3-11. PMID: 29474756
Adjunctive steroid therapy for managing pulmonary tuberculosis.
Critchley JA, Orton LC, Pearson F
Cochrane Database Syst Rev 2014 Nov 12;2014(11):CD011370. doi: 10.1002/14651858.CD011370. PMID: 25387839Free PMC Article
Endobronchial tuberculosis.
Rikimaru T
Expert Rev Anti Infect Ther 2004 Apr;2(2):245-51. doi: 10.1586/14787210.2.2.245. PMID: 15482190
Rifapentine.
Jarvis B, Lamb HM
Drugs 1998 Oct;56(4):607-16; discussion 617. doi: 10.2165/00003495-199856040-00008. PMID: 9806107

Prognosis

Nutritional supplementation to prevent tuberculosis incidence in household contacts of patients with pulmonary tuberculosis in India (RATIONS): a field-based, open-label, cluster-randomised, controlled trial.
Bhargava A, Bhargava M, Meher A, Benedetti A, Velayutham B, Sai Teja G, Watson B, Barik G, Pathak RR, Prasad R, Dayal R, Madhukeshwar AK, Chadha V, Pai M, Joshi R, Menzies D, Swaminathan S
Lancet 2023 Aug 19;402(10402):627-640. Epub 2023 Aug 8 doi: 10.1016/S0140-6736(23)01231-X. PMID: 37567200
Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020.
Dong Z, Wang QQ, Yu SC, Huang F, Liu JJ, Yao HY, Zhao YL
Infect Dis Poverty 2022 Jul 28;11(1):85. doi: 10.1186/s40249-022-01009-4. PMID: 35902982Free PMC Article
Tuberculous meningitis.
Garg RK
Acta Neurol Scand 2010 Aug;122(2):75-90. Epub 2010 Jan 6 doi: 10.1111/j.1600-0404.2009.01316.x. PMID: 20055767
Pulmonary tuberculosis.
Hirsch CS, Johnson JL, Ellner JJ
Curr Opin Pulm Med 1999 May;5(3):143-50. doi: 10.1097/00063198-199905000-00004. PMID: 10228738
Tuberculous empyema.
Bai KJ, Wu IH, Yu MC, Chiang IH, Chiang CY, Lin TP, Lee YC, Luh KT
Respirology 1998 Dec;3(4):261-6. doi: 10.1111/j.1440-1843.1998.tb00132.x. PMID: 10201053

Clinical prediction guides

Evaluation of pulmonary tuberculosis diagnostic tests in children and adolescents at a pediatric reference center.
Rossoni AMO, Lovero KL, Tahan TT, Netto AR, Rossoni MD, Almeida IN, Lizzi EAS, Kritski A, Rodrigues CO
Pulmonology 2022 Mar-Apr;28(2):83-89. Epub 2020 Jan 31 doi: 10.1016/j.pulmoe.2020.01.001. PMID: 32014421Free PMC Article
Tuberculosis in children: screening, diagnosis and management.
Howard-Jones AR, Marais BJ
Curr Opin Pediatr 2020 Jun;32(3):395-404. doi: 10.1097/MOP.0000000000000897. PMID: 32374579
Value of procalcitonin in differentiating pulmonary tuberculosis from other pulmonary infections: a meta-analysis.
Huang SL, Lee HC, Yu CW, Chen HC, Wang CC, Wu JY, Lee CC
Int J Tuberc Lung Dis 2014 Apr;18(4):470-7. doi: 10.5588/ijtld.13.0449. PMID: 24670705
Chronic inactive pulmonary tuberculosis and treatment sequelae: chest radiographic features.
Hicks A, Muthukumarasamy S, Maxwell D, Howlett D
Int J Tuberc Lung Dis 2014 Feb;18(2):128-33. doi: 10.5588/ijtld.13.0360. PMID: 24429302
Advances in the diagnosis of pulmonary tuberculosis in HIV-infected and HIV-uninfected children.
Connell TG, Zar HJ, Nicol MP
J Infect Dis 2011 Nov 15;204 Suppl 4(Suppl 4):S1151-8. doi: 10.1093/infdis/jir413. PMID: 21996697Free PMC Article

Recent systematic reviews

The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis.
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795
Post-tuberculosis sequelae in children and adolescents: a systematic review.
Igbokwe V, Ruby LC, Sultanli A, Bélard S
Lancet Infect Dis 2023 Apr;23(4):e138-e150. doi: 10.1016/S1473-3099(23)00004-X. PMID: 36963920
Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin.
Pillay S, Steingart KR, Davies GR, Chaplin M, De Vos M, Schumacher SG, Warren R, Theron G
Cochrane Database Syst Rev 2022 May 18;5(5):CD014841. doi: 10.1002/14651858.CD014841.pub2. PMID: 35583175Free PMC Article
A systemic review on tuberculosis.
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856
Natural history of tuberculosis: duration and fatality of untreated pulmonary tuberculosis in HIV negative patients: a systematic review.
Tiemersma EW, van der Werf MJ, Borgdorff MW, Williams BG, Nagelkerke NJ
PLoS One 2011 Apr 4;6(4):e17601. doi: 10.1371/journal.pone.0017601. PMID: 21483732Free PMC Article

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