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Iris cyst

MedGen UID:
124385
•Concept ID:
C0271119
•
Disease or Syndrome; Finding
Synonyms: Cyst of iris; Cyst of Iris; Cyst of the Iris; Iris Cyst
SNOMED CT: Iris cyst (37761009); Cyst of iris (37761009)
 
HPO: HP:0011523

Definition

An iris cyst is composed of a single cell layer of epithelium and is filled with fluid. [from HPO]

Conditions with this feature

Iris pigment epithelium anomalies
MedGen UID:
357091
•Concept ID:
C1866608
•
Disease or Syndrome
See: Condition Record
Oculoauricular syndrome
MedGen UID:
393758
•Concept ID:
C2677500
•
Disease or Syndrome
Oculoauricular syndrome (OCACS) is characterized by complex ocular anomalies, including congenital cataract, anterior segment dysgenesis, iris coloboma, and early-onset retinal dystrophy, and dysplastic ears with abnormal external ear cartilage (summary by Gillespie et al., 2015).
See: Condition Record
Intellectual developmental disorder with ocular anomalies and distinctive facial features
MedGen UID:
1824011
•Concept ID:
C5774238
•
Disease or Syndrome
Intellectual developmental disorder with ocular anomalies and distinctive facial features (IDDOF) is characterized by global developmental delay, mildly impaired intellectual development, ophthalmologic anomalies, microcephaly or relative microcephaly, hearing loss, and characteristic facial features (Huang et al., 2022).
See: Condition Record
Intellectual developmental disorder with ocular anomalies and distinctive facial features
Iris pigment epithelium anomalies
Oculoauricular syndrome

Professional guidelines

PubMed

Epithelial iris cyst treatment with intracystic ethanol irrigation.
Behrouzi Z, Khodadoust A
Ophthalmology 2003 Aug;110(8):1601-5. doi: 10.1016/s0161-6420(03)00543-8. PMID: 12917180
Iris cysts in children: classification, incidence, and management. The 1998 Torrence A Makley Jr Lecture.
Shields JA, Shields CL, Lois N, Mercado G
Br J Ophthalmol 1999 Mar;83(3):334-8. doi: 10.1136/bjo.83.3.334. PMID: 10365043Free PMC Article
The differential diagnosis of malignant melanoma of the iris. A clinical study of 200 patients.
Shields JA, Sanborn GE, Augsburger JJ
Ophthalmology 1983 Jun;90(6):716-20. doi: 10.1016/s0161-6420(83)34500-0. PMID: 6888862

Recent clinical studies

Etiology

SPONTANEOUS REGRESSION OF A PRIMARY IRIS STROMAL CYST IN A PATIENT WITH KERATOCONUS. A CASE REPORT.
Galvis V, Shields, Tello A, Niño, Laiton, García, Chaparro, Viteri
Cesk Slov Oftalmol 2021 Fall;77(5):253-256. doi: 10.31348/2021/28. PMID: 34666495
Phacoemulsification in a patient with small pupil and a large iris cyst.
Rotsos T, Diagourtas A, Symeonidis C, Papaconstantinou D, Georgopoulos G
Eur J Ophthalmol 2012 Mar-Apr;22(2):278-9. doi: 10.5301/ejo.5000026. PMID: 21786265
Clinical and histopathological features of posttraumatic iris cyst.
Rishi P, Rishi E, Biswas J, Nandi K
Indian J Ophthalmol 2008 Nov-Dec;56(6):518-21. doi: 10.4103/0301-4738.43383. PMID: 18974530Free PMC Article
Management of congenital nonpigmented iris cyst.
Shen CC, Netland PA, Wilson MW, Morris WR
Ophthalmology 2006 Sep;113(9):1639.e1-7. Epub 2006 Jul 7 doi: 10.1016/j.ophtha.2006.04.014. PMID: 16828513
Epithelial iris cyst treatment with intracystic ethanol irrigation.
Behrouzi Z, Khodadoust A
Ophthalmology 2003 Aug;110(8):1601-5. doi: 10.1016/s0161-6420(03)00543-8. PMID: 12917180

Diagnosis

Pigmented Free-Floating Iris Cyst in the Anterior Chamber.
Lu CW, Liu XF, Qu LM
Ophthalmology 2022 Oct;129(10):1151. Epub 2022 Jun 25 doi: 10.1016/j.ophtha.2022.02.023. PMID: 35764440
A Case of an Iris Cyst Not to Be Missed.
Betsch D, Gupta RR
JAMA Ophthalmol 2020 Jul 1;138(7):793-794. doi: 10.1001/jamaophthalmol.2020.0571. PMID: 32407442
Iris and ciliary body cysts and phakic intraocular lenses.
Gharaibeh AM, Liehneova I, Mojzis P, Ziak P, Alió JL
Eur J Ophthalmol 2020 Sep;30(5):974-977. Epub 2019 Sep 23 doi: 10.1177/1120672119876532. PMID: 31544491
Peripheral pigmentary iris cyst: evaluation and differential diagnosis.
Minavi AZ, Holdeman NR
Clin Exp Optom 2007 Jan;90(1):49-52. doi: 10.1111/j.1444-0938.2006.00087.x. PMID: 17177666
Iris-cyst-simulating luxated lens.
Trivedi RH, Wilson ME Jr, Wells SA, Fraig MM
J Cataract Refract Surg 2006 Oct;32(10):1768-70. doi: 10.1016/j.jcrs.2006.05.022. PMID: 17010884

Therapy

ROCK Inhibitors as an Alternative Therapy for Corneal Grafting: A Systematic Review.
Polopalli S, Saha A, Niri P, Kumar M, Das P, Kamboj DV, Chattopadhyay P
J Ocul Pharmacol Ther 2023 Nov;39(9):585-599. Epub 2023 Sep 22 doi: 10.1089/jop.2023.0040. PMID: 37738326
Iris cyst after femtosecond laser-assisted cataract surgery: a case report.
Wu PY, Wu MH, Wu CC, Sun CC
BMC Ophthalmol 2021 Jan 13;21(1):36. doi: 10.1186/s12886-021-01803-y. PMID: 33441104Free PMC Article
Iris cyst following cataract surgery.
Shah A, Rajesh PS, Dutta Majumder P
Clin Exp Optom 2020 Sep;103(5):701. Epub 2019 Nov 14 doi: 10.1111/cxo.13000. PMID: 31729772
Iris and ciliary body cysts and phakic intraocular lenses.
Gharaibeh AM, Liehneova I, Mojzis P, Ziak P, Alió JL
Eur J Ophthalmol 2020 Sep;30(5):974-977. Epub 2019 Sep 23 doi: 10.1177/1120672119876532. PMID: 31544491
Recurrent iris cyst discharge.
Altan-Yaycioglu R, Canan H, Akova YA
J Cataract Refract Surg 2012 Jan;38(1):163-5. Epub 2011 Nov 10 doi: 10.1016/j.jcrs.2011.09.001. PMID: 22078118

Prognosis

Iris and ciliary body cysts and phakic intraocular lenses.
Gharaibeh AM, Liehneova I, Mojzis P, Ziak P, Alió JL
Eur J Ophthalmol 2020 Sep;30(5):974-977. Epub 2019 Sep 23 doi: 10.1177/1120672119876532. PMID: 31544491
Cogan-Reese syndrome with Iris cyst: A novel presentation.
Selvan H, Brar AS, Angmo D
Cont Lens Anterior Eye 2019 Aug;42(4):467-469. Epub 2019 May 17 doi: 10.1016/j.clae.2019.04.014. PMID: 31104851
Clinical and histopathological features of posttraumatic iris cyst.
Rishi P, Rishi E, Biswas J, Nandi K
Indian J Ophthalmol 2008 Nov-Dec;56(6):518-21. doi: 10.4103/0301-4738.43383. PMID: 18974530Free PMC Article
Iris cysts in children: classification, incidence, and management. The 1998 Torrence A Makley Jr Lecture.
Shields JA, Shields CL, Lois N, Mercado G
Br J Ophthalmol 1999 Mar;83(3):334-8. doi: 10.1136/bjo.83.3.334. PMID: 10365043Free PMC Article
Primary cysts of the iris.
Shields JA
Trans Am Ophthalmol Soc 1981;79:771-809. PMID: 7342411Free PMC Article

Clinical prediction guides

Management of an iris stromal cyst by fine needle aspiration with absolute alcohol irrigation and argon laser photocoagulation to induce sclerosis.
Vigués-Jorba L, Barnils N, Lorenzo D, Sanz S, Moix E, Caminal JM
J Fr Ophtalmol 2021 Sep;44(7):977-980. Epub 2021 Jun 17 doi: 10.1016/j.jfo.2020.12.019. PMID: 34147273
Iris and ciliary body cysts and phakic intraocular lenses.
Gharaibeh AM, Liehneova I, Mojzis P, Ziak P, Alió JL
Eur J Ophthalmol 2020 Sep;30(5):974-977. Epub 2019 Sep 23 doi: 10.1177/1120672119876532. PMID: 31544491
Recurrent iris cyst discharge.
Altan-Yaycioglu R, Canan H, Akova YA
J Cataract Refract Surg 2012 Jan;38(1):163-5. Epub 2011 Nov 10 doi: 10.1016/j.jcrs.2011.09.001. PMID: 22078118
Iris-cyst-simulating luxated lens.
Trivedi RH, Wilson ME Jr, Wells SA, Fraig MM
J Cataract Refract Surg 2006 Oct;32(10):1768-70. doi: 10.1016/j.jcrs.2006.05.022. PMID: 17010884
Primary cysts of the iris.
Shields JA
Trans Am Ophthalmol Soc 1981;79:771-809. PMID: 7342411Free PMC Article

Recent systematic reviews

ROCK Inhibitors as an Alternative Therapy for Corneal Grafting: A Systematic Review.
Polopalli S, Saha A, Niri P, Kumar M, Das P, Kamboj DV, Chattopadhyay P
J Ocul Pharmacol Ther 2023 Nov;39(9):585-599. Epub 2023 Sep 22 doi: 10.1089/jop.2023.0040. PMID: 37738326

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