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Salivary Gland Undifferentiated Carcinoma

MedGen UID:: 124651
•Concept ID:: C0279749
•: Neoplastic Process

Synonyms:

Anaplastic Carcinoma of Salivary Gland; Anaplastic Carcinoma of the Salivary Gland; Anaplastic Salivary Gland Carcinoma; Salivary Gland Anaplastic Carcinoma; Undifferentiated Carcinoma of Salivary Gland; Undifferentiated Carcinoma of the Salivary Gland; Undifferentiated Salivary Gland Carcinoma

Definition

A salivary gland carcinoma characterized by the presence of undifferentiated, anaplastic malignant epithelial cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSalivary Gland Undifferentiated Carcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Head and neck carcinoma
        Salivary gland carcinoma
        Salivary Gland Undifferentiated Carcinoma
        Minor Salivary Gland Undifferentiated Carcinoma
        Parotid Gland Undifferentiated Carcinoma
        Recurrent Parotid Gland Undifferentiated Carcinoma
        Submandibular Gland Undifferentiated Carcinoma
        Recurrent Submandibular Gland Undifferentiated Carcinoma

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.

Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666 Free PMC Article

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944 Free PMC Article

See all (359)

Recent clinical studies

Etiology

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898 Free PMC Article

See all (2876)

Diagnosis

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Mucoepidermoid carcinoma. An update and review of the literature.

Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266

See all (3927)

Therapy

Tubarial salivary gland sparing with proton therapy.

Wright CM, Lee DY, Kim M, Barsky AR, Teo BK, Lukens JN, Swisher-McClure S, Lin A
Med Dosim 2022 Autumn;47(3):222-226. Epub 2022 Apr 12 doi: 10.1016/j.meddos.2022.03.001. PMID: 35428548

Systemic therapy for salivary gland malignancy: current status and future perspectives.

Imamura Y, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Yokota T, Okano S, Tanaka K, Onoe T, Ariizumi Y, Homma A
Jpn J Clin Oncol 2022 Apr 6;52(4):293-302. doi: 10.1093/jjco/hyac008. PMID: 35134985

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

New approaches in salivary gland carcinoma.

Even C, Baste N, Classe M
Curr Opin Oncol 2019 May;31(3):169-174. doi: 10.1097/CCO.0000000000000527. PMID: 30844885

Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.

Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848

See all (986)

Prognosis

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Salivary Gland Tumors: Current Concepts and Controversies.

Seethala RR
Surg Pathol Clin 2017 Mar;10(1):155-176. doi: 10.1016/j.path.2016.11.004. PMID: 28153132

Mammary Analogue Secretory Carcinoma.

Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269

Salivary acinic cell carcinoma: reappraisal and update.

Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679

See all (2924)

Clinical prediction guides

Pediatric primary salivary gland tumors.

Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681

Microsecretory Adenocarcinoma of Salivary Glands.

Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Lymphoepithelial-like carcinomas of the head and neck.

Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

See all (1986)

Recent systematic reviews

Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review.

Lavareze L, Scarini JF, de Lima-Souza RA, Kimura TC, Gondak RO, Egal ESA, Altemani A, Mariano FV
J Oral Pathol Med 2023 Feb;52(2):101-108. Epub 2023 Jan 9 doi: 10.1111/jop.13395. PMID: 36504414

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.

Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695

Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.

Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810

A systematic review of secretory carcinoma of the salivary gland: where are we?

Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686

Salivary gland transfer to prevent radiation-induced xerostomia: a systematic review and meta-analysis.

Sood AJ, Fox NF, O'Connell BP, Lovelace TL, Nguyen SA, Sharma AK, Hornig JD, Day TA
Oral Oncol 2014 Feb;50(2):77-83. Epub 2013 Nov 1 doi: 10.1016/j.oraloncology.2013.10.010. PMID: 24189058

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MedGen

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Salivary Gland Undifferentiated Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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