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Abnormal ossification of the sacrum

MedGen UID:
1369111
•Concept ID:
C4476736
•
Finding
HPO: HP:0025370

Definition

Abnormal bone tissue formation (ossification) affecting the sacrum. [from HPO]

Recent clinical studies

Etiology

The Spine in Patients With Osteogenesis Imperfecta.
Wallace MJ, Kruse RW, Shah SA
J Am Acad Orthop Surg 2017 Feb;25(2):100-109. doi: 10.5435/JAAOS-D-15-00169. PMID: 28009707
New osseous soft markers for trisomy 13, 18 and 21.
Achter A, Hager T, Fimmers R, Gembruch U, Müller AM
Arch Gynecol Obstet 2016 Aug;294(2):251-9. Epub 2015 Nov 30 doi: 10.1007/s00404-015-3971-z. PMID: 26620204
Sciatic nerve compression related to ossification of the sacrospinous ligament secondary to pelvic balance abnomalities.
Goddyn C, Passuti N, Leconte R, Redon H, Gouin F
Orthop Traumatol Surg Res 2009 Dec;95(8):645-8. doi: 10.1016/j.otsr.2009.08.005. PMID: 19910274
Spinal hamartomas: a distinct clinical entity.
Morris GF, Murphy K, Rorke LB, James HE
J Neurosurg 1998 Jun;88(6):954-7. doi: 10.3171/jns.1998.88.6.0954. PMID: 9609287
Fetal bifid sacrum artifact: normal developmental anatomy simulating malformation.
Kliewer MA, Hertzberg BS, George P, Baumeister LA, Black BL, McNally PJ, Ahearn EP, Bowie JD
Radiology 1995 Jun;195(3):673-6. doi: 10.1148/radiology.195.3.7753992. PMID: 7753992

Diagnosis

Unusual Imaging Findings Associated with Germ Cell Tumors.
Magudia K, Menias CO, Bhalla S, Katabathina VS, Craig JW, Hammer MM
Radiographics 2019 Jul-Aug;39(4):1019-1035. Epub 2019 May 24 doi: 10.1148/rg.2019180050. PMID: 31125295
Turning the backbone into an ankylosed concrete-like structure: Case report.
Kaissi AA, Chehida FB, Grill F, Ganger R, Kircher SG
Medicine (Baltimore) 2018 Apr;97(15):e0278. doi: 10.1097/MD.0000000000010278. PMID: 29642148Free PMC Article
The Spine in Patients With Osteogenesis Imperfecta.
Wallace MJ, Kruse RW, Shah SA
J Am Acad Orthop Surg 2017 Feb;25(2):100-109. doi: 10.5435/JAAOS-D-15-00169. PMID: 28009707
New osseous soft markers for trisomy 13, 18 and 21.
Achter A, Hager T, Fimmers R, Gembruch U, Müller AM
Arch Gynecol Obstet 2016 Aug;294(2):251-9. Epub 2015 Nov 30 doi: 10.1007/s00404-015-3971-z. PMID: 26620204
Spinal hamartomas: a distinct clinical entity.
Morris GF, Murphy K, Rorke LB, James HE
J Neurosurg 1998 Jun;88(6):954-7. doi: 10.3171/jns.1998.88.6.0954. PMID: 9609287

Therapy

Intradural mesh: an unusual cause of spinal cord tethering: case report.
Cole JS 4th, Pittman T
J Neurosurg 2005 Apr;102(3 Suppl):311-3. doi: 10.3171/ped.2005.102.3.0311. PMID: 15881757

Prognosis

Sciatic nerve compression related to ossification of the sacrospinous ligament secondary to pelvic balance abnomalities.
Goddyn C, Passuti N, Leconte R, Redon H, Gouin F
Orthop Traumatol Surg Res 2009 Dec;95(8):645-8. doi: 10.1016/j.otsr.2009.08.005. PMID: 19910274
Diaphanospondylodysostosis (DSD): confirmation of a recessive disorder with abnormal vertebral ossification and nephroblastomatosis.
Gonzales M, Verloes A, Saint Frison MH, Perrotez C, Bourdet O, Encha-Razavi F, Joyé N, Taillemite JL, Walbaum R, Pfeiffer R, Maroteaux P
Am J Med Genet A 2005 Aug 1;136A(4):373-6. doi: 10.1002/ajmg.a.30537. PMID: 15988748
Intradural mesh: an unusual cause of spinal cord tethering: case report.
Cole JS 4th, Pittman T
J Neurosurg 2005 Apr;102(3 Suppl):311-3. doi: 10.3171/ped.2005.102.3.0311. PMID: 15881757
Spinal hamartomas: a distinct clinical entity.
Morris GF, Murphy K, Rorke LB, James HE
J Neurosurg 1998 Jun;88(6):954-7. doi: 10.3171/jns.1998.88.6.0954. PMID: 9609287
Simpson-Golabi-Behmel syndrome: congenital diaphragmatic hernia and radiologic findings in two patients and follow-up of a previously reported case.
Chen E, Johnson JP, Cox VA, Golabi M
Am J Med Genet 1993 Jun 15;46(5):574-8. doi: 10.1002/ajmg.1320460523. PMID: 8322824

Clinical prediction guides

Turning the backbone into an ankylosed concrete-like structure: Case report.
Kaissi AA, Chehida FB, Grill F, Ganger R, Kircher SG
Medicine (Baltimore) 2018 Apr;97(15):e0278. doi: 10.1097/MD.0000000000010278. PMID: 29642148Free PMC Article
Type II achondrogenesis-hypochondrogenesis: morphologic and immunohistopathologic studies.
Godfrey M, Keene DR, Blank E, Hori H, Sakai LY, Sherwin LA, Hollister DW
Am J Hum Genet 1988 Dec;43(6):894-903. PMID: 3057886Free PMC Article

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