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Reduced intraabdominal adipose tissue

MedGen UID:
1369752
Concept ID:
C4476602
Finding
HPO: HP:0025128

Definition

An abnormally reduced amount of adipose tissue in the abdominal cavity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced intraabdominal adipose tissue

Conditions with this feature

Congenital generalized lipodystrophy type 1
MedGen UID:
318592
Concept ID:
C1720862
Disease or Syndrome
Berardinelli-Seip congenital lipodystrophy (BSCL) is usually diagnosed at birth or soon thereafter. Because of the absence of functional adipocytes, lipid is stored in other tissues, including muscle and liver. Affected individuals develop insulin resistance and approximately 25%-35% develop diabetes mellitus between ages 15 and 20 years. Hepatomegaly secondary to hepatic steatosis and skeletal muscle hypertrophy occur in all affected individuals. Hypertrophic cardiomyopathy is reported in 20%-25% of affected individuals and is a significant cause of morbidity from cardiac failure and early mortality.
Congenital generalized lipodystrophy type 2
MedGen UID:
318593
Concept ID:
C1720863
Congenital Abnormality
Berardinelli-Seip congenital lipodystrophy (BSCL) is usually diagnosed at birth or soon thereafter. Because of the absence of functional adipocytes, lipid is stored in other tissues, including muscle and liver. Affected individuals develop insulin resistance and approximately 25%-35% develop diabetes mellitus between ages 15 and 20 years. Hepatomegaly secondary to hepatic steatosis and skeletal muscle hypertrophy occur in all affected individuals. Hypertrophic cardiomyopathy is reported in 20%-25% of affected individuals and is a significant cause of morbidity from cardiac failure and early mortality.

Professional guidelines

PubMed

Griffin BA
Proc Nutr Soc 2020 Feb;79(1):1-3. doi: 10.1017/S0029665119001149. PMID: 31985390
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H; Obesity Management Task Force of the European Association for the Study of Obesity
Obes Facts 2015;8(6):402-24. Epub 2015 Dec 5 doi: 10.1159/000442721. PMID: 26641646Free PMC Article
Grams J, Garvey WT
Curr Obes Rep 2015 Jun;4(2):287-302. doi: 10.1007/s13679-015-0155-x. PMID: 26627223

Recent clinical studies

Etiology

D'Oria R, Genchi VA, Caccioppoli C, Calderoni I, Marrano N, Biondi G, Borrelli A, Di Gioia L, Giorgino F, Laviola L
Int J Mol Sci 2022 Nov 18;23(22) doi: 10.3390/ijms232214296. PMID: 36430774Free PMC Article
Engin A
Adv Exp Med Biol 2017;960:415-441. doi: 10.1007/978-3-319-48382-5_18. PMID: 28585210
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H; Obesity Management Task Force of the European Association for the Study of Obesity
Obes Facts 2015;8(6):402-24. Epub 2015 Dec 5 doi: 10.1159/000442721. PMID: 26641646Free PMC Article
Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SE, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost G
Gut 2015 Nov;64(11):1744-54. Epub 2014 Dec 10 doi: 10.1136/gutjnl-2014-307913. PMID: 25500202Free PMC Article
Tchernof A, Després JP
Physiol Rev 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011. PMID: 23303913

Diagnosis

Dumesic DA, Padmanabhan V, Chazenbalk GD, Abbott DH
Reprod Biol Endocrinol 2022 Jan 10;20(1):12. doi: 10.1186/s12958-021-00878-y. PMID: 35012577Free PMC Article
Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL
Aging Cell 2019 Jun;18(3):e12950. Epub 2019 Mar 25 doi: 10.1111/acel.12950. PMID: 30907060Free PMC Article
Kahl KG, Deuschle M, Stubbs B, Schweiger U
Horm Mol Biol Clin Investig 2018 Mar 16;33(1) doi: 10.1515/hmbci-2018-0007. PMID: 29547392
Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SE, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost G
Gut 2015 Nov;64(11):1744-54. Epub 2014 Dec 10 doi: 10.1136/gutjnl-2014-307913. PMID: 25500202Free PMC Article
Després JP
Baillieres Clin Endocrinol Metab 1994 Jul;8(3):629-60. doi: 10.1016/s0950-351x(05)80289-7. PMID: 7980350

Therapy

Sabag A, Way KL, Keating SE, Sultana RN, O'Connor HT, Baker MK, Chuter VH, George J, Johnson NA
Diabetes Metab 2017 Jun;43(3):195-210. Epub 2017 Feb 2 doi: 10.1016/j.diabet.2016.12.006. PMID: 28162956
Grams J, Garvey WT
Curr Obes Rep 2015 Jun;4(2):287-302. doi: 10.1007/s13679-015-0155-x. PMID: 26627223
Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SE, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost G
Gut 2015 Nov;64(11):1744-54. Epub 2014 Dec 10 doi: 10.1136/gutjnl-2014-307913. PMID: 25500202Free PMC Article
Clemente TR, Dos Santos AN, Sturaro JN, Gotardo EM, de Oliveira CC, Acedo SC, Caria CR, Pedrazzoli J Jr, Ribeiro ML, Gambero A
Scand J Gastroenterol 2012 Sep;47(8-9):943-50. Epub 2012 May 28 doi: 10.3109/00365521.2012.688213. PMID: 22630819
Sethi JK, Vidal-Puig A
Trends Mol Med 2005 Aug;11(8):344-7. doi: 10.1016/j.molmed.2005.06.010. PMID: 16005682Free PMC Article

Prognosis

Utzschneider KM, Kahn SE, Polidori DC
J Clin Endocrinol Metab 2019 May 1;104(5):1855-1865. doi: 10.1210/jc.2018-01808. PMID: 30566676Free PMC Article
Nyman K, Granér M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Taskinen MR, Lundbom N, Lauerma K
Nutr Metab Cardiovasc Dis 2018 Jul;28(7):727-734. Epub 2018 Feb 21 doi: 10.1016/j.numecd.2018.02.008. PMID: 29764718
Djurić-Stefanović A, Vasin D, Jovanović S, Lazić Lj, Kovac J, Popović I, Bajec Dj, Saranović Dj
Acta Chir Iugosl 2013;60(3):25-30. doi: 10.2298/aci1303025d. PMID: 24669577
Tchernof A, Després JP
Physiol Rev 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011. PMID: 23303913
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854

Clinical prediction guides

Kahl KG, Deuschle M, Stubbs B, Schweiger U
Horm Mol Biol Clin Investig 2018 Mar 16;33(1) doi: 10.1515/hmbci-2018-0007. PMID: 29547392
Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SE, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost G
Gut 2015 Nov;64(11):1744-54. Epub 2014 Dec 10 doi: 10.1136/gutjnl-2014-307913. PMID: 25500202Free PMC Article
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Magkos F
Curr Opin Lipidol 2010 Dec;21(6):507-17. doi: 10.1097/MOL.0b013e32833ea912. PMID: 21206340
Després JP
Baillieres Clin Endocrinol Metab 1994 Jul;8(3):629-60. doi: 10.1016/s0950-351x(05)80289-7. PMID: 7980350

Recent systematic reviews

Sabag A, Way KL, Keating SE, Sultana RN, O'Connor HT, Baker MK, Chuter VH, George J, Johnson NA
Diabetes Metab 2017 Jun;43(3):195-210. Epub 2017 Feb 2 doi: 10.1016/j.diabet.2016.12.006. PMID: 28162956

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