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Salivary Gland Secretory Carcinoma

MedGen UID:
1373991
•Concept ID:
C4330658
•
Neoplastic Process
Synonyms: Mammary Analogue Secretory Carcinoma of Salivary Gland; Salivary Gland MASC

Definition

A rare, low-grade carcinoma of the salivary gland with favorable clinical outcome. It usually arises from the parotid gland and less often from the minor salivary glands. It shares the same histopathologic features and molecular characteristics (ETV6 gene rearrangement) with secretory breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Secretory Carcinoma

Professional guidelines

PubMed

Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma.
Pang Y, Sun L, Liu H, Ma J
Oral Oncol 2021 Aug;119:105370. Epub 2021 Jun 19 doi: 10.1016/j.oraloncology.2021.105370. PMID: 34157553
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Primary salivary gland malignancies: a review of clinicopathological evolution, molecular mechanisms and management.
Badlani J, Gupta R, Balasubramanian D, Smith J, Luk P, Clark J
ANZ J Surg 2018 Mar;88(3):152-157. Epub 2017 Oct 5 doi: 10.1111/ans.14201. PMID: 28982213

Recent clinical studies

Etiology

Salivary Gland Secretory Carcinoma; Review of 13 Years World-Wide Experience and Meta-Analysis.
Yosefof E, Boldes T, Dan D, Robenshtok E, Strenov Y, Bachar G, Shpitzer T, Mizrachi A
Laryngoscope 2024 Apr;134(4):1716-1724. Epub 2023 Nov 1 doi: 10.1002/lary.31123. PMID: 37909690
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739

Diagnosis

Salivary Gland Secretory Carcinoma; Review of 13 Years World-Wide Experience and Meta-Analysis.
Yosefof E, Boldes T, Dan D, Robenshtok E, Strenov Y, Bachar G, Shpitzer T, Mizrachi A
Laryngoscope 2024 Apr;134(4):1716-1724. Epub 2023 Nov 1 doi: 10.1002/lary.31123. PMID: 37909690
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Using pan-TRK and RET Immunohistochemistry for the Detection of Fusion Types of Salivary Gland Secretory Carcinoma.
Su YJ, Lee YH, Jin YT, Hsieh MS
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):264-272. doi: 10.1097/PAI.0000000000001003. PMID: 35384876
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Characterization of novel genetic alterations in salivary gland secretory carcinoma.
Na K, Hernandez-Prera JC, Lim JY, Woo HY, Yoon SO
Mod Pathol 2020 Apr;33(4):541-550. Epub 2019 Dec 10 doi: 10.1038/s41379-019-0427-1. PMID: 31822803Free PMC Article

Therapy

Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib.
Cipriani NA, Blair EA, Finkle J, Kraninger JL, Straus CM, Villaflor VM, Ginat DT
Int J Surg Pathol 2017 Oct;25(7):613-618. Epub 2017 May 12 doi: 10.1177/1066896917709350. PMID: 28497708

Prognosis

Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis.
Kala PS, Gupta M, Thapliyal N
Acta Cytol 2024;68(2):83-106. Epub 2024 Jan 16 doi: 10.1159/000536249. PMID: 38228123
Salivary Gland Secretory Carcinoma; Review of 13 Years World-Wide Experience and Meta-Analysis.
Yosefof E, Boldes T, Dan D, Robenshtok E, Strenov Y, Bachar G, Shpitzer T, Mizrachi A
Laryngoscope 2024 Apr;134(4):1716-1724. Epub 2023 Nov 1 doi: 10.1002/lary.31123. PMID: 37909690
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib.
Cipriani NA, Blair EA, Finkle J, Kraninger JL, Straus CM, Villaflor VM, Ginat DT
Int J Surg Pathol 2017 Oct;25(7):613-618. Epub 2017 May 12 doi: 10.1177/1066896917709350. PMID: 28497708

Clinical prediction guides

Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis.
Kala PS, Gupta M, Thapliyal N
Acta Cytol 2024;68(2):83-106. Epub 2024 Jan 16 doi: 10.1159/000536249. PMID: 38228123
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Molecular identification of an ETV6-RET fusion in a secretory carcinoma associated with a pleomorphic adenoma.
Smith ME, Surrey LF, Zhang PJ, Weinstein GS, LiVolsi VA
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Dec;134(6):733-738. Epub 2022 Apr 21 doi: 10.1016/j.oooo.2022.04.043. PMID: 35915042
Characterization of novel genetic alterations in salivary gland secretory carcinoma.
Na K, Hernandez-Prera JC, Lim JY, Woo HY, Yoon SO
Mod Pathol 2020 Apr;33(4):541-550. Epub 2019 Dec 10 doi: 10.1038/s41379-019-0427-1. PMID: 31822803Free PMC Article

Recent systematic reviews

Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis.
Kala PS, Gupta M, Thapliyal N
Acta Cytol 2024;68(2):83-106. Epub 2024 Jan 16 doi: 10.1159/000536249. PMID: 38228123
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686

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