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Hypothyroid Goiter

MedGen UID:
1374992
•Concept ID:
C4331894
•
Disease or Syndrome

Definition

Goiter associated with reduced thyroid hormone secretion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypothyroid Goiter

Professional guidelines

PubMed

Thyroiditis: Evaluation and Treatment.
Martinez Quintero B, Yazbeck C, Sweeney LB
Am Fam Physician 2021 Dec 1;104(6):609-617. PMID: 34913664
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation.
Liontiris MI, Mazokopakis EE
Hell J Nucl Med 2017 Jan-Apr;20(1):51-56. Epub 2017 Mar 20 doi: 10.1967/s002449910507. PMID: 28315909
Hashimoto thyroiditis: clinical and diagnostic criteria.
Caturegli P, De Remigis A, Rose NR
Autoimmun Rev 2014 Apr-May;13(4-5):391-7. Epub 2014 Jan 13 doi: 10.1016/j.autrev.2014.01.007. PMID: 24434360

Recent clinical studies

Etiology

Management of fetal goiters: 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays De Loire Perinatal Network.
Delay F, Dochez V, Biquard F, Cheve MT, Gillard P, Arthuis CJ, Winer N
J Matern Fetal Neonatal Med 2020 Aug;33(15):2561-2569. Epub 2019 Jan 8 doi: 10.1080/14767058.2018.1555803. PMID: 30513035
Surgical treatment of primitive thyroid lymphoma.
Avenia N, Ragusa M, Cirocchi R, Puxeddu E, Cavaliere A, De Feo P, Sidoni A, Roila F, Sanguinetti A, Puma F
Tumori 2009 Nov-Dec;95(6):712-9. doi: 10.1177/030089160909500613. PMID: 20210235
Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter.
Huel C, Guibourdenche J, Vuillard E, Ouahba J, Piketty M, Oury JF, Luton D
Ultrasound Obstet Gynecol 2009 Apr;33(4):412-20. doi: 10.1002/uog.6315. PMID: 19306478
Serum 3,5,3'-triiodothyronine, thyroxine, and thyrotropin in hypothyroid infants with congenital goiter and the response to iodine.
Heidemann P, Stubbe P
J Clin Endocrinol Metab 1978 Jul;47(1):189-92. doi: 10.1210/jcem-47-1-189. PMID: 263290

Diagnosis

Management of fetal goiters: 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays De Loire Perinatal Network.
Delay F, Dochez V, Biquard F, Cheve MT, Gillard P, Arthuis CJ, Winer N
J Matern Fetal Neonatal Med 2020 Aug;33(15):2561-2569. Epub 2019 Jan 8 doi: 10.1080/14767058.2018.1555803. PMID: 30513035
Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine.
Hardley MT, Chon AH, Mestman J, Nguyen CT, Geffner ME, Chmait RH
Horm Res Paediatr 2018;90(6):419-423. Epub 2018 May 23 doi: 10.1159/000488776. PMID: 29791909
Surgical treatment of primitive thyroid lymphoma.
Avenia N, Ragusa M, Cirocchi R, Puxeddu E, Cavaliere A, De Feo P, Sidoni A, Roila F, Sanguinetti A, Puma F
Tumori 2009 Nov-Dec;95(6):712-9. doi: 10.1177/030089160909500613. PMID: 20210235
Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter.
Huel C, Guibourdenche J, Vuillard E, Ouahba J, Piketty M, Oury JF, Luton D
Ultrasound Obstet Gynecol 2009 Apr;33(4):412-20. doi: 10.1002/uog.6315. PMID: 19306478
Early prenatal diagnosis and therapy of fetal hypothyroid goiter.
Noia G, De Santis M, Tocci A, Maussier ML, D'Errico G, Bianchi A, Romagnoli C, Masini L, Caruso A, Mancuso S
Fetal Diagn Ther 1992;7(2):138-43. doi: 10.1159/000263661. PMID: 1503649

Therapy

Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism.
Dufort G, Larrivée-Vanier S, Eugène D, De Deken X, Seebauer B, Heinimann K, Lévesque S, Gravel S, Szinnai G, Van Vliet G, Deladoëy J
Thyroid 2019 Jul;29(7):1018-1022. Epub 2019 May 31 doi: 10.1089/thy.2018.0461. PMID: 31030636
Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine.
Hardley MT, Chon AH, Mestman J, Nguyen CT, Geffner ME, Chmait RH
Horm Res Paediatr 2018;90(6):419-423. Epub 2018 May 23 doi: 10.1159/000488776. PMID: 29791909
Early prenatal diagnosis and therapy of fetal hypothyroid goiter.
Noia G, De Santis M, Tocci A, Maussier ML, D'Errico G, Bianchi A, Romagnoli C, Masini L, Caruso A, Mancuso S
Fetal Diagn Ther 1992;7(2):138-43. doi: 10.1159/000263661. PMID: 1503649
Congenital hypothyroid goiter and amiodarone.
De Wolf D, De Schepper J, Verhaaren H, Deneyer M, Smitz J, Sacre-Smits L
Acta Paediatr Scand 1988 Jul;77(4):616-8. doi: 10.1111/j.1651-2227.1988.tb10717.x. PMID: 3394521
Serum 3,5,3'-triiodothyronine, thyroxine, and thyrotropin in hypothyroid infants with congenital goiter and the response to iodine.
Heidemann P, Stubbe P
J Clin Endocrinol Metab 1978 Jul;47(1):189-92. doi: 10.1210/jcem-47-1-189. PMID: 263290

Prognosis

Surgical treatment of primitive thyroid lymphoma.
Avenia N, Ragusa M, Cirocchi R, Puxeddu E, Cavaliere A, De Feo P, Sidoni A, Roila F, Sanguinetti A, Puma F
Tumori 2009 Nov-Dec;95(6):712-9. doi: 10.1177/030089160909500613. PMID: 20210235
Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter.
Huel C, Guibourdenche J, Vuillard E, Ouahba J, Piketty M, Oury JF, Luton D
Ultrasound Obstet Gynecol 2009 Apr;33(4):412-20. doi: 10.1002/uog.6315. PMID: 19306478

Clinical prediction guides

Management of fetal goiters: 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays De Loire Perinatal Network.
Delay F, Dochez V, Biquard F, Cheve MT, Gillard P, Arthuis CJ, Winer N
J Matern Fetal Neonatal Med 2020 Aug;33(15):2561-2569. Epub 2019 Jan 8 doi: 10.1080/14767058.2018.1555803. PMID: 30513035
Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter.
Huel C, Guibourdenche J, Vuillard E, Ouahba J, Piketty M, Oury JF, Luton D
Ultrasound Obstet Gynecol 2009 Apr;33(4):412-20. doi: 10.1002/uog.6315. PMID: 19306478
Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism.
Baryshev M, Sargsyan E, Wallin G, Lejnieks A, Furudate S, Hishinuma A, Mkrtchian S
J Mol Endocrinol 2004 Jun;32(3):903-20. doi: 10.1677/jme.0.0320903. PMID: 15171721
Congenital hypothyroid goiter and amiodarone.
De Wolf D, De Schepper J, Verhaaren H, Deneyer M, Smitz J, Sacre-Smits L
Acta Paediatr Scand 1988 Jul;77(4):616-8. doi: 10.1111/j.1651-2227.1988.tb10717.x. PMID: 3394521
Serum 3,5,3'-triiodothyronine, thyroxine, and thyrotropin in hypothyroid infants with congenital goiter and the response to iodine.
Heidemann P, Stubbe P
J Clin Endocrinol Metab 1978 Jul;47(1):189-92. doi: 10.1210/jcem-47-1-189. PMID: 263290

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