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Metastatic Malignant Neoplasm in the Bladder

MedGen UID:
138074
•Concept ID:
C0347011
•
Neoplastic Process
Synonyms: Cancer metastatic to urinary bladder; Metastases to Bladder; Metastasis to bladder; Metastasis to Bladder; Metastatic malignant neoplasm of bladder; Metastatic malignant neoplasm to bladder; Metastatic Malignant Neoplasm to the Bladder; Metastatic Neoplasm to the Bladder; Metastatic Neoplasm to the Urinary Bladder; Metastatic tumor to bladder; Metastatic Tumor to the Bladder; Metastatic Tumor to the Urinary Bladder; Secondary malignant neoplasm of bladder
SNOMED CT: Secondary malignant neoplasm of bladder (94186002); Metastatic malignant neoplasm to bladder (94186002); Cancer metastatic to urinary bladder (94186002); Metastatic malignant neoplasm of bladder (94186002); Metastasis to bladder (94186002); Metastatic tumor to bladder (94186002)

Definition

The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Bladder

Professional guidelines

PubMed

Advances in diagnosis and treatment of bladder cancer.
Lopez-Beltran A, Cookson MS, Guercio BJ, Cheng L
BMJ 2024 Feb 12;384:e076743. doi: 10.1136/bmj-2023-076743. PMID: 38346808
Current best practice for bladder cancer: a narrative review of diagnostics and treatments.
Compérat E, Amin MB, Cathomas R, Choudhury A, De Santis M, Kamat A, Stenzl A, Thoeny HC, Witjes JA
Lancet 2022 Nov 12;400(10364):1712-1721. Epub 2022 Sep 26 doi: 10.1016/S0140-6736(22)01188-6. PMID: 36174585
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488

Recent clinical studies

Etiology

Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: a multi-institutional propensity score matched and weighted analysis.
Zlotta AR, Ballas LK, Niemierko A, Lajkosz K, Kuk C, Miranda G, Drumm M, Mari A, Thio E, Fleshner NE, Kulkarni GS, Jewett MAS, Bristow RG, Catton C, Berlin A, Sridhar SS, Schuckman A, Feldman AS, Wszolek M, Dahl DM, Lee RJ, Saylor PJ, Michaelson MD, Miyamoto DT, Zietman A, Shipley W, Chung P, Daneshmand S, Efstathiou JA
Lancet Oncol 2023 Jun;24(6):669-681. Epub 2023 May 12 doi: 10.1016/S1470-2045(23)00170-5. PMID: 37187202
Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial.
Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Defining cisplatin eligibility in patients with muscle-invasive bladder cancer.
Jiang DM, Gupta S, Kitchlu A, Meraz-Munoz A, North SA, Alimohamed NS, Blais N, Sridhar SS
Nat Rev Urol 2021 Feb;18(2):104-114. Epub 2021 Jan 11 doi: 10.1038/s41585-020-00404-6. PMID: 33432181
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822

Diagnosis

Bladder cancer.
Dyrskjøt L, Hansel DE, Efstathiou JA, Knowles MA, Galsky MD, Teoh J, Theodorescu D
Nat Rev Dis Primers 2023 Oct 26;9(1):58. doi: 10.1038/s41572-023-00468-9. PMID: 37884563
Defining cisplatin eligibility in patients with muscle-invasive bladder cancer.
Jiang DM, Gupta S, Kitchlu A, Meraz-Munoz A, North SA, Alimohamed NS, Blais N, Sridhar SS
Nat Rev Urol 2021 Feb;18(2):104-114. Epub 2021 Jan 11 doi: 10.1038/s41585-020-00404-6. PMID: 33432181
The applicability and utility of immunohistochemical biomarkers in bladder pathology.
Akgul M, MacLennan GT, Cheng L
Hum Pathol 2020 Apr;98:32-55. Epub 2020 Feb 6 doi: 10.1016/j.humpath.2020.01.004. PMID: 32035992
Urologic Complications Following Pelvic Radiotherapy.
Lobo N, Kulkarni M, Hughes S, Nair R, Khan MS, Thurairaja R
Urology 2018 Dec;122:1-9. Epub 2018 Jul 20 doi: 10.1016/j.urology.2018.07.017. PMID: 30036617
Advancements in optical techniques and imaging in the diagnosis and management of bladder cancer.
Rose TL, Lotan Y
Urol Oncol 2018 Mar;36(3):97-102. Epub 2017 Dec 26 doi: 10.1016/j.urolonc.2017.11.014. PMID: 29288006

Therapy

Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: a multi-institutional propensity score matched and weighted analysis.
Zlotta AR, Ballas LK, Niemierko A, Lajkosz K, Kuk C, Miranda G, Drumm M, Mari A, Thio E, Fleshner NE, Kulkarni GS, Jewett MAS, Bristow RG, Catton C, Berlin A, Sridhar SS, Schuckman A, Feldman AS, Wszolek M, Dahl DM, Lee RJ, Saylor PJ, Michaelson MD, Miyamoto DT, Zietman A, Shipley W, Chung P, Daneshmand S, Efstathiou JA
Lancet Oncol 2023 Jun;24(6):669-681. Epub 2023 May 12 doi: 10.1016/S1470-2045(23)00170-5. PMID: 37187202
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Defining cisplatin eligibility in patients with muscle-invasive bladder cancer.
Jiang DM, Gupta S, Kitchlu A, Meraz-Munoz A, North SA, Alimohamed NS, Blais N, Sridhar SS
Nat Rev Urol 2021 Feb;18(2):104-114. Epub 2021 Jan 11 doi: 10.1038/s41585-020-00404-6. PMID: 33432181
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
The biology and rationale of targeting nectin-4 in urothelial carcinoma.
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713

Prognosis

Bladder cancer.
Dyrskjøt L, Hansel DE, Efstathiou JA, Knowles MA, Galsky MD, Teoh J, Theodorescu D
Nat Rev Dis Primers 2023 Oct 26;9(1):58. doi: 10.1038/s41572-023-00468-9. PMID: 37884563
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer.
Gouin KH 3rd, Ing N, Plummer JT, Rosser CJ, Ben Cheikh B, Oh C, Chen SS, Chan KS, Furuya H, Tourtellotte WG, Knott SRV, Theodorescu D
Nat Commun 2021 Aug 12;12(1):4906. doi: 10.1038/s41467-021-25103-7. PMID: 34385456Free PMC Article
Immunotherapy Advances in Urothelial Carcinoma.
Jain RK, Snyders T, Nandagopal L, Garje R, Zakharia Y, Gupta S
Curr Treat Options Oncol 2018 Dec 15;19(12):79. doi: 10.1007/s11864-018-0598-x. PMID: 30554335
The latest treatment options for bladder cancer.
Crabb SJ, Douglas J
Br Med Bull 2018 Dec 1;128(1):85-95. doi: 10.1093/bmb/ldy034. PMID: 30371744

Clinical prediction guides

Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: a multi-institutional propensity score matched and weighted analysis.
Zlotta AR, Ballas LK, Niemierko A, Lajkosz K, Kuk C, Miranda G, Drumm M, Mari A, Thio E, Fleshner NE, Kulkarni GS, Jewett MAS, Bristow RG, Catton C, Berlin A, Sridhar SS, Schuckman A, Feldman AS, Wszolek M, Dahl DM, Lee RJ, Saylor PJ, Michaelson MD, Miyamoto DT, Zietman A, Shipley W, Chung P, Daneshmand S, Efstathiou JA
Lancet Oncol 2023 Jun;24(6):669-681. Epub 2023 May 12 doi: 10.1016/S1470-2045(23)00170-5. PMID: 37187202
Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial.
Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer.
Gouin KH 3rd, Ing N, Plummer JT, Rosser CJ, Ben Cheikh B, Oh C, Chen SS, Chan KS, Furuya H, Tourtellotte WG, Knott SRV, Theodorescu D
Nat Commun 2021 Aug 12;12(1):4906. doi: 10.1038/s41467-021-25103-7. PMID: 34385456Free PMC Article
Molecular pathology of urothelial carcinoma.
Lopez-Beltran A, Cimadamore A, Montironi R, Cheng L
Hum Pathol 2021 Jul;113:67-83. Epub 2021 Apr 19 doi: 10.1016/j.humpath.2021.04.001. PMID: 33887300
Immunotherapy Advances in Urothelial Carcinoma.
Jain RK, Snyders T, Nandagopal L, Garje R, Zakharia Y, Gupta S
Curr Treat Options Oncol 2018 Dec 15;19(12):79. doi: 10.1007/s11864-018-0598-x. PMID: 30554335

Recent systematic reviews

Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials.
Khetrapal P, Wong JKL, Tan WP, Rupasinghe T, Tan WS, Williams SB, Boorjian SA, Wijburg C, Parekh DJ, Wiklund P, Vasdev N, Khan MS, Guru KA, Catto JWF, Kelly JD
Eur Urol 2023 Oct;84(4):393-405. Epub 2023 May 9 doi: 10.1016/j.eururo.2023.04.004. PMID: 37169638
The evolving panorama of HER2-targeted treatments in metastatic urothelial cancer: A systematic review and future perspectives.
Patelli G, Zeppellini A, Spina F, Righetti E, Stabile S, Amatu A, Tosi F, Ghezzi S, Siena S, Sartore-Bianchi A
Cancer Treat Rev 2022 Mar;104:102351. Epub 2022 Jan 31 doi: 10.1016/j.ctrv.2022.102351. PMID: 35180563
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Systemic therapies for metastatic hormone-sensitive prostate cancer: network meta-analysis.
Mori K, Mostafaei H, Sari Motlagh R, Pradere B, Quhal F, Laukhtina E, Schuettfort VM, Kramer G, Abufaraj M, Karakiewicz PI, Kimura T, Egawa S, Shariat SF
BJU Int 2022 Apr;129(4):423-433. Epub 2021 Jul 21 doi: 10.1111/bju.15507. PMID: 34171173Free PMC Article
Diagnostic Accuracy of Novel Urinary Biomarker Tests in Non-muscle-invasive Bladder Cancer: A Systematic Review and Network Meta-analysis.
Laukhtina E, Shim SR, Mori K, D'Andrea D, Soria F, Rajwa P, Mostafaei H, Compérat E, Cimadamore A, Moschini M, Teoh JY, Enikeev D, Xylinas E, Lotan Y, Palou J, Gontero P, Babjuk M, Witjes JA, Kamat AM, Roupret M, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group
Eur Urol Oncol 2021 Dec;4(6):927-942. Epub 2021 Nov 6 doi: 10.1016/j.euo.2021.10.003. PMID: 34753702

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