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Advanced Malignant Solid Neoplasm

MedGen UID:
1393457
Concept ID:
C4329281
Neoplastic Process
Synonyms: Advanced Malignant Solid Tumor; Advanced Non-Hematologic Malignancy; Advanced Solid Neoplasm; Advanced Solid Tumor

Definition

A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Malignant Solid Neoplasm

Professional guidelines

PubMed

Lorentzen CL, Haanen JB, Met Ö, Svane IM
Lancet Oncol 2022 Oct;23(10):e450-e458. doi: 10.1016/S1470-2045(22)00372-2. PMID: 36174631Free PMC Article
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article
Seymour L, Bogaerts J, Perrone A, Ford R, Schwartz LH, Mandrekar S, Lin NU, Litière S, Dancey J, Chen A, Hodi FS, Therasse P, Hoekstra OS, Shankar LK, Wolchok JD, Ballinger M, Caramella C, de Vries EGE; RECIST working group
Lancet Oncol 2017 Mar;18(3):e143-e152. Epub 2017 Mar 2 doi: 10.1016/S1470-2045(17)30074-8. PMID: 28271869Free PMC Article

Recent clinical studies

Etiology

Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
Sivori S, Pende D, Quatrini L, Pietra G, Della Chiesa M, Vacca P, Tumino N, Moretta F, Mingari MC, Locatelli F, Moretta L
Mol Aspects Med 2021 Aug;80:100870. Epub 2020 Aug 13 doi: 10.1016/j.mam.2020.100870. PMID: 32800530
Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D
EMBO Mol Med 2020 Nov 6;12(11):e11131. Epub 2020 Oct 13 doi: 10.15252/emmm.201911131. PMID: 33047515Free PMC Article
Orr BA
Brain Pathol 2020 May;30(3):664-678. doi: 10.1111/bpa.12837. PMID: 32239782Free PMC Article
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891

Diagnosis

Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
Swanson K, Wu E, Zhang A, Alizadeh AA, Zou J
Cell 2023 Apr 13;186(8):1772-1791. Epub 2023 Mar 10 doi: 10.1016/j.cell.2023.01.035. PMID: 36905928
Yang C, Zhang H, Zhang L, Zhu AX, Bernards R, Qin W, Wang C
Nat Rev Gastroenterol Hepatol 2023 Apr;20(4):203-222. Epub 2022 Nov 11 doi: 10.1038/s41575-022-00704-9. PMID: 36369487
Orr BA
Brain Pathol 2020 May;30(3):664-678. doi: 10.1111/bpa.12837. PMID: 32239782Free PMC Article
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909

Therapy

Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Wagner DL, Fritsche E, Pulsipher MA, Ahmed N, Hamieh M, Hegde M, Ruella M, Savoldo B, Shah NN, Turtle CJ, Wayne AS, Abou-El-Enein M
Nat Rev Clin Oncol 2021 Jun;18(6):379-393. Epub 2021 Feb 25 doi: 10.1038/s41571-021-00476-2. PMID: 33633361Free PMC Article
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Thomas R, Al-Khadairi G, Roelands J, Hendrickx W, Dermime S, Bedognetti D, Decock J
Front Immunol 2018;9:947. Epub 2018 May 1 doi: 10.3389/fimmu.2018.00947. PMID: 29770138Free PMC Article
Mun EJ, Babiker HM, Weinberg U, Kirson ED, Von Hoff DD
Clin Cancer Res 2018 Jan 15;24(2):266-275. Epub 2017 Aug 1 doi: 10.1158/1078-0432.CCR-17-1117. PMID: 28765323

Prognosis

Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Italiano A, Mir O, Mathoulin-Pelissier S, Penel N, Piperno-Neumann S, Bompas E, Chevreau C, Duffaud F, Entz-Werlé N, Saada E, Ray-Coquard I, Lervat C, Gaspar N, Marec-Berard P, Pacquement H, Wright J, Toulmonde M, Bessede A, Crombe A, Kind M, Bellera C, Blay JY
Lancet Oncol 2020 Mar;21(3):446-455. Epub 2020 Feb 17 doi: 10.1016/S1470-2045(19)30825-3. PMID: 32078813Free PMC Article
Fradet Y, Bellmunt J, Vaughn DJ, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Nam K, Frenkl TL, Perini RF, de Wit R, Bajorin DF
Ann Oncol 2019 Jun 1;30(6):970-976. doi: 10.1093/annonc/mdz127. PMID: 31050707Free PMC Article
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891

Clinical prediction guides

Swanson K, Wu E, Zhang A, Alizadeh AA, Zou J
Cell 2023 Apr 13;186(8):1772-1791. Epub 2023 Mar 10 doi: 10.1016/j.cell.2023.01.035. PMID: 36905928
Xie N, Shen G, Gao W, Huang Z, Huang C, Fu L
Signal Transduct Target Ther 2023 Jan 6;8(1):9. doi: 10.1038/s41392-022-01270-x. PMID: 36604431Free PMC Article
Zhao W, Jin L, Chen P, Li D, Gao W, Dong G
Cancer Lett 2022 Oct 1;545:215816. Epub 2022 Jul 8 doi: 10.1016/j.canlet.2022.215816. PMID: 35810989
Hart NH, Crawford-Williams F, Crichton M, Yee J, Smith TJ, Koczwara B, Fitch MI, Crawford GB, Mukhopadhyay S, Mahony J, Cheah C, Townsend J, Cook O, Agar MR, Chan RJ
Crit Rev Oncol Hematol 2022 Aug;176:103728. Epub 2022 Jun 1 doi: 10.1016/j.critrevonc.2022.103728. PMID: 35662585
Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D
EMBO Mol Med 2020 Nov 6;12(11):e11131. Epub 2020 Oct 13 doi: 10.15252/emmm.201911131. PMID: 33047515Free PMC Article

Recent systematic reviews

Rousseau A, Parisi C, Barlesi F
ESMO Open 2023 Apr;8(2):101184. Epub 2023 Mar 16 doi: 10.1016/j.esmoop.2023.101184. PMID: 36933320Free PMC Article
Hart NH, Crawford-Williams F, Crichton M, Yee J, Smith TJ, Koczwara B, Fitch MI, Crawford GB, Mukhopadhyay S, Mahony J, Cheah C, Townsend J, Cook O, Agar MR, Chan RJ
Crit Rev Oncol Hematol 2022 Aug;176:103728. Epub 2022 Jun 1 doi: 10.1016/j.critrevonc.2022.103728. PMID: 35662585
Harding-Theobald E, Louissaint J, Maraj B, Cuaresma E, Townsend W, Mendiratta-Lala M, Singal AG, Su GL, Lok AS, Parikh ND
Aliment Pharmacol Ther 2021 Oct;54(7):890-901. Epub 2021 Aug 12 doi: 10.1111/apt.16563. PMID: 34390014Free PMC Article
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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