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Compression Syndromes, Nerve

MedGen UID:
14333
•Concept ID:
C0027743
•
Disease or Syndrome
Synonyms: Compression Syndrome, Nerve; Nerve Compression Syndrome; Nerve Compression Syndromes; Syndrome, Nerve Compression; Syndromes, Nerve Compression

Definition

Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect. [from MeSH]

Professional guidelines

PubMed

Treatment of Peripheral Nerve Compression Syndromes of the Upper Extremities: a Systematic Review.
Freund G, Dafotakis M, Bahm J, Beier JP
Z Orthop Unfall 2023 Apr;161(2):182-194. Epub 2021 Jul 14 doi: 10.1055/a-1498-3197. PMID: 34261169
Microneurosurgical treatment options in peripheral nerve compression syndromes after chemotherapy and radiation treatment.
Chang EI, Rose MI, Rossi K, Elkwood AI
J Surg Oncol 2018 Oct;118(5):793-799. Epub 2018 Sep 27 doi: 10.1002/jso.25254. PMID: 30261113
Biology and Treatment of Paget's Disease of Bone.
Vallet M, Ralston SH
J Cell Biochem 2016 Feb;117(2):289-99. Epub 2015 Sep 3 doi: 10.1002/jcb.25291. PMID: 26212817

Recent clinical studies

Etiology

Meralgia paresthetica.
Chalk C, Namiranian D
Handb Clin Neurol 2024;201:195-201. doi: 10.1016/B978-0-323-90108-6.00013-2. PMID: 38697741
Proximal Median Nerve Compression: Pronator Syndrome.
Adler JA, Wolf JM
J Hand Surg Am 2020 Dec;45(12):1157-1165. Epub 2020 Sep 4 doi: 10.1016/j.jhsa.2020.07.006. PMID: 32893044
Entrapment neuropathies.
Arnold WD, Elsheikh BH
Neurol Clin 2013 May;31(2):405-24. Epub 2013 Feb 8 doi: 10.1016/j.ncl.2013.01.002. PMID: 23642716
Entrapment neuropathies of the lower extremity.
Craig A
PM R 2013 May;5(5 Suppl):S31-40. Epub 2013 Mar 28 doi: 10.1016/j.pmrj.2013.03.029. PMID: 23542774
Perioperative neuropathies.
Warner MA
Mayo Clin Proc 1998 Jun;73(6):567-74. doi: 10.4065/73.6.567. PMID: 9621866

Diagnosis

Meralgia paresthetica.
Chalk C, Namiranian D
Handb Clin Neurol 2024;201:195-201. doi: 10.1016/B978-0-323-90108-6.00013-2. PMID: 38697741
Meralgia Paresthetica.
Solomons JNT, Sagir A, Yazdi C
Curr Pain Headache Rep 2022 Jul;26(7):525-531. Epub 2022 May 27 doi: 10.1007/s11916-022-01053-7. PMID: 35622311
Entrapment Neuropathies of the Lower Extremity.
Bowley MP, Doughty CT
Med Clin North Am 2019 Mar;103(2):371-382. Epub 2018 Dec 3 doi: 10.1016/j.mcna.2018.10.013. PMID: 30704688
Entrapment Neuropathies of the Upper Extremity.
Doughty CT, Bowley MP
Med Clin North Am 2019 Mar;103(2):357-370. doi: 10.1016/j.mcna.2018.10.012. PMID: 30704687
Entrapment neuropathies of the lower extremity.
Craig A
PM R 2013 May;5(5 Suppl):S31-40. Epub 2013 Mar 28 doi: 10.1016/j.pmrj.2013.03.029. PMID: 23542774

Therapy

Meralgia Paresthetica: Relevance, Diagnosis, and Treatment.
Scholz C, Hohenhaus M, Pedro MT, Uerschels AK, Dengler NF
Dtsch Arztebl Int 2023 Sep 29;120(39):655-661. doi: 10.3238/arztebl.m2023.0170. PMID: 37534445Free PMC Article
Non-surgical treatments for Morton's neuroma: A systematic review.
Thomson L, Aujla RS, Divall P, Bhatia M
Foot Ankle Surg 2020 Oct;26(7):736-743. Epub 2019 Nov 2 doi: 10.1016/j.fas.2019.09.009. PMID: 31718949
Peripheral Neuropathy and Nerve Compression Syndromes in Burns.
Strong AL, Agarwal S, Cederna PS, Levi B
Clin Plast Surg 2017 Oct;44(4):793-803. Epub 2017 Jul 21 doi: 10.1016/j.cps.2017.05.010. PMID: 28888304Free PMC Article
Treatment for ulnar neuropathy at the elbow.
Caliandro P, La Torre G, Padua R, Giannini F, Padua L
Cochrane Database Syst Rev 2016 Nov 15;11(11):CD006839. doi: 10.1002/14651858.CD006839.pub4. PMID: 27845501Free PMC Article
Piriformis syndrome, diagnosis and treatment.
Kirschner JS, Foye PM, Cole JL
Muscle Nerve 2009 Jul;40(1):10-8. doi: 10.1002/mus.21318. PMID: 19466717

Prognosis

Nerve and Muscle Abnormalities.
Rubin DA
Magn Reson Imaging Clin N Am 2020 May;28(2):285-300. Epub 2020 Feb 17 doi: 10.1016/j.mric.2019.12.010. PMID: 32241664
Nerve Entrapments.
Jacobson L, Dengler J, Moore AM
Clin Plast Surg 2020 Apr;47(2):267-278. doi: 10.1016/j.cps.2019.12.006. PMID: 32115052
Double Crush Syndrome.
Kane PM, Daniels AH, Akelman E
J Am Acad Orthop Surg 2015 Sep;23(9):558-62. doi: 10.5435/JAAOS-D-14-00176. PMID: 26306807
Sciatic neuropathy.
Yuen EC, So YT
Neurol Clin 1999 Aug;17(3):617-31, viii. doi: 10.1016/s0733-8619(05)70155-9. PMID: 10393756
Radial neuropathy.
Carlson N, Logigian EL
Neurol Clin 1999 Aug;17(3):499-523, vi. doi: 10.1016/s0733-8619(05)70150-x. PMID: 10393751

Clinical prediction guides

Meralgia Paresthetica: Relevance, Diagnosis, and Treatment.
Scholz C, Hohenhaus M, Pedro MT, Uerschels AK, Dengler NF
Dtsch Arztebl Int 2023 Sep 29;120(39):655-661. doi: 10.3238/arztebl.m2023.0170. PMID: 37534445Free PMC Article
Meralgia Paresthetica.
Solomons JNT, Sagir A, Yazdi C
Curr Pain Headache Rep 2022 Jul;26(7):525-531. Epub 2022 May 27 doi: 10.1007/s11916-022-01053-7. PMID: 35622311
Nerve and Muscle Abnormalities.
Rubin DA
Magn Reson Imaging Clin N Am 2020 May;28(2):285-300. Epub 2020 Feb 17 doi: 10.1016/j.mric.2019.12.010. PMID: 32241664
Nerve Entrapments.
Jacobson L, Dengler J, Moore AM
Clin Plast Surg 2020 Apr;47(2):267-278. doi: 10.1016/j.cps.2019.12.006. PMID: 32115052
Diagnostic criteria for pudendal neuralgia by pudendal nerve entrapment (Nantes criteria).
Labat JJ, Riant T, Robert R, Amarenco G, Lefaucheur JP, Rigaud J
Neurourol Urodyn 2008;27(4):306-10. doi: 10.1002/nau.20505. PMID: 17828787

Recent systematic reviews

The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: a systematic review and meta-analysis.
Jiménez-Del-Barrio S, Cadellans-Arróniz A, Ceballos-Laita L, Estébanez-de-Miguel E, López-de-Celis C, Bueno-Gracia E, Pérez-Bellmunt A
Int Orthop 2022 Feb;46(2):301-312. Epub 2021 Dec 3 doi: 10.1007/s00264-021-05272-2. PMID: 34862562Free PMC Article
Prevalence of Work-Related Musculoskeletal Disorders Among Surgeons and Interventionalists: A Systematic Review and Meta-analysis.
Epstein S, Sparer EH, Tran BN, Ruan QZ, Dennerlein JT, Singhal D, Lee BT
JAMA Surg 2018 Feb 21;153(2):e174947. doi: 10.1001/jamasurg.2017.4947. PMID: 29282463Free PMC Article
The Effectiveness of Neural Mobilization for Neuromusculoskeletal Conditions: A Systematic Review and Meta-analysis.
Basson A, Olivier B, Ellis R, Coppieters M, Stewart A, Mudzi W
J Orthop Sports Phys Ther 2017 Sep;47(9):593-615. Epub 2017 Jul 13 doi: 10.2519/jospt.2017.7117. PMID: 28704626
Effectiveness of Occupational Therapy Interventions for Adults With Musculoskeletal Conditions of the Forearm, Wrist, and Hand: A Systematic Review.
Roll SC, Hardison ME
Am J Occup Ther 2017 Jan/Feb;71(1):7101180010p1-7101180010p12. doi: 10.5014/ajot.2017.023234. PMID: 28027038Free PMC Article
Effectiveness of Nerve Gliding Exercises on Carpal Tunnel Syndrome: A Systematic Review.
Ballestero-Pérez R, Plaza-Manzano G, Urraca-Gesto A, Romo-Romo F, Atín-Arratibel MLÁ, Pecos-Martín D, Gallego-Izquierdo T, Romero-Franco N
J Manipulative Physiol Ther 2017 Jan;40(1):50-59. Epub 2016 Nov 11 doi: 10.1016/j.jmpt.2016.10.004. PMID: 27842937

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