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Metastatic Malignant Neoplasm in the Thymus

MedGen UID:
146356
•Concept ID:
C0686617
•
Neoplastic Process
Synonyms: Metastasis to the Thymus; Metastasis to thymus; Metastatic malignant neoplasm of thymus; Metastatic Malignant Neoplasm to the Thymus; Metastatic malignant neoplasm to thymus; Metastatic Malignant Tumor to the Thymus; Metastatic Neoplasm to the Thymus; Metastatic Tumor to the Thymus; Secondary malignant neoplasm of thymus; Secondary Malignant Neoplasm to the Thymus; Secondary malignant tumor of thymus; Secondary Malignant Tumor to the Thymus
SNOMED CT: Secondary malignant neoplasm of thymus (94632009); Metastatic malignant neoplasm to thymus (94632009); Metastatic malignant neoplasm of thymus (94632009); Metastasis to thymus (94632009); Secondary malignant tumor of thymus (94632009)

Definition

A malignant neoplasm that has spread to the thymus from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Thymus

Professional guidelines

PubMed

Everolimus in the treatment of metastatic thymic epithelial tumors.
Hellyer JA, Ouseph MM, Padda SK, Wakelee HA
Lung Cancer 2020 Nov;149:97-102. Epub 2020 Sep 17 doi: 10.1016/j.lungcan.2020.09.006. PMID: 33007678
Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.
Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Endocr Pathol 2020 Sep;31(3):197-217. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09638-x. PMID: 32632840Free PMC Article
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Recent clinical studies

Etiology

Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA): a multicentre, phase 2 trial.
Sato J, Satouchi M, Itoh S, Okuma Y, Niho S, Mizugaki H, Murakami H, Fujisaka Y, Kozuki T, Nakamura K, Nagasaka Y, Kawasaki M, Yamada T, Machida R, Kuchiba A, Ohe Y, Yamamoto N
Lancet Oncol 2020 Jun;21(6):843-850. doi: 10.1016/S1470-2045(20)30162-5. PMID: 32502444
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Myasthenic syndromes.
Farrugia ME
J R Coll Physicians Edinb 2011 Mar;41(1):43-7; quiz 48. doi: 10.4997/JRCPE.2011.111. PMID: 21365067
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Therapy

Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA): a multicentre, phase 2 trial.
Sato J, Satouchi M, Itoh S, Okuma Y, Niho S, Mizugaki H, Murakami H, Fujisaka Y, Kozuki T, Nakamura K, Nagasaka Y, Kawasaki M, Yamada T, Machida R, Kuchiba A, Ohe Y, Yamamoto N
Lancet Oncol 2020 Jun;21(6):843-850. doi: 10.1016/S1470-2045(20)30162-5. PMID: 32502444
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550
Carcinoid tumor.
Kinova S, Duris I
Bratisl Lek Listy 2001;102(11):495-504. PMID: 11901706

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
The role of targeted therapy in thymic carcinoma.
Krishnan M, Ganti AK
J Oncol Pharm Pract 2019 Oct;25(7):1712-1718. Epub 2019 Jun 4 doi: 10.1177/1078155219852758. PMID: 31159657
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Thymoma and thymic carcinoma.
Venuta F, Rendina EA, Anile M, de Giacomo T, Vitolo D, Coloni GF
Gen Thorac Cardiovasc Surg 2012 Jan;60(1):1-12. Epub 2012 Jan 13 doi: 10.1007/s11748-011-0814-0. PMID: 22237733

Clinical prediction guides

On the Histologic Classification of Thymoma.
Suster D, Suster S
Adv Anat Pathol 2024 Jan 1;31(1):22-33. Epub 2023 Sep 13 doi: 10.1097/PAP.0000000000000412. PMID: 37702296
Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Everolimus in the treatment of metastatic thymic epithelial tumors.
Hellyer JA, Ouseph MM, Padda SK, Wakelee HA
Lung Cancer 2020 Nov;149:97-102. Epub 2020 Sep 17 doi: 10.1016/j.lungcan.2020.09.006. PMID: 33007678
Thymoma and thymic carcinoma.
Venuta F, Rendina EA, Anile M, de Giacomo T, Vitolo D, Coloni GF
Gen Thorac Cardiovasc Surg 2012 Jan;60(1):1-12. Epub 2012 Jan 13 doi: 10.1007/s11748-011-0814-0. PMID: 22237733
Cardiac tamponade.
Knoop T, Willenberg K
Semin Oncol Nurs 1999 Aug;15(3):168-73. doi: 10.1016/s0749-2081(99)80004-7. PMID: 10461701

Recent systematic reviews

Postoperative Radiotherapy for Completely Resected Masaoka/Masaoka-Koga Stage II/III Thymoma Improves Overall Survival: An Updated Meta-Analysis of 4746 Patients.
Tateishi Y, Horita N, Namkoong H, Enomoto T, Takeda A, Kaneko T
J Thorac Oncol 2021 Apr;16(4):677-685. Epub 2021 Jan 27 doi: 10.1016/j.jtho.2020.12.023. PMID: 33515812
Pathological and clinical features of enteric adenocarcinoma of the thymus. A pooled analysis of cases from a reference center and systematic review of the literature.
Conforti F, Tarantino P, Trillo P, Pala L, Zagami P, Pirola S, Di Venosa B, Catania C, Queirolo P, Pennacchioli E, Della Vigna P, Curigliano G, De Pas TM
Cancer Treat Rev 2021 Jan;92:102133. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102133. PMID: 33296826
Adjuvant radiotherapy for thymic epithelial tumors: a systematic review and meta-analysis.
Korst RJ, Kansler AL, Christos PJ, Mandal S
Ann Thorac Surg 2009 May;87(5):1641-7. doi: 10.1016/j.athoracsur.2008.11.022. PMID: 19379938
Primary intrapulmonary thymoma: a systematic review.
Myers PO, Kritikos N, Bongiovanni M, Triponez F, Collaud S, Pache JC, Robert JH
Eur J Surg Oncol 2007 Dec;33(10):1137-41. Epub 2007 Apr 17 doi: 10.1016/j.ejso.2007.02.033. PMID: 17442530

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