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Radiculopathy

MedGen UID:
147133
•Concept ID:
C0700594
•
Disease or Syndrome
Synonym: Radiculopathies
SNOMED CT: Radiculopathy (72274001)
 
Monarch Initiative: MONDO:0002959

Definition

Disease involving a spinal nerve root (see spinal nerve roots) which may result from compression related to intervertebral disk displacement; spinal cord injuries; spinal diseases; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiculopathy

Professional guidelines

PubMed

Low Back Pain, a Comprehensive Review: Pathophysiology, Diagnosis, and Treatment.
Urits I, Burshtein A, Sharma M, Testa L, Gold PA, Orhurhu V, Viswanath O, Jones MR, Sidransky MA, Spektor B, Kaye AD
Curr Pain Headache Rep 2019 Mar 11;23(3):23. doi: 10.1007/s11916-019-0757-1. PMID: 30854609
Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview.
Oliveira CB, Maher CG, Pinto RZ, Traeger AC, Lin CC, Chenot JF, van Tulder M, Koes BW
Eur Spine J 2018 Nov;27(11):2791-2803. Epub 2018 Jul 3 doi: 10.1007/s00586-018-5673-2. PMID: 29971708
Epidemiology, diagnosis, and treatment of neck pain.
Cohen SP
Mayo Clin Proc 2015 Feb;90(2):284-99. doi: 10.1016/j.mayocp.2014.09.008. PMID: 25659245

Recent clinical studies

Etiology

Manual Therapy in Cervical and Lumbar Radiculopathy: A Systematic Review of the Literature.
Kuligowski T, Skrzek A, Cieślik B
Int J Environ Res Public Health 2021 Jun 7;18(11) doi: 10.3390/ijerph18116176. PMID: 34200510Free PMC Article
Cervical Disc Herniations, Radiculopathy, and Myelopathy.
Watkins RG 4th, Watkins RG 3rd
Clin Sports Med 2021 Jul;40(3):513-539. doi: 10.1016/j.csm.2021.03.006. PMID: 34051944
Nonoperative Management of Cervical Radiculopathy.
Childress MA, Becker BA
Am Fam Physician 2016 May 1;93(9):746-54. PMID: 27175952
An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy.
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P 2nd, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF; North American Spine Society
Spine J 2014 Jan;14(1):180-91. Epub 2013 Nov 14 doi: 10.1016/j.spinee.2013.08.003. PMID: 24239490
Reliability and diagnostic accuracy of the clinical examination and patient self-report measures for cervical radiculopathy.
Wainner RS, Fritz JM, Irrgang JJ, Boninger ML, Delitto A, Allison S
Spine (Phila Pa 1976) 2003 Jan 1;28(1):52-62. doi: 10.1097/00007632-200301010-00014. PMID: 12544957

Diagnosis

Musculoskeletal mimics of cervical radiculopathy.
Chiou-Tan FY
Muscle Nerve 2022 Jul;66(1):6-14. Epub 2022 Apr 24 doi: 10.1002/mus.27553. PMID: 35466429
Cervical Disc Herniations, Radiculopathy, and Myelopathy.
Watkins RG 4th, Watkins RG 3rd
Clin Sports Med 2021 Jul;40(3):513-539. doi: 10.1016/j.csm.2021.03.006. PMID: 34051944
Nonoperative Management of Cervical Radiculopathy.
Childress MA, Becker BA
Am Fam Physician 2016 May 1;93(9):746-54. PMID: 27175952
Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment.
Woods BI, Hilibrand AS
J Spinal Disord Tech 2015 Jun;28(5):E251-9. doi: 10.1097/BSD.0000000000000284. PMID: 25985461
Reliability and diagnostic accuracy of the clinical examination and patient self-report measures for cervical radiculopathy.
Wainner RS, Fritz JM, Irrgang JJ, Boninger ML, Delitto A, Allison S
Spine (Phila Pa 1976) 2003 Jan 1;28(1):52-62. doi: 10.1097/00007632-200301010-00014. PMID: 12544957

Therapy

Manual Therapy in Cervical and Lumbar Radiculopathy: A Systematic Review of the Literature.
Kuligowski T, Skrzek A, Cieślik B
Int J Environ Res Public Health 2021 Jun 7;18(11) doi: 10.3390/ijerph18116176. PMID: 34200510Free PMC Article
Manual Therapy as a Management of Cervical Radiculopathy: A Systematic Review.
Borrella-Andrés S, Marqués-García I, Lucha-López MO, Fanlo-Mazas P, Hernández-Secorún M, Pérez-Bellmunt A, Tricás-Moreno JM, Hidalgo-García C
Biomed Res Int 2021;2021:9936981. Epub 2021 Jun 3 doi: 10.1155/2021/9936981. PMID: 34189141Free PMC Article
Two manual therapy techniques for management of lumbar radiculopathy: a randomized clinical trial.
Danazumi MS, Bello B, Yakasai AM, Kaka B
J Osteopath Med 2021 Feb 26;121(4):391-400. doi: 10.1515/jom-2020-0261. PMID: 33705612
Exercises for mechanical neck disorders.
Gross A, Kay TM, Paquin JP, Blanchette S, Lalonde P, Christie T, Dupont G, Graham N, Burnie SJ, Gelley G, Goldsmith CH, Forget M, Hoving JL, Brønfort G, Santaguida PL; Cervical Overview Group
Cochrane Database Syst Rev 2015 Jan 28;1(1):CD004250. doi: 10.1002/14651858.CD004250.pub5. PMID: 25629215Free PMC Article
Reliability and diagnostic accuracy of the clinical examination and patient self-report measures for cervical radiculopathy.
Wainner RS, Fritz JM, Irrgang JJ, Boninger ML, Delitto A, Allison S
Spine (Phila Pa 1976) 2003 Jan 1;28(1):52-62. doi: 10.1097/00007632-200301010-00014. PMID: 12544957

Prognosis

Management Considerations for Total Intervertebral Disc Replacement.
Foreman M, Patel A, Nguyen A, Foster D, Orriols A, Lucke-Wold B
World Neurosurg 2024 Jan;181:125-136. Epub 2023 Sep 28 doi: 10.1016/j.wneu.2023.09.100. PMID: 37777178
A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy.
Taso M, Sommernes JH, Kolstad F, Sundseth J, Bjorland S, Pripp AH, Zwart JA, Brox JI
BMC Musculoskelet Disord 2020 Mar 16;21(1):171. doi: 10.1186/s12891-020-3188-6. PMID: 32178655Free PMC Article
Vertebral artery loops in surgical perspective.
Ekşi MŞ, Toktaş ZO, Yılmaz B, Demir MK, Özcan-Ekşi EE, Bayoumi AB, Yener Y, Akakın A, Konya D
Eur Spine J 2016 Dec;25(12):4171-4180. Epub 2016 Jul 7 doi: 10.1007/s00586-016-4691-1. PMID: 27388018
Cervical radiculopathy.
Polston DW
Neurol Clin 2007 May;25(2):373-85. doi: 10.1016/j.ncl.2007.01.012. PMID: 17445734
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708

Clinical prediction guides

Spinal Manipulation for Subacute and Chronic Lumbar Radiculopathy: A Randomized Controlled Trial.
Ghasabmahaleh SH, Rezasoltani Z, Dadarkhah A, Hamidipanah S, Mofrad RK, Najafi S
Am J Med 2021 Jan;134(1):135-141. Epub 2020 Sep 13 doi: 10.1016/j.amjmed.2020.08.005. PMID: 32931763
How should we grade lumbar disc herniation and nerve root compression? A systematic review.
Li Y, Fredrickson V, Resnick DK
Clin Orthop Relat Res 2015 Jun;473(6):1896-902. doi: 10.1007/s11999-014-3674-y. PMID: 24825130Free PMC Article
Pelvic floor muscle exercise for chronic low back pain.
Bi X, Zhao J, Zhao L, Liu Z, Zhang J, Sun D, Song L, Xia Y
J Int Med Res 2013 Feb;41(1):146-52. Epub 2013 Jan 23 doi: 10.1177/0300060513475383. PMID: 23569140
The flip test: a reappraisal.
Summers B, Mishra V, Jones JM
Spine (Phila Pa 1976) 2009 Jul 1;34(15):1585-9. doi: 10.1097/BRS.0b013e3181aa1bf0. PMID: 19564769
Reliability and diagnostic accuracy of the clinical examination and patient self-report measures for cervical radiculopathy.
Wainner RS, Fritz JM, Irrgang JJ, Boninger ML, Delitto A, Allison S
Spine (Phila Pa 1976) 2003 Jan 1;28(1):52-62. doi: 10.1097/00007632-200301010-00014. PMID: 12544957

Recent systematic reviews

A Systematic Review of Clinical Practice Guidelines for Persons With Non-specific Low Back Pain With and Without Radiculopathy: Identification of Best Evidence for Rehabilitation to Develop the WHO's Package of Interventions for Rehabilitation.
Zaina F, Côté P, Cancelliere C, Di Felice F, Donzelli S, Rauch A, Verville L, Negrini S, Nordin M
Arch Phys Med Rehabil 2023 Nov;104(11):1913-1927. Epub 2023 Mar 23 doi: 10.1016/j.apmr.2023.02.022. PMID: 36963709
Manual Therapy in Cervical and Lumbar Radiculopathy: A Systematic Review of the Literature.
Kuligowski T, Skrzek A, Cieślik B
Int J Environ Res Public Health 2021 Jun 7;18(11) doi: 10.3390/ijerph18116176. PMID: 34200510Free PMC Article
Exercises for mechanical neck disorders.
Gross A, Kay TM, Paquin JP, Blanchette S, Lalonde P, Christie T, Dupont G, Graham N, Burnie SJ, Gelley G, Goldsmith CH, Forget M, Hoving JL, Brønfort G, Santaguida PL; Cervical Overview Group
Cochrane Database Syst Rev 2015 Jan 28;1(1):CD004250. doi: 10.1002/14651858.CD004250.pub5. PMID: 25629215Free PMC Article
An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy.
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P 2nd, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF; North American Spine Society
Spine J 2014 Jan;14(1):180-91. Epub 2013 Nov 14 doi: 10.1016/j.spinee.2013.08.003. PMID: 24239490
Neck pain.
Binder AI
BMJ Clin Evid 2008 Aug 4;2008 PMID: 19445809Free PMC Article

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