U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lung Diseases, Obstructive

MedGen UID:
154671
•Concept ID:
C0600260
•
Disease or Syndrome
Synonyms: Lung Disease, Obstructive; Obstructive Lung Disease; Obstructive Lung Diseases; Obstructive Pulmonary Disease; Obstructive Pulmonary Diseases; Pulmonary Disease, Obstructive; Pulmonary Diseases, Obstructive

Definition

Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent. [from MeSH]

Professional guidelines

PubMed

Inhalation therapy devices for the treatment of obstructive lung diseases: the history of inhalers towards the ideal inhaler.
Sorino C, Negri S, Spanevello A, Visca D, Scichilone N
Eur J Intern Med 2020 May;75:15-18. Epub 2020 Feb 26 doi: 10.1016/j.ejim.2020.02.023. PMID: 32113944
Statins in the treatment of COPD and asthma-where do we stand?
So JY, Dhungana S, Beros JJ, Criner GJ
Curr Opin Pharmacol 2018 Jun;40:26-33. Epub 2018 Jan 13 doi: 10.1016/j.coph.2018.01.001. PMID: 29334676
Outpatient Management for Acute Exacerbations of Obstructive Lung Diseases.
Marsh B, Drake MG
Med Clin North Am 2017 May;101(3):537-551. Epub 2017 Mar 9 doi: 10.1016/j.mcna.2016.12.008. PMID: 28372712

Recent clinical studies

Etiology

Is there a role for screening spirometry?
MacIntyre NR, Selecky PA
Respir Care 2010 Jan;55(1):35-42. PMID: 20040122
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary.
Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS; GOLD Scientific Committee
Am J Respir Crit Care Med 2001 Apr;163(5):1256-76. doi: 10.1164/ajrccm.163.5.2101039. PMID: 11316667
Exacerbations of COPD: environmental mechanisms.
MacNee W, Donaldson K
Chest 2000 May;117(5 Suppl 2):390S-7S. doi: 10.1378/chest.117.5_suppl_2.390s. PMID: 10843983
Lung Transplantation for COPD.
Trulock EP 3rd
Chest 1998 Apr;113(4 Suppl):269S-276S. doi: 10.1378/chest.113.4_supplement.269s. PMID: 9552017
Respiratory symptoms.
Burge S
Occup Med (Lond) 1997 Jan;47(1):55-6. doi: 10.1093/occmed/47.1.55. PMID: 9136220

Diagnosis

Editorial overview: Pulmonary 2020 - advances in the pharmacology of obstructive lung diseases.
Deshpande DA
Curr Opin Pharmacol 2020 Apr;51:iii-vii. doi: 10.1016/j.coph.2020.08.016. PMID: 32994043
Spirometry.
Patra KP
Pediatr Rev 2012 Oct;33(10):469-72. doi: 10.1542/pir.33-10-469. PMID: 23027602
Is there a role for screening spirometry?
MacIntyre NR, Selecky PA
Respir Care 2010 Jan;55(1):35-42. PMID: 20040122
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary.
Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS; GOLD Scientific Committee
Am J Respir Crit Care Med 2001 Apr;163(5):1256-76. doi: 10.1164/ajrccm.163.5.2101039. PMID: 11316667
Spirometry.
Ruppel GL
Respir Care Clin N Am 1997 Jun;3(2):155-81. PMID: 9390907

Therapy

Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer.
Truong KK, Lam MT, Grandner MA, Sassoon CS, Malhotra A
Ann Am Thorac Soc 2016 Jul;13(7):1144-54. doi: 10.1513/AnnalsATS.201602-125FR. PMID: 27104378Free PMC Article
Almitrine bismesylate.
Smith PD, Gotz VP, Ryerson GG
Drug Intell Clin Pharm 1987 May;21(5):417-21. doi: 10.1177/106002808702100503. PMID: 3556128
Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.
Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA
Ann Intern Med 1987 Feb;106(2):196-204. doi: 10.7326/0003-4819-106-2-196. PMID: 3492164
Long-term oxygen therapy.
Anthonisen NR
Ann Intern Med 1983 Oct;99(4):519-27. doi: 10.7326/0003-4819-99-4-519. PMID: 6354031
Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group.
Ann Intern Med 1980 Sep;93(3):391-8. doi: 10.7326/0003-4819-93-3-391. PMID: 6776858

Prognosis

Integrating the overlap of obstructive lung disease and obstructive sleep apnoea: OLDOSA syndrome.
Ioachimescu OC, Teodorescu M
Respirology 2013 Apr;18(3):421-31. doi: 10.1111/resp.12062. PMID: 23368952
Exacerbations of COPD: environmental mechanisms.
MacNee W, Donaldson K
Chest 2000 May;117(5 Suppl 2):390S-7S. doi: 10.1378/chest.117.5_suppl_2.390s. PMID: 10843983
Cigarette smoking and women's respiratory health.
Tanoue LT
Clin Chest Med 2000 Mar;21(1):47-65, viii. doi: 10.1016/s0272-5231(05)70007-1. PMID: 10763089
Lung Transplantation for COPD.
Trulock EP 3rd
Chest 1998 Apr;113(4 Suppl):269S-276S. doi: 10.1378/chest.113.4_supplement.269s. PMID: 9552017
Lung cancer and chronic obstructive pulmonary disease.
Petty TL
Med Clin North Am 1996 May;80(3):645-55. doi: 10.1016/s0025-7125(05)70458-2. PMID: 8637308

Clinical prediction guides

Impact of bronchial wall thickness on airflow obstruction in bronchiectasis.
Yamamoto Y, Kuge T, Miki K, Tsujino K, Kawasaki T, Matsuki T, Miki M, Mori M, Kida H
Respir Physiol Neurobiol 2022 Jan;295:103788. Epub 2021 Sep 23 doi: 10.1016/j.resp.2021.103788. PMID: 34555525
Respiratory symptoms and 30 year mortality from obstructive lung disease and pneumonia.
Frostad A, Soyseth V, Haldorsen T, Andersen A, Gulsvik A
Thorax 2006 Nov;61(11):951-6. Epub 2006 Jun 29 doi: 10.1136/thx.2006.059436. PMID: 16809414Free PMC Article
Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease.
Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA
Thorax 1999 Jul;54(7):581-6. doi: 10.1136/thx.54.7.581. PMID: 10377201Free PMC Article
Analysis of variability in interpretation of spirometric tests.
Quadrelli SA, Roncoroni AJ, Porcel G
Respiration 1996;63(3):131-6. doi: 10.1159/000196532. PMID: 8739481
A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
Jones PW, Quirk FH, Baveystock CM, Littlejohns P
Am Rev Respir Dis 1992 Jun;145(6):1321-7. doi: 10.1164/ajrccm/145.6.1321. PMID: 1595997

Recent systematic reviews

Therapeutic effect of nebulized hypertonic saline for muco-obstructive lung diseases: a systematic review and meta-analysis with trial sequential analysis.
Zhang Y, Song A, Liu J, Dai J, Lin J
J Investig Med 2021 Mar;69(3):742-748. Epub 2020 Dec 3 doi: 10.1136/jim-2020-001479. PMID: 33272932
Risk of obstructive pulmonary diseases and occupational exposure to pesticides: a systematic review and meta-analysis.
Pourhassan B, Meysamie A, Alizadeh S, Habibian A, Beigzadeh Z
Public Health 2019 Sep;174:31-41. Epub 2019 Jul 12 doi: 10.1016/j.puhe.2019.05.024. PMID: 31306887
Physical activity, sedentary behaviour and sleep in COPD guidelines: A systematic review.
Lewthwaite H, Effing TW, Olds T, Williams MT
Chron Respir Dis 2017 Aug;14(3):231-244. Epub 2017 Feb 24 doi: 10.1177/1479972316687224. PMID: 28774202Free PMC Article
Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis.
Saad NJ, Patel J, Burney P, Minelli C
Ann Am Thorac Soc 2017 Jun;14(6):994-1004. doi: 10.1513/AnnalsATS.201609-746SR. PMID: 28362513
Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?
Muñoz-Torrico M, Rendon A, Centis R, D'Ambrosio L, Fuentes Z, Torres-Duque C, Mello F, Dalcolmo M, Pérez-Padilla R, Spanevello A, Migliori GB
J Bras Pneumol 2016 Sep-Oct;42(5):374-385. doi: 10.1590/S1806-37562016000000226. PMID: 27812638Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...